Clobetasol propionate_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.113502
FKBP5 FK506 binding protein 5 0.0987464
IRAK3 interleukin-1 receptor-associated kinase 3 0.0957926
NRG1 neuregulin 1 0.0926938
HMGA2 high mobility group AT-hook 2 0.0873611
SAMD4A sterile alpha motif domain containing 4A 0.0853849
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0718898
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0609377
HIPK2 homeodomain interacting protein kinase 2 0.0574977
HOMER2 homer scaffolding protein 2 0.0574112
ASPH aspartate beta-hydroxylase 0.0572948
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0570457
VCL vinculin 0.0570268
EFNA5 ephrin-A5 0.0538925
IL6ST interleukin 6 signal transducer 0.0536481
TMEM156 transmembrane protein 156 0.0533941
BIRC3 baculoviral IAP repeat containing 3 0.0526613
FNDC3B fibronectin type III domain containing 3B 0.0525527
AKAP12 A kinase (PRKA) anchor protein 12 0.051324
EPS8 epidermal growth factor receptor pathway substrate 8 0.049134
GLUL glutamate-ammonia ligase 0.0488923
PRELID2 PRELI domain containing 2 0.0415764
ACSL1 acyl-CoA synthetase long-chain family member 1 0.0406033
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0399837
OSMR oncostatin M receptor 0.0399145
TNS3 tensin 3 0.0389146
TOP1 topoisomerase (DNA) I 0.0388406
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0380314
ITGA1 integrin, alpha 1 0.0375002
FTH1 ferritin, heavy polypeptide 1 0.0367609
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0365577
JAK2 Janus kinase 2 0.0358513
RUNX2 runt-related transcription factor 2 0.0355129
SLC44A1 solute carrier family 44 (choline transporter), member 1 0.0343387
STK39 serine threonine kinase 39 0.0343224
RNF145 ring finger protein 145 0.0333572
MBNL1 muscleblind-like splicing regulator 1 0.0333126
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0332156
PTK2 protein tyrosine kinase 2 0.0325853
FNDC3A fibronectin type III domain containing 3A 0.0320835
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) 0.0318252
FRY furry homolog (Drosophila) 0.0317985
IRS2 insulin receptor substrate 2 0.0317899
KLHL5 kelch-like family member 5 0.0312472
DPYD dihydropyrimidine dehydrogenase 0.0305971
ZBTB16 zinc finger and BTB domain containing 16 0.0298955
NRP1 neuropilin 1 0.0298001
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0294262
MYH9 myosin, heavy chain 9, non-muscle 0.0292253
ENAH enabled homolog (Drosophila) 0.0281383
SSBP2 single-stranded DNA binding protein 2 0.0277143
TAS2R14 taste receptor, type 2, member 14 0.0276001
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0273306
MAML2 mastermind-like 2 (Drosophila) 0.0271142
PDLIM5 PDZ and LIM domain 5 0.0265205
ERRFI1 ERBB receptor feedback inhibitor 1 0.0264892
CLASP1 cytoplasmic linker associated protein 1 0.0264298
DOCK5 dedicator of cytokinesis 5 0.0262996
CCND3 cyclin D3 0.0261571
NRIP1 nuclear receptor interacting protein 1 0.0259729
HPCAL1 hippocalcin-like 1 0.0256435
AHNAK AHNAK nucleoprotein 0.0255441
MT1X metallothionein 1X 0.0246873
AEBP2 AE binding protein 2 0.0245616
SORT1 sortilin 1 0.0243021
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0234443
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.0234008
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0233619
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0229344
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0229076
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0228769
ZMYND8 zinc finger, MYND-type containing 8 0.0222936
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0222235
NPAS2 neuronal PAS domain protein 2 0.0219029
PALLD palladin, cytoskeletal associated protein 0.0218836
NEBL nebulette 0.0218573
LIMCH1 LIM and calponin homology domains 1 0.021423
ZFYVE28 zinc finger, FYVE domain containing 28 0.0213651
MT1E metallothionein 1E 0.0210243
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 0.0209721
ZSWIM6 zinc finger, SWIM-type containing 6 0.020644
LRMDA leucine rich melanocyte differentiation associated 0.0204209
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0203797
TGM2 transglutaminase 2 0.0202905
DNAH5 dynein, axonemal, heavy chain 5 0.0200341
MAP3K5 mitogen-activated protein kinase kinase kinase 5 0.0199209
RAD51B RAD51 paralog B 0.0197818
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0197608
SMYD3 SET and MYND domain containing 3 0.0196514
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0195877
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0194236
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0193981
TRIO trio Rho guanine nucleotide exchange factor 0.0193911
FGD4 FYVE, RhoGEF and PH domain containing 4 0.0192578
LOX lysyl oxidase 0.019239
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0191468
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0190173
