Clofarabine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.129007
PTMA prothymosin, alpha 0.11386
ERRFI1 ERBB receptor feedback inhibitor 1 0.111508
RPS3 ribosomal protein S3 0.0958905
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0762246
RPS8 ribosomal protein S8 0.0745649
EZR ezrin 0.0671358
RPS6 ribosomal protein S6 0.0655029
TMSB4X thymosin beta 4, X-linked 0.0645626
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0623344
RPS2 ribosomal protein S2 0.0589291
RPL26 ribosomal protein L26 0.0588234
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0561523
TXNRD1 thioredoxin reductase 1 0.0560689
RAI1 retinoic acid induced 1 0.0559874
HSPA8 heat shock 70kDa protein 8 0.0552013
RPL37A ribosomal protein L37a 0.0523997
SET SET nuclear proto-oncogene 0.0501819
RPS12 ribosomal protein S12 0.0501574
CENPF centromere protein F, 350/400kDa 0.0493668
MT2A metallothionein 2A 0.0489648
MYH9 myosin, heavy chain 9, non-muscle 0.0485223
RACK1 receptor for activated C kinase 1 0.0461837
MKI67 marker of proliferation Ki-67 0.0450283
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0408815
MACF1 microtubule-actin crosslinking factor 1 0.0398427
RPL35A ribosomal protein L35a 0.0398057
RPL36 ribosomal protein L36 0.0396355
SRGN serglycin 0.0390328
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0376747
RPL14 ribosomal protein L14 0.0360931
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0358547
RPS19 ribosomal protein S19 0.0357154
CXCL8 chemokine (C-X-C motif) ligand 8 0.0340874
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0339283
RSRC2 arginine/serine-rich coiled-coil 2 0.0336682
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0336642
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0327624
GARS1 glycyl-tRNA synthetase 1 0.0322782
BZW1 basic leucine zipper and W2 domains 1 0.0321574
RTN4 reticulon 4 0.0320686
BHLHE40 basic helix-loop-helix family, member e40 0.0318575
RPL13A ribosomal protein L13a 0.031503
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0312133
YBX3 Y box binding protein 3 0.0310119
KTN1 kinectin 1 (kinesin receptor) 0.030743
SQSTM1 sequestosome 1 0.0306545
YBX1 Y box binding protein 1 0.0305798
WDR43 WD repeat domain 43 0.0302907
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0301287
RPL18 ribosomal protein L18 0.030026
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0299087
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0294125
SERINC1 serine incorporator 1 0.0292811
RPS27A ribosomal protein S27a 0.0285747
RPL37 ribosomal protein L37 0.0284204
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0283099
EIF4A2 eukaryotic translation initiation factor 4A2 0.0282472
HDGF hepatoma-derived growth factor 0.0282044
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0281056
GOLGA4 golgin A4 0.0272211
PNISR PNN-interacting serine/arginine-rich protein 0.0270557
AREG amphiregulin 0.0269753
HSPA4 heat shock 70kDa protein 4 0.0262528
RPL23 ribosomal protein L23 0.0258395
FLNB filamin B, beta 0.0254388
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0252682
ARRDC3 arrestin domain containing 3 0.0249647
RPL11 ribosomal protein L11 0.0246804
RPL34 ribosomal protein L34 0.024554
PLK2 polo-like kinase 2 0.0244456
BIRC2 baculoviral IAP repeat containing 2 0.0244267
RBM25 RNA binding motif protein 25 0.0241297
TOP1 topoisomerase (DNA) I 0.0236947
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.023671
TRIO trio Rho guanine nucleotide exchange factor 0.0236265
TAPBP TAP binding protein (tapasin) 0.0235837
HMGB2 high mobility group box 2 0.0235521
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 0.023483
NAP1L1 nucleosome assembly protein 1-like 1 0.0234538
RPL19 ribosomal protein L19 0.0231436
EEF1G eukaryotic translation elongation factor 1 gamma 0.0230708
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0230608
RPS18 ribosomal protein S18 0.0230325
PRRC2C proline-rich coiled-coil 2C 0.0230156
RSL1D1 ribosomal L1 domain containing 1 0.0229577
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0228571
GIGYF2 GRB10 interacting GYF protein 2 0.0227384
FNIP1 folliculin interacting protein 1 0.0225836
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0221566
HOOK2 hook microtubule-tethering protein 2 0.0221389
UPP1 uridine phosphorylase 1 0.0220429
BRD4 bromodomain containing 4 0.0220427
PNN pinin, desmosome associated protein 0.021958
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.021619
ZFP36L1 ZFP36 ring finger protein-like 1 0.0216051
RPL4 ribosomal protein L4 0.0215127
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0214979
RPS4X ribosomal protein S4, X-linked 0.0214322
RPS27 ribosomal protein S27 0.0213279

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.383985
VIM vimentin -0.311404
TP63 tumor protein p63 -0.139546
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.113111
CD44 CD44 molecule (Indian blood group) -0.111476
