Clobetasol propionate_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.213342
FAM13A family with sequence similarity 13, member A 0.112557
MT2A metallothionein 2A 0.108898
ERRFI1 ERBB receptor feedback inhibitor 1 0.0924761
HIP1 huntingtin interacting protein 1 0.0856368
FTH1 ferritin, heavy polypeptide 1 0.0838822
IGFBP3 insulin-like growth factor binding protein 3 0.0725056
MT1X metallothionein 1X 0.0682592
HMGA2 high mobility group AT-hook 2 0.0617108
PRELID2 PRELI domain containing 2 0.0610448
CALD1 caldesmon 1 0.0584487
MAP1B microtubule-associated protein 1B 0.0564848
ABLIM3 actin binding LIM protein family, member 3 0.0555067
LOX lysyl oxidase 0.0552861
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0547186
CXCL8 chemokine (C-X-C motif) ligand 8 0.0527325
FN1 fibronectin 1 0.0482513
SSBP2 single-stranded DNA binding protein 2 0.0455337
ARRDC3 arrestin domain containing 3 0.0439916
AKAP9 A kinase (PRKA) anchor protein 9 0.043074
AVL9 AVL9 homolog (S. cerevisiase) 0.0430562
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0428675
SOD2 superoxide dismutase 2, mitochondrial 0.0415651
IL6 interleukin 6 0.0403461
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0401383
ZMYND8 zinc finger, MYND-type containing 8 0.039442
PID1 phosphotyrosine interaction domain containing 1 0.038706
HIPK2 homeodomain interacting protein kinase 2 0.0381085
IL6ST interleukin 6 signal transducer 0.0378311
UBC ubiquitin C 0.0362326
GLUL glutamate-ammonia ligase 0.0360092
MBD5 methyl-CpG binding domain protein 5 0.0358026
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0355301
COL5A2 collagen, type V, alpha 2 0.0355155
FKBP5 FK506 binding protein 5 0.0351155
MBNL2 muscleblind-like splicing regulator 2 0.0351097
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0348616
MT1E metallothionein 1E 0.0343099
RAB8B RAB8B, member RAS oncogene family 0.0340916
AHNAK AHNAK nucleoprotein 0.0340053
CAND1 cullin-associated and neddylation-dissociated 1 0.0339796
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0333593
ESYT2 extended synaptotagmin-like protein 2 0.0330855
MYOF myoferlin 0.0327507
SKIC3 SKI3 subunit of superkiller complex 0.0327223
ZCCHC7 zinc finger, CCHC domain containing 7 0.0325394
ANLN anillin, actin binding protein 0.0321487
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0316003
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0314985
TANK TRAF family member-associated NFKB activator 0.0311915
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0304621
POLK polymerase (DNA directed) kappa 0.0302511
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0301332
PDE4D phosphodiesterase 4D, cAMP-specific 0.029894
SH3RF3 SH3 domain containing ring finger 3 0.0297638
TNIP1 TNFAIP3 interacting protein 1 0.0297301
TNS3 tensin 3 0.0293584
RNF220 ring finger protein 220 0.0290785
IL1R1 interleukin 1 receptor, type I 0.0284727
BIRC3 baculoviral IAP repeat containing 3 0.0284505
SNX13 sorting nexin 13 0.0284121
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0284097
ROS1 ROS proto-oncogene 1 , receptor tyrosine kinase 0.0283959
DSCAM Down syndrome cell adhesion molecule 0.0279462
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 0.0279228
ZNF148 zinc finger protein 148 0.0277581
WDFY3 WD repeat and FYVE domain containing 3 0.027538
CCDC14 coiled-coil domain containing 14 0.0269144
CDC27 cell division cycle 27 0.0268638
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0264394
PUM1 pumilio RNA-binding family member 1 0.026389
SAMD4A sterile alpha motif domain containing 4A 0.0262852
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 0.0259506
PDZD2 PDZ domain containing 2 0.0255238
CAV1 caveolin 1, caveolae protein, 22kDa 0.0253952
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.025348
TSC22D3 TSC22 domain family, member 3 0.0247575
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0243106
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0240834
NCK1 NCK adaptor protein 1 0.023881
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0238422
METTL15 methyltransferase like 15 0.0237503
PTBP2 polypyrimidine tract binding protein 2 0.0235085
UGP2 UDP-glucose pyrophosphorylase 2 0.0235078
SND1 staphylococcal nuclease and tudor domain containing 1 0.0234672
PGM3 phosphoglucomutase 3 0.02333
ZNF451 zinc finger protein 451 0.0232116
RBM39 RNA binding motif protein 39 0.0232011
ZBTB20 zinc finger and BTB domain containing 20 0.023057
LYSMD3 LysM, putative peptidoglycan-binding, domain containing 3 0.0229157
PHF3 PHD finger protein 3 0.0229147
RASAL2 RAS protein activator like 2 0.0228531
MPZ myelin protein zero 0.0222795
LAMB1 laminin, beta 1 0.0222628
ZBTB16 zinc finger and BTB domain containing 16 0.022112
DEPP1 DEPP autophagy regulator 1 0.0221013
FOSL1 FOS-like antigen 1 0.0220594
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0217635
SMAD4 SMAD family member 4 0.0217596
