Clofarabine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.258736
PDE4D phosphodiesterase 4D, cAMP-specific 0.240274
NALF1 NALCN channel auxiliary factor 1 0.186891
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.178162
EFNA5 ephrin-A5 0.145855
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.138805
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.118219
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.10886
GOLGA4 golgin A4 0.105564
PGK1 phosphoglycerate kinase 1 0.104673
PDLIM5 PDZ and LIM domain 5 0.10329
PSD3 pleckstrin and Sec7 domain containing 3 0.0967784
NCAM1 neural cell adhesion molecule 1 0.0916911
CXCL8 chemokine (C-X-C motif) ligand 8 0.0916668
STC1 stanniocalcin 1 0.0877077
PDE10A phosphodiesterase 10A 0.0868013
TENM1 teneurin transmembrane protein 1 0.0781686
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0765778
RTN4 reticulon 4 0.0745358
NAMPT nicotinamide phosphoribosyltransferase 0.0718986
HOOK2 hook microtubule-tethering protein 2 0.0691651
RNF145 ring finger protein 145 0.0669039
FAM13A family with sequence similarity 13, member A 0.0644163
NKTR natural killer cell triggering receptor 0.0641944
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0633674
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 0.0633588
FLNB filamin B, beta 0.0618992
CD46 CD46 molecule, complement regulatory protein 0.0615785
MAML3 mastermind-like 3 (Drosophila) 0.0589115
BIRC6 baculoviral IAP repeat containing 6 0.0581542
DNER delta/notch-like EGF repeat containing 0.0564229
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0546474
SUCO SUN domain containing ossification factor 0.0537239
PKM pyruvate kinase, muscle 0.0532627
PDIA6 protein disulfide isomerase family A, member 6 0.052988
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0527826
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0482797
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0462132
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0460405
EXT1 exostosin glycosyltransferase 1 0.0445531
LIMCH1 LIM and calponin homology domains 1 0.0428715
ANXA1 annexin A1 0.0428326
SND1 staphylococcal nuclease and tudor domain containing 1 0.042548
PRRC2C proline-rich coiled-coil 2C 0.0410777
SOS1 son of sevenless homolog 1 (Drosophila) 0.0397792
PPP1R12B protein phosphatase 1, regulatory subunit 12B 0.0390269
TTC17 tetratricopeptide repeat domain 17 0.0386548
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0380597
PCNX1 pecanex 1 0.0368461
SEPTIN2 septin 2 0.035809
ASPH aspartate beta-hydroxylase 0.0352116
FAM193A family with sequence similarity 193, member A 0.0343207
WDR43 WD repeat domain 43 0.0342698
ZNF292 zinc finger protein 292 0.0341226
RAP1B RAP1B, member of RAS oncogene family 0.0335436
CLIC4 chloride intracellular channel 4 0.0334154
WDR45B WD repeat domain 45B 0.03297
RREB1 ras responsive element binding protein 1 0.0323963
SNX14 sorting nexin 14 0.0322521
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0316609
IQGAP1 IQ motif containing GTPase activating protein 1 0.0309371
SSR1 signal sequence receptor, alpha 0.0297411
INHBA inhibin, beta A 0.0280359
CLTC clathrin, heavy chain (Hc) 0.0279788
PTK2 protein tyrosine kinase 2 0.0273159
RORA RAR-related orphan receptor A 0.0261716
ZCCHC7 zinc finger, CCHC domain containing 7 0.0251077
TENT2 terminal nucleotidyltransferase 2 0.0247695
COL5A2 collagen, type V, alpha 2 0.0230941
TNPO1 transportin 1 0.0229851
NIPBL Nipped-B homolog (Drosophila) 0.0221044
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0219261
CANX calnexin 0.0214478
FNDC3B fibronectin type III domain containing 3B 0.021254
FBXO11 F-box protein 11 0.0203168
TPD52 tumor protein D52 0.0201495
NDRG1 N-myc downstream regulated 1 0.0199824
NPAS2 neuronal PAS domain protein 2 0.0196241
SBF2 SET binding factor 2 0.0185476
MAP1B microtubule-associated protein 1B 0.0184528
USP34 ubiquitin specific peptidase 34 0.0183117
TCF12 transcription factor 12 0.0181284
DIAPH1 diaphanous-related formin 1 0.0163747
TXNRD1 thioredoxin reductase 1 0.0161684
LMAN1 lectin, mannose-binding, 1 0.0151154
PRELID2 PRELI domain containing 2 0.014493
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0144215
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0141536
ANKRD17 ankyrin repeat domain 17 0.014069
RPS3 ribosomal protein S3 0.0140074
PTGR1 prostaglandin reductase 1 0.013883
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.013854
AKAP13 A kinase (PRKA) anchor protein 13 0.013799
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.013589
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0134254
SOD2 superoxide dismutase 2, mitochondrial 0.0133585
WAC WW domain containing adaptor with coiled-coil 0.0123687
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0123169
PHF21A PHD finger protein 21A 0.0115804
ERC2 ELKS/RAB6-interacting/CAST family member 2 0.011547

decreased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor -0.152802
