Clobetasol propionate_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.188263
ARHGAP26 Rho GTPase activating protein 26 0.146019
DNAH5 dynein, axonemal, heavy chain 5 0.13478
PDE4D phosphodiesterase 4D, cAMP-specific 0.115631
TRIO trio Rho guanine nucleotide exchange factor 0.0739711
SASH1 SAM and SH3 domain containing 1 0.0720274
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0718516
TACC2 transforming, acidic coiled-coil containing protein 2 0.066115
SPIDR scaffolding protein involved in DNA repair 0.0655923
ZBTB16 zinc finger and BTB domain containing 16 0.0653465
CEMIP cell migration inducing protein, hyaluronan binding 0.0651082
NAMPT nicotinamide phosphoribosyltransferase 0.0632894
STXBP5 syntaxin binding protein 5 (tomosyn) 0.06308
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.061596
FNDC3A fibronectin type III domain containing 3A 0.0606859
TOX thymocyte selection-associated high mobility group box 0.0582628
TPK1 thiamin pyrophosphokinase 1 0.0557665
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0554721
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0500554
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0495425
PEG10 paternally expressed 10 0.0483307
NEBL nebulette 0.0430102
LIFR leukemia inhibitory factor receptor alpha 0.0404771
TENM1 teneurin transmembrane protein 1 0.0403103
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0392823
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.037338
THSD7A thrombospondin, type I, domain containing 7A 0.0369083
TXNRD1 thioredoxin reductase 1 0.0365812
FGL1 fibrinogen-like 1 0.0361758
OTULINL OTU deubiquitinase with linear linkage specificity like 0.0356858
FMN1 formin 1 0.0326445
ARHGAP24 Rho GTPase activating protein 24 0.0312894
IRS2 insulin receptor substrate 2 0.0309054
MTUS1 microtubule associated tumor suppressor 1 0.0308395
MBNL1 muscleblind-like splicing regulator 1 0.030593
ZNF804A zinc finger protein 804A 0.0305608
FOXO1 forkhead box O1 0.0300614
PSD3 pleckstrin and Sec7 domain containing 3 0.0296309
RNF150 ring finger protein 150 0.0294088
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0293612
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0289284
AGBL4 ATP/GTP binding protein-like 4 0.0286088
FAT1 FAT atypical cadherin 1 0.0278025
NNMT nicotinamide N-methyltransferase 0.0265367
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0262862
SLC38A2 solute carrier family 38, member 2 0.0260684
NFIA nuclear factor I/A 0.0247534
CADM2 cell adhesion molecule 2 0.024137
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0240489
STXBP5L syntaxin binding protein 5-like 0.0239291
HDAC4 histone deacetylase 4 0.0236455
RTN4 reticulon 4 0.0233896
SSBP2 single-stranded DNA binding protein 2 0.0233191
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0227813
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0225708
ADGRB3 adhesion G protein-coupled receptor B3 0.0225426
METAP2 methionyl aminopeptidase 2 0.0222344
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0220493
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0218937
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like 0.0215859
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0213034
ARHGAP5 Rho GTPase activating protein 5 0.0209662
DPYD dihydropyrimidine dehydrogenase 0.0205853
DISC1 disrupted in schizophrenia 1 0.020531
UGP2 UDP-glucose pyrophosphorylase 2 0.0204701
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0203532
KLF9 Kruppel-like factor 9 0.0201891
MGAT4C MGAT4 family, member C 0.020072
AOPEP aminopeptidase O (putative) 0.0196844
ATF6 activating transcription factor 6 0.0195491
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0193136
PCM1 pericentriolar material 1 0.019141
MIPOL1 mirror-image polydactyly 1 0.0189866
SIK2 salt-inducible kinase 2 0.0186783
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0186654
RIPOR2 RHO family interacting cell polarization regulator 2 0.0185852
TSR1 TSR1, 20S rRNA accumulation, homolog (S. cerevisiae) 0.018482
DNER delta/notch-like EGF repeat containing 0.0179864
LPP LIM domain containing preferred translocation partner in lipoma 0.0178575
NAA25 N(alpha)-acetyltransferase 25, NatB auxiliary subunit 0.0177497
PM20D1 peptidase M20 domain containing 1 0.0177294
CHD1 chromodomain helicase DNA binding protein 1 0.0174833
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0174655
TENT5A terminal nucleotidyltransferase 5A 0.017451
SCFD2 sec1 family domain containing 2 0.017299
PER1 period circadian clock 1 0.0172711
MCF2L MCF.2 cell line derived transforming sequence-like 0.0172655
ABLIM3 actin binding LIM protein family, member 3 0.0171936
RNF144A ring finger protein 144A 0.016619
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0164487
SOD2 superoxide dismutase 2, mitochondrial 0.0164484
SINHCAF SIN3-HDAC complex associated factor 0.0161617
WRN Werner syndrome, RecQ helicase-like 0.0160552
MAN2A1 mannosidase, alpha, class 2A, member 1 0.0160173
SFPQ splicing factor proline/glutamine-rich 0.0159707
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.015967
