Clomipramine Gene Set

Dataset CTD Gene-Chemical Interactions
Category physical interactions
Type chemical
Description A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias. (Chemical Entities of Biological Interest Ontology, CHEBI_47780)
External Link http://ctdbase.org/detail.go?type=chem&acc=D002997
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Genes

19 genes/proteins interacting with the chemical Clomipramine from the curated CTD Gene-Chemical Interactions dataset.

Symbol Name
CASP3 caspase 3, apoptosis-related cysteine peptidase
CASP7 caspase 7, apoptosis-related cysteine peptidase
CAT catalase
DRD2 dopamine receptor D2
GSTP1 glutathione S-transferase pi 1
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
IL1A interleukin 1, alpha
IL6 interleukin 6
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
PARP1 poly (ADP-ribose) polymerase 1
PRL prolactin
PROC protein C (inactivator of coagulation factors Va and VIIIa)
SLC22A2 solute carrier family 22 (organic cation transporter), member 2
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4
SREBF1 sterol regulatory element binding transcription factor 1
SREBF2 sterol regulatory element binding transcription factor 2
TAC1 tachykinin, precursor 1
TNF tumor necrosis factor