Clobetasol propionate_RPMI-7951 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in RPMI-7951 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_RPMI-7951 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.213463
AKAP12 A kinase (PRKA) anchor protein 12 0.0926387
PTPRG protein tyrosine phosphatase, receptor type, G 0.0823845
NAV2 neuron navigator 2 0.075935
IRAK3 interleukin-1 receptor-associated kinase 3 0.0748939
ESYT2 extended synaptotagmin-like protein 2 0.0679033
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0613502
SH3RF3 SH3 domain containing ring finger 3 0.0514719
HMGA2 high mobility group AT-hook 2 0.049784
ABLIM3 actin binding LIM protein family, member 3 0.0486983
TOP1 topoisomerase (DNA) I 0.0469691
ZMYND8 zinc finger, MYND-type containing 8 0.0463965
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0410215
HIPK2 homeodomain interacting protein kinase 2 0.0384698
MT1E metallothionein 1E 0.0376868
HIP1 huntingtin interacting protein 1 0.0348815
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0345642
CD109 CD109 molecule 0.0345067
MT1X metallothionein 1X 0.0327759
MYO1B myosin IB 0.0311551
SDK1 sidekick cell adhesion molecule 1 0.0302161
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0299052
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0291352
FAM13A family with sequence similarity 13, member A 0.0285847
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0274085
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0268331
CENPF centromere protein F, 350/400kDa 0.0254652
PID1 phosphotyrosine interaction domain containing 1 0.0252002
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.024711
FNDC3A fibronectin type III domain containing 3A 0.0245652
TGM2 transglutaminase 2 0.0239528
JPH2 junctophilin 2 0.0237993
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0228357
RBM39 RNA binding motif protein 39 0.0218595
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0209682
LAMB1 laminin, beta 1 0.0205511
PCBP3 poly(rC) binding protein 3 0.0205263
LOX lysyl oxidase 0.0199155
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0198998
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0194839
ZEB2 zinc finger E-box binding homeobox 2 0.0190754
TRAM2 translocation associated membrane protein 2 0.0189911
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0187316
SNAP25 synaptosomal-associated protein, 25kDa 0.0186345
YEATS2 YEATS domain containing 2 0.0185373
SNED1 sushi, nidogen and EGF-like domains 1 0.0180055
SETD5 SET domain containing 5 0.0179667
ANKRD28 ankyrin repeat domain 28 0.0166391
DIAPH3 diaphanous-related formin 3 0.0165994
SSBP2 single-stranded DNA binding protein 2 0.0162528
TSC22D3 TSC22 domain family, member 3 0.0162016
TFG TRK-fused gene 0.0160783
FOXO3 forkhead box O3 0.0156742
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.015403
CACNA1C calcium channel, voltage-dependent, L type, alpha 1C subunit 0.0153702
RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 0.0150655
LPAR1 lysophosphatidic acid receptor 1 0.0146406
FKBP5 FK506 binding protein 5 0.0143518
ZNF292 zinc finger protein 292 0.0143511
PER1 period circadian clock 1 0.0142716
OGA O-GlcNAcase 0.0141983
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0141172
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0140936
FN1 fibronectin 1 0.0140334
DNER delta/notch-like EGF repeat containing 0.0139007
CDK19 cyclin-dependent kinase 19 0.0137862
PTBP2 polypyrimidine tract binding protein 2 0.0135823
DDR2 discoidin domain receptor tyrosine kinase 2 0.0135524
XPO1 exportin 1 0.0135331
PDLIM5 PDZ and LIM domain 5 0.0131659
SEC23A Sec23 homolog A (S. cerevisiae) 0.0130505
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0130251
FOXO1 forkhead box O1 0.012976
ZNF148 zinc finger protein 148 0.0129558
AKAP13 A kinase (PRKA) anchor protein 13 0.0126703
CCN4 cellular communication network factor 4 0.0126288
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0124922
TMEM39A transmembrane protein 39A 0.0123648
ANGPTL4 angiopoietin-like 4 0.0123377
AUH AU RNA binding protein/enoyl-CoA hydratase 0.0122749
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0122123
STXBP5 syntaxin binding protein 5 (tomosyn) 0.012132
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0120498
HELZ helicase with zinc finger 0.0120438
GIGYF2 GRB10 interacting GYF protein 2 0.0120289
DAAM2 dishevelled associated activator of morphogenesis 2 0.0118876
SNX13 sorting nexin 13 0.0118762
FNIP1 folliculin interacting protein 1 0.0118751
AGFG1 ArfGAP with FG repeats 1 0.0118639
UGP2 UDP-glucose pyrophosphorylase 2 0.0118268
NCOA3 nuclear receptor coactivator 3 0.0117876
CRLS1 cardiolipin synthase 1 0.0116206
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.011606
TPX2 TPX2, microtubule-associated 0.0114853
NUP58 nucleoporin 58 0.0111618
ELL2 elongation factor, RNA polymerase II, 2 0.0110914
SLC19A2 solute carrier family 19 (thiamine transporter), member 2 0.0110354
ECT2 epithelial cell transforming 2 0.0110322
ZNF451 zinc finger protein 451 0.01093