XRN2 5'-3' exoribonuclease 2 0.0159256
OSBPL9 oxysterol binding protein-like 9 0.0158754
KCNMB4 potassium channel subfamily M regulatory beta subunit 4 0.0157622
NLRP5 NLR family, pyrin domain containing 5 0.015762

decreased expression

Symbol Name Standardized Value
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.156906
GPC6 glypican 6 -0.145717
NRG1 neuregulin 1 -0.144055
NDRG1 N-myc downstream regulated 1 -0.136561
NALF1 NALCN channel auxiliary factor 1 -0.132343
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.12928
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0954679
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0911225
RORA RAR-related orphan receptor A -0.0899367
SNTG1 syntrophin, gamma 1 -0.0821447
STC1 stanniocalcin 1 -0.0773806
SMYD3 SET and MYND domain containing 3 -0.0767342
ESRRG estrogen-related receptor gamma -0.0763634
IGFBP5 insulin-like growth factor binding protein 5 -0.0745681
DTNA dystrobrevin, alpha -0.0736029
TSHZ2 teashirt zinc finger homeobox 2 -0.0728426
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0721652
MCL1 myeloid cell leukemia 1 -0.0703794
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.06954
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.066017
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0659772
CNKSR3 CNKSR family member 3 -0.0642635
ENO1 enolase 1, (alpha) -0.0634295
ACTG1 actin gamma 1 -0.0617797
GPC5 glypican 5 -0.0605327
ZBTB20 zinc finger and BTB domain containing 20 -0.0604437
GMDS GDP-mannose 4,6-dehydratase -0.0599621
PTMA prothymosin, alpha -0.058292
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0575768
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0573572
EFNA5 ephrin-A5 -0.0571023
INHBA inhibin, beta A -0.0556192
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0521832
SCG2 secretogranin II -0.050166
KIF26B kinesin family member 26B -0.0498105
COL22A1 collagen, type XXII, alpha 1 -0.048537
MCTP1 multiple C2 domains, transmembrane 1 -0.0480437
CALCA calcitonin-related polypeptide alpha -0.0478164
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0477087
RIT2 Ras-like without CAAX 2 -0.0464068
GRB10 growth factor receptor-bound protein 10 -0.0454094
ST18 suppression of tumorigenicity 18, zinc finger -0.0445323
FTL ferritin, light polypeptide -0.0438734
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0421658
SMOC1 SPARC related modular calcium binding 1 -0.0415539
VGF VGF nerve growth factor inducible -0.0408797
CPE carboxypeptidase E -0.0400802
RPS21 ribosomal protein S21 -0.0392164
RNF213 ring finger protein 213 -0.0390011
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0381637
PTCHD4 patched domain containing 4 -0.0379642
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0376375
PITPNM2 phosphatidylinositol transfer protein, membrane-associated 2 -0.037252
EGR1 early growth response 1 -0.0370233
LSAMP limbic system-associated membrane protein -0.0368663
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0351108
RPS6 ribosomal protein S6 -0.0347769
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0346108
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0341006
NELL1 NEL-like 1 (chicken) -0.0337401
ASIC2 acid sensing (proton gated) ion channel 2 -0.0336118
BACE2 beta-site APP-cleaving enzyme 2 -0.0329685
EPHA6 EPH receptor A6 -0.0323976
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0323911
BCL2 B-cell CLL/lymphoma 2 -0.0323122
CHGB chromogranin B -0.0319861
KLHL29 kelch-like family member 29 -0.0312355
RPL37A ribosomal protein L37a -0.0310719
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0305601
RPS3 ribosomal protein S3 -0.0304741
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0304394
S100A9 S100 calcium binding protein A9 -0.029998
ARFGEF3 ARFGEF family member 3 -0.0299645
NAV1 neuron navigator 1 -0.0294217
GNAS GNAS complex locus -0.0290096
MT2A metallothionein 2A -0.0289899
PDE8A phosphodiesterase 8A -0.0285114
DGKB diacylglycerol kinase, beta 90kDa -0.0282398
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0281792
CADM1 cell adhesion molecule 1 -0.0277791
LRFN2 leucine rich repeat and fibronectin type III domain containing 2 -0.0275809
ZFHX3 zinc finger homeobox 3 -0.0274738
FAM13A family with sequence similarity 13, member A -0.0274482
RPL8 ribosomal protein L8 -0.0274267
ZSWIM5 zinc finger, SWIM-type containing 5 -0.0273574
PGK1 phosphoglycerate kinase 1 -0.0268617
KTN1 kinectin 1 (kinesin receptor) -0.0265356
CHD7 chromodomain helicase DNA binding protein 7 -0.0263193
DENND4A DENN/MADD domain containing 4A -0.0251811
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.024742
RPL26 ribosomal protein L26 -0.0245778
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0244196
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0243741
TMSB10 thymosin beta 10 -0.0243475
IQSEC1 IQ motif and Sec7 domain 1 -0.0242267
RPS8 ribosomal protein S8 -0.0240345
DENND1A DENN/MADD domain containing 1A -0.0239753
SVIL supervillin -0.0239189
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0238187
SERGEF secretion regulating guanine nucleotide exchange factor -0.0237313