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.110999
TMSB10 thymosin beta 10 -0.109963
THSD4 thrombospondin, type I, domain containing 4 -0.109638
AKAP12 A kinase (PRKA) anchor protein 12 -0.10878
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0984612
DSCAM Down syndrome cell adhesion molecule -0.0975385
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0970309
PRKCA protein kinase C, alpha -0.0943467
ANKRD12 ankyrin repeat domain 12 -0.0941676
ANKHD1 ankyrin repeat and KH domain containing 1 -0.09396
IGF2 insulin-like growth factor 2 -0.0934353
SLTM SAFB-like, transcription modulator -0.0903275
LPP LIM domain containing preferred translocation partner in lipoma -0.0885366
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0869299
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0869081
PTMA prothymosin, alpha -0.0846457
FN1 fibronectin 1 -0.0796363
RPLP1 ribosomal protein, large, P1 -0.0775217
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0768371
JMJD1C jumonji domain containing 1C -0.0763212
ITGA6 integrin, alpha 6 -0.0760967
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0733279
CMIP c-Maf inducing protein -0.0701365
VMP1 vacuole membrane protein 1 -0.0686826
TTC3 tetratricopeptide repeat domain 3 -0.0669778
MYO10 myosin X -0.0669251
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0664897
RERE arginine-glutamic acid dipeptide (RE) repeats -0.066056
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0658889
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0642921
MACF1 microtubule-actin crosslinking factor 1 -0.0624154
ZBTB20 zinc finger and BTB domain containing 20 -0.06219
NKD1 naked cuticle homolog 1 (Drosophila) -0.0618078
NF1 neurofibromin 1 -0.0582282
ANXA2 annexin A2 -0.0562776
RPS6 ribosomal protein S6 -0.0547117
NAV2 neuron navigator 2 -0.0540871
EGR1 early growth response 1 -0.0537852
TBC1D22A TBC1 domain family, member 22A -0.0529773
ENO1 enolase 1, (alpha) -0.0493482
MCL1 myeloid cell leukemia 1 -0.0486183
FTH1 ferritin, heavy polypeptide 1 -0.0484237
MAML2 mastermind-like 2 (Drosophila) -0.0442079
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0438247
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0372385
GOLGB1 golgin B1 -0.0340498
LMO7 LIM domain 7 -0.0334351
INTS6 integrator complex subunit 6 -0.0331349
MEF2A myocyte enhancer factor 2A -0.0325308
RABGAP1L RAB GTPase activating protein 1-like -0.032311
IGFBP3 insulin-like growth factor binding protein 3 -0.031731
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0314809
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0306339
EEF2 eukaryotic translation elongation factor 2 -0.0306015
SYT1 synaptotagmin I -0.0305348
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0304843
NCOR1 nuclear receptor corepressor 1 -0.0293945
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0277191
AKAP9 A kinase (PRKA) anchor protein 9 -0.0276849
RPL26 ribosomal protein L26 -0.0265982
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0256388
FNIP1 folliculin interacting protein 1 -0.0247021
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0236271
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0235779
TRIO trio Rho guanine nucleotide exchange factor -0.0234884
RPL27A ribosomal protein L27a -0.0232346
BACE2 beta-site APP-cleaving enzyme 2 -0.0230046
CARD16 caspase recruitment domain family, member 16 -0.0227947
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0204923
SLC38A2 solute carrier family 38, member 2 -0.0204466
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0202855
MBD5 methyl-CpG binding domain protein 5 -0.0194826
PTPRM protein tyrosine phosphatase, receptor type, M -0.0193395
MBNL2 muscleblind-like splicing regulator 2 -0.0190572
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0186877
UBC ubiquitin C -0.0183497
CSDE1 cold shock domain containing E1, RNA-binding -0.0176269
VCL vinculin -0.0170966
GSK3B glycogen synthase kinase 3 beta -0.0163648
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0161893
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0159306
CHD1 chromodomain helicase DNA binding protein 1 -0.0151374
ATP13A3 ATPase type 13A3 -0.0136468
VIM vimentin -0.0135659
KMT2C lysine (K)-specific methyltransferase 2C -0.0132771
DENND4A DENN/MADD domain containing 4A -0.0130326
BBX bobby sox homolog (Drosophila) -0.012503
ELL2 elongation factor, RNA polymerase II, 2 -0.0121754
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0115178
MYOF myoferlin -0.0113053
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.011218
MSI2 musashi RNA-binding protein 2 -0.0109303
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0103483
EP400 E1A binding protein p400 -0.0093537
ANKRD11 ankyrin repeat domain 11 -0.00926041
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.00885867
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.00844534
HDLBP high density lipoprotein binding protein -0.00727806
KDM3A lysine (K)-specific demethylase 3A -0.00630793