Clofarabine_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS3 ribosomal protein S3 0.155686
BHLHE40 basic helix-loop-helix family, member e40 0.145138
LAMB3 laminin, beta 3 0.145014
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.138695
PTMA prothymosin, alpha 0.13764
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.131568
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.100738
MYH9 myosin, heavy chain 9, non-muscle 0.0933117
LAMC2 laminin, gamma 2 0.0881799
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0841276
RPS6 ribosomal protein S6 0.0798818
TMSB4X thymosin beta 4, X-linked 0.0798091
ASPH aspartate beta-hydroxylase 0.0752901
CTSB cathepsin B 0.0732026
RPL35A ribosomal protein L35a 0.0692577
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0677418
RPS8 ribosomal protein S8 0.0653407
RPL14 ribosomal protein L14 0.0649119
APLP2 amyloid beta (A4) precursor-like protein 2 0.0642265
TMED9 transmembrane emp24 protein transport domain containing 9 0.0610391
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0594088
RPL37A ribosomal protein L37a 0.0582224
RACK1 receptor for activated C kinase 1 0.0568308
HSPA8 heat shock 70kDa protein 8 0.0549812
RPS12 ribosomal protein S12 0.0543566
TMSB10 thymosin beta 10 0.0536939
RSRC2 arginine/serine-rich coiled-coil 2 0.0523872
NAP1L1 nucleosome assembly protein 1-like 1 0.0520959
RPL23 ribosomal protein L23 0.0499617
RPL34 ribosomal protein L34 0.0496759
TOP1 topoisomerase (DNA) I 0.049024
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0482635
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0482397
RPL13A ribosomal protein L13a 0.0473962
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0472341
PRRC2C proline-rich coiled-coil 2C 0.0466859
RPS19 ribosomal protein S19 0.0452483
MT2A metallothionein 2A 0.0452021
KTN1 kinectin 1 (kinesin receptor) 0.0442168
AHNAK AHNAK nucleoprotein 0.0439638
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0439315
BZW1 basic leucine zipper and W2 domains 1 0.0438554
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0436971
TMEM263 transmembrane protein 263 0.0431718
HMGB2 high mobility group box 2 0.0424585
NAMPT nicotinamide phosphoribosyltransferase 0.0421053
AREG amphiregulin 0.0420479
SET SET nuclear proto-oncogene 0.0417832
EEF1G eukaryotic translation elongation factor 1 gamma 0.0417564
FNDC3B fibronectin type III domain containing 3B 0.0417332
TMA7 translation machinery associated 7 homolog (S. cerevisiae) 0.0417031
RPS17 ribosomal protein S17 0.0411791
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0405219
GOLGA4 golgin A4 0.0403869
LMO7 LIM domain 7 0.039969
GARS1 glycyl-tRNA synthetase 1 0.039449
RPL36 ribosomal protein L36 0.0392689
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0389731
CSDE1 cold shock domain containing E1, RNA-binding 0.0373164
TAPBP TAP binding protein (tapasin) 0.0371139
SH3KBP1 SH3-domain kinase binding protein 1 0.036673
RBM25 RNA binding motif protein 25 0.0361554
G0S2 G0/G1 switch 2 0.0360997
PABPN1 poly(A) binding protein, nuclear 1 0.0348022
RPL37 ribosomal protein L37 0.0340796
NCKAP1 NCK-associated protein 1 0.0339829
RPS29 ribosomal protein S29 0.0337882
CD47 CD47 molecule 0.0336145
ISG15 ISG15 ubiquitin-like modifier 0.0335142
FTL ferritin, light polypeptide 0.03351
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.03311
GPX4 glutathione peroxidase 4 0.0330453
RPL9 ribosomal protein L9 0.0329498
HDGF hepatoma-derived growth factor 0.0329057
PGK1 phosphoglycerate kinase 1 0.0324729
MSN moesin 0.032441
ARRDC3 arrestin domain containing 3 0.0321586
KDM3A lysine (K)-specific demethylase 3A 0.0321049
RPL26 ribosomal protein L26 0.0321044
RPS21 ribosomal protein S21 0.0318869
COX6C cytochrome c oxidase subunit VIc 0.0317612
TPM3 tropomyosin 3 0.0314741
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.031023
PLAUR plasminogen activator, urokinase receptor 0.0309977
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0307596
YBX3 Y box binding protein 3 0.0306016
RAD23B RAD23 homolog B (S. cerevisiae) 0.0303814
KLF6 Kruppel-like factor 6 0.0302674
SERINC1 serine incorporator 1 0.0300607
CENPF centromere protein F, 350/400kDa 0.0299895
RPL19 ribosomal protein L19 0.0299365
TPR translocated promoter region, nuclear basket protein 0.0299218
TMF1 TATA element modulatory factor 1 0.0294598
RPS27 ribosomal protein S27 0.0294266
EIF3E eukaryotic translation initiation factor 3, subunit E 0.0293971
EPCAM epithelial cell adhesion molecule 0.0293585
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0288287
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0285938
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0285077
CD63 CD63 molecule 0.0281535

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.348383
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.193759
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.127212
