Clofarabine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.178109
NAMPT nicotinamide phosphoribosyltransferase 0.168145
RPS3 ribosomal protein S3 0.0952319
RPS12 ribosomal protein S12 0.0918595
MSN moesin 0.0909384
TAPBP TAP binding protein (tapasin) 0.0892947
RPS6 ribosomal protein S6 0.0875618
AKAP12 A kinase (PRKA) anchor protein 12 0.0838154
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0750474
SOD2 superoxide dismutase 2, mitochondrial 0.0736409
APLP2 amyloid beta (A4) precursor-like protein 2 0.0716818
B2M beta-2-microglobulin 0.0714264
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.066985
VEGFA vascular endothelial growth factor A 0.0658477
RTN4 reticulon 4 0.0650264
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0645903
MT2A metallothionein 2A 0.0645724
FNDC3B fibronectin type III domain containing 3B 0.0629751
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0610896
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0603036
RB1CC1 RB1-inducible coiled-coil 1 0.0586242
ELL2 elongation factor, RNA polymerase II, 2 0.0571013
RPS2 ribosomal protein S2 0.0569636
ARRDC3 arrestin domain containing 3 0.0561406
TNIP1 TNFAIP3 interacting protein 1 0.0549143
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0542354
ZFP36L1 ZFP36 ring finger protein-like 1 0.0536872
C3 complement component 3 0.0532654
NAV2 neuron navigator 2 0.0531618
SPTBN1 spectrin, beta, non-erythrocytic 1 0.052958
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0499947
FLNB filamin B, beta 0.0462056
MKI67 marker of proliferation Ki-67 0.0461312
CENPF centromere protein F, 350/400kDa 0.0456119
EEF1G eukaryotic translation elongation factor 1 gamma 0.0410081
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0392377
TENT5A terminal nucleotidyltransferase 5A 0.0391779
ADM adrenomedullin 0.0388237
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0369588
UBA6 ubiquitin-like modifier activating enzyme 6 0.0366791
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0365532
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0358845
RPS8 ribosomal protein S8 0.0356489
IRAK2 interleukin-1 receptor-associated kinase 2 0.0352808
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0352386
FAM219A family with sequence similarity 219, member A 0.0350904
AMPD3 adenosine monophosphate deaminase 3 0.034697
PDE10A phosphodiesterase 10A 0.0344465
BCLAF1 BCL2-associated transcription factor 1 0.0334922
SEPTIN9 septin 9 0.0327329
TOP2A topoisomerase (DNA) II alpha 170kDa 0.032582
LOXL2 lysyl oxidase-like 2 0.0324323
RACK1 receptor for activated C kinase 1 0.0320465
RPS17 ribosomal protein S17 0.03149
NRIP1 nuclear receptor interacting protein 1 0.0313975
RPL11 ribosomal protein L11 0.0309757
KTN1 kinectin 1 (kinesin receptor) 0.0305122
RPS4X ribosomal protein S4, X-linked 0.0303576
EZR ezrin 0.0303329
PLIN2 perilipin 2 0.0293743
TPM3 tropomyosin 3 0.0291035
RPL37A ribosomal protein L37a 0.0290372
SDK1 sidekick cell adhesion molecule 1 0.0289728
ERRFI1 ERBB receptor feedback inhibitor 1 0.028694
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0285782
FOSL1 FOS-like antigen 1 0.0282453
YBX1 Y box binding protein 1 0.0281476
RND3 Rho family GTPase 3 0.0277042
MXI1 MAX interactor 1, dimerization protein 0.0275295
SFTPA2 surfactant protein A2 0.027496
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0273734
ZNF395 zinc finger protein 395 0.0271617
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0270758
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0268292
TRIO trio Rho guanine nucleotide exchange factor 0.026703
SRRM2 serine/arginine repetitive matrix 2 0.0264173
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0263108
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0261963
CALD1 caldesmon 1 0.0261286
AKAP9 A kinase (PRKA) anchor protein 9 0.0260681
CDK19 cyclin-dependent kinase 19 0.0258234
AFDN afadin, adherens junction formation factor 0.0257442
SET SET nuclear proto-oncogene 0.0254773
TLN1 talin 1 0.0253334
TMED9 transmembrane emp24 protein transport domain containing 9 0.0252066
DSCAM Down syndrome cell adhesion molecule 0.0252004
NGLY1 N-glycanase 1 0.0247941
NOTCH2 notch 2 0.0247506
CKAP5 cytoskeleton associated protein 5 0.0246607
FAM13A family with sequence similarity 13, member A 0.0240459
IFI6 interferon, alpha-inducible protein 6 0.0239484
OPTN optineurin 0.0238012
PCBP2 poly(rC) binding protein 2 0.0235518
RPL37 ribosomal protein L37 0.023463
ESYT2 extended synaptotagmin-like protein 2 0.0233147
CDCP1 CUB domain containing protein 1 0.0233038
SMAD3 SMAD family member 3 0.0230696
TMF1 TATA element modulatory factor 1 0.0230125
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0229828
HSPA8 heat shock 70kDa protein 8 0.0228983

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.217642
