Clobetasol propionate_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clobetasol propionate perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clobetasol propionate_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAV2 neuron navigator 2 0.139161
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.1095
CDH13 cadherin 13 0.0964552
KRT18 keratin 18, type I 0.087588
MAML2 mastermind-like 2 (Drosophila) 0.0799572
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0775881
AKAP12 A kinase (PRKA) anchor protein 12 0.0711015
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0672568
PGK1 phosphoglycerate kinase 1 0.0651406
KIZ kizuna centrosomal protein 0.0648169
DST dystonin 0.0567816
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0561792
ANO1 anoctamin 1, calcium activated chloride channel 0.0552966
ASPH aspartate beta-hydroxylase 0.0542172
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0534255
SYT1 synaptotagmin I 0.0533191
SDK1 sidekick cell adhesion molecule 1 0.0531878
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0511393
NKD1 naked cuticle homolog 1 (Drosophila) 0.0507803
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0492694
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0477601
CANX calnexin 0.0472669
ZBTB20 zinc finger and BTB domain containing 20 0.0466464
ITPRID2 ITPR interacting domain containing 2 0.0452499
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0447213
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 0.0433434
CEMIP cell migration inducing protein, hyaluronan binding 0.0429743
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0427907
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0413361
CDK6 cyclin-dependent kinase 6 0.0412925
CBX5 chromobox homolog 5 0.0406975
BIRC6 baculoviral IAP repeat containing 6 0.0406941
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0405655
PCBP2 poly(rC) binding protein 2 0.0403938
TNIK TRAF2 and NCK interacting kinase 0.0403892
RAD51B RAD51 paralog B 0.0403365
ENO1 enolase 1, (alpha) 0.0396363
SKAP1 src kinase associated phosphoprotein 1 0.0392522
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.0386831
PDE4D phosphodiesterase 4D, cAMP-specific 0.0372787
EHBP1 EH domain binding protein 1 0.0368087
LIMS1 LIM and senescent cell antigen-like domains 1 0.0363684
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0353066
GMDS GDP-mannose 4,6-dehydratase 0.0351957
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0351198
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0346722
AIG1 androgen-induced 1 0.0342222
SFPQ splicing factor proline/glutamine-rich 0.0338833
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0333493
EXOC4 exocyst complex component 4 0.0333177
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0327724
RPL7 ribosomal protein L7 0.0321342
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0320315
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0318239
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0313224
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 0.0311702
FLNB filamin B, beta 0.0307697
ITGA6 integrin, alpha 6 0.0304509
ARGLU1 arginine and glutamate rich 1 0.0303978
PCCA propionyl CoA carboxylase, alpha polypeptide 0.030318
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0299292
SEPTIN9 septin 9 0.0291985
ACACA acetyl-CoA carboxylase alpha 0.0290292
ADGRL2 adhesion G protein-coupled receptor L2 0.0286774
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0286254
DOCK9 dedicator of cytokinesis 9 0.0284246
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.028334
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0277574
APP amyloid beta (A4) precursor protein 0.0276229
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0274499
NPAS2 neuronal PAS domain protein 2 0.0270806
MACF1 microtubule-actin crosslinking factor 1 0.0268693
EIF4B eukaryotic translation initiation factor 4B 0.0263226
MSN moesin 0.0262759
ARHGAP12 Rho GTPase activating protein 12 0.0261562
RASGRF2 Ras protein-specific guanine nucleotide-releasing factor 2 0.026059
GRIK5 glutamate receptor, ionotropic, kainate 5 0.0260121
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) 0.0259146
PEAK1 pseudopodium-enriched atypical kinase 1 0.0252893
MYH9 myosin, heavy chain 9, non-muscle 0.0252181
DSPP dentin sialophosphoprotein 0.025134
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0249711
HNRNPR heterogeneous nuclear ribonucleoprotein R 0.0248551
KDM4C lysine (K)-specific demethylase 4C 0.0247227
NSD1 nuclear receptor binding SET domain protein 1 0.0245128
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 0.0244648
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0243548
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0242708
SRSF1 serine/arginine-rich splicing factor 1 0.0242058
RBMS1 RNA binding motif, single stranded interacting protein 1 0.0240222
