Clofarabine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.141499
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.134474
EFNA5 ephrin-A5 0.118431
ASPH aspartate beta-hydroxylase 0.116416
TMSB10 thymosin beta 10 0.104751
RPS6 ribosomal protein S6 0.100349
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0975604
CXCL8 chemokine (C-X-C motif) ligand 8 0.0924749
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0907736
RPS3 ribosomal protein S3 0.0836589
RPL26 ribosomal protein L26 0.0825934
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0824637
NAMPT nicotinamide phosphoribosyltransferase 0.0787855
PRRC2C proline-rich coiled-coil 2C 0.0729746
RPL23 ribosomal protein L23 0.0726501
RPS8 ribosomal protein S8 0.0714297
RPL37A ribosomal protein L37a 0.070649
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0700567
RPS12 ribosomal protein S12 0.06917
RPL12 ribosomal protein L12 0.0673837
TRIO trio Rho guanine nucleotide exchange factor 0.0665681
NAP1L1 nucleosome assembly protein 1-like 1 0.0634366
TXNRD1 thioredoxin reductase 1 0.0633596
TFPI2 tissue factor pathway inhibitor 2 0.0614482
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0606682
RPL19 ribosomal protein L19 0.0603667
RPS19 ribosomal protein S19 0.0555222
GRAMD1B GRAM domain containing 1B 0.0549036
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0541732
FTL ferritin, light polypeptide 0.0541471
EIF1 eukaryotic translation initiation factor 1 0.0524417
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0524126
NEK7 NIMA-related kinase 7 0.0515858
RTN4 reticulon 4 0.0503925
RPL35A ribosomal protein L35a 0.050187
CENPF centromere protein F, 350/400kDa 0.0499377
TM4SF1 transmembrane 4 L six family member 1 0.048966
RPL36 ribosomal protein L36 0.0486008
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0480256
RPS21 ribosomal protein S21 0.0464587
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0457369
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.045605
RPL13A ribosomal protein L13a 0.0439024
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0426649
RGS2 regulator of G-protein signaling 2 0.0424485
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0415532
B2M beta-2-microglobulin 0.0415294
RPS27A ribosomal protein S27a 0.0410653
SRGN serglycin 0.0408572
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 0.0405382
RPL11 ribosomal protein L11 0.0402602
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0402011
MT2A metallothionein 2A 0.0401415
RPS2 ribosomal protein S2 0.0400886
RPL34 ribosomal protein L34 0.0396994
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0387101
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0384166
OGA O-GlcNAcase 0.0376288
PSD3 pleckstrin and Sec7 domain containing 3 0.0375118
RPL31 ribosomal protein L31 0.0374131
RACK1 receptor for activated C kinase 1 0.0371903
RBM39 RNA binding motif protein 39 0.0370639
KYNU kynureninase 0.0368512
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0368277
RPL35 ribosomal protein L35 0.0365397
RPS29 ribosomal protein S29 0.0363622
KTN1 kinectin 1 (kinesin receptor) 0.0359288
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0351669
WDR43 WD repeat domain 43 0.0350411
NRCAM neuronal cell adhesion molecule 0.0349319
DST dystonin 0.0348349
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0347213
MFF mitochondrial fission factor 0.0346137
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0345218
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.034504
RPLP2 ribosomal protein, large, P2 0.0343282
EIF5B eukaryotic translation initiation factor 5B 0.0343029
CTSC cathepsin C 0.0341829
MKI67 marker of proliferation Ki-67 0.0339889
GOLGA4 golgin A4 0.0338447
COL8A1 collagen, type VIII, alpha 1 0.0338081
RPS4X ribosomal protein S4, X-linked 0.0338056
TNPO1 transportin 1 0.0328468
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) 0.0328184
RPS17 ribosomal protein S17 0.0320864
RPS27 ribosomal protein S27 0.031784
SET SET nuclear proto-oncogene 0.031733
RPL9 ribosomal protein L9 0.031456
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0313527
RPL18 ribosomal protein L18 0.0313082
APLP2 amyloid beta (A4) precursor-like protein 2 0.0309034
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0307731
PCBP2 poly(rC) binding protein 2 0.0306034
YBX1 Y box binding protein 1 0.0305709
SFPQ splicing factor proline/glutamine-rich 0.0303145
ENAH enabled homolog (Drosophila) 0.0300003
ACTG1 actin gamma 1 0.0298364
RPS23 ribosomal protein S23 0.0296839
GDA guanine deaminase 0.0296274
TPR translocated promoter region, nuclear basket protein 0.0296018

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.227809
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.19051
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0766195
PDE4D phosphodiesterase 4D, cAMP-specific -0.0704224
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0483944
