Clobetasol propionate_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 0.178718
BIRC3 baculoviral IAP repeat containing 3 0.12316
AKAP12 A kinase (PRKA) anchor protein 12 0.100529
ZMYND8 zinc finger, MYND-type containing 8 0.092409
ERRFI1 ERBB receptor feedback inhibitor 1 0.0913006
MBNL1 muscleblind-like splicing regulator 1 0.0883513
MT2A metallothionein 2A 0.08706
EFNA5 ephrin-A5 0.0838212
FMNL2 formin-like 2 0.0757541
HMGA2 high mobility group AT-hook 2 0.0718704
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.071374
FKBP5 FK506 binding protein 5 0.066171
ESYT2 extended synaptotagmin-like protein 2 0.0622422
ANXA2 annexin A2 0.0616089
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.061043
LDHA lactate dehydrogenase A 0.0589449
PTPRG protein tyrosine phosphatase, receptor type, G 0.0587907
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0577976
MT1X metallothionein 1X 0.057744
SOD2 superoxide dismutase 2, mitochondrial 0.0565977
MBNL2 muscleblind-like splicing regulator 2 0.054621
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0545493
FNDC3B fibronectin type III domain containing 3B 0.0544694
DNER delta/notch-like EGF repeat containing 0.0497943
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0487222
ZFHX3 zinc finger homeobox 3 0.0467614
ZBTB38 zinc finger and BTB domain containing 38 0.0466834
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0456365
KLF9 Kruppel-like factor 9 0.0446279
PNRC1 proline-rich nuclear receptor coactivator 1 0.0442926
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0428361
DPYD dihydropyrimidine dehydrogenase 0.0414394
FTH1 ferritin, heavy polypeptide 1 0.041074
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0403908
TOP1 topoisomerase (DNA) I 0.0390751
RBM39 RNA binding motif protein 39 0.0377434
N4BP2L2 NEDD4 binding protein 2-like 2 0.0376016
HOMER2 homer scaffolding protein 2 0.0375979
RPGR retinitis pigmentosa GTPase regulator 0.0352347
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0351329
ADAM10 ADAM metallopeptidase domain 10 0.0341688
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.0341085
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0336758
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0336395
ELL2 elongation factor, RNA polymerase II, 2 0.033353
RNF145 ring finger protein 145 0.0332184
ELOF1 elongation factor 1 homolog (S. cerevisiae) 0.0330993
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.0324022
PAN3 PAN3 poly(A) specific ribonuclease subunit 0.0315701
CLASP1 cytoplasmic linker associated protein 1 0.0313895
BCL2L1 BCL2-like 1 0.0308027
RECQL RecQ helicase-like 0.0304848
DEK DEK proto-oncogene 0.0304027
AKAP13 A kinase (PRKA) anchor protein 13 0.0303425
ALCAM activated leukocyte cell adhesion molecule 0.0302559
LPP LIM domain containing preferred translocation partner in lipoma 0.0298053
PTK2 protein tyrosine kinase 2 0.0296046
TSC22D3 TSC22 domain family, member 3 0.0295206
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0294426
PDS5A PDS5 cohesin associated factor A 0.0293684
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0279981
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0274973
SNX13 sorting nexin 13 0.027481
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0272871
WAC WW domain containing adaptor with coiled-coil 0.0272565
DUSP12 dual specificity phosphatase 12 0.0272203
DYNC2I1 dynein 2 intermediate chain 1 0.0270278
PRR16 proline rich 16 0.0269894
VCL vinculin 0.0267693
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0267644
GPHN gephyrin 0.0264224
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0263223
JAK1 Janus kinase 1 0.0260131
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.025958
LDLRAD3 low density lipoprotein receptor class A domain containing 3 0.0257881
FAR1 fatty acyl CoA reductase 1 0.0257482
ZBTB16 zinc finger and BTB domain containing 16 0.0255424
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0254825
CKAP5 cytoskeleton associated protein 5 0.0254786
KIF5B kinesin family member 5B 0.0246873
SLC35F2 solute carrier family 35, member F2 0.0246181
SCAPER S-phase cyclin A-associated protein in the ER 0.0245224
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0245178
GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 0.0244361
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0242765
WDFY3 WD repeat and FYVE domain containing 3 0.0242521
KLF6 Kruppel-like factor 6 0.02424
BCLAF1 BCL2-associated transcription factor 1 0.0241937
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0241856
EPAS1 endothelial PAS domain protein 1 0.0240609
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0240405
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.023957
SSH2 slingshot protein phosphatase 2 0.0238392
TXNIP thioredoxin interacting protein 0.0238032
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0235695
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.023488
PHF21A PHD finger protein 21A 0.0234709
MYOF myoferlin 0.0234553
YTHDC2 YTH domain containing 2 0.0233973
FCHO2 FCH domain only 2 0.0232156

