Clofarabine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in COLO 205 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Clofarabine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 0.0587988
ERRFI1 ERBB receptor feedback inhibitor 1 0.0547934
PRELID2 PRELI domain containing 2 0.0497227
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.045755
IFNGR1 interferon gamma receptor 1 0.0455907
MYH9 myosin, heavy chain 9, non-muscle 0.0454353
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0448125
RNF43 ring finger protein 43 0.0446678
NRIP1 nuclear receptor interacting protein 1 0.0416983
ZMYM2 zinc finger, MYM-type 2 0.041541
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0403473
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0392537
PHF3 PHD finger protein 3 0.0383559
RPS6 ribosomal protein S6 0.038012
GOLGA4 golgin A4 0.0367835
RBM26 RNA binding motif protein 26 0.0367763
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0355797
RAD51B RAD51 paralog B 0.0341039
ASPH aspartate beta-hydroxylase 0.0340461
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0339195
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0335488
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.032203
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0312343
BCLAF1 BCL2-associated transcription factor 1 0.0311366
TM9SF2 transmembrane 9 superfamily member 2 0.0300571
MCTP2 multiple C2 domains, transmembrane 2 0.029839
ARRDC3 arrestin domain containing 3 0.0293093
RPS3 ribosomal protein S3 0.0293004
SORBS1 sorbin and SH3 domain containing 1 0.0292346
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.0289951
BHLHE40 basic helix-loop-helix family, member e40 0.0285755
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0271078
EHF ets homologous factor 0.0266741
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0264202
DIAPH3 diaphanous-related formin 3 0.0264196
BRWD3 bromodomain and WD repeat domain containing 3 0.026165
ARGLU1 arginine and glutamate rich 1 0.02588
SAMD12 sterile alpha motif domain containing 12 0.025863
ARHGAP32 Rho GTPase activating protein 32 0.0249645
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0246108
PDIA4 protein disulfide isomerase family A, member 4 0.024546
RBM39 RNA binding motif protein 39 0.024506
KMT2C lysine (K)-specific methyltransferase 2C 0.0243769
EIF4B eukaryotic translation initiation factor 4B 0.0243088
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0239088
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0236517
EIF4A2 eukaryotic translation initiation factor 4A2 0.0235229
UBAC2 UBA domain containing 2 0.0234111
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0233471
NCOR1 nuclear receptor corepressor 1 0.0229613
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0229451
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0228411
TUBGCP3 tubulin, gamma complex associated protein 3 0.0228293
FNIP1 folliculin interacting protein 1 0.0228284
MEF2A myocyte enhancer factor 2A 0.0228195
SUCO SUN domain containing ossification factor 0.0228135
RSRC2 arginine/serine-rich coiled-coil 2 0.0227599
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 0.0225426
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0224787
KIF16B kinesin family member 16B 0.0224056
GIGYF2 GRB10 interacting GYF protein 2 0.0223305
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0222754
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.022255
SBF2 SET binding factor 2 0.0222025
GOLGB1 golgin B1 0.0220721
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0220191
FAT1 FAT atypical cadherin 1 0.0216742
LDHA lactate dehydrogenase A 0.0213295
DSPP dentin sialophosphoprotein 0.021287
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0211891
STK24 serine/threonine kinase 24 0.0210906
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0209729
FNDC3A fibronectin type III domain containing 3A 0.020961
SPRED1 sprouty-related, EVH1 domain containing 1 0.020935
ZDHHC20 zinc finger, DHHC-type containing 20 0.020834
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0207285
RNF145 ring finger protein 145 0.0202808
PTEN phosphatase and tensin homolog 0.0202316
YEATS2 YEATS domain containing 2 0.020177
OGA O-GlcNAcase 0.0201187
NFE2L1 nuclear factor, erythroid 2-like 1 0.020067
MLPH melanophilin 0.0200281
ZNF148 zinc finger protein 148 0.0200162
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0199143
PUM2 pumilio RNA-binding family member 2 0.0198248
CUL3 cullin 3 0.0196475
LRRC1 leucine rich repeat containing 1 0.0196023
PDS5B PDS5 cohesin associated factor B 0.0195872
TMED9 transmembrane emp24 protein transport domain containing 9 0.0195338
ANO6 anoctamin 6 0.0195261
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0194748
WDR26 WD repeat domain 26 0.0193459
PTBP3 polypyrimidine tract binding protein 3 0.0193296
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0192617
WDR33 WD repeat domain 33 0.0192196
TBC1D22A TBC1 domain family, member 22A 0.0191645
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0189065
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0188337