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0452891
CDH13 cadherin 13 -0.042415
AUTS2 autism susceptibility candidate 2 -0.0393225
P3H2 prolyl 3-hydroxylase 2 -0.0391655
FNDC3A fibronectin type III domain containing 3A -0.0386617
WARS1 tryptophanyl-tRNA synthetase 1 -0.0372534
NBEAL1 neurobeachin-like 1 -0.035525
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0353411
MAP7 microtubule-associated protein 7 -0.0321663
ESYT2 extended synaptotagmin-like protein 2 -0.031524
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.030608
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0303833
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0302051
FTH1 ferritin, heavy polypeptide 1 -0.0289049
IGFBP3 insulin-like growth factor binding protein 3 -0.0287589
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0273158
DHRSX dehydrogenase/reductase (SDR family) X-linked -0.0270022
IL6 interleukin 6 -0.0266698
DENND1A DENN/MADD domain containing 1A -0.0248427
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0242165
COPA coatomer protein complex, subunit alpha -0.0238009
LSAMP limbic system-associated membrane protein -0.0232202
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0227474
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0226282
CA12 carbonic anhydrase XII -0.022503
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0223269
PDIA3 protein disulfide isomerase family A, member 3 -0.0222865
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0221226
CAMTA1 calmodulin binding transcription activator 1 -0.021572
PTPRM protein tyrosine phosphatase, receptor type, M -0.0213722
CHL1 cell adhesion molecule L1-like -0.0211666
AGTPBP1 ATP/GTP binding protein 1 -0.020861
DNER delta/notch-like EGF repeat containing -0.0203404
FNIP1 folliculin interacting protein 1 -0.0200094
XYLT1 xylosyltransferase I -0.0197022
NCOR2 nuclear receptor corepressor 2 -0.0194227
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1 -0.0191299
SMAD2 SMAD family member 2 -0.0191149
RAB31 RAB31, member RAS oncogene family -0.0187081
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 -0.0185798
EGR1 early growth response 1 -0.0185461
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0185056
TTC28 tetratricopeptide repeat domain 28 -0.0184132
CTBP2 C-terminal binding protein 2 -0.018214
TENM2 teneurin transmembrane protein 2 -0.0181321
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0180837
RAD51B RAD51 paralog B -0.0180653
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0179134
SOD2 superoxide dismutase 2, mitochondrial -0.0175896
TPT1 tumor protein, translationally-controlled 1 -0.0174755
LAMA5 laminin, alpha 5 -0.0172701
SEC31A SEC31 homolog A (S. cerevisiae) -0.0171641
COL5A2 collagen, type V, alpha 2 -0.0167677
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0165196
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0164371
NDRG1 N-myc downstream regulated 1 -0.0163786
IFIH1 interferon induced with helicase C domain 1 -0.0160925
CUX1 cut-like homeobox 1 -0.0159614
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0159188
PM20D1 peptidase M20 domain containing 1 -0.0159091
PDE10A phosphodiesterase 10A -0.0156453
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0155385
NR4A2 nuclear receptor subfamily 4, group A, member 2 -0.0153909
HILPDA hypoxia inducible lipid droplet-associated -0.0153671
PRELID2 PRELI domain containing 2 -0.0150268
KDM7A lysine (K)-specific demethylase 7A -0.014629
C1D C1D nuclear receptor corepressor -0.0141778
PRKN parkin RBR E3 ubiquitin protein ligase -0.0139084
NCKAP5 NCK-associated protein 5 -0.0138966
AGR2 anterior gradient 2 -0.0138846
NR4A3 nuclear receptor subfamily 4, group A, member 3 -0.0138822
SOX6 SRY (sex determining region Y)-box 6 -0.0138725
CRTC3 CREB regulated transcription coactivator 3 -0.0136328
HBP1 HMG-box transcription factor 1 -0.013613
SVIL supervillin -0.0135651
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0135135
STC1 stanniocalcin 1 -0.0134179
ERO1B endoplasmic reticulum oxidoreductase 1 beta -0.0132983
GRB10 growth factor receptor-bound protein 10 -0.0130926
SDK1 sidekick cell adhesion molecule 1 -0.0130645
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0129335
MAGT1 magnesium transporter 1 -0.0128838
CD44 CD44 molecule (Indian blood group) -0.0126283
CTNND2 catenin (cadherin-associated protein), delta 2 -0.0125505
TENT5A terminal nucleotidyltransferase 5A -0.0123899
TMEM135 transmembrane protein 135 -0.0123589
SLC16A6 solute carrier family 16, member 6 -0.0121835
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0121774
TENM3 teneurin transmembrane protein 3 -0.0118769
OASL 2'-5'-oligoadenylate synthetase-like -0.0118399
INTS6 integrator complex subunit 6 -0.0118032
C9ORF153 chromosome 9 open reading frame 153 -0.0116902
SQSTM1 sequestosome 1 -0.0116816
WSB1 WD repeat and SOCS box containing 1 -0.0114432
RORA RAR-related orphan receptor A -0.0113878