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0216721

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.176997
VIM vimentin -0.162507
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16195
TMSB10 thymosin beta 10 -0.148602
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.118729
HLA-B major histocompatibility complex, class I, B -0.110392
TIMP3 TIMP metallopeptidase inhibitor 3 -0.102914
PTMA prothymosin, alpha -0.10229
FTL ferritin, light polypeptide -0.085201
TPT1 tumor protein, translationally-controlled 1 -0.0846291
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0836781
NAMPT nicotinamide phosphoribosyltransferase -0.0590383
RPL37 ribosomal protein L37 -0.0570677
RPL35A ribosomal protein L35a -0.0540927
PSD3 pleckstrin and Sec7 domain containing 3 -0.0540252
LGALS1 lectin, galactoside-binding, soluble, 1 -0.052093
RRBP1 ribosome binding protein 1 -0.0509413
VDAC1 voltage-dependent anion channel 1 -0.0507314
COL1A1 collagen, type I, alpha 1 -0.0503605
EXT1 exostosin glycosyltransferase 1 -0.0499532
TGFBI transforming growth factor, beta-induced, 68kDa -0.0494424
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0486444
ENO1 enolase 1, (alpha) -0.047805
RALY RALY heterogeneous nuclear ribonucleoprotein -0.0463158
DPYD dihydropyrimidine dehydrogenase -0.0459512
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0453187
RPL37A ribosomal protein L37a -0.0451918
NDRG1 N-myc downstream regulated 1 -0.0445414
WSB1 WD repeat and SOCS box containing 1 -0.0442651
GNAS GNAS complex locus -0.0442277
MACF1 microtubule-actin crosslinking factor 1 -0.0433197
CDH13 cadherin 13 -0.0423911
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0412531
RPLP1 ribosomal protein, large, P1 -0.0408178
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0394615
KMT2C lysine (K)-specific methyltransferase 2C -0.0393354
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0382214
RPL34 ribosomal protein L34 -0.0377777
CLIP2 CAP-GLY domain containing linker protein 2 -0.0376335
CAVIN1 caveolae associated protein 1 -0.0374744
KTN1 kinectin 1 (kinesin receptor) -0.0373831
GCC2 GRIP and coiled-coil domain containing 2 -0.0373368
RPS3 ribosomal protein S3 -0.0366178
SPDYA speedy/RINGO cell cycle regulator family member A -0.0353055
COL1A2 collagen, type I, alpha 2 -0.0348605
CADM1 cell adhesion molecule 1 -0.0347903
ASPH aspartate beta-hydroxylase -0.034214
VMP1 vacuole membrane protein 1 -0.0342086
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0339754
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0339155
TPM4 tropomyosin 4 -0.0334025
ADM adrenomedullin -0.0329124
COL6A2 collagen, type VI, alpha 2 -0.0327606
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0322033
RPS23 ribosomal protein S23 -0.0321056
HLA-C major histocompatibility complex, class I, C -0.0320631
TM4SF1 transmembrane 4 L six family member 1 -0.0319791
RPL31 ribosomal protein L31 -0.03185
CD44 CD44 molecule (Indian blood group) -0.031486
CDK6 cyclin-dependent kinase 6 -0.0313041
RPS8 ribosomal protein S8 -0.0312736
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0311676
STAU1 staufen double-stranded RNA binding protein 1 -0.0308581
HM13 histocompatibility (minor) 13 -0.0306703
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0305299
FBXO11 F-box protein 11 -0.0303649
CAPN2 calpain 2, (m/II) large subunit -0.0301208
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0300613
NAP1L1 nucleosome assembly protein 1-like 1 -0.0296876
COPB1 coatomer protein complex, subunit beta 1 -0.029358
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0291118
DSTN destrin (actin depolymerizing factor) -0.0288701
RPL23 ribosomal protein L23 -0.0286896
COL6A1 collagen, type VI, alpha 1 -0.0286212
ZFAND3 zinc finger, AN1-type domain 3 -0.0285452
EGR1 early growth response 1 -0.0285339
LMNA lamin A/C -0.0282517
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0280602
PDE10A phosphodiesterase 10A -0.027619
ANKRD12 ankyrin repeat domain 12 -0.0275947
RPL15 ribosomal protein L15 -0.0272648
ENO2 enolase 2 (gamma, neuronal) -0.0272124
PGK1 phosphoglycerate kinase 1 -0.0272025
FMNL2 formin-like 2 -0.0271051
QKI QKI, KH domain containing, RNA binding -0.026734
RPS6 ribosomal protein S6 -0.0265222
SBF2 SET binding factor 2 -0.0264168
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0260913
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.026071
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.026065
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0260583
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0260257
MYO9B myosin IXB -0.0258359
RPLP2 ribosomal protein, large, P2 -0.0258067
S100A10 S100 calcium binding protein A10 -0.0257745
TAS2R14 taste receptor, type 2, member 14 -0.0255725
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0255553
SQSTM1 sequestosome 1 -0.0255392
EIF1 eukaryotic translation initiation factor 1 -0.0254753
CSNK1A1 casein kinase 1, alpha 1 -0.0254102