Clobetasol propionate_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.243243
AKAP12 A kinase (PRKA) anchor protein 12 0.168005
SOD2 superoxide dismutase 2, mitochondrial 0.115597
FKBP5 FK506 binding protein 5 0.101266
FTH1 ferritin, heavy polypeptide 1 0.074923
BICC1 BicC family RNA binding protein 1 0.0714397
ERRFI1 ERBB receptor feedback inhibitor 1 0.0608525
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.060072
MT2A metallothionein 2A 0.0593285
MT1X metallothionein 1X 0.0591278
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0516539
NAMPT nicotinamide phosphoribosyltransferase 0.0485778
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0464593
SAA2 serum amyloid A2 0.04542
LDHA lactate dehydrogenase A 0.0453156
PCBP3 poly(rC) binding protein 3 0.0349766
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0348498
CLMP CXADR-like membrane protein 0.0327388
AHNAK AHNAK nucleoprotein 0.0315389
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0312843
RUNX2 runt-related transcription factor 2 0.0300129
ZMYND8 zinc finger, MYND-type containing 8 0.0300078
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0297737
MYH9 myosin, heavy chain 9, non-muscle 0.0289422
LOX lysyl oxidase 0.0288547
JAK2 Janus kinase 2 0.0287744
ELL2 elongation factor, RNA polymerase II, 2 0.0280957
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0267995
TOP1 topoisomerase (DNA) I 0.0262607
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0260219
VCL vinculin 0.0254647
SSBP2 single-stranded DNA binding protein 2 0.0254339
IL6ST interleukin 6 signal transducer 0.0252557
AGTPBP1 ATP/GTP binding protein 1 0.0244666
HIPK2 homeodomain interacting protein kinase 2 0.0244231
CUL4B cullin 4B 0.0243187
HOMER2 homer scaffolding protein 2 0.0241212
LAMB1 laminin, beta 1 0.0240532
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0230166
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0228342
PLIN2 perilipin 2 0.0227529
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0224244
STOM stomatin 0.0217486
UTRN utrophin 0.0211847
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0208956
ABLIM3 actin binding LIM protein family, member 3 0.020851
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0208264
SAA2-SAA4 SAA2-SAA4 readthrough 0.020776
TNS3 tensin 3 0.0207403
SDC4 syndecan 4 0.0199401
JPH2 junctophilin 2 0.0194822
DPYD dihydropyrimidine dehydrogenase 0.0183106
TSC22D3 TSC22 domain family, member 3 0.0179082
NNMT nicotinamide N-methyltransferase 0.0177325
SGMS1 sphingomyelin synthase 1 0.0170159
FLNA filamin A, alpha 0.0167307
ACSL4 acyl-CoA synthetase long-chain family member 4 0.0161898
MT1E metallothionein 1E 0.0160985
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.0158558
TGFB2 transforming growth factor, beta 2 0.0151679
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0151053
EFNA5 ephrin-A5 0.0150736
DNER delta/notch-like EGF repeat containing 0.0149641
CCBE1 collagen and calcium binding EGF domains 1 0.0148836
SDK1 sidekick cell adhesion molecule 1 0.0147803
BCL2L1 BCL2-like 1 0.0145572
ESYT2 extended synaptotagmin-like protein 2 0.0140952
DLC1 DLC1 Rho GTPase activating protein 0.0138197
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0137907
LPP LIM domain containing preferred translocation partner in lipoma 0.013622
MBNL1 muscleblind-like splicing regulator 1 0.0135902
ZBTB16 zinc finger and BTB domain containing 16 0.0133731
ELOVL5 ELOVL fatty acid elongase 5 0.0132976
MSN moesin 0.0132596
HELZ helicase with zinc finger 0.0131503
MYO1B myosin IB 0.0131423
HEG1 heart development protein with EGF-like domains 1 0.0131245
MED13L mediator complex subunit 13-like 0.013119
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.0130008
DGKH diacylglycerol kinase, eta 0.0128135
ANKRD28 ankyrin repeat domain 28 0.0127382
ANGPTL4 angiopoietin-like 4 0.0126762
BCL6 B-cell CLL/lymphoma 6 0.0126104
ZNF608 zinc finger protein 608 0.0125832
BCLAF1 BCL2-associated transcription factor 1 0.0123794
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0123621
TMTC1 transmembrane and tetratricopeptide repeat containing 1 0.0123507
FNDC3B fibronectin type III domain containing 3B 0.0123318
CEP250 centrosomal protein 250kDa 0.0123186
PALLD palladin, cytoskeletal associated protein 0.0122177
CD109 CD109 molecule 0.012124
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0119867
DCBLD1 discoidin, CUB and LCCL domain containing 1 0.0118911
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0118493
FOXO3 forkhead box O3 0.0118353
MYOF myoferlin 0.0115698
CEMIP2 cell migration inducing hyaluronidase 2 0.0115195
NCOA3 nuclear receptor coactivator 3 0.0114749
RCL1 RNA terminal phosphate cyclase-like 1 0.0114655
