Clofarabine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clofarabine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clofarabine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.194006
RPS6 ribosomal protein S6 0.157414
PTMA prothymosin, alpha 0.156657
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.128178
B2M beta-2-microglobulin 0.115195
TMSB10 thymosin beta 10 0.107521
IFI27 interferon, alpha-inducible protein 27 0.10693
FTL ferritin, light polypeptide 0.100521
RPL37A ribosomal protein L37a 0.0910248
RPL35A ribosomal protein L35a 0.0842564
RPS19 ribosomal protein S19 0.0815357
RPS12 ribosomal protein S12 0.0791002
RPS27 ribosomal protein S27 0.0728173
NDRG1 N-myc downstream regulated 1 0.0714589
RPL12 ribosomal protein L12 0.0674433
FTH1 ferritin, heavy polypeptide 1 0.0654516
RPS3 ribosomal protein S3 0.0649114
VIM vimentin 0.0648737
RPL36 ribosomal protein L36 0.0624822
RACK1 receptor for activated C kinase 1 0.0599315
PRRC2C proline-rich coiled-coil 2C 0.0598053
GOLGA4 golgin A4 0.0595684
RPS8 ribosomal protein S8 0.0591871
RPL26 ribosomal protein L26 0.0583276
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0575441
RPL37 ribosomal protein L37 0.0546411
RNF145 ring finger protein 145 0.0537463
RPS21 ribosomal protein S21 0.0533987
NAP1L1 nucleosome assembly protein 1-like 1 0.0532603
RPL11 ribosomal protein L11 0.0532116
KTN1 kinectin 1 (kinesin receptor) 0.0528488
TMED9 transmembrane emp24 protein transport domain containing 9 0.0522579
SFTPA2 surfactant protein A2 0.05017
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0499912
APLP2 amyloid beta (A4) precursor-like protein 2 0.0491358
RPL31 ribosomal protein L31 0.0473618
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0466466
RPL18 ribosomal protein L18 0.0459528
RPL19 ribosomal protein L19 0.0458042
VEGFA vascular endothelial growth factor A 0.0457614
TPI1 triosephosphate isomerase 1 0.0445466
ENO2 enolase 2 (gamma, neuronal) 0.0442858
HILPDA hypoxia inducible lipid droplet-associated 0.0442836
RPL23 ribosomal protein L23 0.0435416
RPL34 ribosomal protein L34 0.0428059
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0426902
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0419086
S100A9 S100 calcium binding protein A9 0.0403924
RPS11 ribosomal protein S11 0.0399256
YBX1 Y box binding protein 1 0.039678
RPS16 ribosomal protein S16 0.0394032
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0386754
RPL9 ribosomal protein L9 0.0384635
RPS29 ribosomal protein S29 0.0382818
RSRC2 arginine/serine-rich coiled-coil 2 0.0381948
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0380972
RPL13A ribosomal protein L13a 0.0378118
CXCL8 chemokine (C-X-C motif) ligand 8 0.0367818
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0367731
RPLP2 ribosomal protein, large, P2 0.0367594
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0361046
BHLHE40 basic helix-loop-helix family, member e40 0.0360686
RPS23 ribosomal protein S23 0.0352624
FAM13A family with sequence similarity 13, member A 0.0349493
LGALS1 lectin, galactoside-binding, soluble, 1 0.0340774
RPLP1 ribosomal protein, large, P1 0.0339922
RPL8 ribosomal protein L8 0.0331079
RPS25 ribosomal protein S25 0.0329885
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0329283
SERF2 small EDRK-rich factor 2 0.0327406
PFN1 profilin 1 0.0322522
HDGF hepatoma-derived growth factor 0.0320235
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0315443
RTN4 reticulon 4 0.0314057
COX4I1 cytochrome c oxidase subunit IV isoform 1 0.0313988
LY6E lymphocyte antigen 6 complex, locus E 0.0312953
S100A6 S100 calcium binding protein A6 0.0309111
NOP58 NOP58 ribonucleoprotein 0.0305219
RPL28 ribosomal protein L28 0.0303133
UBA6 ubiquitin-like modifier activating enzyme 6 0.0302694
RPL32 ribosomal protein L32 0.0300292
PNN pinin, desmosome associated protein 0.0299084
EIF1 eukaryotic translation initiation factor 1 0.0298278
RPL35 ribosomal protein L35 0.0292973
RPS2 ribosomal protein S2 0.0292158
TIMP1 TIMP metallopeptidase inhibitor 1 0.0291553
PNISR PNN-interacting serine/arginine-rich protein 0.0289912
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0288849
ZNF292 zinc finger protein 292 0.0284668
FOSL1 FOS-like antigen 1 0.0280294
SETD5 SET domain containing 5 0.0280073
RPS17 ribosomal protein S17 0.0276925
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.027389
RBM39 RNA binding motif protein 39 0.026892
RBM25 RNA binding motif protein 25 0.0265995
ZFP36L1 ZFP36 ring finger protein-like 1 0.0265144
EPS8 epidermal growth factor receptor pathway substrate 8 0.0262776
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0262269
PKM pyruvate kinase, muscle 0.0260557
ATP5F1E ATP synthase F1 subunit epsilon 0.0259262

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.211349
