Clonidine (hydrochloride)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in C-33 A cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Clonidine (hydrochloride)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule 0.103745
COL5A2 collagen, type V, alpha 2 0.103016
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.098667
ZNF608 zinc finger protein 608 0.0966329
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0902483
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.07586
VCL vinculin 0.0743547
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0729866
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0720768
DST dystonin 0.0664945
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0656506
USP9X ubiquitin specific peptidase 9, X-linked 0.0654106
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.064508
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0615203
JMJD1C jumonji domain containing 1C 0.0608849
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0588228
NALF1 NALCN channel auxiliary factor 1 0.0588044
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0558403
HSPA8 heat shock 70kDa protein 8 0.0530214
CDH18 cadherin 18, type 2 0.0519501
SFPQ splicing factor proline/glutamine-rich 0.0516163
MED13 mediator complex subunit 13 0.0506818
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0483719
NFIA nuclear factor I/A 0.0472487
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0457175
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0455309
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0454437
MACF1 microtubule-actin crosslinking factor 1 0.0448737
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0444163
RAB10 RAB10, member RAS oncogene family 0.043195
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0428695
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa 0.0423607
SRRM2 serine/arginine repetitive matrix 2 0.0414915
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0407378
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.039532
KMT2C lysine (K)-specific methyltransferase 2C 0.0389711
OGA O-GlcNAcase 0.0387599
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0387001
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0382827
AEBP2 AE binding protein 2 0.0382393
HNRNPUL2 heterogeneous nuclear ribonucleoprotein U-like 2 0.0380038
KTN1 kinectin 1 (kinesin receptor) 0.037906
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.037622
TAOK1 TAO kinase 1 0.0375004
SKI SKI proto-oncogene 0.0373742
RPL3 ribosomal protein L3 0.0367191
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0367181
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0363847
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0358539
SOX5 SRY (sex determining region Y)-box 5 0.035491
PCM1 pericentriolar material 1 0.0354432
AFDN afadin, adherens junction formation factor 0.035154
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0347238
PEAK1 pseudopodium-enriched atypical kinase 1 0.034481
CCNY cyclin Y 0.0339252
CAPZB capping protein (actin filament) muscle Z-line, beta 0.0338375
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0334179
SIK3 SIK family kinase 3 0.0332696
SERTAD2 SERTA domain containing 2 0.0331736
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 0.0331137
ANKRD36 ankyrin repeat domain 36 0.0327195
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0323863
HELLS helicase, lymphoid-specific 0.0323793
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0320567
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0320268
TOP2B topoisomerase (DNA) II beta 180kDa 0.0319502
WLS wntless Wnt ligand secretion mediator 0.0317524
ANKRD17 ankyrin repeat domain 17 0.0311277
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0310773
PDS5A PDS5 cohesin associated factor A 0.0309405
TUSC3 tumor suppressor candidate 3 0.0307766
ANO6 anoctamin 6 0.0307665
SMC1A structural maintenance of chromosomes 1A 0.0306446
SMAD6 SMAD family member 6 0.0306031
ZEB1 zinc finger E-box binding homeobox 1 0.0305738
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 0.0305675
TPR translocated promoter region, nuclear basket protein 0.0305414
NRG1 neuregulin 1 0.0303747
XPO1 exportin 1 0.0302394
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0299803
CLTC clathrin, heavy chain (Hc) 0.0298394
SLIT2 slit homolog 2 (Drosophila) 0.0298261
TUT4 terminal uridylyl transferase 4 0.0297209
MATR3 matrin 3 0.0297045
NBEAL1 neurobeachin-like 1 0.0295993
ANKRD11 ankyrin repeat domain 11 0.0295792
H1-4 H1.4 linker histone, cluster member 0.0291253
CHD7 chromodomain helicase DNA binding protein 7 0.0290911
SRSF4 serine/arginine-rich splicing factor 4 0.0290133
SMG6 SMG6 nonsense mediated mRNA decay factor 0.028849
SPATS2 spermatogenesis associated, serine-rich 2 0.0288283
SEMA3D sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 0.02881
FNDC3B fibronectin type III domain containing 3B 0.0287276
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0283299
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0281251
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0279646