IER3 immediate early response 3 -0.149134
GLIS3 GLIS family zinc finger 3 -0.126391
TPT1 tumor protein, translationally-controlled 1 -0.123272
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.116783
EXT1 exostosin glycosyltransferase 1 -0.114182
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.111932
HMGA2 high mobility group AT-hook 2 -0.10518
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.104201
CDH13 cadherin 13 -0.0840381
RPS24 ribosomal protein S24 -0.0837796
ZFAND3 zinc finger, AN1-type domain 3 -0.0706611
BICC1 BicC family RNA binding protein 1 -0.0685805
COL6A3 collagen, type VI, alpha 3 -0.0682317
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0646218
CANX calnexin -0.0614388
TUBB tubulin, beta class I -0.0570642
SFRP1 secreted frizzled-related protein 1 -0.0567685
FN1 fibronectin 1 -0.0562427
PGK1 phosphoglycerate kinase 1 -0.0547704
IGFBP3 insulin-like growth factor binding protein 3 -0.0535001
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0526867
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0472367
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0471358
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0465009
AHNAK AHNAK nucleoprotein -0.0459606
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0448433
CTSD cathepsin D -0.0447777
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0447757
VCL vinculin -0.0445222
SMYD3 SET and MYND domain containing 3 -0.0426245
QKI QKI, KH domain containing, RNA binding -0.0409338
INTS6 integrator complex subunit 6 -0.0408863
PTPRK protein tyrosine phosphatase, receptor type, K -0.0401552
TGFBI transforming growth factor, beta-induced, 68kDa -0.03996
KDM3A lysine (K)-specific demethylase 3A -0.0397153
EEF2 eukaryotic translation elongation factor 2 -0.0396877
VDAC1 voltage-dependent anion channel 1 -0.0394942
ACTG1 actin gamma 1 -0.0393001
WSB1 WD repeat and SOCS box containing 1 -0.0385955
ABI3BP ABI family, member 3 (NESH) binding protein -0.0381792
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.038095
TMEM123 transmembrane protein 123 -0.037923
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0370505
THBS1 thrombospondin 1 -0.0366015
SLC35F3 solute carrier family 35, member F3 -0.0365823
HMGA1 high mobility group AT-hook 1 -0.0358551
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0350787
TKT transketolase -0.0347927
ERBIN erbb2 interacting protein -0.0346677
GNAS GNAS complex locus -0.0346607
CALR calreticulin -0.0342476
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0335085
NF1 neurofibromin 1 -0.0333727
OGA O-GlcNAcase -0.0329594
MED13 mediator complex subunit 13 -0.0325077
RPL36A ribosomal protein L36a -0.032183
ZBTB20 zinc finger and BTB domain containing 20 -0.0319769
RBM39 RNA binding motif protein 39 -0.0317115
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.031495
IARS1 isoleucyl-tRNA synthetase 1 -0.0311465
RHEB Ras homolog enriched in brain -0.0310254
SOX5 SRY (sex determining region Y)-box 5 -0.0309976
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0308306
FRMD4A FERM domain containing 4A -0.0303552
TMSB10 thymosin beta 10 -0.0303042
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0301208
ZNF207 zinc finger protein 207 -0.0300502
AFF4 AF4/FMR2 family, member 4 -0.0299303
FMR1 fragile X mental retardation 1 -0.0292791
MED13L mediator complex subunit 13-like -0.0292545
NABP1 nucleic acid binding protein 1 -0.0285204
CUX1 cut-like homeobox 1 -0.0284428
THBS2 thrombospondin 2 -0.0281646
LAMP2 lysosomal-associated membrane protein 2 -0.0280643
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0276544
VCAN versican -0.0275668
STAU1 staufen double-stranded RNA binding protein 1 -0.0271681
AK1 adenylate kinase 1 -0.027158
PARD3 par-3 family cell polarity regulator -0.0270952
NAP1L1 nucleosome assembly protein 1-like 1 -0.0263974
GLIPR1 GLI pathogenesis-related 1 -0.026329
STRN3 striatin, calmodulin binding protein 3 -0.0261319
SAMD3 sterile alpha motif domain containing 3 -0.0257689
SEPTIN7 septin 7 -0.0257444
RBM3 RNA binding motif (RNP1, RRM) protein 3 -0.0256352
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.025586
AUTS2 autism susceptibility candidate 2 -0.025541
PRKCA protein kinase C, alpha -0.0251287
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0248293
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0248195
PRR16 proline rich 16 -0.0247831
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0247797
RPLP1 ribosomal protein, large, P1 -0.0246586
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0245255
FBXO11 F-box protein 11 -0.0245064
IFI16 interferon, gamma-inducible protein 16 -0.0244654
SVIL supervillin -0.0244558
BPTF bromodomain PHD finger transcription factor -0.0242446
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0241804