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.191531
FN1 fibronectin 1 -0.143404
EXT1 exostosin glycosyltransferase 1 -0.0921088
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0918564
HMGA2 high mobility group AT-hook 2 -0.0807459
SQSTM1 sequestosome 1 -0.0745131
UBC ubiquitin C -0.0643401
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0566038
GLIS3 GLIS family zinc finger 3 -0.0552238
HIPK2 homeodomain interacting protein kinase 2 -0.0503063
ITGA1 integrin, alpha 1 -0.0484992
SMAD3 SMAD family member 3 -0.0460561
AHR aryl hydrocarbon receptor -0.0385379
ARHGAP35 Rho GTPase activating protein 35 -0.0364594
AEBP2 AE binding protein 2 -0.0357416
TAS2R14 taste receptor, type 2, member 14 -0.0351973
NRG1 neuregulin 1 -0.0351578
AOPEP aminopeptidase O (putative) -0.0345343
OSMR oncostatin M receptor -0.0344071
NRIP1 nuclear receptor interacting protein 1 -0.0344031
ETV6 ets variant 6 -0.0343979
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0336739
VCL vinculin -0.0331443
CALU calumenin -0.0327624
CANX calnexin -0.0321159
NCOA7 nuclear receptor coactivator 7 -0.0318655
KLHL5 kelch-like family member 5 -0.0318485
AHRR aryl-hydrocarbon receptor repressor -0.0315483
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0310516
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0303555
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0302876
EFNA5 ephrin-A5 -0.0291999
ZC3H12C zinc finger CCCH-type containing 12C -0.0291358
PDE4D phosphodiesterase 4D, cAMP-specific -0.0290571
SMYD3 SET and MYND domain containing 3 -0.0289822
USP34 ubiquitin specific peptidase 34 -0.0287828
CAB39 calcium binding protein 39 -0.0278164
THBS1 thrombospondin 1 -0.0273844
AHNAK AHNAK nucleoprotein -0.0272654
UGDH UDP-glucose 6-dehydrogenase -0.0268185
ANKRD28 ankyrin repeat domain 28 -0.026667
LIMCH1 LIM and calponin homology domains 1 -0.0264627
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0259004
FAM20C family with sequence similarity 20, member C -0.0253401
TMEM156 transmembrane protein 156 -0.0252302
LRMDA leucine rich melanocyte differentiation associated -0.0248764
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0247126
FBN1 fibrillin 1 -0.024652
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 -0.0237105
RAI14 retinoic acid induced 14 -0.0236756
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0233087
AHNAK2 AHNAK nucleoprotein 2 -0.0232017
SYT1 synaptotagmin I -0.0231548
SLC35F3 solute carrier family 35, member F3 -0.0226328
ZNF217 zinc finger protein 217 -0.0225092
ASPH aspartate beta-hydroxylase -0.0219462
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0219001
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0216698
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0212984
NAMPT nicotinamide phosphoribosyltransferase -0.0209692
NPAS2 neuronal PAS domain protein 2 -0.0205064
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0204888
RAB31 RAB31, member RAS oncogene family -0.0196639
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0194056
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0193161
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0191633
CAPN2 calpain 2, (m/II) large subunit -0.019036
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0187499
ARF1 ADP-ribosylation factor 1 -0.0187036
APP amyloid beta (A4) precursor protein -0.0186965
MYH9 myosin, heavy chain 9, non-muscle -0.0185954
MED13 mediator complex subunit 13 -0.0185482
MCTP2 multiple C2 domains, transmembrane 2 -0.01851
CCDC138 coiled-coil domain containing 138 -0.0184793
FLNA filamin A, alpha -0.0182411
WDR1 WD repeat domain 1 -0.0181809
TXNRD1 thioredoxin reductase 1 -0.0180472
TNS3 tensin 3 -0.0178792
PRPF3 pre-mRNA processing factor 3 -0.0177909
CDC50A cell division cycle 50 P4-ATPase accessory subunit A -0.0176066
RNF213 ring finger protein 213 -0.0175337
RPH3AL rabphilin 3A-like (without C2 domains) -0.0174011
SAMD4A sterile alpha motif domain containing 4A -0.017138
PCBP3 poly(rC) binding protein 3 -0.0169331
LTBP1 latent transforming growth factor beta binding protein 1 -0.0168755
CELSR1 cadherin, EGF LAG seven-pass G-type receptor 1 -0.0168436
ANTXR2 anthrax toxin receptor 2 -0.01675
SEC31A SEC31 homolog A (S. cerevisiae) -0.0167464
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0167317
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0165874
RAD21 RAD21 homolog (S. pombe) -0.0164096
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0161228
FBXO34 F-box protein 34 -0.0161007
DNAH5 dynein, axonemal, heavy chain 5 -0.0160396
DNAH14 dynein, axonemal, heavy chain 14 -0.015891
AFF4 AF4/FMR2 family, member 4 -0.0158827
JUN jun proto-oncogene -0.0157186
RBPMS RNA binding protein with multiple splicing -0.0157027
DOCK5 dedicator of cytokinesis 5 -0.0156539