NAV2 neuron navigator 2 0.0189757
SPIDR scaffolding protein involved in DNA repair 0.0188656
BICD1 bicaudal D homolog 1 (Drosophila) 0.0187319

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.424914
NDRG1 N-myc downstream regulated 1 -0.110802
PTMA prothymosin, alpha -0.106989
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.100252
FTL ferritin, light polypeptide -0.0958603
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0877738
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0802378
VIM vimentin -0.0747527
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0681545
HLA-B major histocompatibility complex, class I, B -0.0655554
RPS6 ribosomal protein S6 -0.0608917
B2M beta-2-microglobulin -0.058078
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0538281
SQSTM1 sequestosome 1 -0.0526628
TMSB10 thymosin beta 10 -0.0521641
TPT1 tumor protein, translationally-controlled 1 -0.050569
RPLP1 ribosomal protein, large, P1 -0.0446662
RPL31 ribosomal protein L31 -0.0427902
RPL37A ribosomal protein L37a -0.0416359
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0411949
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0406285
RPS19 ribosomal protein S19 -0.0404465
EXT1 exostosin glycosyltransferase 1 -0.0386558
IER3 immediate early response 3 -0.0382123
RPL35A ribosomal protein L35a -0.0380882
RPL9 ribosomal protein L9 -0.0361627
RPS8 ribosomal protein S8 -0.0346514
S100A6 S100 calcium binding protein A6 -0.0340167
RPL12 ribosomal protein L12 -0.0339312
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0331947
RPS24 ribosomal protein S24 -0.0331569
PRRC2C proline-rich coiled-coil 2C -0.0328347
RPS29 ribosomal protein S29 -0.0326036
IFI27 interferon, alpha-inducible protein 27 -0.0322624
RPL28 ribosomal protein L28 -0.031822
MAP1B microtubule-associated protein 1B -0.0316307
RPL19 ribosomal protein L19 -0.0316166
RPS3 ribosomal protein S3 -0.0310554
RPS25 ribosomal protein S25 -0.0309635
RPS27 ribosomal protein S27 -0.0307935
RPL11 ribosomal protein L11 -0.0306664
RPL23 ribosomal protein L23 -0.0305902
LMNA lamin A/C -0.0305058
RPS12 ribosomal protein S12 -0.0297499
RPL26 ribosomal protein L26 -0.0296946
RPS21 ribosomal protein S21 -0.0295783
EIF1 eukaryotic translation initiation factor 1 -0.0290811
HMGA1 high mobility group AT-hook 1 -0.0290684
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0290485
LOC112694756 uncharaterized LOC112694756 -0.0283921
S100A10 S100 calcium binding protein A10 -0.0283189
RPS23 ribosomal protein S23 -0.0281951
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0281029
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.028029
GNAS GNAS complex locus -0.0278739
RPLP2 ribosomal protein, large, P2 -0.0275076
RPL36 ribosomal protein L36 -0.0274766
FNBP1 formin binding protein 1 -0.0274677
RACK1 receptor for activated C kinase 1 -0.0273398
RPL34 ribosomal protein L34 -0.0272568
RPL8 ribosomal protein L8 -0.0272448
RPS16 ribosomal protein S16 -0.0268165
NAP1L1 nucleosome assembly protein 1-like 1 -0.0267925
RPS27A ribosomal protein S27a -0.026479
TPI1 triosephosphate isomerase 1 -0.026425
RPL37 ribosomal protein L37 -0.0260525
SOX4 SRY (sex determining region Y)-box 4 -0.0259383
AHR aryl hydrocarbon receptor -0.0258588
PKM pyruvate kinase, muscle -0.0257658
RPL32 ribosomal protein L32 -0.0250768
RPL38 ribosomal protein L38 -0.0248621
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0243628
TMSB4X thymosin beta 4, X-linked -0.0242591
CD44 CD44 molecule (Indian blood group) -0.0240308
RPS11 ribosomal protein S11 -0.0238056
DUSP5 dual specificity phosphatase 5 -0.0235922
RPS20 ribosomal protein S20 -0.022769
S100A9 S100 calcium binding protein A9 -0.0223501
RPLP0 ribosomal protein, large, P0 -0.0221589
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0221027
HILPDA hypoxia inducible lipid droplet-associated -0.021811
VEGFA vascular endothelial growth factor A -0.0214481
ENO2 enolase 2 (gamma, neuronal) -0.0213679
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0211173
SERF2 small EDRK-rich factor 2 -0.0208508
TXNIP thioredoxin interacting protein -0.020326
TXNRD1 thioredoxin reductase 1 -0.0198689
RPL36A ribosomal protein L36a -0.0198685
TFPI2 tissue factor pathway inhibitor 2 -0.0192933
RPL7A ribosomal protein L7a -0.0189816
MRPS6 mitochondrial ribosomal protein S6 -0.0185678
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0185134
BASP1 brain abundant, membrane attached signal protein 1 -0.0184962
BHLHE40 basic helix-loop-helix family, member e40 -0.0184744
CDCP1 CUB domain containing protein 1 -0.018321
RPS5 ribosomal protein S5 -0.0182702
CD63 CD63 molecule -0.0180936
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0180386
RPL36AL ribosomal protein L36a-like -0.0178929
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0178318