NCAPG2 non-SMC condensin II complex, subunit G2 0.0278986
SUN1 Sad1 and UNC84 domain containing 1 0.0277023
NFIB nuclear factor I/B 0.0276597
NUDC nudC nuclear distribution protein 0.0276181

decreased expression

Symbol Name Standardized Value
RAD51B RAD51 paralog B -0.207982
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.147548
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.13002
NPAS3 neuronal PAS domain protein 3 -0.0955069
TENM3 teneurin transmembrane protein 3 -0.0686921
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0666311
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0565844
EGR1 early growth response 1 -0.0506638
EFNA5 ephrin-A5 -0.0454031
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0448802
RPL28 ribosomal protein L28 -0.0448327
RPLP1 ribosomal protein, large, P1 -0.0439471
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0433199
CCSER1 coiled-coil serine-rich protein 1 -0.0408995
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0391667
RPL36 ribosomal protein L36 -0.0391157
IGF2 insulin-like growth factor 2 -0.0373115
RPS8 ribosomal protein S8 -0.0363509
CADM2 cell adhesion molecule 2 -0.0358224
IFI6 interferon, alpha-inducible protein 6 -0.0357044
MT2A metallothionein 2A -0.0355631
FASN fatty acid synthase -0.0349767
CANX calnexin -0.0340197
RPS19 ribosomal protein S19 -0.0339644
RPLP2 ribosomal protein, large, P2 -0.0338651
GAB2 GRB2-associated binding protein 2 -0.0332709
FTL ferritin, light polypeptide -0.0324541
RPS23 ribosomal protein S23 -0.0302595
BCAS3 breast carcinoma amplified sequence 3 -0.0296148
TOM1L2 target of myb1-like 2 (chicken) -0.0291448
RPS6 ribosomal protein S6 -0.0289828
RPL31 ribosomal protein L31 -0.028392
NEBL nebulette -0.0277135
CELF1 CUGBP, Elav-like family member 1 -0.0273829
NR5A2 nuclear receptor subfamily 5, group A, member 2 -0.0266878
COL11A1 collagen, type XI, alpha 1 -0.0265528
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0264433
TMEM259 transmembrane protein 259 -0.0264007
RPS29 ribosomal protein S29 -0.0261965
PHACTR4 phosphatase and actin regulator 4 -0.0261229
RPL5 ribosomal protein L5 -0.0256861
HLA-B major histocompatibility complex, class I, B -0.0253989
FBXL7 F-box and leucine-rich repeat protein 7 -0.0253979
RPL37A ribosomal protein L37a -0.0253082
TOX thymocyte selection-associated high mobility group box -0.0251357
ANK2 ankyrin 2, neuronal -0.0251306
ARB2A ARB2 cotranscriptional regulator A -0.0250603
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0250444
TTC3 tetratricopeptide repeat domain 3 -0.0245775
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0243809
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0243778
RAP1B RAP1B, member of RAS oncogene family -0.0241573
RPL34 ribosomal protein L34 -0.0235223
RPL13A ribosomal protein L13a -0.0230804
TMSB10 thymosin beta 10 -0.0230381
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0227543
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0227259
RFX7 regulatory factor X, 7 -0.0218669
TBC1D32 TBC1 domain family, member 32 -0.0217056
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0216437
CCAR1 cell division cycle and apoptosis regulator 1 -0.021625
NBAS neuroblastoma amplified sequence -0.021546
TPT1 tumor protein, translationally-controlled 1 -0.0214581
GRID2 glutamate receptor, ionotropic, delta 2 -0.0214419
RPL32 ribosomal protein L32 -0.0212686
HHIP hedgehog interacting protein -0.0212413
LAMA5 laminin, alpha 5 -0.0211307
SOX4 SRY (sex determining region Y)-box 4 -0.0209663
RPS28 ribosomal protein S28 -0.0207926
RPS16 ribosomal protein S16 -0.0206449
TPD52 tumor protein D52 -0.0203943
HMGA1 high mobility group AT-hook 1 -0.0203723
FAM162A family with sequence similarity 162, member A -0.0199829
TET1 tet methylcytosine dioxygenase 1 -0.019578
SALL4 spalt-like transcription factor 4 -0.0195517
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein -0.0194135
ZFP64 ZFP64 zinc finger protein -0.0193848
FBXL2 F-box and leucine-rich repeat protein 2 -0.0192974
SLF1 SMC5-SMC6 complex localization factor 1 -0.0192662
TMEM117 transmembrane protein 117 -0.0192373
RIGI RNA sensor RIG-I -0.0191152
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.0190692
LDLRAD3 low density lipoprotein receptor class A domain containing 3 -0.0190044
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 -0.0185062
MED14 mediator complex subunit 14 -0.0181567
ERCC6L2 excision repair cross-complementation group 6-like 2 -0.0181384
MON2 MON2 homolog (S. cerevisiae) -0.0179362
FBXL20 F-box and leucine-rich repeat protein 20 -0.0178982
RACK1 receptor for activated C kinase 1 -0.0178482
COX5A cytochrome c oxidase subunit Va -0.0176982
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0176706
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0174972
ISG15 ISG15 ubiquitin-like modifier -0.0174441
TNPO3 transportin 3 -0.017386
RPS27 ribosomal protein S27 -0.017362
RPL9 ribosomal protein L9 -0.0173449
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0172658
NXN nucleoredoxin -0.0172409
COG6 component of oligomeric golgi complex 6 -0.0171988
RPL37 ribosomal protein L37 -0.0170374