Clofarabine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.158447
MT2A metallothionein 2A 0.101708
FAM13A family with sequence similarity 13, member A 0.0957258
RPS6 ribosomal protein S6 0.0708768
RPL37A ribosomal protein L37a 0.0700999
PTMA prothymosin, alpha 0.0681445
SEC61G Sec61 gamma subunit 0.0678009
MYH9 myosin, heavy chain 9, non-muscle 0.0643329
MKI67 marker of proliferation Ki-67 0.0635133
FTL ferritin, light polypeptide 0.0634142
RPS8 ribosomal protein S8 0.0586376
RPS12 ribosomal protein S12 0.0573212
LAMB3 laminin, beta 3 0.0531161
NAMPT nicotinamide phosphoribosyltransferase 0.05271
TOP1 topoisomerase (DNA) I 0.0505232
TMSB10 thymosin beta 10 0.0483306
ARRDC3 arrestin domain containing 3 0.0477942
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0456775
GCLC glutamate-cysteine ligase, catalytic subunit 0.0440231
LAMC2 laminin, gamma 2 0.0422519
PRRC2C proline-rich coiled-coil 2C 0.0414183
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0412906
RPL35A ribosomal protein L35a 0.041219
RPS2 ribosomal protein S2 0.0407128
RPL11 ribosomal protein L11 0.0399267
B2M beta-2-microglobulin 0.0399066
NGLY1 N-glycanase 1 0.0395885
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0395514
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0391157
RNF145 ring finger protein 145 0.0376683
CAMTA1 calmodulin binding transcription activator 1 0.0367895
KTN1 kinectin 1 (kinesin receptor) 0.03675
HSPA8 heat shock 70kDa protein 8 0.0363748
RPL34 ribosomal protein L34 0.0361628
KDM6A lysine (K)-specific demethylase 6A 0.0360173
UBA6 ubiquitin-like modifier activating enzyme 6 0.0357538
EIF4A2 eukaryotic translation initiation factor 4A2 0.0356535
RPS17 ribosomal protein S17 0.0346626
ADAM17 ADAM metallopeptidase domain 17 0.0340196
BHLHE40 basic helix-loop-helix family, member e40 0.0335322
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0326143
RPL7 ribosomal protein L7 0.0324025
CXCL8 chemokine (C-X-C motif) ligand 8 0.0320749
RUNX1 runt-related transcription factor 1 0.0319601
ANKRD12 ankyrin repeat domain 12 0.0318318
NCKAP1 NCK-associated protein 1 0.0310283
MSN moesin 0.0309262
KMT2E lysine (K)-specific methyltransferase 2E 0.0305429
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.030065
RPS27 ribosomal protein S27 0.0296405
S100P S100 calcium binding protein P 0.0292868
RPL5 ribosomal protein L5 0.029204
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0287147
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0283458
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0279828
AKAP12 A kinase (PRKA) anchor protein 12 0.0277115
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0276972
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0275467
RPL26 ribosomal protein L26 0.0274452
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0274051
SRRM2 serine/arginine repetitive matrix 2 0.0273583
RPL13A ribosomal protein L13a 0.0273524
DDIT4 DNA-damage-inducible transcript 4 0.0265824
PUM2 pumilio RNA-binding family member 2 0.026151
RPS19 ribosomal protein S19 0.0260988
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0260098
RPS27A ribosomal protein S27a 0.0258363
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0256865
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 0.0255541
TAPBP TAP binding protein (tapasin) 0.0254576
RASA2 RAS p21 protein activator 2 0.0254026
RACK1 receptor for activated C kinase 1 0.0253993
RPL36 ribosomal protein L36 0.0252931
IFNAR2 interferon (alpha, beta and omega) receptor 2 0.0246806
EEF1G eukaryotic translation elongation factor 1 gamma 0.0245521
GOLGA4 golgin A4 0.024358
CSDE1 cold shock domain containing E1, RNA-binding 0.0241966
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.024128
ZNF292 zinc finger protein 292 0.0239816
PDE4D phosphodiesterase 4D, cAMP-specific 0.0238757
UVRAG UV radiation resistance associated 0.0237382
PNN pinin, desmosome associated protein 0.0235143
SRP54 signal recognition particle 54kDa 0.0234943
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.02346
BZW1 basic leucine zipper and W2 domains 1 0.0231516
WAC WW domain containing adaptor with coiled-coil 0.0229462
GIGYF2 GRB10 interacting GYF protein 2 0.0228643
SLK STE20-like kinase 0.0221989
CENPF centromere protein F, 350/400kDa 0.0221653
CYLD cylindromatosis (turban tumor syndrome) 0.022151
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0220829
RPL37 ribosomal protein L37 0.021983
PDIA6 protein disulfide isomerase family A, member 6 0.0219753
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0218637
RPS4X ribosomal protein S4, X-linked 0.0218617
ATP13A3 ATPase type 13A3 0.0217766
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0217574
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0216174
RPL12 ribosomal protein L12 0.0215883
RPS14 ribosomal protein S14 0.0215586

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.320158