NDRG1 N-myc downstream regulated 1 -0.111287
TSC22D2 TSC22 domain family, member 2 -0.0895535
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.086253
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0800194
ERBIN erbb2 interacting protein -0.0679347
HMGA1 high mobility group AT-hook 1 -0.0666694
EXT1 exostosin glycosyltransferase 1 -0.0605262
IGFBP3 insulin-like growth factor binding protein 3 -0.0587118
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0573141
RPLP1 ribosomal protein, large, P1 -0.056664
ACTG1 actin gamma 1 -0.0541886
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0526303
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0515879
SAMD4A sterile alpha motif domain containing 4A -0.0502502
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0480119
EEF2 eukaryotic translation elongation factor 2 -0.0455435
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.044755
FN1 fibronectin 1 -0.0444327
ZNF207 zinc finger protein 207 -0.0440676
PKM pyruvate kinase, muscle -0.0425069
RYBP RING1 and YY1 binding protein -0.0400774
RAB7A RAB7A, member RAS oncogene family -0.0394736
FTH1 ferritin, heavy polypeptide 1 -0.0388801
S100A6 S100 calcium binding protein A6 -0.0386891
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0382639
CSNK1A1 casein kinase 1, alpha 1 -0.0345815
S100A10 S100 calcium binding protein A10 -0.0341962
IFI16 interferon, gamma-inducible protein 16 -0.0328381
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0326786
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.032258
PPP1R13B protein phosphatase 1, regulatory subunit 13B -0.0319389
TMEM123 transmembrane protein 123 -0.0315138
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0314821
MED13 mediator complex subunit 13 -0.03128
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0310787
MX1 MX dynamin-like GTPase 1 -0.0306297
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0305141
PALLD palladin, cytoskeletal associated protein -0.0299382
ZFAND3 zinc finger, AN1-type domain 3 -0.0295779
MYO1E myosin IE -0.0295352
UGDH UDP-glucose 6-dehydrogenase -0.0295305
CTSD cathepsin D -0.0292816
STEAP4 STEAP family member 4 -0.0288601
VDAC1 voltage-dependent anion channel 1 -0.0287453
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0281002
OCLN occludin -0.0279581
WASF2 WAS protein family, member 2 -0.0279209
MCL1 myeloid cell leukemia 1 -0.0277223
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 -0.0276264
UBC ubiquitin C -0.0275322
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0272823
RPL8 ribosomal protein L8 -0.027079
TXNIP thioredoxin interacting protein -0.026635
AFF4 AF4/FMR2 family, member 4 -0.0265477
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0263162
ANKRD17 ankyrin repeat domain 17 -0.0262089
PTK2 protein tyrosine kinase 2 -0.0260802
MX2 MX dynamin-like GTPase 2 -0.0259367
RPL15 ribosomal protein L15 -0.0257606
EGFR epidermal growth factor receptor -0.0255848
LAP3 leucine aminopeptidase 3 -0.0255201
ARHGAP20 Rho GTPase activating protein 20 -0.0255003
PLSCR1 phospholipid scramblase 1 -0.0254199
KDM2A lysine (K)-specific demethylase 2A -0.0253908
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0250251
PDIA3 protein disulfide isomerase family A, member 3 -0.0249938
BTBD7 BTB (POZ) domain containing 7 -0.0249453
RPLP0 ribosomal protein, large, P0 -0.0248799
RPL27A ribosomal protein L27a -0.0248672
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0240949
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0238737
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0238413
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0238057
ICAM1 intercellular adhesion molecule 1 -0.0236983
SEC31A SEC31 homolog A (S. cerevisiae) -0.0234806
RASAL2 RAS protein activator like 2 -0.0232743
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0230096
OSMR oncostatin M receptor -0.0229537
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0228727
RPS25 ribosomal protein S25 -0.0227741
SPAG9 sperm associated antigen 9 -0.0226417
RAB10 RAB10, member RAS oncogene family -0.0224297
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.022312
TKT transketolase -0.022121
SLC34A2 solute carrier family 34 (type II sodium/phosphate cotransporter), member 2 -0.0220908
SSBP2 single-stranded DNA binding protein 2 -0.0219429
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.021738
STAU1 staufen double-stranded RNA binding protein 1 -0.0217128
ALCAM activated leukocyte cell adhesion molecule -0.0214697
RPS24 ribosomal protein S24 -0.0213285
LIMCH1 LIM and calponin homology domains 1 -0.021112
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0210778
ELL2 elongation factor, RNA polymerase II, 2 -0.0209685
CDK13 cyclin-dependent kinase 13 -0.0209541
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0208295
POTEF POTE ankyrin domain family, member F -0.0206185
NF1 neurofibromin 1 -0.0205416