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0901607
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0895472
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0842704
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0771239
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0719713
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0712846
TXNIP thioredoxin interacting protein -0.0671961
CADM2 cell adhesion molecule 2 -0.0661146
HMGA1 high mobility group AT-hook 1 -0.0655076
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0595025
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0587364
HLA-B major histocompatibility complex, class I, B -0.0561129
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0558074
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0557375
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0555371
RNF213 ring finger protein 213 -0.0545583
PSD3 pleckstrin and Sec7 domain containing 3 -0.0519324
WARS1 tryptophanyl-tRNA synthetase 1 -0.0512045
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0480229
TSC22D1 TSC22 domain family, member 1 -0.0471056
PDIA3 protein disulfide isomerase family A, member 3 -0.0470627
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.045818
SP100 SP100 nuclear antigen -0.0450279
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.044624
GCLM glutamate-cysteine ligase, modifier subunit -0.0438383
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0421669
VDAC1 voltage-dependent anion channel 1 -0.0420816
RIGI RNA sensor RIG-I -0.0419311
IFIH1 interferon induced with helicase C domain 1 -0.0402047
PLSCR1 phospholipid scramblase 1 -0.0386495
RAB7A RAB7A, member RAS oncogene family -0.0383988
ADGRG6 adhesion G protein-coupled receptor G6 -0.0378578
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.036976
TMEM123 transmembrane protein 123 -0.0366762
EEF2 eukaryotic translation elongation factor 2 -0.0360586
DPYD dihydropyrimidine dehydrogenase -0.0359477
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 -0.0344982
TPT1 tumor protein, translationally-controlled 1 -0.0341504
FBXO11 F-box protein 11 -0.0336241
SLC38A2 solute carrier family 38, member 2 -0.0335028
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0333668
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0317813
ZNF207 zinc finger protein 207 -0.031714
ECE1 endothelin converting enzyme 1 -0.0311662
BRWD1 bromodomain and WD repeat domain containing 1 -0.0310507
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0307568
EHBP1 EH domain binding protein 1 -0.0302671
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.0301994
RPS24 ribosomal protein S24 -0.0299071
HDAC9 histone deacetylase 9 -0.029439
EPHA4 EPH receptor A4 -0.0293019
BPTF bromodomain PHD finger transcription factor -0.0284522
PKM pyruvate kinase, muscle -0.0281309
EGR1 early growth response 1 -0.0279522
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.0279215
USP34 ubiquitin specific peptidase 34 -0.027693
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0273102
BICD1 bicaudal D homolog 1 (Drosophila) -0.0272572
NF1 neurofibromin 1 -0.0266867
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0266269
COL5A2 collagen, type V, alpha 2 -0.0265511
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0264699
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0261017
NCEH1 neutral cholesterol ester hydrolase 1 -0.0256186
RPL36A ribosomal protein L36a -0.0251396
MT1E metallothionein 1E -0.02513
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0251295
GLG1 golgi glycoprotein 1 -0.0250519
ZNF217 zinc finger protein 217 -0.0250464
PGAP1 post-GPI attachment to proteins 1 -0.0249192
BSG basigin (Ok blood group) -0.024872
LMAN1 lectin, mannose-binding, 1 -0.0248365
MBNL1 muscleblind-like splicing regulator 1 -0.024832
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0245884
FOXK1 forkhead box K1 -0.0245204
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0244884
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0244144
MYADM myeloid-associated differentiation marker -0.0243824
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0243162
INTS6 integrator complex subunit 6 -0.0238611
TAOK1 TAO kinase 1 -0.0237589
CSMD3 CUB and Sushi multiple domains 3 -0.0235966
XPO1 exportin 1 -0.0235031
RAP2B RAP2B, member of RAS oncogene family -0.0232769
TGM2 transglutaminase 2 -0.0230548
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.022958
DTX3L deltex 3 like, E3 ubiquitin ligase -0.022901
PTK2 protein tyrosine kinase 2 -0.0228834
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0228739
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0223984
PMP22 peripheral myelin protein 22 -0.0222588
DENND5B DENN/MADD domain containing 5B -0.0221559
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0220248
WSB1 WD repeat and SOCS box containing 1 -0.0218612
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.02177