SCAPER S-phase cyclin A-associated protein in the ER 0.0186508
TMED2 transmembrane emp24 domain trafficking protein 2 0.018626

decreased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 -0.206404
EGR1 early growth response 1 -0.188858
ANXA2 annexin A2 -0.1396
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.129256
B2M beta-2-microglobulin -0.12262
FOS FBJ murine osteosarcoma viral oncogene homolog -0.113139
EPSTI1 epithelial stromal interaction 1 (breast) -0.110147
TPT1 tumor protein, translationally-controlled 1 -0.10809
EZR ezrin -0.10088
PERP PERP, TP53 apoptosis effector -0.0997201
RAB7A RAB7A, member RAS oncogene family -0.0988394
MYO1E myosin IE -0.0968081
LOC102724023 ES1 protein homolog, mitochondrial -0.0961614
RNF213 ring finger protein 213 -0.0957032
INTS6 integrator complex subunit 6 -0.0897613
SQSTM1 sequestosome 1 -0.0830727
LCN2 lipocalin 2 -0.0830542
HLA-B major histocompatibility complex, class I, B -0.0826373
RIGI RNA sensor RIG-I -0.0805914
PKM pyruvate kinase, muscle -0.0787466
LYZ lysozyme -0.0780512
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0745399
MX1 MX dynamin-like GTPase 1 -0.0743499
EXT1 exostosin glycosyltransferase 1 -0.0732287
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0728104
JUN jun proto-oncogene -0.0701402
MX2 MX dynamin-like GTPase 2 -0.0694734
GCLC glutamate-cysteine ligase, catalytic subunit -0.0689721
TMC5 transmembrane channel-like 5 -0.0682794
C6ORF132 chromosome 6 open reading frame 132 -0.0655397
PLSCR1 phospholipid scramblase 1 -0.0651658
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0649679
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0647627
MACC1 metastasis associated in colon cancer 1 -0.062664
IRF1 interferon regulatory factor 1 -0.0611084
AREG amphiregulin -0.0606361
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0603637
SP100 SP100 nuclear antigen -0.0575272
TJP1 tight junction protein 1 -0.0568762
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) -0.054103
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0540796
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0526854
HLA-E major histocompatibility complex, class I, E -0.0514198
GMDS GDP-mannose 4,6-dehydratase -0.0493646
FTH1 ferritin, heavy polypeptide 1 -0.0485202
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0478749
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0476274
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0459866
PHACTR4 phosphatase and actin regulator 4 -0.0455737
ITPKC inositol-trisphosphate 3-kinase C -0.0455354
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -0.0451427
BLZF1 basic leucine zipper nuclear factor 1 -0.0441249
EPHB2 EPH receptor B2 -0.0437663
IFI6 interferon, alpha-inducible protein 6 -0.0426606
SPDYA speedy/RINGO cell cycle regulator family member A -0.0420135
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0418466
ITGA6 integrin, alpha 6 -0.0410908
RBM47 RNA binding motif protein 47 -0.0409875
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0404497
MCL1 myeloid cell leukemia 1 -0.0404317
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0397015
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0394918
ACTG1 actin gamma 1 -0.0386515
MORF4L2 mortality factor 4 like 2 -0.0386229
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0375424
DDIT3 DNA-damage-inducible transcript 3 -0.0374776
S100A6 S100 calcium binding protein A6 -0.0373167
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0371658
PDIA3 protein disulfide isomerase family A, member 3 -0.0368514
FTL ferritin, light polypeptide -0.0366814
STS steroid sulfatase (microsomal), isozyme S -0.0366445
EFNB2 ephrin-B2 -0.0363646
NCOA7 nuclear receptor coactivator 7 -0.0359739
CYSTM1 cysteine-rich transmembrane module containing 1 -0.0359541
UBC ubiquitin C -0.0359071
MUC20 mucin 20, cell surface associated -0.0358119
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0354792
IFI27 interferon, alpha-inducible protein 27 -0.0352826
HLA-A major histocompatibility complex, class I, A -0.0352438
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0352313
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0350264
HM13 histocompatibility (minor) 13 -0.0348974
UGDH UDP-glucose 6-dehydrogenase -0.0346942
IRS2 insulin receptor substrate 2 -0.034406
UBAP2 ubiquitin associated protein 2 -0.0343073
VDAC1 voltage-dependent anion channel 1 -0.0342492
MAP7 microtubule-associated protein 7 -0.0339738
SLC38A1 solute carrier family 38, member 1 -0.0337437
HLA-C major histocompatibility complex, class I, C -0.0337072
TRIM2 tripartite motif containing 2 -0.0336818
DUSP10 dual specificity phosphatase 10 -0.0335225
PMP22 peripheral myelin protein 22 -0.0331125
AKAP13 A kinase (PRKA) anchor protein 13 -0.0327025
CATSPERB catsper channel auxiliary subunit beta -0.0326154
MUC13 mucin 13, cell surface associated -0.0323963
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0321686
S100A10 S100 calcium binding protein A10 -0.0318265
CCNL1 cyclin L1 -0.0317683
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 -0.0317562
ERBIN erbb2 interacting protein -0.0313123