Clofarabine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.20287
PTMA prothymosin, alpha 0.161398
RPS3 ribosomal protein S3 0.150666
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.12661
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0906078
KTN1 kinectin 1 (kinesin receptor) 0.0849073
RPS8 ribosomal protein S8 0.0791055
RPL37A ribosomal protein L37a 0.079041
RPS12 ribosomal protein S12 0.0718338
TPM3 tropomyosin 3 0.0715276
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0710374
RPL26 ribosomal protein L26 0.0674598
RPL37 ribosomal protein L37 0.0615679
RPS6 ribosomal protein S6 0.0555585
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.054432
YBX1 Y box binding protein 1 0.0541983
SET SET nuclear proto-oncogene 0.0528347
ERRFI1 ERBB receptor feedback inhibitor 1 0.0521578
RPS27 ribosomal protein S27 0.0507675
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0481027
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0474328
RPS21 ribosomal protein S21 0.0473624
CSDE1 cold shock domain containing E1, RNA-binding 0.0470386
RPL11 ribosomal protein L11 0.0470145
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0468588
RPS2 ribosomal protein S2 0.0460229
GOLGA4 golgin A4 0.045628
HSPA8 heat shock 70kDa protein 8 0.0449044
ZCCHC7 zinc finger, CCHC domain containing 7 0.0446185
HDGF hepatoma-derived growth factor 0.0440568
RPL12 ribosomal protein L12 0.0425269
NAP1L1 nucleosome assembly protein 1-like 1 0.0421065
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0409329
PNN pinin, desmosome associated protein 0.0401361
RPS27A ribosomal protein S27a 0.0394951
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0384378
RPS17 ribosomal protein S17 0.037826
EEF1G eukaryotic translation elongation factor 1 gamma 0.0376522
PDIA6 protein disulfide isomerase family A, member 6 0.0375697
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0375578
RPS19 ribosomal protein S19 0.0371415
RPL35A ribosomal protein L35a 0.0369209
RPL36 ribosomal protein L36 0.0358473
RACK1 receptor for activated C kinase 1 0.0354827
RSRC2 arginine/serine-rich coiled-coil 2 0.0353833
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0345029
OGA O-GlcNAcase 0.0340725
CAMTA1 calmodulin binding transcription activator 1 0.0337537
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.033395
MORF4L2 mortality factor 4 like 2 0.0330546
RPL23 ribosomal protein L23 0.0329169
WBP11 WW domain binding protein 11 0.0325666
RPL13A ribosomal protein L13a 0.0324156
ANKRD36 ankyrin repeat domain 36 0.0319873
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0313712
MKI67 marker of proliferation Ki-67 0.0312911
RPL18 ribosomal protein L18 0.0308812
BBX bobby sox homolog (Drosophila) 0.0307513
RPL19 ribosomal protein L19 0.0305883
RBM25 RNA binding motif protein 25 0.0305423
SRRM1 serine/arginine repetitive matrix 1 0.0301395
TLN1 talin 1 0.0297741
RPS29 ribosomal protein S29 0.0282328
AKAP9 A kinase (PRKA) anchor protein 9 0.0279437
GPX4 glutathione peroxidase 4 0.0279421
TPI1 triosephosphate isomerase 1 0.0272258
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0271849
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0270583
PRRC2C proline-rich coiled-coil 2C 0.0269494
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 0.0267684
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 0.0267024
EIF5B eukaryotic translation initiation factor 5B 0.0266417
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0265248
CANX calnexin 0.0263464
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0263189
CENPF centromere protein F, 350/400kDa 0.026304
CNBP CCHC-type zinc finger, nucleic acid binding protein 0.0261601
MYH9 myosin, heavy chain 9, non-muscle 0.0261529
GOLGB1 golgin B1 0.0259448
RPS4X ribosomal protein S4, X-linked 0.0257754
RPL14 ribosomal protein L14 0.0256479
SRRM2 serine/arginine repetitive matrix 2 0.0255923
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0255577
CEP192 centrosomal protein 192kDa 0.0253965
RPL3 ribosomal protein L3 0.0252518
RAB1A RAB1A, member RAS oncogene family 0.0251927
RBM39 RNA binding motif protein 39 0.0250128
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0247377
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0247224
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0247009
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E 0.024553
RPL34 ribosomal protein L34 0.0245225
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0244662
KMT2E lysine (K)-specific methyltransferase 2E 0.0244135
LDHA lactate dehydrogenase A 0.0243924
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0240472
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0237349
RPS10 ribosomal protein S10 0.0237027
PRPF4B pre-mRNA processing factor 4B 0.0236737
LDHB lactate dehydrogenase B 0.0231989

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13755
TXNRD1 thioredoxin reductase 1 -0.119154
OSMR oncostatin M receptor -0.109873
