Clobetasol propionate_SK-MEL-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in SK-MEL-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_SK-MEL-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.28591
FMN1 formin 1 0.190883
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.116619
AKAP13 A kinase (PRKA) anchor protein 13 0.0704317
FNDC3B fibronectin type III domain containing 3B 0.0683449
NLGN1 neuroligin 1 0.0599938
ZMYND8 zinc finger, MYND-type containing 8 0.057469
LINGO2 leucine rich repeat and Ig domain containing 2 0.0538774
OSBPL10 oxysterol binding protein-like 10 0.053433
SLC26A2 solute carrier family 26 (anion exchanger), member 2 0.0529669
ABLIM3 actin binding LIM protein family, member 3 0.0520623
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0487138
CD109 CD109 molecule 0.0482935
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0482278
ANKRD28 ankyrin repeat domain 28 0.0443033
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0431776
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0430689
PLAT plasminogen activator, tissue 0.0418515
PTPRG protein tyrosine phosphatase, receptor type, G 0.0411149
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0395156
ARHGAP26 Rho GTPase activating protein 26 0.0389341
NAV2 neuron navigator 2 0.0377886
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0377659
NRG3 neuregulin 3 0.0373703
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0368767
IL6ST interleukin 6 signal transducer 0.0352722
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0308412
CCND3 cyclin D3 0.0305516
LPP LIM domain containing preferred translocation partner in lipoma 0.0300628
CDK6 cyclin-dependent kinase 6 0.02974
FKBP5 FK506 binding protein 5 0.0282663
TBC1D5 TBC1 domain family, member 5 0.0276366
FHIT fragile histidine triad 0.0270004
DST dystonin 0.0258881
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0254341
RPGR retinitis pigmentosa GTPase regulator 0.0251769
TRABD2B TraB domain containing 2B 0.0239765
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0239493
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0236342
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0235702
GALNT18 polypeptide N-acetylgalactosaminyltransferase 18 0.0233852
HIPK2 homeodomain interacting protein kinase 2 0.0233729
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0228543
USP53 ubiquitin specific peptidase 53 0.0223296
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0218075
RNF144A ring finger protein 144A 0.0215065
LSAMP limbic system-associated membrane protein 0.0210627
SOD2 superoxide dismutase 2, mitochondrial 0.0209433
TENM1 teneurin transmembrane protein 1 0.0207635
SFPQ splicing factor proline/glutamine-rich 0.02046
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0201368
ARMC8 armadillo repeat containing 8 0.0200515
AHNAK AHNAK nucleoprotein 0.0197439
PYGB phosphorylase, glycogen; brain 0.0195143
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0194414
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.019309
MSN moesin 0.0192361
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 0.0191744
EXOC4 exocyst complex component 4 0.0188412
EMP1 epithelial membrane protein 1 0.0187254
CADM1 cell adhesion molecule 1 0.0182343
APOLD1 apolipoprotein L domain containing 1 0.0181759
FBXL17 F-box and leucine-rich repeat protein 17 0.0179572
RAD51B RAD51 paralog B 0.0178826
SOX6 SRY (sex determining region Y)-box 6 0.017768
FNDC3A fibronectin type III domain containing 3A 0.0175084
AGTPBP1 ATP/GTP binding protein 1 0.0170805
NPAS2 neuronal PAS domain protein 2 0.0168928
BBS9 Bardet-Biedl syndrome 9 0.016886
HDAC9 histone deacetylase 9 0.0162704
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0162337
CRYBG3 beta-gamma crystallin domain containing 3 0.0161946
PRELID2 PRELI domain containing 2 0.015784
NHSL1 NHS-like 1 0.0157839
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0156411
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0156218
ANO4 anoctamin 4 0.0155262
TRIP12 thyroid hormone receptor interactor 12 0.0154088
DPYD dihydropyrimidine dehydrogenase 0.0153108
TUSC3 tumor suppressor candidate 3 0.0152552
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0151903
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0151633
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 0.0150993
ZNF608 zinc finger protein 608 0.0150736
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0150355
CPEB2 cytoplasmic polyadenylation element binding protein 2 0.0150056
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.0149336
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0148967
SNX30 sorting nexin family member 30 0.014892
GAS7 growth arrest-specific 7 0.0147769
NFE2L1 nuclear factor, erythroid 2-like 1 0.0146295
OTUD7B OTU deubiquitinase 7B 0.0145485
MYO1B myosin IB 0.0144904
MACROD2 MACRO domain containing 2 0.0144299
