Clofarabine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.372395
RPS6 ribosomal protein S6 0.16141
RPS3 ribosomal protein S3 0.113372
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.101211
RPS8 ribosomal protein S8 0.076021
EIF4A2 eukaryotic translation initiation factor 4A2 0.0697315
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0694456
RPS12 ribosomal protein S12 0.0687107
RPL37A ribosomal protein L37a 0.0666844
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0635968
B2M beta-2-microglobulin 0.0577984
RPL26 ribosomal protein L26 0.0551803
RPS2 ribosomal protein S2 0.0537715
RPS19 ribosomal protein S19 0.0514495
GOLGA4 golgin A4 0.0509483
RPL36 ribosomal protein L36 0.0506046
ENO2 enolase 2 (gamma, neuronal) 0.0495549
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0494782
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0457474
RPL35A ribosomal protein L35a 0.0440527
MT2A metallothionein 2A 0.0417403
RPL14 ribosomal protein L14 0.0407156
CENPF centromere protein F, 350/400kDa 0.0403874
HDGF hepatoma-derived growth factor 0.0393815
RPL19 ribosomal protein L19 0.0393249
RPL13A ribosomal protein L13a 0.0385728
RPLP2 ribosomal protein, large, P2 0.0384667
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.038033
SRRM2 serine/arginine repetitive matrix 2 0.0379133
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0376885
RPL18 ribosomal protein L18 0.0375462
TMF1 TATA element modulatory factor 1 0.0372529
SMC3 structural maintenance of chromosomes 3 0.0372191
SET SET nuclear proto-oncogene 0.0367668
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0356205
DSCAM Down syndrome cell adhesion molecule 0.0356116
AKAP9 A kinase (PRKA) anchor protein 9 0.0354768
GOLGB1 golgin B1 0.0352085
APLP2 amyloid beta (A4) precursor-like protein 2 0.0350963
RPL31 ribosomal protein L31 0.0346388
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.034636
BRD2 bromodomain containing 2 0.0344066
RPS27A ribosomal protein S27a 0.0338212
PFN1 profilin 1 0.0334807
PCBP2 poly(rC) binding protein 2 0.0334678
FTL ferritin, light polypeptide 0.0334077
EEF1G eukaryotic translation elongation factor 1 gamma 0.0325774
CD47 CD47 molecule 0.0325359
RPL9 ribosomal protein L9 0.0321706
RPL37 ribosomal protein L37 0.0317399
RPL23 ribosomal protein L23 0.0315395
RPL12 ribosomal protein L12 0.0306437
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0293496
KMT2E lysine (K)-specific methyltransferase 2E 0.0292405
KTN1 kinectin 1 (kinesin receptor) 0.0286999
RPS29 ribosomal protein S29 0.0278757
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0276754
RPS27 ribosomal protein S27 0.0275933
RBM25 RNA binding motif protein 25 0.0275017
MKI67 marker of proliferation Ki-67 0.0268565
RPS17 ribosomal protein S17 0.0265588
PNN pinin, desmosome associated protein 0.0265388
RPL34 ribosomal protein L34 0.02643
DSTN destrin (actin depolymerizing factor) 0.026308
PDIA6 protein disulfide isomerase family A, member 6 0.0256972
RSRC2 arginine/serine-rich coiled-coil 2 0.025533
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0253589
LDHB lactate dehydrogenase B 0.0252577
SRSF11 serine/arginine-rich splicing factor 11 0.0251708
SRRM1 serine/arginine repetitive matrix 1 0.0251052
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0250235
YBX1 Y box binding protein 1 0.0248528
TPR translocated promoter region, nuclear basket protein 0.0246191
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0239193
HMGB2 high mobility group box 2 0.0235291
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0231044
RACK1 receptor for activated C kinase 1 0.0230861
RPL7 ribosomal protein L7 0.02299
RFC3 replication factor C (activator 1) 3, 38kDa 0.022822
EZR ezrin 0.0228044
SMC4 structural maintenance of chromosomes 4 0.0227739
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0227124
RPS21 ribosomal protein S21 0.0223951
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0220707
RPL35 ribosomal protein L35 0.0220675
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0220472
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.021954
TMED9 transmembrane emp24 protein transport domain containing 9 0.0218484
TXNIP thioredoxin interacting protein 0.0215117
RYK receptor-like tyrosine kinase 0.0214917
VMP1 vacuole membrane protein 1 0.0214391
UBA6 ubiquitin-like modifier activating enzyme 6 0.0211853
S100A9 S100 calcium binding protein A9 0.0209378
RPL3 ribosomal protein L3 0.0208757
RPL10A ribosomal protein L10a 0.0206795
RAD18 RAD18 E3 ubiquitin protein ligase 0.0199569
NDRG1 N-myc downstream regulated 1 0.0199539
PRPF4B pre-mRNA processing factor 4B 0.0196696
RPL21 ribosomal protein L21 0.0196512
ANXA1 annexin A1 0.0196479

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.176425
PDE4D phosphodiesterase 4D, cAMP-specific -0.15881
EGFR epidermal growth factor receptor -0.115233
VCL vinculin -0.109784
