Clobetasol propionate_SW48 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in SW48 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_SW48 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.125447
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.100163
OXR1 oxidation resistance 1 0.0929487
TXNRD1 thioredoxin reductase 1 0.085896
AREG amphiregulin 0.0761422
FAT1 FAT atypical cadherin 1 0.0756377
EGFR epidermal growth factor receptor 0.0735695
NCEH1 neutral cholesterol ester hydrolase 1 0.0728589
ITPRID2 ITPR interacting domain containing 2 0.0718511
CD36 CD36 molecule (thrombospondin receptor) 0.0675089
RNF43 ring finger protein 43 0.0644805
GCLC glutamate-cysteine ligase, catalytic subunit 0.0628546
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0604008
GOLGA4 golgin A4 0.0584929
ANXA1 annexin A1 0.0583935
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0555227
PDE4B phosphodiesterase 4B, cAMP-specific 0.055296
DSCAM Down syndrome cell adhesion molecule 0.0505807
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0500681
TOP1 topoisomerase (DNA) I 0.0480367
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 0.0475706
EVA1C eva-1 homolog C (C. elegans) 0.0454158
KMT2C lysine (K)-specific methyltransferase 2C 0.0450982
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.044383
EREG epiregulin 0.0435917
RUNX2 runt-related transcription factor 2 0.042277
YAP1 Yes-associated protein 1 0.0414437
PLAUR plasminogen activator, urokinase receptor 0.0384939
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0383256
GARS1 glycyl-tRNA synthetase 1 0.0380695
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0373135
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0368832
KDM6A lysine (K)-specific demethylase 6A 0.0361436
COG5 component of oligomeric golgi complex 5 0.0361411
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0358583
ATXN1 ataxin 1 0.0355944
ITPKC inositol-trisphosphate 3-kinase C 0.0355592
DSPP dentin sialophosphoprotein 0.0353538
STRN3 striatin, calmodulin binding protein 3 0.0352193
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0344019
AXIN2 axin 2 0.0331402
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0330612
NUP58 nucleoporin 58 0.0324154
RAB10 RAB10, member RAS oncogene family 0.0322619
ARL5B ADP-ribosylation factor-like 5B 0.032024
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0320213
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.030031
USP6NL USP6 N-terminal like 0.0300067
PDLIM5 PDZ and LIM domain 5 0.0297075
PTBP2 polypyrimidine tract binding protein 2 0.0294516
ARHGAP32 Rho GTPase activating protein 32 0.0293463
FHL2 four and a half LIM domains 2 0.0291597
OSBPL10 oxysterol binding protein-like 10 0.0288043
SPRED2 sprouty-related, EVH1 domain containing 2 0.0287509
SAMD5 sterile alpha motif domain containing 5 0.0285877
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0284446
RANBP9 RAN binding protein 9 0.0281196
TSC22D2 TSC22 domain family, member 2 0.0280295
MED13 mediator complex subunit 13 0.027882
NBAS neuroblastoma amplified sequence 0.0270943
MPZL3 myelin protein zero-like 3 0.0267625
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0265748
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0265169
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0264582
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0261585
SFPQ splicing factor proline/glutamine-rich 0.0260721
ZNF292 zinc finger protein 292 0.0260043
AHNAK AHNAK nucleoprotein 0.025921
TJP1 tight junction protein 1 0.0254664
ZMYM2 zinc finger, MYM-type 2 0.0249278
NAMPT nicotinamide phosphoribosyltransferase 0.0248774
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0246204
TPM4 tropomyosin 4 0.0244821
RTN4 reticulon 4 0.0242889
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0240178
ARHGAP42 Rho GTPase activating protein 42 0.0238604
KIF5B kinesin family member 5B 0.0238466
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0237485
OGA O-GlcNAcase 0.0236202
ARRDC3 arrestin domain containing 3 0.0235656
MTUS1 microtubule associated tumor suppressor 1 0.0234647
TMEM41B transmembrane protein 41B 0.0233095
ESRP1 epithelial splicing regulatory protein 1 0.0230952
NUP50 nucleoporin 50kDa 0.0228609
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0226712
SH3D19 SH3 domain containing 19 0.0226294
MACF1 microtubule-actin crosslinking factor 1 0.0225924
LRP12 low density lipoprotein receptor-related protein 12 0.0225874
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.0223835
ANXA11 annexin A11 0.0221999
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.022166
ECT2 epithelial cell transforming 2 0.0221057
ANKRD12 ankyrin repeat domain 12 0.0220923