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 0.0143325
ECPAS Ecm29 proteasome adaptor and scaffold 0.0142234
SUMF1 sulfatase modifying factor 1 0.0142043
RNF13 ring finger protein 13 0.0141466
DAAM2 dishevelled associated activator of morphogenesis 2 0.0141279
SPAG9 sperm associated antigen 9 0.014123

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.274971
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.20427
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.141949
MT2A metallothionein 2A -0.136645
FN1 fibronectin 1 -0.11544
RPS3 ribosomal protein S3 -0.103706
TMSB10 thymosin beta 10 -0.0942253
FTL ferritin, light polypeptide -0.0892748
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0813406
RPS6 ribosomal protein S6 -0.0788333
RPL35A ribosomal protein L35a -0.0766466
EIF1 eukaryotic translation initiation factor 1 -0.06685
RPLP1 ribosomal protein, large, P1 -0.0657633
PTMA prothymosin, alpha -0.0605644
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0605537
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0597417
NDRG1 N-myc downstream regulated 1 -0.057556
RPL23 ribosomal protein L23 -0.0564425
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0544656
GOLGA4 golgin A4 -0.0495897
RPS8 ribosomal protein S8 -0.0495508
PMEL premelanosome protein -0.0483008
RPL34 ribosomal protein L34 -0.0455405
ACTG1 actin gamma 1 -0.0441457
TPT1 tumor protein, translationally-controlled 1 -0.0433726
SQSTM1 sequestosome 1 -0.0425014
RACK1 receptor for activated C kinase 1 -0.042099
NAP1L1 nucleosome assembly protein 1-like 1 -0.041878
RPL12 ribosomal protein L12 -0.0409267
RPL32 ribosomal protein L32 -0.0407811
RPL31 ribosomal protein L31 -0.0402901
RPS23 ribosomal protein S23 -0.040024
TPI1 triosephosphate isomerase 1 -0.0397829
LOC112694756 uncharaterized LOC112694756 -0.0393547
RPL37A ribosomal protein L37a -0.03924
RPL11 ribosomal protein L11 -0.0392251
RPS13 ribosomal protein S13 -0.039195
S100A9 S100 calcium binding protein A9 -0.0385432
PGK1 phosphoglycerate kinase 1 -0.0383664
PKM pyruvate kinase, muscle -0.0375417
ICAM1 intercellular adhesion molecule 1 -0.0369928
RPL36A ribosomal protein L36a -0.0363779
CCND1 cyclin D1 -0.0355097
HLA-B major histocompatibility complex, class I, B -0.0353568
RPLP2 ribosomal protein, large, P2 -0.0350061
RPS21 ribosomal protein S21 -0.034461
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0343444
VDAC1 voltage-dependent anion channel 1 -0.033802
RPS12 ribosomal protein S12 -0.0337907
IGFBP3 insulin-like growth factor binding protein 3 -0.0334934
RPL38 ribosomal protein L38 -0.0334784
RPS19 ribosomal protein S19 -0.0331753
RPS14 ribosomal protein S14 -0.0330635
RPL36 ribosomal protein L36 -0.0329808
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0324417
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0314851
RPS16 ribosomal protein S16 -0.0314422
MT1X metallothionein 1X -0.0311659
RPL19 ribosomal protein L19 -0.030525
TM4SF1 transmembrane 4 L six family member 1 -0.0304406
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0298865
HMGA1 high mobility group AT-hook 1 -0.0289762
RPS24 ribosomal protein S24 -0.0289543
SREBF2 sterol regulatory element binding transcription factor 2 -0.0287053
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0286173
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0284353
RPS27A ribosomal protein S27a -0.027769
B2M beta-2-microglobulin -0.0277462
RPL5 ribosomal protein L5 -0.0274184
RPL27 ribosomal protein L27 -0.0273271
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0272837
EEF2 eukaryotic translation elongation factor 2 -0.0271238
WSB1 WD repeat and SOCS box containing 1 -0.0270353
RPS29 ribosomal protein S29 -0.0265883
CD44 CD44 molecule (Indian blood group) -0.0264611
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0258596
LDHA lactate dehydrogenase A -0.0257976
RPS4X ribosomal protein S4, X-linked -0.0257601
ENO1 enolase 1, (alpha) -0.0254512
S100A6 S100 calcium binding protein A6 -0.0251122
RPL28 ribosomal protein L28 -0.0251031
GNAS GNAS complex locus -0.0246671
RPS5 ribosomal protein S5 -0.0245885
RPL8 ribosomal protein L8 -0.0245618
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0242217
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0239701
SLC39A11 solute carrier family 39, member 11 -0.0236181
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0228329
CSNK1E casein kinase 1, epsilon -0.0225292
RPS20 ribosomal protein S20 -0.0223002
RPS27 ribosomal protein S27 -0.0221843
RPL9 ribosomal protein L9 -0.0217694
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0215874
KMT2E lysine (K)-specific methyltransferase 2E -0.0215313
ENO2 enolase 2 (gamma, neuronal) -0.0213423
IFI6 interferon, alpha-inducible protein 6 -0.0211849
RPLP0 ribosomal protein, large, P0 -0.0210936
RPL13A ribosomal protein L13a -0.0210876
IER3 immediate early response 3 -0.0208205
S100A10 S100 calcium binding protein A10 -0.020603