TPM4 tropomyosin 4 0.0239937
CCNY cyclin Y 0.0239626
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0239246
PUM3 pumilio RNA binding family member 3 0.0237524
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0237145
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 0.0235933
N4BP2L2 NEDD4 binding protein 2-like 2 0.0235085
ARHGAP26 Rho GTPase activating protein 26 0.0230552
XPO1 exportin 1 0.0228978
RIMBP2 RIMS binding protein 2 0.0227341

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.182942
TPT1 tumor protein, translationally-controlled 1 -0.103123
ACTN4 actinin, alpha 4 -0.0994159
RPS6 ribosomal protein S6 -0.0967858
EGR1 early growth response 1 -0.0916174
EZR ezrin -0.0887524
NCEH1 neutral cholesterol ester hydrolase 1 -0.0838419
RPL35A ribosomal protein L35a -0.0835475
ACTG1 actin gamma 1 -0.0783426
RPLP1 ribosomal protein, large, P1 -0.0730003
LOC102724023 ES1 protein homolog, mitochondrial -0.0723263
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0640268
TMSB10 thymosin beta 10 -0.0634102
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0615985
RPS8 ribosomal protein S8 -0.0609134
ANXA2 annexin A2 -0.0593674
RPS19 ribosomal protein S19 -0.0544093
RPS24 ribosomal protein S24 -0.0523668
NAP1L1 nucleosome assembly protein 1-like 1 -0.0501444
RPS12 ribosomal protein S12 -0.0488039
RPL37A ribosomal protein L37a -0.0481997
RPL23 ribosomal protein L23 -0.0478741
PTPN14 protein tyrosine phosphatase, non-receptor type 14 -0.047383
RPL36A ribosomal protein L36a -0.047315
RPLP2 ribosomal protein, large, P2 -0.0456279
RPS3 ribosomal protein S3 -0.0448243
RPL26 ribosomal protein L26 -0.0446929
RPS2 ribosomal protein S2 -0.0445635
VMP1 vacuole membrane protein 1 -0.0444173
RPL12 ribosomal protein L12 -0.0432721
EFNB2 ephrin-B2 -0.043271
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0427504
LMO7 LIM domain 7 -0.0422689
LOC112694756 uncharaterized LOC112694756 -0.0399124
SMAD3 SMAD family member 3 -0.0389136
RACK1 receptor for activated C kinase 1 -0.0375025
KLF6 Kruppel-like factor 6 -0.036796
PTMA prothymosin, alpha -0.0366988
RPL4 ribosomal protein L4 -0.0365135
RPS4X ribosomal protein S4, X-linked -0.0364903
IER3 immediate early response 3 -0.0363419
RPL32 ribosomal protein L32 -0.0359919
RPL9 ribosomal protein L9 -0.0346402
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0345325
JUN jun proto-oncogene -0.0344376
PERP PERP, TP53 apoptosis effector -0.0338502
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0335448
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0330741
RPL37 ribosomal protein L37 -0.0328443
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 -0.0324917
MT2A metallothionein 2A -0.0323775
RPL34 ribosomal protein L34 -0.0320558
EMP1 epithelial membrane protein 1 -0.0319053
SOX4 SRY (sex determining region Y)-box 4 -0.0318498
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.031696
FTL ferritin, light polypeptide -0.031332
RPL36 ribosomal protein L36 -0.031189
RPS25 ribosomal protein S25 -0.0311554
FOXP1 forkhead box P1 -0.0307429
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0306746
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0302375
VCL vinculin -0.0301174
RPL38 ribosomal protein L38 -0.0300792
RPL35 ribosomal protein L35 -0.0299203
SQSTM1 sequestosome 1 -0.0296587
RPL11 ribosomal protein L11 -0.0296284
GNAS GNAS complex locus -0.0292738
RPL31 ribosomal protein L31 -0.0292308
TM4SF1 transmembrane 4 L six family member 1 -0.0290375
RPL19 ribosomal protein L19 -0.0289481
RPS21 ribosomal protein S21 -0.0286686
SVIL supervillin -0.0286505
EIF1 eukaryotic translation initiation factor 1 -0.0284547
RPS13 ribosomal protein S13 -0.0281709
HMGB1 high mobility group box 1 -0.0280881
SMC4 structural maintenance of chromosomes 4 -0.0280838
BMP5 bone morphogenetic protein 5 -0.0274237
RPS23 ribosomal protein S23 -0.0272047
RPLP0 ribosomal protein, large, P0 -0.0270872
RPL5 ribosomal protein L5 -0.0262095
S100A10 S100 calcium binding protein A10 -0.0260844
RPS27A ribosomal protein S27a -0.0259162
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0258029
GCC2 GRIP and coiled-coil domain containing 2 -0.0257236
SOX9 SRY (sex determining region Y)-box 9 -0.0257188
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.025639
RPL28 ribosomal protein L28 -0.0255886
SDC4 syndecan 4 -0.0255685
RPL13A ribosomal protein L13a -0.0255012
MYO1E myosin IE -0.025288
MYL12B myosin, light chain 12B, regulatory -0.0246961
DUSP6 dual specificity phosphatase 6 -0.0243472
RPL39 ribosomal protein L39 -0.0242073
RPS14 ribosomal protein S14 -0.0239586
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0239379
MORF4L2 mortality factor 4 like 2 -0.0237266
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0236325
TJP1 tight junction protein 1 -0.0236154
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0233445
RPS20 ribosomal protein S20 -0.0229347