Clonidine (hydrochloride)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clonidine (hydrochloride)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.116491
PRKG1 protein kinase, cGMP-dependent, type I 0.0766219
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0765989
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0755895
FNDC3B fibronectin type III domain containing 3B 0.0754983
THSD4 thrombospondin, type I, domain containing 4 0.0749231
PRELID2 PRELI domain containing 2 0.0747653
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0731369
PDE10A phosphodiesterase 10A 0.0699227
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0644419
GSE1 Gse1 coiled-coil protein 0.063442
UTRN utrophin 0.0632453
MYOF myoferlin 0.0630211
CADM2 cell adhesion molecule 2 0.0607629
FGFR1 fibroblast growth factor receptor 1 0.0586161
HMGA2 high mobility group AT-hook 2 0.0544999
TMSB4X thymosin beta 4, X-linked 0.0502142
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.046656
IGF2R insulin-like growth factor 2 receptor 0.0465909
TSHZ2 teashirt zinc finger homeobox 2 0.0462118
PDE4B phosphodiesterase 4B, cAMP-specific 0.0456914
TRIO trio Rho guanine nucleotide exchange factor 0.0443114
NCOR2 nuclear receptor corepressor 2 0.0442336
VEGFA vascular endothelial growth factor A 0.0441092
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0433123
ZEB1 zinc finger E-box binding homeobox 1 0.0433116
SMYD3 SET and MYND domain containing 3 0.0425308
CTBP2 C-terminal binding protein 2 0.0419594
NUMA1 nuclear mitotic apparatus protein 1 0.0407216
MYO9A myosin IXA 0.0406654
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0405621
EXOC4 exocyst complex component 4 0.0385219
SFPQ splicing factor proline/glutamine-rich 0.0382575
SAMD4A sterile alpha motif domain containing 4A 0.0377881
MACF1 microtubule-actin crosslinking factor 1 0.0372511
ZNF608 zinc finger protein 608 0.0372249
KTN1 kinectin 1 (kinesin receptor) 0.0371383
TPST1 tyrosylprotein sulfotransferase 1 0.0367484
MYH10 myosin, heavy chain 10, non-muscle 0.0361913
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0360603
BCOR BCL6 corepressor 0.0359325
H1-4 H1.4 linker histone, cluster member 0.0353688
NFIA nuclear factor I/A 0.0352671
TBC1D5 TBC1 domain family, member 5 0.0345629
EGFR epidermal growth factor receptor 0.0339001
COL5A2 collagen, type V, alpha 2 0.0338488
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0333227
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0328696
FRYL FRY-like 0.0326631
GMDS GDP-mannose 4,6-dehydratase 0.0324456
EP300 E1A binding protein p300 0.0322214
OGA O-GlcNAcase 0.0320299
PRKD1 protein kinase D1 0.0320044
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0317563
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0315009
CEP250 centrosomal protein 250kDa 0.0314079
TBL1X transducin (beta)-like 1X-linked 0.0310823
SRRM2 serine/arginine repetitive matrix 2 0.0310698
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0309202
USP9X ubiquitin specific peptidase 9, X-linked 0.030746
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0307061
RAD51B RAD51 paralog B 0.0306687
KIAA1328 KIAA1328 0.0303915
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0303375
CUL3 cullin 3 0.0303094
LYPD6 LY6/PLAUR domain containing 6 0.0300528
PDK4 pyruvate dehydrogenase kinase, isozyme 4 0.0294418
HSPA8 heat shock 70kDa protein 8 0.0293116
FBXL7 F-box and leucine-rich repeat protein 7 0.0291827
CHD3 chromodomain helicase DNA binding protein 3 0.029019
PRKCE protein kinase C, epsilon 0.0289994
BOC BOC cell adhesion associated, oncogene regulated 0.0289428
KAZN kazrin, periplakin interacting protein 0.0287814
FNIP1 folliculin interacting protein 1 0.0287489
WDPCP WD repeat containing planar cell polarity effector 0.0287087
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0285998
APLP2 amyloid beta (A4) precursor-like protein 2 0.0285865
WDR26 WD repeat domain 26 0.0283694
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.02823
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0278289
MYH9 myosin, heavy chain 9, non-muscle 0.0278153
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0277216
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0277012
KDM6A lysine (K)-specific demethylase 6A 0.0276681
RREB1 ras responsive element binding protein 1 0.0275903
ANKRD11 ankyrin repeat domain 11 0.0274896
RBM26 RNA binding motif protein 26 0.0272197
BTBD9 BTB (POZ) domain containing 9 0.0271922
KDM3A lysine (K)-specific demethylase 3A 0.0271038
DOCK1 dedicator of cytokinesis 1 0.0270864
LPP LIM domain containing preferred translocation partner in lipoma 0.0266297
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0266264
CSNK1A1 casein kinase 1, alpha 1 0.0266238
ZNF532 zinc finger protein 532 0.0264624