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0109041

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.344592
TIMP3 TIMP metallopeptidase inhibitor 3 -0.165399
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.162684
B2M beta-2-microglobulin -0.16245
STC1 stanniocalcin 1 -0.152097
HLA-B major histocompatibility complex, class I, B -0.146793
COL1A2 collagen, type I, alpha 2 -0.141629
CXCL8 chemokine (C-X-C motif) ligand 8 -0.127742
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.11917
COL1A1 collagen, type I, alpha 1 -0.110946
FRMD4A FERM domain containing 4A -0.103519
FTL ferritin, light polypeptide -0.102158
NDRG1 N-myc downstream regulated 1 -0.101854
CD44 CD44 molecule (Indian blood group) -0.0948749
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0944817
PSD3 pleckstrin and Sec7 domain containing 3 -0.0901884
EXT1 exostosin glycosyltransferase 1 -0.0743681
TMSB10 thymosin beta 10 -0.0719056
INHBA inhibin, beta A -0.0717557
IFI6 interferon, alpha-inducible protein 6 -0.0670424
TFPI2 tissue factor pathway inhibitor 2 -0.0669655
PTMA prothymosin, alpha -0.0648997
COL6A2 collagen, type VI, alpha 2 -0.064719
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0643556
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0637073
CDH13 cadherin 13 -0.0600559
TPM1 tropomyosin 1 (alpha) -0.05878
SP100 SP100 nuclear antigen -0.057074
NAV1 neuron navigator 1 -0.0569731
COL6A1 collagen, type VI, alpha 1 -0.0568838
POTEF POTE ankyrin domain family, member F -0.0560572
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0556258
IGFBP3 insulin-like growth factor binding protein 3 -0.0550998
LOXL2 lysyl oxidase-like 2 -0.0550054
HLA-A major histocompatibility complex, class I, A -0.0541825
IFIH1 interferon induced with helicase C domain 1 -0.0515338
NRP1 neuropilin 1 -0.0513854
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0507289
IER3 immediate early response 3 -0.0504748
TPT1 tumor protein, translationally-controlled 1 -0.049932
ENO1 enolase 1, (alpha) -0.0486024
TPM4 tropomyosin 4 -0.0481914
IL1B interleukin 1, beta -0.0466771
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0466337
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0461026
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0455351
EML5 echinoderm microtubule associated protein like 5 -0.0453655
RPLP1 ribosomal protein, large, P1 -0.0437487
APCDD1L adenomatosis polyposis coli down-regulated 1-like -0.0433185
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0424268
EGR1 early growth response 1 -0.0422361
IFITM3 interferon induced transmembrane protein 3 -0.0422095
CEMIP cell migration inducing protein, hyaluronan binding -0.0422012
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.041285
TNNC1 troponin C type 1 (slow) -0.039972
PKM pyruvate kinase, muscle -0.0399395
RPS6 ribosomal protein S6 -0.039814
CALR calreticulin -0.0394982
TMEM178B transmembrane protein 178B -0.0394089
HDAC9 histone deacetylase 9 -0.0393719
ZBTB38 zinc finger and BTB domain containing 38 -0.039214
IFI16 interferon, gamma-inducible protein 16 -0.0391691
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0386087
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0374435
TRIO trio Rho guanine nucleotide exchange factor -0.037246
ZBTB20 zinc finger and BTB domain containing 20 -0.0367344
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0362652
LOC102724023 ES1 protein homolog, mitochondrial -0.0361361
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0359803
HLA-C major histocompatibility complex, class I, C -0.0357943
ARL4C ADP-ribosylation factor-like 4C -0.0355824
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0354961
IFI44L interferon-induced protein 44-like -0.0351549
SLIT2 slit homolog 2 (Drosophila) -0.0347981
ZEB1 zinc finger E-box binding homeobox 1 -0.0347488
COL5A3 collagen, type V, alpha 3 -0.0339853
ACTG1 actin gamma 1 -0.0339672
TGFBI transforming growth factor, beta-induced, 68kDa -0.0336666
S100A6 S100 calcium binding protein A6 -0.0335661
DLG1 discs, large homolog 1 (Drosophila) -0.0329383
GNAS GNAS complex locus -0.0324018
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0319783
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0318793
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0316815
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0314719
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0314541
MX2 MX dynamin-like GTPase 2 -0.0311788
RIGI RNA sensor RIG-I -0.0307222
ICAM1 intercellular adhesion molecule 1 -0.0306034
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0302155
BHLHE40 basic helix-loop-helix family, member e40 -0.0301162
EPSTI1 epithelial stromal interaction 1 (breast) -0.0300166
RPL35A ribosomal protein L35a -0.0299263
PMP22 peripheral myelin protein 22 -0.0298087
CADM1 cell adhesion molecule 1 -0.0294471
MX1 MX dynamin-like GTPase 1 -0.0294387
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0294016
HLA-E major histocompatibility complex, class I, E -0.0292491
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0291088
MMP2 matrix metallopeptidase 2 -0.0290804