| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Clonidine (hydrochloride) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Clonidine (hydrochloride)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.149503 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0908902 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0883384 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0757461 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0655447 |
| ASPH | aspartate beta-hydroxylase | 0.063531 |
| RPL3 | ribosomal protein L3 | 0.058011 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0539821 |
| ATXN1 | ataxin 1 | 0.0534283 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.052608 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.051542 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0513299 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0485202 |
| VEGFA | vascular endothelial growth factor A | 0.046504 |
| FMNL2 | formin-like 2 | 0.0405801 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0377526 |
| RPS2 | ribosomal protein S2 | 0.037234 |
| PCBP2 | poly(rC) binding protein 2 | 0.036079 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0357234 |
| TF | transferrin | 0.0353149 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0350398 |
| USP47 | ubiquitin specific peptidase 47 | 0.0341597 |
| TNS1 | tensin 1 | 0.0336396 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0335909 |
| SVIL | supervillin | 0.0331058 |
| DTNA | dystrobrevin, alpha | 0.0325249 |
| SET | SET nuclear proto-oncogene | 0.0315743 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0297361 |
| ANO6 | anoctamin 6 | 0.0291214 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0285842 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0283825 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0279618 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0279155 |
| FLNB | filamin B, beta | 0.02778 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0275418 |
| LCOR | ligand dependent nuclear receptor corepressor | 0.0270617 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0269342 |
| DSPP | dentin sialophosphoprotein | 0.0266413 |
| ZNF292 | zinc finger protein 292 | 0.0266298 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0262 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0260233 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | 0.0259025 |
| SMAD3 | SMAD family member 3 | 0.0258327 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.025825 |
| RAD51B | RAD51 paralog B | 0.0254906 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.025388 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0252165 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | 0.0251156 |
| PLEC | plectin | 0.0250095 |
| KYNU | kynureninase | 0.0242683 |
| FOXP1 | forkhead box P1 | 0.024068 |
| HPCAL1 | hippocalcin-like 1 | 0.0239152 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0234259 |
| EXOC6B | exocyst complex component 6B | 0.0232745 |
| SLC41A2 | solute carrier family 41 (magnesium transporter), member 2 | 0.0230695 |
| NRIP1 | nuclear receptor interacting protein 1 | 0.0227324 |
| ABCD3 | ATP-binding cassette, sub-family D (ALD), member 3 | 0.0226304 |
| CCNL1 | cyclin L1 | 0.0226223 |
| GSE1 | Gse1 coiled-coil protein | 0.0226081 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0223032 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0222833 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.022063 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0219471 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0219185 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0219162 |
| ADAM17 | ADAM metallopeptidase domain 17 | 0.0217114 |
| PAPOLA | poly(A) polymerase alpha | 0.0216979 |
| CCNY | cyclin Y | 0.0215969 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0214744 |
| JAG1 | jagged 1 | 0.0211929 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0210996 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0210437 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0207637 |
| MYO5B | myosin VB | 0.0207594 |
| NCKAP1 | NCK-associated protein 1 | 0.0206637 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.020615 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.0206073 |
| BRD2 | bromodomain containing 2 | 0.0205601 |
| KIF1B | kinesin family member 1B | 0.0204452 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0204238 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.020264 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0201832 |
| ZFC3H1 | zinc finger, C3H1-type containing | 0.0197979 |
| RASA2 | RAS p21 protein activator 2 | 0.0197441 |
| DENND1A | DENN/MADD domain containing 1A | 0.0196866 |
| AFDN | afadin, adherens junction formation factor | 0.0195667 |
| RPS18 | ribosomal protein S18 | 0.0194688 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | 0.0192264 |
| INSIG2 | insulin induced gene 2 | 0.0191959 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0191853 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0190664 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.018993 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0189294 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0189032 |
| RBM19 | RNA binding motif protein 19 | 0.0188981 |
| C3 | complement component 3 | 0.018893 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0188926 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.018782 |
| TPM3 | tropomyosin 3 | 0.0187512 |
