Clofarabine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.230292
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.185482
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.14168
RPS3 ribosomal protein S3 0.125943
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.109635
RPS6 ribosomal protein S6 0.108402
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.107904
RPS12 ribosomal protein S12 0.0919723
RPS19 ribosomal protein S19 0.090626
GOLGA4 golgin A4 0.0901635
RPL26 ribosomal protein L26 0.0895186
RPS8 ribosomal protein S8 0.0882013
RPL37A ribosomal protein L37a 0.0871833
TXNIP thioredoxin interacting protein 0.0790429
TMSB10 thymosin beta 10 0.0773749
LDHA lactate dehydrogenase A 0.0770097
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0746743
NDRG1 N-myc downstream regulated 1 0.0725794
AREG amphiregulin 0.0701007
S100P S100 calcium binding protein P 0.0682596
RPL36 ribosomal protein L36 0.0679515
FAM13A family with sequence similarity 13, member A 0.0676148
RPS2 ribosomal protein S2 0.0665656
RPL23 ribosomal protein L23 0.065901
RPL12 ribosomal protein L12 0.0629798
RPL19 ribosomal protein L19 0.0611286
RPL11 ribosomal protein L11 0.0597308
RPL34 ribosomal protein L34 0.058546
EREG epiregulin 0.0578047
RNF145 ring finger protein 145 0.0577651
EIF1 eukaryotic translation initiation factor 1 0.0570401
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0563438
VCL vinculin 0.0557602
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0556779
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0537133
PRRC2C proline-rich coiled-coil 2C 0.0525272
VMP1 vacuole membrane protein 1 0.0490967
DDIT4 DNA-damage-inducible transcript 4 0.0474386
MYH9 myosin, heavy chain 9, non-muscle 0.0474069
RPL35A ribosomal protein L35a 0.0466738
RPL13A ribosomal protein L13a 0.0466701
RPS17 ribosomal protein S17 0.0458948
RPL18 ribosomal protein L18 0.0441952
CALR calreticulin 0.0432465
ERRFI1 ERBB receptor feedback inhibitor 1 0.0431943
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0430428
RPL5 ribosomal protein L5 0.042929
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0424927
UBA6 ubiquitin-like modifier activating enzyme 6 0.042203
RACK1 receptor for activated C kinase 1 0.0415308
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0401494
YBX1 Y box binding protein 1 0.0399761
GARS1 glycyl-tRNA synthetase 1 0.0398363
RPS21 ribosomal protein S21 0.0396309
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0394428
EEF1G eukaryotic translation elongation factor 1 gamma 0.0389343
ANKRD11 ankyrin repeat domain 11 0.0388273
RPS29 ribosomal protein S29 0.037981
ATF4 activating transcription factor 4 0.0379563
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.037794
RBM39 RNA binding motif protein 39 0.0377889
APLP2 amyloid beta (A4) precursor-like protein 2 0.0376785
PCBP2 poly(rC) binding protein 2 0.0375733
MED13L mediator complex subunit 13-like 0.0375675
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 0.0375009
RPL32 ribosomal protein L32 0.0370914
CD46 CD46 molecule, complement regulatory protein 0.0364656
FTL ferritin, light polypeptide 0.0362018
H1-0 H1.0 linker histone 0.0356458
RPLP2 ribosomal protein, large, P2 0.0354636
RPL7 ribosomal protein L7 0.0347527
RAB1A RAB1A, member RAS oncogene family 0.0347138
PDIA4 protein disulfide isomerase family A, member 4 0.0346736
RNF43 ring finger protein 43 0.034597
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0345652
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0341371
DSCAM Down syndrome cell adhesion molecule 0.0339624
RPL35 ribosomal protein L35 0.0339613
RPL9 ribosomal protein L9 0.0339256
PRELID2 PRELI domain containing 2 0.0337132
PNN pinin, desmosome associated protein 0.033354
CSDE1 cold shock domain containing E1, RNA-binding 0.0333148
ITPRID2 ITPR interacting domain containing 2 0.0331634
VEGFA vascular endothelial growth factor A 0.0331015
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.032555
TNS4 tensin 4 0.0324884
BRD2 bromodomain containing 2 0.0324726
KRT8 keratin 8, type II 0.0324124
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0322573
KMT2E lysine (K)-specific methyltransferase 2E 0.0322137
MACF1 microtubule-actin crosslinking factor 1 0.0320918
RPS23 ribosomal protein S23 0.0320226
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0320056
RPS27 ribosomal protein S27 0.0319313
UQCRB ubiquinol-cytochrome c reductase binding protein 0.031815
ZNF292 zinc finger protein 292 0.0316567
S100A14 S100 calcium binding protein A14 0.0314724
SRRM1 serine/arginine repetitive matrix 1 0.0311141
AKAP9 A kinase (PRKA) anchor protein 9 0.0309628
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.030784

decreased expression

Symbol Name Standardized Value
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.128404
TPT1 tumor protein, translationally-controlled 1 -0.115101
NPSR1 neuropeptide S receptor 1 -0.111709