TFPI2 tissue factor pathway inhibitor 2 -0.0979974
GRAMD1B GRAM domain containing 1B -0.096243
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0737123
KPNA4 karyopherin alpha 4 (importin alpha 3) -0.0726127
THSD4 thrombospondin, type I, domain containing 4 -0.0701164
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0637321
IGF1R insulin-like growth factor 1 receptor -0.063414
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0628372
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0619955
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0615178
EGR1 early growth response 1 -0.0606502
RIMS2 regulating synaptic membrane exocytosis 2 -0.0599029
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0553121
NABP1 nucleic acid binding protein 1 -0.0541853
NF1 neurofibromin 1 -0.0539721
VCL vinculin -0.0522326
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0517764
ELL2 elongation factor, RNA polymerase II, 2 -0.0509201
EXT1 exostosin glycosyltransferase 1 -0.0493916
BPTF bromodomain PHD finger transcription factor -0.0487126
SLC38A2 solute carrier family 38, member 2 -0.0483346
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0478949
EML4 echinoderm microtubule associated protein like 4 -0.0470816
CDK17 cyclin-dependent kinase 17 -0.0463142
AKAP12 A kinase (PRKA) anchor protein 12 -0.0457576
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0447635
FBXO11 F-box protein 11 -0.0447409
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0447408
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0429782
MCL1 myeloid cell leukemia 1 -0.0425098
PNPT1 polyribonucleotide nucleotidyltransferase 1 -0.041773
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0416363
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0403408
RAB7A RAB7A, member RAS oncogene family -0.0394867
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0387079
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0379628
PDE10A phosphodiesterase 10A -0.0376689
EGFR epidermal growth factor receptor -0.0373719
LOC102724023 ES1 protein homolog, mitochondrial -0.0371392
DNAH14 dynein, axonemal, heavy chain 14 -0.0369692
PRH1 proline-rich protein HaeIII subfamily 1 -0.0369457
DOCK5 dedicator of cytokinesis 5 -0.036653
PLSCR1 phospholipid scramblase 1 -0.035414
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0351014
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0343086
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0340102
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0333843
STC1 stanniocalcin 1 -0.0329746
WNT2B wingless-type MMTV integration site family, member 2B -0.0329105
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0328956
ZNFX1 zinc finger, NFX1-type containing 1 -0.0326021
PDLIM5 PDZ and LIM domain 5 -0.0324763
ZFAND3 zinc finger, AN1-type domain 3 -0.0323315
TM4SF1 transmembrane 4 L six family member 1 -0.0321168
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0319426
PHF14 PHD finger protein 14 -0.0306439
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0304816
ACTG1 actin gamma 1 -0.0302582
BICD1 bicaudal D homolog 1 (Drosophila) -0.0301161
USP34 ubiquitin specific peptidase 34 -0.0300245
PDE4D phosphodiesterase 4D, cAMP-specific -0.0300235
RASAL2 RAS protein activator like 2 -0.0297545
ANKRD17 ankyrin repeat domain 17 -0.0295298
HELZ2 helicase with zinc finger 2, transcriptional coactivator -0.029519
NCOA7 nuclear receptor coactivator 7 -0.0293346
HMGA2 high mobility group AT-hook 2 -0.0293316
TAS2R14 taste receptor, type 2, member 14 -0.0292003
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0291183
E2F3 E2F transcription factor 3 -0.02907
VDAC1 voltage-dependent anion channel 1 -0.0285
CALD1 caldesmon 1 -0.0284291
SENP6 SUMO1/sentrin specific peptidase 6 -0.0284257
TRIP12 thyroid hormone receptor interactor 12 -0.0282418
KLF7 Kruppel-like factor 7 (ubiquitous) -0.028174
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0280905
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0278854
PRKCE protein kinase C, epsilon -0.0277654
POGZ pogo transposable element with ZNF domain -0.0276657
PYGL phosphorylase, glycogen, liver -0.0275442
ADGRG6 adhesion G protein-coupled receptor G6 -0.0275253
ATG7 autophagy related 7 -0.0273984
WDR70 WD repeat domain 70 -0.0270073
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.0269986
JMJD1C jumonji domain containing 1C -0.0260599
RIGI RNA sensor RIG-I -0.0260116
CRK v-crk avian sarcoma virus CT10 oncogene homolog -0.0259982
CCND1 cyclin D1 -0.025832
ATF6 activating transcription factor 6 -0.0257581
R3HDM2 R3H domain containing 2 -0.0257347
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0256768
MED13 mediator complex subunit 13 -0.0253307
YBX3 Y box binding protein 3 -0.0252951
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0250458
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.025045
INTS6 integrator complex subunit 6 -0.0247816
SETX senataxin -0.0247147
CLDN1 claudin 1 -0.0246361