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide 0.0263576
ZNF638 zinc finger protein 638 0.0261996
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0260464
VPS13D vacuolar protein sorting 13 homolog D (S. cerevisiae) 0.0259296
BBX bobby sox homolog (Drosophila) 0.0259042
FAM13A family with sequence similarity 13, member A 0.0257538

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.25381
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.178324
PTMA prothymosin, alpha -0.120698
RPS6 ribosomal protein S6 -0.0997259
RPLP1 ribosomal protein, large, P1 -0.0895881
MGP matrix Gla protein -0.0871052
PEG10 paternally expressed 10 -0.0729223
RPL34 ribosomal protein L34 -0.0726619
RPS8 ribosomal protein S8 -0.0699838
IER3 immediate early response 3 -0.061683
RPS24 ribosomal protein S24 -0.0612801
RPLP0 ribosomal protein, large, P0 -0.0610017
MT2A metallothionein 2A -0.0609126
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0582115
RPL35A ribosomal protein L35a -0.057278
HMGA1 high mobility group AT-hook 1 -0.0559116
RPS19 ribosomal protein S19 -0.0537343
MEST mesoderm specific transcript -0.0527439
RPS23 ribosomal protein S23 -0.0518046
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0515932
RACK1 receptor for activated C kinase 1 -0.0470183
LDHA lactate dehydrogenase A -0.046245
RPL37 ribosomal protein L37 -0.0451162
RPL37A ribosomal protein L37a -0.0441325
TPT1 tumor protein, translationally-controlled 1 -0.0439145
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0439108
RPL28 ribosomal protein L28 -0.0437087
RPL12 ribosomal protein L12 -0.0436881
RPS14 ribosomal protein S14 -0.0434857
S100A9 S100 calcium binding protein A9 -0.0423569
RPS12 ribosomal protein S12 -0.0416233
RPLP2 ribosomal protein, large, P2 -0.0400439
TPK1 thiamin pyrophosphokinase 1 -0.0399965
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.039071
TUBB tubulin, beta class I -0.0388547
HMGB1 high mobility group box 1 -0.0379192
CBX3 chromobox homolog 3 -0.0377605
PDIA3 protein disulfide isomerase family A, member 3 -0.0370931
MAP1B microtubule-associated protein 1B -0.0369536
RPL19 ribosomal protein L19 -0.0368959
COL1A2 collagen, type I, alpha 2 -0.0361891
YBX1 Y box binding protein 1 -0.0359662
RPL23 ribosomal protein L23 -0.0354759
ZNF292 zinc finger protein 292 -0.0350942
RPS13 ribosomal protein S13 -0.0344737
ACTG1 actin gamma 1 -0.0344021
FTL ferritin, light polypeptide -0.0337381
KPNB1 karyopherin (importin) beta 1 -0.0334705
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.033448
POTEF POTE ankyrin domain family, member F -0.0333536
BSG basigin (Ok blood group) -0.0329934
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0326855
SEPTIN7 septin 7 -0.0324192
ENO1 enolase 1, (alpha) -0.0320838
RPL11 ribosomal protein L11 -0.0319948
RPS4X ribosomal protein S4, X-linked -0.0310766
TUBA1B tubulin, alpha 1b -0.0307484
PELI1 pellino E3 ubiquitin protein ligase 1 -0.030497
VDAC1 voltage-dependent anion channel 1 -0.0302263
FTH1 ferritin, heavy polypeptide 1 -0.0299306
GOLGA4 golgin A4 -0.0297464
RPL7 ribosomal protein L7 -0.0294713
KMT2C lysine (K)-specific methyltransferase 2C -0.0279802
TMSB10 thymosin beta 10 -0.0279641
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0278922
ATP5F1B ATP synthase F1 subunit beta -0.0275359
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0273741
RPS16 ribosomal protein S16 -0.0273672
RPS11 ribosomal protein S11 -0.0266505
SOX4 SRY (sex determining region Y)-box 4 -0.0266301
PIBF1 progesterone immunomodulatory binding factor 1 -0.026374
CLINT1 clathrin interactor 1 -0.0258548
PNISR PNN-interacting serine/arginine-rich protein -0.0258398
RNF145 ring finger protein 145 -0.0257497
DEK DEK proto-oncogene -0.025541
RPS27A ribosomal protein S27a -0.0254398
RPL27A ribosomal protein L27a -0.0254059
RPL32 ribosomal protein L32 -0.0247945
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B -0.0246903
RPL5 ribosomal protein L5 -0.024426
RNF24 ring finger protein 24 -0.0241214
GMPS guanine monphosphate synthase -0.0241146
B2M beta-2-microglobulin -0.0240655
CALR calreticulin -0.0239659
GSPT1 G1 to S phase transition 1 -0.0238948
RPS20 ribosomal protein S20 -0.0235807
RPL30 ribosomal protein L30 -0.0235117
RPS25 ribosomal protein S25 -0.0233642
KMT2E lysine (K)-specific methyltransferase 2E -0.0232871
TP53 tumor protein p53 -0.0231902
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0230711
COG5 component of oligomeric golgi complex 5 -0.0228879
UBC ubiquitin C -0.0228622
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0228267
HOXC10 homeobox C10 -0.0226878
RPL31 ribosomal protein L31 -0.022517
RPS17 ribosomal protein S17 -0.0224831
RPS3 ribosomal protein S3 -0.0224072
EIF5B eukaryotic translation initiation factor 5B -0.0221409
BIRC6 baculoviral IAP repeat containing 6 -0.0220837