SERINC5 serine incorporator 5 0.0218506
MYO5B myosin VB 0.0216535
SPATA13 spermatogenesis associated 13 0.021608
SEPTIN7 septin 7 0.0212413
ADGRA3 adhesion G protein-coupled receptor A3 0.0211988
BCL2L1 BCL2-like 1 0.0211869
NCKAP1 NCK-associated protein 1 0.0210956

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.132184
ACTG1 actin gamma 1 -0.122595
FHIT fragile histidine triad -0.109877
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.100179
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0977773
TMSB10 thymosin beta 10 -0.0870951
RPL35A ribosomal protein L35a -0.0752579
FRAS1 Fraser extracellular matrix complex subunit 1 -0.0692005
HMGA2 high mobility group AT-hook 2 -0.0672366
RAD51B RAD51 paralog B -0.0644222
LAMB3 laminin, beta 3 -0.0627739
EGR1 early growth response 1 -0.0575701
IER3 immediate early response 3 -0.0559814
RPS8 ribosomal protein S8 -0.0505308
RPS6 ribosomal protein S6 -0.044624
RPL5 ribosomal protein L5 -0.0413281
RPL36 ribosomal protein L36 -0.0401387
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0378863
ITGB4 integrin, beta 4 -0.0376372
CCSER1 coiled-coil serine-rich protein 1 -0.0374092
RPLP1 ribosomal protein, large, P1 -0.0365773
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0358079
RPL37A ribosomal protein L37a -0.0355898
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0354791
RPS29 ribosomal protein S29 -0.0352766
RPL23 ribosomal protein L23 -0.0342896
RPS24 ribosomal protein S24 -0.0342115
RPS19 ribosomal protein S19 -0.0331723
RPS3 ribosomal protein S3 -0.0323241
RPS17 ribosomal protein S17 -0.0316349
RPS25 ribosomal protein S25 -0.0308097
EXOC4 exocyst complex component 4 -0.0302466
AKAP12 A kinase (PRKA) anchor protein 12 -0.0300823
GPC5 glypican 5 -0.0300134
RPS12 ribosomal protein S12 -0.0297145
RPL34 ribosomal protein L34 -0.0291519
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0286768
RPL9 ribosomal protein L9 -0.0278364
CTDSPL CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like -0.0270868
LAMA4 laminin, alpha 4 -0.0269364
WWOX WW domain containing oxidoreductase -0.0259648
HILPDA hypoxia inducible lipid droplet-associated -0.0256534
S100A6 S100 calcium binding protein A6 -0.0245273
EFNB2 ephrin-B2 -0.0238228
RPS10 ribosomal protein S10 -0.0232266
RPL8 ribosomal protein L8 -0.0230873
CUX1 cut-like homeobox 1 -0.0230601
RPL7A ribosomal protein L7a -0.0230389
RPS13 ribosomal protein S13 -0.0223799
RPL11 ribosomal protein L11 -0.0218388
KRT18 keratin 18, type I -0.0218345
RPL35 ribosomal protein L35 -0.0218016
RPL31 ribosomal protein L31 -0.0211757
ZBTB7C zinc finger and BTB domain containing 7C -0.0207177
RPS14 ribosomal protein S14 -0.0205644
DIAPH2 diaphanous-related formin 2 -0.02053
RPL19 ribosomal protein L19 -0.0205289
RPS21 ribosomal protein S21 -0.0204999
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0204427
RPS4X ribosomal protein S4, X-linked -0.0197678
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0196083
RPS27A ribosomal protein S27a -0.0196054
MTAP methylthioadenosine phosphorylase -0.0192223
S100A9 S100 calcium binding protein A9 -0.0190164
RPL26 ribosomal protein L26 -0.0188711
MPRIP myosin phosphatase Rho interacting protein -0.018845
HDAC2 histone deacetylase 2 -0.0185358
DENND1A DENN/MADD domain containing 1A -0.0185005
XYLT1 xylosyltransferase I -0.0182695
FOXK1 forkhead box K1 -0.0181659
RPL38 ribosomal protein L38 -0.0179802
RPLP2 ribosomal protein, large, P2 -0.0177808
SPIDR scaffolding protein involved in DNA repair -0.0175961
SQSTM1 sequestosome 1 -0.0175623
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0173278
RRM2 ribonucleotide reductase M2 -0.0173025
RCOR1 REST corepressor 1 -0.0171963
RPS28 ribosomal protein S28 -0.0171401
GMDS GDP-mannose 4,6-dehydratase -0.0168352
TPT1 tumor protein, translationally-controlled 1 -0.0166951
SERBP1 SERPINE1 mRNA binding protein 1 -0.0165002
ASTN2 astrotactin 2 -0.0164546
RPL28 ribosomal protein L28 -0.0163174
CDHR3 cadherin-related family member 3 -0.0162441
RPL32 ribosomal protein L32 -0.0159216
RPL27 ribosomal protein L27 -0.0156965
RPS15 ribosomal protein S15 -0.0156225
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 -0.0152
RPS27 ribosomal protein S27 -0.0151802
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0150973
ACTN4 actinin, alpha 4 -0.0150051
RACK1 receptor for activated C kinase 1 -0.0148767
SMYD3 SET and MYND domain containing 3 -0.0147882
NAV2 neuron navigator 2 -0.0146909
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0145951
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0145728
UBAP2 ubiquitin associated protein 2 -0.0145533
FLNB filamin B, beta -0.0144554
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0143576
TBCA tubulin folding cofactor A -0.0140512