Clofarabine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LPIN1 lipin 1 0.121999
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0915138
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.088741
FAM13A family with sequence similarity 13, member A 0.0751989
PTMA prothymosin, alpha 0.0731366
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0594893
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0552549
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0529692
NAMPT nicotinamide phosphoribosyltransferase 0.05296
MEIS2 Meis homeobox 2 0.05125
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0510769
RPS6 ribosomal protein S6 0.0504912
HSPA8 heat shock 70kDa protein 8 0.0479918
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0477468
DSCAM Down syndrome cell adhesion molecule 0.0427672
TRIO trio Rho guanine nucleotide exchange factor 0.0422012
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0411029
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0394509
PRRC2C proline-rich coiled-coil 2C 0.0387786
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0384686
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0381769
COL3A1 collagen, type III, alpha 1 0.0377489
DST dystonin 0.0376947
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0366954
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0345573
RPS2 ribosomal protein S2 0.0339765
AHNAK AHNAK nucleoprotein 0.0336061
MYH9 myosin, heavy chain 9, non-muscle 0.0331066
FNDC3B fibronectin type III domain containing 3B 0.0328285
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0325882
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0325686
TLE4 transducin-like enhancer of split 4 0.0322895
SET SET nuclear proto-oncogene 0.0320283
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0318848
AOPEP aminopeptidase O (putative) 0.0315618
HMGB2 high mobility group box 2 0.0314669
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0312291
NPEPPS aminopeptidase puromycin sensitive 0.0302922
APP amyloid beta (A4) precursor protein 0.0287768
RNF213 ring finger protein 213 0.0286902
NCKAP1 NCK-associated protein 1 0.0286502
KLHL13 kelch-like family member 13 0.0283788
SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 0.0280077
RBM25 RNA binding motif protein 25 0.0279701
WDR43 WD repeat domain 43 0.0275527
AKAP12 A kinase (PRKA) anchor protein 12 0.0275369
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0274654
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0272704
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0270403
EEF1G eukaryotic translation elongation factor 1 gamma 0.0270007
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0268339
KIF5B kinesin family member 5B 0.0262048
HNRNPK heterogeneous nuclear ribonucleoprotein K 0.0260798
RSRC2 arginine/serine-rich coiled-coil 2 0.0259709
RPL14 ribosomal protein L14 0.0257471
RPS3 ribosomal protein S3 0.0257402
RPL26 ribosomal protein L26 0.025666
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0256147
RAD23B RAD23 homolog B (S. cerevisiae) 0.0250309
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0248795
SEPTIN9 septin 9 0.0241988
FOXO3 forkhead box O3 0.0236866
CSDE1 cold shock domain containing E1, RNA-binding 0.0235188
PUM2 pumilio RNA-binding family member 2 0.0234206
BIRC2 baculoviral IAP repeat containing 2 0.0233105
YME1L1 YME1-like 1 ATPase 0.0232088
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0232032
NCOR1 nuclear receptor corepressor 1 0.0231101
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0230362
HAS2 hyaluronan synthase 2 0.0228958
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0226009
SERINC1 serine incorporator 1 0.0225532
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0224241
WAC WW domain containing adaptor with coiled-coil 0.0222837
NRIP1 nuclear receptor interacting protein 1 0.0221955
TOP2B topoisomerase (DNA) II beta 180kDa 0.0221855
SBF2 SET binding factor 2 0.022159
KDM3A lysine (K)-specific demethylase 3A 0.0220629
TBX2 T-box 2 0.0219416
ASPH aspartate beta-hydroxylase 0.0218798
PNN pinin, desmosome associated protein 0.0218646
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0214504
PARD3 par-3 family cell polarity regulator 0.021364
SMAD3 SMAD family member 3 0.0213215
PHF3 PHD finger protein 3 0.0213114
RBM39 RNA binding motif protein 39 0.0212688
OSBPL8 oxysterol binding protein-like 8 0.021161
PELI1 pellino E3 ubiquitin protein ligase 1 0.0211428
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0210134
ARRDC3 arrestin domain containing 3 0.0209105
CENPF centromere protein F, 350/400kDa 0.0208655
PNISR PNN-interacting serine/arginine-rich protein 0.0208439
ARHGAP9 Rho GTPase activating protein 9 0.0207814
CD36 CD36 molecule (thrombospondin receptor) 0.0207735
NAP1L1 nucleosome assembly protein 1-like 1 0.0207203
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0205932
SOX9 SRY (sex determining region Y)-box 9 0.0203253
CLTC clathrin, heavy chain (Hc) 0.0202885
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0202146
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0201618

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.39416
