Clonidine (hydrochloride)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clonidine (hydrochloride)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.209745
COL6A3 collagen, type VI, alpha 3 0.184181
VEGFA vascular endothelial growth factor A 0.139747
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.103008
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0938315
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0718132
PLEC plectin 0.07057
TRIO trio Rho guanine nucleotide exchange factor 0.0665437
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0653872
MT2A metallothionein 2A 0.0627097
MSN moesin 0.0592899
MYO10 myosin X 0.058831
SDC2 syndecan 2 0.0434961
PDIA6 protein disulfide isomerase family A, member 6 0.0428521
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0418899
ZSWIM6 zinc finger, SWIM-type containing 6 0.041512
RPS2 ribosomal protein S2 0.0414496
PABPC1 poly(A) binding protein, cytoplasmic 1 0.039792
RPL3 ribosomal protein L3 0.0395687
COL5A1 collagen, type V, alpha 1 0.0392685
COL6A1 collagen, type VI, alpha 1 0.0391112
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0387352
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0383674
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0381354
BRD2 bromodomain containing 2 0.0365725
HYOU1 hypoxia up-regulated 1 0.0361464
NDRG1 N-myc downstream regulated 1 0.0360804
DST dystonin 0.0338315
NFE2L1 nuclear factor, erythroid 2-like 1 0.0337569
MACF1 microtubule-actin crosslinking factor 1 0.033504
EGFR epidermal growth factor receptor 0.0327514
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0326148
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0322641
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0318208
SFPQ splicing factor proline/glutamine-rich 0.0310727
PICALM phosphatidylinositol binding clathrin assembly protein 0.0306855
FNDC3B fibronectin type III domain containing 3B 0.030359
ANKRD11 ankyrin repeat domain 11 0.0300741
HDAC9 histone deacetylase 9 0.0299177
B2M beta-2-microglobulin 0.0295873
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0294895
TMF1 TATA element modulatory factor 1 0.0292669
FBN1 fibrillin 1 0.0292365
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0292043
COL7A1 collagen, type VII, alpha 1 0.0291679
CDH13 cadherin 13 0.0282204
NAV2 neuron navigator 2 0.0279514
HSPA8 heat shock 70kDa protein 8 0.0278331
WWTR1 WW domain containing transcription regulator 1 0.0274908
CALD1 caldesmon 1 0.0274234
ZBTB38 zinc finger and BTB domain containing 38 0.027338
PKM pyruvate kinase, muscle 0.0273093
NOTCH2 notch 2 0.027084
GOLGB1 golgin B1 0.0265017
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0262994
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0260181
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.025178
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0248835
HILPDA hypoxia inducible lipid droplet-associated 0.0247824
SRRM2 serine/arginine repetitive matrix 2 0.0247503
JARID2 jumonji, AT rich interactive domain 2 0.0247048
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0246792
MRTFA myocardin related transcription factor A 0.0242308
TSC22D2 TSC22 domain family, member 2 0.024225
ASPH aspartate beta-hydroxylase 0.0241553
FMNL2 formin-like 2 0.023816
COL6A2 collagen, type VI, alpha 2 0.023471
SLC38A2 solute carrier family 38, member 2 0.0230929
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0230907
BRD4 bromodomain containing 4 0.0228112
NEK10 NIMA-related kinase 10 0.0227463
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0223895
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0222344
ZMIZ1 zinc finger, MIZ-type containing 1 0.022202
RUNX1 runt-related transcription factor 1 0.0221704
FLNA filamin A, alpha 0.0220953
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0215733
CHD1 chromodomain helicase DNA binding protein 1 0.0212233
PCBP2 poly(rC) binding protein 2 0.0208642
SETD5 SET domain containing 5 0.020815
COPA coatomer protein complex, subunit alpha 0.020269
EEF2 eukaryotic translation elongation factor 2 0.0200536
SQSTM1 sequestosome 1 0.0199442
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0198793
RPS6 ribosomal protein S6 0.0195879
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0195328
ADAM19 ADAM metallopeptidase domain 19 0.01947
CCNY cyclin Y 0.0193105
TNIP1 TNFAIP3 interacting protein 1 0.0192876
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0192557
DSPP dentin sialophosphoprotein 0.01922
FXR1 fragile X mental retardation, autosomal homolog 1 0.0191314
OPTN optineurin 0.0190992
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0189513
RND3 Rho family GTPase 3 0.018767
CSNK1A1 casein kinase 1, alpha 1 0.0187294
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3 0.0186814
FAM107B family with sequence similarity 107, member B 0.0186299
TNS1 tensin 1 0.0186213
JAG1 jagged 1 0.018571

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.35312