| ITCH | itchy E3 ubiquitin protein ligase | 0.0187382 |
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.210534 |
| IGF2 | insulin-like growth factor 2 | -0.183417 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.123349 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.118313 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.109468 |
| APOA2 | apolipoprotein A-II | -0.106784 |
| FN1 | fibronectin 1 | -0.0986039 |
| GPC3 | glypican 3 | -0.098458 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0949877 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0889233 |
| EGR1 | early growth response 1 | -0.0832409 |
| APOB | apolipoprotein B | -0.0766151 |
| VCL | vinculin | -0.0759452 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0754319 |
| RPS24 | ribosomal protein S24 | -0.0750673 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0733491 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0723427 |
| RPL35A | ribosomal protein L35a | -0.0709216 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0695651 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | -0.0683558 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0679937 |
| CP | ceruloplasmin (ferroxidase) | -0.0675903 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0667055 |
| FTL | ferritin, light polypeptide | -0.0661878 |
| RPLP1 | ribosomal protein, large, P1 | -0.0615844 |
| DLC1 | DLC1 Rho GTPase activating protein | -0.0556571 |
| RPS8 | ribosomal protein S8 | -0.0553636 |
| GPC6 | glypican 6 | -0.054096 |
| RPL11 | ribosomal protein L11 | -0.053524 |
| MT2A | metallothionein 2A | -0.0516498 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0501183 |
| TPM4 | tropomyosin 4 | -0.0494485 |
| RPL31 | ribosomal protein L31 | -0.0493082 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0490834 |
| RPL34 | ribosomal protein L34 | -0.0478599 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0438318 |
| ITGAV | integrin, alpha V | -0.0436152 |
| EHBP1 | EH domain binding protein 1 | -0.0434685 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0431048 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0429607 |
| GK | glycerol kinase | -0.0428137 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0427588 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0420213 |
| RPS27A | ribosomal protein S27a | -0.0418883 |
| STK17A | serine/threonine kinase 17a | -0.0411288 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0408408 |
| TMSB10 | thymosin beta 10 | -0.0407279 |
| IER3 | immediate early response 3 | -0.0405862 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | -0.040019 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0387739 |
| PTCHD4 | patched domain containing 4 | -0.0382568 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0371951 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | -0.0363781 |
| TNFSF14 | tumor necrosis factor (ligand) superfamily, member 14 | -0.0363503 |
| TMEM123 | transmembrane protein 123 | -0.0361597 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0359759 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0358197 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0357414 |
| GDF15 | growth differentiation factor 15 | -0.0353956 |
| RPL37A | ribosomal protein L37a | -0.0353404 |
| RPS23 | ribosomal protein S23 | -0.0353312 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0345935 |
| SDC4 | syndecan 4 | -0.0344339 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0344273 |
| A2M | alpha-2-macroglobulin | -0.03428 |
| FILIP1L | filamin A interacting protein 1-like | -0.0341175 |
| RPS14 | ribosomal protein S14 | -0.0331462 |
| RACK1 | receptor for activated C kinase 1 | -0.0323368 |
| IFI6 | interferon, alpha-inducible protein 6 | -0.0321798 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0320888 |
| PEG3 | paternally expressed 3 | -0.0319555 |
| PERP | PERP, TP53 apoptosis effector | -0.0318666 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0316173 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0315611 |
| OSMR | oncostatin M receptor | -0.0314785 |
| RPS29 | ribosomal protein S29 | -0.0313839 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0312734 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0309043 |
| PRAG1 | PEAK1 related, kinase-activating pseudokinase 1 | -0.0305728 |
| AHSG | alpha-2-HS-glycoprotein | -0.029898 |
| RPLP2 | ribosomal protein, large, P2 | -0.0298722 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0298488 |
| GNAS | GNAS complex locus | -0.0296428 |
| DOK6 | docking protein 6 | -0.0293564 |
| ACTG1 | actin gamma 1 | -0.0288407 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0288263 |
| TRIM26 | tripartite motif containing 26 | -0.0285575 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0282233 |
| APOA1 | apolipoprotein A-I | -0.0281691 |
| DNAH5 | dynein, axonemal, heavy chain 5 | -0.0280991 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0278684 |
| ARL5A | ADP-ribosylation factor-like 5A | -0.0275934 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | -0.0275551 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0271396 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0270487 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0269311 |
| ISG15 | ISG15 ubiquitin-like modifier | -0.0266875 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.0266828 |
| RPS19 | ribosomal protein S19 | -0.0260045 |
| FAM135A | family with sequence similarity 135, member A | -0.025946 |