NRG1 neuregulin 1 -0.141939
VIM vimentin -0.0659745
VCL vinculin -0.0632759
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0616822
GDF15 growth differentiation factor 15 -0.059025
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0572033
BPTF bromodomain PHD finger transcription factor -0.054896
NALF1 NALCN channel auxiliary factor 1 -0.0546883
NDRG1 N-myc downstream regulated 1 -0.0538894
SYT1 synaptotagmin I -0.0538403
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0532909
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0522236
COL4A5 collagen, type IV, alpha 5 -0.0429086
CEMIP cell migration inducing protein, hyaluronan binding -0.0428823
MCL1 myeloid cell leukemia 1 -0.0392643
ZBTB20 zinc finger and BTB domain containing 20 -0.0378318
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.037731
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0364799
KDM2A lysine (K)-specific demethylase 2A -0.0361036
MAML2 mastermind-like 2 (Drosophila) -0.0355642
SEC31A SEC31 homolog A (S. cerevisiae) -0.0352076
LIMCH1 LIM and calponin homology domains 1 -0.033701
VDAC1 voltage-dependent anion channel 1 -0.0335272
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0333813
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0331233
EXT1 exostosin glycosyltransferase 1 -0.032504
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0320562
STC1 stanniocalcin 1 -0.0309298
GPC5 glypican 5 -0.0306296
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0293948
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0292584
EGR1 early growth response 1 -0.0284153
ZCCHC7 zinc finger, CCHC domain containing 7 -0.028017
NPAS2 neuronal PAS domain protein 2 -0.0280102
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.027769
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0276136
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0275247
COPA coatomer protein complex, subunit alpha -0.0273526
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0265956
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0264263
SLIT2 slit homolog 2 (Drosophila) -0.0262271
LPP LIM domain containing preferred translocation partner in lipoma -0.0259135
ATRNL1 attractin-like 1 -0.0257115
PDIA3 protein disulfide isomerase family A, member 3 -0.0254639
TPT1 tumor protein, translationally-controlled 1 -0.0253623
CTBP2 C-terminal binding protein 2 -0.0253605
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.025147
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0250604
GREM2 gremlin 2, DAN family BMP antagonist -0.0244461
ACTG1 actin gamma 1 -0.0240601
ZNF609 zinc finger protein 609 -0.0240284
DCAF7 DDB1 and CUL4 associated factor 7 -0.0235512
IGFBP3 insulin-like growth factor binding protein 3 -0.0234661
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0232321
PLAT plasminogen activator, tissue -0.0230166
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0228715
DLG1 discs, large homolog 1 (Drosophila) -0.0228696
AEBP2 AE binding protein 2 -0.0227957
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0225707
NPAS3 neuronal PAS domain protein 3 -0.0222529
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0221952
HM13 histocompatibility (minor) 13 -0.0219348
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0217021
INTS6 integrator complex subunit 6 -0.0216793
TMSB10 thymosin beta 10 -0.0216592
EXOC4 exocyst complex component 4 -0.021638
BRWD1 bromodomain and WD repeat domain containing 1 -0.0214984
FTH1 ferritin, heavy polypeptide 1 -0.0214754
NBEA neurobeachin -0.0210393
HMGA1 high mobility group AT-hook 1 -0.0209545
ADAMTS19 ADAM metallopeptidase with thrombospondin type 1 motif, 19 -0.0207472
PIBF1 progesterone immunomodulatory binding factor 1 -0.0206812
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0205664
ZNF804A zinc finger protein 804A -0.0204994
AHR aryl hydrocarbon receptor -0.0204322
UNC5C unc-5 homolog C (C. elegans) -0.020304
CADM2 cell adhesion molecule 2 -0.0200899
BICD1 bicaudal D homolog 1 (Drosophila) -0.0200829
SCFD1 sec1 family domain containing 1 -0.0200279
LIMA1 LIM domain and actin binding 1 -0.0197657
HMGA2 high mobility group AT-hook 2 -0.01973
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0197233
GOLPH3L golgi phosphoprotein 3-like -0.0195982
MYO1E myosin IE -0.0194844
CHD9 chromodomain helicase DNA binding protein 9 -0.0194628
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0194015
IARS1 isoleucyl-tRNA synthetase 1 -0.0193734
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0190129
FRMD4A FERM domain containing 4A -0.0189957
ALCAM activated leukocyte cell adhesion molecule -0.0188923
KCNIP4 Kv channel interacting protein 4 -0.0188679
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0185578
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0185049
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0184756
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0184122
FTL ferritin, light polypeptide -0.0183969
DIAPH2 diaphanous-related formin 2 -0.0183714
SLITRK6 SLIT and NTRK-like family, member 6 -0.018353
SCARB1 scavenger receptor class B, member 1 -0.0182934