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.314532
EGFR epidermal growth factor receptor -0.157838
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.132693
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0898144
OSMR oncostatin M receptor -0.077301
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0755624
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0751581
NDRG1 N-myc downstream regulated 1 -0.0720584
TXNRD1 thioredoxin reductase 1 -0.0719759
DOCK5 dedicator of cytokinesis 5 -0.0572147
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0544317
NABP1 nucleic acid binding protein 1 -0.0536098
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0514055
RNF213 ring finger protein 213 -0.0504025
PATJ PATJ crumbs cell polarity complex component -0.0483845
FTH1 ferritin, heavy polypeptide 1 -0.0476503
EGR1 early growth response 1 -0.0476262
LMO7 LIM domain 7 -0.0475629
CAV1 caveolin 1, caveolae protein, 22kDa -0.046548
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.046516
INTS6 integrator complex subunit 6 -0.0457613
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0438021
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0436141
EXT1 exostosin glycosyltransferase 1 -0.0415336
VCL vinculin -0.0409273
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0407477
ANXA2 annexin A2 -0.0404362
TRAPPC9 trafficking protein particle complex 9 -0.0403975
SLC38A2 solute carrier family 38, member 2 -0.0403231
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0400003
LOC112694756 uncharaterized LOC112694756 -0.0383621
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0379237
MYO1E myosin IE -0.0376383
EFNA5 ephrin-A5 -0.036608
LAMA4 laminin, alpha 4 -0.0352714
PDIA3 protein disulfide isomerase family A, member 3 -0.0348059
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.034578
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0345099
S100A10 S100 calcium binding protein A10 -0.0343432
NPC1 Niemann-Pick disease, type C1 -0.0340046
USP34 ubiquitin specific peptidase 34 -0.0339569
TES testin LIM domain protein -0.033774
ZBTB20 zinc finger and BTB domain containing 20 -0.033558
SEC31A SEC31 homolog A (S. cerevisiae) -0.0331306
TJP1 tight junction protein 1 -0.0331249
BLZF1 basic leucine zipper nuclear factor 1 -0.0331197
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0330297
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -0.0328178
MYOF myoferlin -0.0328014
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0323056
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0321381
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0314756
LRP12 low density lipoprotein receptor-related protein 12 -0.0312886
RIMS2 regulating synaptic membrane exocytosis 2 -0.0311849
CCND1 cyclin D1 -0.0311177
CES1 carboxylesterase 1 -0.0310706
BPTF bromodomain PHD finger transcription factor -0.0308868
NF1 neurofibromin 1 -0.030365
TPT1 tumor protein, translationally-controlled 1 -0.0300825
STC1 stanniocalcin 1 -0.029497
SMYD3 SET and MYND domain containing 3 -0.028957
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0283807
FBXO11 F-box protein 11 -0.0282709
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0279625
IGF1R insulin-like growth factor 1 receptor -0.0278249
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0278171
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0278047
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0271224
ECD ecdysoneless homolog (Drosophila) -0.027037
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0270119
SLTM SAFB-like, transcription modulator -0.0266828
GM2A GM2 ganglioside activator -0.02667
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.02643
ASPH aspartate beta-hydroxylase -0.0263811
VDAC1 voltage-dependent anion channel 1 -0.0254258
LRP1B low density lipoprotein receptor-related protein 1B -0.0253242
EHBP1 EH domain binding protein 1 -0.0249859
FOXP1 forkhead box P1 -0.0248951
ZNF638 zinc finger protein 638 -0.0246132
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) -0.0246074
MAML3 mastermind-like 3 (Drosophila) -0.024583
ARCN1 archain 1 -0.0244645
TAOK1 TAO kinase 1 -0.0243103
ARF1 ADP-ribosylation factor 1 -0.0242319
RAB10 RAB10, member RAS oncogene family -0.0242172
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0238334
NCOA7 nuclear receptor coactivator 7 -0.0237045
AHNAK AHNAK nucleoprotein -0.023682
CANX calnexin -0.023605
KDM2A lysine (K)-specific demethylase 2A -0.0227456
BRWD1 bromodomain and WD repeat domain containing 1 -0.0225445
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.0223418
PKM pyruvate kinase, muscle -0.0223314
MBNL2 muscleblind-like splicing regulator 2 -0.0222967
BMAL2 basic helix-loop-helix ARNT like 2 -0.0219511
PDLIM5 PDZ and LIM domain 5 -0.0217861
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0216688
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0215866
SPAG9 sperm associated antigen 9 -0.0214072