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.248562
COL1A1 collagen, type I, alpha 1 -0.209284
CXCL8 chemokine (C-X-C motif) ligand 8 -0.12846
TIMP3 TIMP metallopeptidase inhibitor 3 -0.127649
VIM vimentin -0.115068
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0974715
IGFBP3 insulin-like growth factor binding protein 3 -0.0959441
TPM4 tropomyosin 4 -0.0948721
COL1A2 collagen, type I, alpha 2 -0.0791652
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0662361
IER3 immediate early response 3 -0.0646927
DPYD dihydropyrimidine dehydrogenase -0.0633942
TM4SF1 transmembrane 4 L six family member 1 -0.0591375
ATP13A3 ATPase type 13A3 -0.0571497
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0568309
FTH1 ferritin, heavy polypeptide 1 -0.0542118
OSMR oncostatin M receptor -0.0511971
LOXL2 lysyl oxidase-like 2 -0.0486661
PSD3 pleckstrin and Sec7 domain containing 3 -0.0485619
TMSB10 thymosin beta 10 -0.0471968
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0453775
F3 coagulation factor III (thromboplastin, tissue factor) -0.0436752
DPYSL3 dihydropyrimidinase-like 3 -0.0426466
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0414425
LMAN1 lectin, mannose-binding, 1 -0.0408397
CD44 CD44 molecule (Indian blood group) -0.0405372
RPL35A ribosomal protein L35a -0.0400281
ZBTB20 zinc finger and BTB domain containing 20 -0.038929
LOX lysyl oxidase -0.0386514
TRPS1 trichorhinophalangeal syndrome I -0.0383629
ANXA2 annexin A2 -0.0381975
NAMPT nicotinamide phosphoribosyltransferase -0.0377385
PDE4D phosphodiesterase 4D, cAMP-specific -0.035746
PRELID2 PRELI domain containing 2 -0.0355787
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0342006
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0334696
CANX calnexin -0.033318
KLF7 Kruppel-like factor 7 (ubiquitous) -0.0328124
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0322485
LTBP1 latent transforming growth factor beta binding protein 1 -0.0318341
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0312017
ELL2 elongation factor, RNA polymerase II, 2 -0.0299255
COL3A1 collagen, type III, alpha 1 -0.0298315
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0292711
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0292519
CAVIN1 caveolae associated protein 1 -0.0286645
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -0.0284369
SBF2 SET binding factor 2 -0.0280828
HMGA2 high mobility group AT-hook 2 -0.0280685
STC1 stanniocalcin 1 -0.0279155
RRBP1 ribosome binding protein 1 -0.0275279
ACTG1 actin gamma 1 -0.0272683
RIPK2 receptor-interacting serine-threonine kinase 2 -0.0270472
PALLD palladin, cytoskeletal associated protein -0.0268109
TPT1 tumor protein, translationally-controlled 1 -0.0259268
KLF6 Kruppel-like factor 6 -0.0259261
MAML2 mastermind-like 2 (Drosophila) -0.0255756
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0252056
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0247032
RAD21 RAD21 homolog (S. pombe) -0.0244554
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0240961
BZW1 basic leucine zipper and W2 domains 1 -0.024041
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0237113
TMEM263 transmembrane protein 263 -0.0236981
GNAS GNAS complex locus -0.0236858
POSTN periostin, osteoblast specific factor -0.0235492
CLIC4 chloride intracellular channel 4 -0.0234886
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0234004
FKBP10 FK506 binding protein 10, 65 kDa -0.023308
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0232027
RNF168 ring finger protein 168, E3 ubiquitin protein ligase -0.0229569
IL6ST interleukin 6 signal transducer -0.0228747
TMSB4X thymosin beta 4, X-linked -0.0225584
LDHA lactate dehydrogenase A -0.0220778
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0217977
TUBB tubulin, beta class I -0.0215813
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0215307
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0213578
NRP1 neuropilin 1 -0.0212336
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.021217
ICAM1 intercellular adhesion molecule 1 -0.0211496
LOC112694756 uncharaterized LOC112694756 -0.0211221
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0206575
PLSCR1 phospholipid scramblase 1 -0.0204861
PXDN peroxidasin -0.0204064
SRGN serglycin -0.0203862
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0203091
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0202991
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.020214
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0196696
RPS24 ribosomal protein S24 -0.0195885
SULF1 sulfatase 1 -0.0194296
HLA-B major histocompatibility complex, class I, B -0.0190696
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0190616
S100A6 S100 calcium binding protein A6 -0.0190479
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0189925
MON2 MON2 homolog (S. cerevisiae) -0.0187308
BHLHE40 basic helix-loop-helix family, member e40 -0.0186122
MX2 MX dynamin-like GTPase 2 -0.0185797