PKM pyruvate kinase, muscle -0.104046
FOXP1 forkhead box P1 -0.0949796
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0947532
EEF2 eukaryotic translation elongation factor 2 -0.0844026
TXNRD1 thioredoxin reductase 1 -0.0817572
ADAM10 ADAM metallopeptidase domain 10 -0.0795283
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.079312
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0771162
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0730161
TPT1 tumor protein, translationally-controlled 1 -0.0710326
NBEA neurobeachin -0.0687793
RTN4 reticulon 4 -0.0682407
AHNAK AHNAK nucleoprotein -0.0629394
ZBTB20 zinc finger and BTB domain containing 20 -0.0580265
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 -0.05637
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0557048
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0540441
NF1 neurofibromin 1 -0.0537312
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0518752
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0518104
OSMR oncostatin M receptor -0.0507066
TJP1 tight junction protein 1 -0.0492087
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0486051
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0470888
PYGB phosphorylase, glycogen; brain -0.0470411
FLNB filamin B, beta -0.0466979
USP34 ubiquitin specific peptidase 34 -0.046332
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0444362
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0440494
EML4 echinoderm microtubule associated protein like 4 -0.0433973
EXOC6B exocyst complex component 6B -0.0422807
ATP9B ATPase, class II, type 9B -0.0419103
ANKRD17 ankyrin repeat domain 17 -0.0404457
ACTG1 actin gamma 1 -0.0402871
NPAS2 neuronal PAS domain protein 2 -0.0402671
ANK2 ankyrin 2, neuronal -0.039916
ZFAND3 zinc finger, AN1-type domain 3 -0.0394635
CCND1 cyclin D1 -0.0384265
SPRY4 sprouty homolog 4 (Drosophila) -0.0379515
HDLBP high density lipoprotein binding protein -0.0357405
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0350166
EFNA5 ephrin-A5 -0.0349694
ARL4C ADP-ribosylation factor-like 4C -0.0346728
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0344193
DPYD dihydropyrimidine dehydrogenase -0.0341806
SLC38A2 solute carrier family 38, member 2 -0.0341346
ACACA acetyl-CoA carboxylase alpha -0.0341326
DOCK3 dedicator of cytokinesis 3 -0.033563
GLI2 GLI family zinc finger 2 -0.0333209
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0331816
IARS1 isoleucyl-tRNA synthetase 1 -0.0330411
RHBDD1 rhomboid domain containing 1 -0.0325593
DLG1 discs, large homolog 1 (Drosophila) -0.0323325
MAP4 microtubule-associated protein 4 -0.0320824
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0318684
GNAS GNAS complex locus -0.0316732
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0308634
ADNP activity-dependent neuroprotector homeobox -0.0306527
SMYD3 SET and MYND domain containing 3 -0.0302842
EXT1 exostosin glycosyltransferase 1 -0.0299507
ZMYND8 zinc finger, MYND-type containing 8 -0.0298891
NCEH1 neutral cholesterol ester hydrolase 1 -0.0296843
SSBP2 single-stranded DNA binding protein 2 -0.0296663
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0295586
ENOSF1 enolase superfamily member 1 -0.0293795
DGKH diacylglycerol kinase, eta -0.0290663
STRN3 striatin, calmodulin binding protein 3 -0.0288573
GLI3 GLI family zinc finger 3 -0.0285948
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0283108
TNPO1 transportin 1 -0.0282924
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0282627
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0282484
PAN3 PAN3 poly(A) specific ribonuclease subunit -0.0276632
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.0269586
TCF12 transcription factor 12 -0.0269466
TMSB4X thymosin beta 4, X-linked -0.0267189
SPIDR scaffolding protein involved in DNA repair -0.0266634
IGF1R insulin-like growth factor 1 receptor -0.0266066
LOC112694756 uncharaterized LOC112694756 -0.0258798
NT5C2 5'-nucleotidase, cytosolic II -0.0258467
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0257401
SPRED2 sprouty-related, EVH1 domain containing 2 -0.0255185
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0252881
ARB2A ARB2 cotranscriptional regulator A -0.0252513
CEP95 centrosomal protein 95kDa -0.0248874
RERE arginine-glutamic acid dipeptide (RE) repeats -0.024883
VDAC1 voltage-dependent anion channel 1 -0.0248427
TRIP12 thyroid hormone receptor interactor 12 -0.0247814
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0247364
LOXL3 lysyl oxidase-like 3 -0.0244881
PRUNE2 prune homolog 2 (Drosophila) -0.0244722
ARL15 ADP-ribosylation factor-like 15 -0.0244583
UBE2V1 ubiquitin-conjugating enzyme E2 variant 1 -0.0243734
BRWD1 bromodomain and WD repeat domain containing 1 -0.023924
ZEB1 zinc finger E-box binding homeobox 1 -0.0238831
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0238566