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0728254
NALF1 NALCN channel auxiliary factor 1 -0.0691508
ALCAM activated leukocyte cell adhesion molecule -0.0526148
PDE4D phosphodiesterase 4D, cAMP-specific -0.0507715
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0456279
ACTG1 actin gamma 1 -0.0446697
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0434162
CCND1 cyclin D1 -0.0378554
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0352217
MUC17 mucin 17, cell surface associated -0.0348764
SLC35F3 solute carrier family 35, member F3 -0.0320243
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.032024
PTPRK protein tyrosine phosphatase, receptor type, K -0.0318656
TFF1 trefoil factor 1 -0.0313788
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0309796
PSD3 pleckstrin and Sec7 domain containing 3 -0.030576
VDAC1 voltage-dependent anion channel 1 -0.0303703
RNF217 ring finger protein 217 -0.0301159
KLK10 kallikrein-related peptidase 10 -0.0298934
PPARG peroxisome proliferator-activated receptor gamma -0.0298029
ZNF33A zinc finger protein 33A -0.0296597
ANTXR2 anthrax toxin receptor 2 -0.0291368
FAF1 Fas (TNFRSF6) associated factor 1 -0.028488
KPNB1 karyopherin (importin) beta 1 -0.0284617
GTF2IRD1 GTF2I repeat domain containing 1 -0.0282461
PRSS3 protease, serine, 3 -0.0277714
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0276236
MAML3 mastermind-like 3 (Drosophila) -0.0269739
FRMD5 FERM domain containing 5 -0.0268167
EGFR epidermal growth factor receptor -0.0266797
SOX4 SRY (sex determining region Y)-box 4 -0.0266027
EPHB2 EPH receptor B2 -0.0257602
GCC2 GRIP and coiled-coil domain containing 2 -0.0256746
SH3D19 SH3 domain containing 19 -0.0252178
DEK DEK proto-oncogene -0.0250214
HMGB1 high mobility group box 1 -0.0248546
DIAPH2 diaphanous-related formin 2 -0.0242846
MSI2 musashi RNA-binding protein 2 -0.0239351
REEP3 receptor accessory protein 3 -0.0238161
RABGAP1L RAB GTPase activating protein 1-like -0.0235375
GREB1L growth regulation by estrogen in breast cancer-like -0.0230462
PPP1R9A protein phosphatase 1, regulatory subunit 9A -0.0223409
SAMD5 sterile alpha motif domain containing 5 -0.0220232
FHIT fragile histidine triad -0.0218031
RIN2 Ras and Rab interactor 2 -0.0217323
MED13 mediator complex subunit 13 -0.0216568
PKP4 plakophilin 4 -0.02117
FERMT1 fermitin family member 1 -0.020988
MTAP methylthioadenosine phosphorylase -0.020931
DGKH diacylglycerol kinase, eta -0.0208224
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0207577
TRAPPC9 trafficking protein particle complex 9 -0.020547
FOXP1 forkhead box P1 -0.0203656
TUBA1B tubulin, alpha 1b -0.020128
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0199626
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.0197596
SMYD3 SET and MYND domain containing 3 -0.0195819
PATJ PATJ crumbs cell polarity complex component -0.0195159
IGF1R insulin-like growth factor 1 receptor -0.0194357
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0193381
RPLP1 ribosomal protein, large, P1 -0.0189496
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0188423
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0187898
SORBS2 sorbin and SH3 domain containing 2 -0.0185848
SLCO3A1 solute carrier organic anion transporter family, member 3A1 -0.0185846
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0184375
R3HDM2 R3H domain containing 2 -0.0184019
BACE2 beta-site APP-cleaving enzyme 2 -0.0183406
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0182184
TMEM45B transmembrane protein 45B -0.0181001
AHI1 Abelson helper integration site 1 -0.0179957
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0179342
SCMH1 sex comb on midleg homolog 1 (Drosophila) -0.0179294
NSD2 nuclear receptor binding SET domain protein 2 -0.01786
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0176952
VWA8 von Willebrand factor A domain containing 8 -0.0175938
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0175518
EHBP1 EH domain binding protein 1 -0.0175302
CUL4A cullin 4A -0.0174243
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0174048
TMEM117 transmembrane protein 117 -0.0173506
COBL cordon-bleu WH2 repeat protein -0.0173129
ANO1 anoctamin 1, calcium activated chloride channel -0.0172308
CNKSR3 CNKSR family member 3 -0.0171139
SEPTIN11 septin 11 -0.0170988
HMGA2 high mobility group AT-hook 2 -0.0170848
IER3 immediate early response 3 -0.0170385
MARCHF3 membrane associated ring-CH-type finger 3 -0.0169232
JMJD1C jumonji domain containing 1C -0.0169168
CLOCK clock circadian regulator -0.0169026
ITGB4 integrin, beta 4 -0.0168936
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0168363
LARP1 La ribonucleoprotein domain family, member 1 -0.0164872
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0164852
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0164545
TMEM123 transmembrane protein 123 -0.0164323
RAD51B RAD51 paralog B -0.0164273