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.266493
PTMA prothymosin, alpha -0.121196
VIM vimentin -0.0890117
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0733912
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0686951
CD44 CD44 molecule (Indian blood group) -0.0661691
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0590845
RIGI RNA sensor RIG-I -0.058035
GNAS GNAS complex locus -0.0551677
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0512401
SQSTM1 sequestosome 1 -0.0497235
TPT1 tumor protein, translationally-controlled 1 -0.0462406
GOLGA4 golgin A4 -0.0460048
JMJD1C jumonji domain containing 1C -0.0451725
PDE4D phosphodiesterase 4D, cAMP-specific -0.0443167
DTNA dystrobrevin, alpha -0.0437037
BHLHE40 basic helix-loop-helix family, member e40 -0.0412645
ZNF292 zinc finger protein 292 -0.0410088
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0403057
NDRG1 N-myc downstream regulated 1 -0.0395376
HILPDA hypoxia inducible lipid droplet-associated -0.0392518
SDC4 syndecan 4 -0.0386429
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0386324
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0379878
PDE8A phosphodiesterase 8A -0.0378497
ASPH aspartate beta-hydroxylase -0.0377691
WSB1 WD repeat and SOCS box containing 1 -0.0364281
JUN jun proto-oncogene -0.0363832
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0355272
IGFBP3 insulin-like growth factor binding protein 3 -0.0354136
LOC112694756 uncharaterized LOC112694756 -0.0353195
KIAA1958 KIAA1958 -0.0350371
SNX14 sorting nexin 14 -0.0339602
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0338984
ZBTB35 zinc finger and BTB domain containing 35 -0.0337075
ANO6 anoctamin 6 -0.0329854
DERA deoxyribose-phosphate aldolase (putative) -0.0329119
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 -0.0325064
SMAD3 SMAD family member 3 -0.0324401
BIRC6 baculoviral IAP repeat containing 6 -0.0324134
RPS6 ribosomal protein S6 -0.0320662
BRD2 bromodomain containing 2 -0.0317991
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0314215
CMC1 C-x(9)-C motif containing 1 -0.0311587
RDX radixin -0.0310376
HM13 histocompatibility (minor) 13 -0.0309917
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0309699
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0307612
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -0.0303575
HDAC9 histone deacetylase 9 -0.0302023
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0302004
ENO2 enolase 2 (gamma, neuronal) -0.0296457
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0295818
DENND4A DENN/MADD domain containing 4A -0.0294087
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0290801
TM4SF1 transmembrane 4 L six family member 1 -0.029072
SPAG9 sperm associated antigen 9 -0.0290013
BRD4 bromodomain containing 4 -0.0289039
MSANTD3 Myb/SANT-like DNA-binding domain containing 3 -0.028786
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0280299
ARFGEF3 ARFGEF family member 3 -0.0278494
FTL ferritin, light polypeptide -0.0278218
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0276065
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0272346
ATF7IP activating transcription factor 7 interacting protein -0.026812
FGD6 FYVE, RhoGEF and PH domain containing 6 -0.0267805
SMC5 structural maintenance of chromosomes 5 -0.0267794
ARRDC3 arrestin domain containing 3 -0.026691
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0266176
UMAD1 UBAP1-MVB12-associated (UMA) domain containing 1 -0.0265694
CEP290 centrosomal protein 290kDa -0.0264203
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0263371
SETX senataxin -0.0263019
ZNF638 zinc finger protein 638 -0.0261181
SAMD4A sterile alpha motif domain containing 4A -0.0260162
TMEM167A transmembrane protein 167A -0.0258455
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0257987
NUP214 nucleoporin 214kDa -0.0256954
COG5 component of oligomeric golgi complex 5 -0.0255114
WWTR1 WW domain containing transcription regulator 1 -0.025238
TUBA1B tubulin, alpha 1b -0.0251951
ZBTB10 zinc finger and BTB domain containing 10 -0.0248668
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0247989
YBX3 Y box binding protein 3 -0.0246912
FAM3C family with sequence similarity 3, member C -0.0246691
ACTG1 actin gamma 1 -0.0246212
SKIC3 SKI3 subunit of superkiller complex -0.0244992
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.024212
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0238727
PTMS parathymosin -0.0238517
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0237952
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0237348
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0234907
KPNA5 karyopherin alpha 5 (importin alpha 6) -0.0233568
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0231762
WDR45B WD repeat domain 45B -0.0231603
YEATS2 YEATS domain containing 2 -0.0229287
EEF2 eukaryotic translation elongation factor 2 -0.022778
ANKRD37 ankyrin repeat domain 37 -0.0225567
SLC36A4 solute carrier family 36 (proton/amino acid symporter), member 4 -0.0225171