IL1R1 interleukin 1 receptor, type I 0.0114228

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.273055
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.190659
HLA-B major histocompatibility complex, class I, B -0.134012
IER3 immediate early response 3 -0.116659
CD44 CD44 molecule (Indian blood group) -0.114644
TPT1 tumor protein, translationally-controlled 1 -0.113448
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0962074
FTL ferritin, light polypeptide -0.0938476
NDRG1 N-myc downstream regulated 1 -0.085247
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0718513
FRMD4A FERM domain containing 4A -0.068912
PTMA prothymosin, alpha -0.0678754
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.062056
TRIO trio Rho guanine nucleotide exchange factor -0.061428
RPS6 ribosomal protein S6 -0.0602936
RPS24 ribosomal protein S24 -0.0580615
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0549897
B2M beta-2-microglobulin -0.0538988
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0530565
RPS12 ribosomal protein S12 -0.0525371
RPLP2 ribosomal protein, large, P2 -0.0502029
NAP1L1 nucleosome assembly protein 1-like 1 -0.0487137
EXT1 exostosin glycosyltransferase 1 -0.048196
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0471336
RPS8 ribosomal protein S8 -0.0464337
RPL36A ribosomal protein L36a -0.0458389
BTG1 B-cell translocation gene 1, anti-proliferative -0.0452828
RPLP1 ribosomal protein, large, P1 -0.0451748
RPS3 ribosomal protein S3 -0.0449863
CADM1 cell adhesion molecule 1 -0.0445204
PDE10A phosphodiesterase 10A -0.044447
RPL37A ribosomal protein L37a -0.0421368
ENO1 enolase 1, (alpha) -0.0421186
RPL7A ribosomal protein L7a -0.0408362
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0402165
IFI16 interferon, gamma-inducible protein 16 -0.0400876
SQSTM1 sequestosome 1 -0.0395665
HDAC9 histone deacetylase 9 -0.0394235
RPL35A ribosomal protein L35a -0.0386196
HLA-E major histocompatibility complex, class I, E -0.0380226
GNAS GNAS complex locus -0.0378075
RPL23 ribosomal protein L23 -0.0377116
RPL31 ribosomal protein L31 -0.0369077
HLA-A major histocompatibility complex, class I, A -0.0367726
RPS23 ribosomal protein S23 -0.0367228
SYNJ2 synaptojanin 2 -0.0365327
RPS19 ribosomal protein S19 -0.0365054
COL1A1 collagen, type I, alpha 1 -0.0358173
RPS13 ribosomal protein S13 -0.0350702
EIF1 eukaryotic translation initiation factor 1 -0.0347674
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0346941
DLG1 discs, large homolog 1 (Drosophila) -0.0346347
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0338387
RPL19 ribosomal protein L19 -0.0336889
RACK1 receptor for activated C kinase 1 -0.033504
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0332889
IFI6 interferon, alpha-inducible protein 6 -0.0331329
UGCG UDP-glucose ceramide glucosyltransferase -0.0326306
CDH13 cadherin 13 -0.032403
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0323976
SMAD3 SMAD family member 3 -0.0322507
EGR1 early growth response 1 -0.0321619
RPS27A ribosomal protein S27a -0.0315169
RPL36 ribosomal protein L36 -0.0290138
RPS4X ribosomal protein S4, X-linked -0.0289769
SP100 SP100 nuclear antigen -0.0286939
SFTPA2 surfactant protein A2 -0.0286654
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0285455
RPS25 ribosomal protein S25 -0.0283076
RPL37 ribosomal protein L37 -0.0279718
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0277807
IFITM3 interferon induced transmembrane protein 3 -0.0275566
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0273609
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0273507
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0272996
LOXL2 lysyl oxidase-like 2 -0.0271994
LOC112694756 uncharaterized LOC112694756 -0.027105
RPL38 ribosomal protein L38 -0.0267459
RPL5 ribosomal protein L5 -0.0265687
CTSD cathepsin D -0.0265606
RPL9 ribosomal protein L9 -0.0265396
FRMD5 FERM domain containing 5 -0.026511
RPL32 ribosomal protein L32 -0.0264736
RPL28 ribosomal protein L28 -0.026465
TMSB4X thymosin beta 4, X-linked -0.0261792
NAV2 neuron navigator 2 -0.0251189
RPL11 ribosomal protein L11 -0.0250678
TGFBI transforming growth factor, beta-induced, 68kDa -0.0250259
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0248931
IFIH1 interferon induced with helicase C domain 1 -0.0247165
RPL34 ribosomal protein L34 -0.024591
CDCP1 CUB domain containing protein 1 -0.024095
RPL12 ribosomal protein L12 -0.0239733
WSB1 WD repeat and SOCS box containing 1 -0.0239632
RPS21 ribosomal protein S21 -0.0239345
ATXN1 ataxin 1 -0.023534
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0234918
AFF3 AF4/FMR2 family, member 3 -0.0234149
STC1 stanniocalcin 1 -0.023369
RIGI RNA sensor RIG-I -0.0233584