Clonidine (hydrochloride)_LoVo Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in LoVo cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clonidine (hydrochloride)_LoVo drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.079523
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0733533
LMO7 LIM domain 7 0.0700993
EPS8 epidermal growth factor receptor pathway substrate 8 0.0656712
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0645316
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.055247
CTBP2 C-terminal binding protein 2 0.0491614
EXT1 exostosin glycosyltransferase 1 0.0473158
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0472362
PTPRG protein tyrosine phosphatase, receptor type, G 0.0425346
RIMKLB ribosomal modification protein rimK-like family member B 0.0422469
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0413157
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 0.0396897
ANKRD11 ankyrin repeat domain 11 0.0384728
MYH9 myosin, heavy chain 9, non-muscle 0.0364113
TRIO trio Rho guanine nucleotide exchange factor 0.0361006
PRELID2 PRELI domain containing 2 0.0356789
IARS1 isoleucyl-tRNA synthetase 1 0.0354428
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0349628
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0339726
PLEC plectin 0.0337928
RNF145 ring finger protein 145 0.0332458
FOXO1 forkhead box O1 0.0314511
CEMIP cell migration inducing protein, hyaluronan binding 0.0312828
SHROOM3 shroom family member 3 0.0310246
ATXN1 ataxin 1 0.0306775
TNRC18 trinucleotide repeat containing 18 0.0303591
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.030148
WWOX WW domain containing oxidoreductase 0.0299304
OGA O-GlcNAcase 0.0294207
DSCAM Down syndrome cell adhesion molecule 0.0289667
GOLGA3 golgin A3 0.0287054
MYO5B myosin VB 0.0283681
SMYD3 SET and MYND domain containing 3 0.0279074
ZFC3H1 zinc finger, C3H1-type containing 0.0276601
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.027599
SND1 staphylococcal nuclease and tudor domain containing 1 0.0275401
AHNAK AHNAK nucleoprotein 0.0275273
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0271622
EGFR epidermal growth factor receptor 0.0266644
MYO1E myosin IE 0.0262368
FNDC3B fibronectin type III domain containing 3B 0.0257398
PARD3B par-3 family cell polarity regulator beta 0.0256974
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0255494
RNF43 ring finger protein 43 0.0253793
THSD4 thrombospondin, type I, domain containing 4 0.0253714
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0243317
MPRIP myosin phosphatase Rho interacting protein 0.0239782
SAMD4A sterile alpha motif domain containing 4A 0.0239495
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0239332
ZFAND3 zinc finger, AN1-type domain 3 0.0239183
LGALS12 lectin, galactoside-binding, soluble, 12 0.0235974
ASPH aspartate beta-hydroxylase 0.0234828
FBXL17 F-box and leucine-rich repeat protein 17 0.0234485
LOC105378220 macrophage receptor MARCO-like 0.0232106
PKP2 plakophilin 2 0.023199
NOS1AP nitric oxide synthase 1 (neuronal) adaptor protein 0.0231458
MARCHF6 membrane associated ring-CH-type finger 6 0.0230974
GRB10 growth factor receptor-bound protein 10 0.0230919
EIF4B eukaryotic translation initiation factor 4B 0.0230829
CTNND1 catenin (cadherin-associated protein), delta 1 0.0229944
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0229858
ARL15 ADP-ribosylation factor-like 15 0.0224891
WWC1 WW and C2 domain containing 1 0.0223919
AFDN afadin, adherens junction formation factor 0.0222974
MSI2 musashi RNA-binding protein 2 0.0221242
AFF1 AF4/FMR2 family, member 1 0.0215854
PLEKHG1 pleckstrin homology domain containing, family G (with RhoGef domain) member 1 0.0215632
FOXP1 forkhead box P1 0.0214589
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0211838
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0208379
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0205151
AARS1 alanyl-tRNA synthetase 1 0.0202683
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0201655
BTBD9 BTB (POZ) domain containing 9 0.0201371
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0201259
TXNRD1 thioredoxin reductase 1 0.0200681
UGT1A6 UDP glucuronosyltransferase 1 family, polypeptide A6 0.0198859
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0197224
UTRN utrophin 0.0197018
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0195158
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0194029
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.0193553
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0193187
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0190934
BCAS3 breast carcinoma amplified sequence 3 0.0189922
HDLBP high density lipoprotein binding protein 0.0189441
SLC38A2 solute carrier family 38, member 2 0.0189202
MARS1 methionyl-tRNA synthetase 1 0.0187378
LARGE1 LARGE xylosyl- and glucuronyltransferase 1 0.0186553
ABHD17C abhydrolase domain containing 17C 0.0184693
PDZD8 PDZ domain containing 8 0.0183691
DOCK5 dedicator of cytokinesis 5 0.0183012
AUTS2 autism susceptibility candidate 2 0.0182614
ZNF638 zinc finger protein 638 0.0182043
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0180528
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0179898
XPOT exportin, tRNA 0.0179272
HDAC4 histone deacetylase 4 0.0179008
ATP10B ATPase, class V, type 10B 0.0178717

decreased expression

Symbol Name Standardized Value
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.197442
RPS12 ribosomal protein S12 -0.145735
RPS6 ribosomal protein S6 -0.109318
CALB1 calbindin 1, 28kDa -0.0978074
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0961053
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0958644
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0946985
ANXA2 annexin A2 -0.0916162
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0909789
RPLP0 ribosomal protein, large, P0 -0.0886562
RPLP1 ribosomal protein, large, P1 -0.0785084
TMSB10 thymosin beta 10 -0.0764823
CLDN4 claudin 4 -0.0742283
RPS8 ribosomal protein S8 -0.073584
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0714703
RACK1 receptor for activated C kinase 1 -0.0713495
RPS19 ribosomal protein S19 -0.0709656
TPT1 tumor protein, translationally-controlled 1 -0.0709384
RPL34 ribosomal protein L34 -0.0642417
RPL35A ribosomal protein L35a -0.0619404
RPS2 ribosomal protein S2 -0.0592005
RPL26 ribosomal protein L26 -0.0591991
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0580273
EZR ezrin -0.0565675
LDHA lactate dehydrogenase A -0.0563753
RPL37A ribosomal protein L37a -0.0559362
ACTG1 actin gamma 1 -0.0559167
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0550453
RPL23 ribosomal protein L23 -0.0537567
DSG3 desmoglein 3 -0.0535821
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 -0.0527222
RPL12 ribosomal protein L12 -0.0516918
RPS17 ribosomal protein S17 -0.049846
RPL9 ribosomal protein L9 -0.0496883
RPS3 ribosomal protein S3 -0.0495769
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0484759
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0455401
HLA-B major histocompatibility complex, class I, B -0.0451038
PTMA prothymosin, alpha -0.0440349
POTEF POTE ankyrin domain family, member F -0.043135
PERP PERP, TP53 apoptosis effector -0.0425689
RPS13 ribosomal protein S13 -0.0425554
PDIA3 protein disulfide isomerase family A, member 3 -0.0422491
F3 coagulation factor III (thromboplastin, tissue factor) -0.0417067
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0406236
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0404803
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0401518
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.038186
RPL31 ribosomal protein L31 -0.0375232
RPL36 ribosomal protein L36 -0.0373728
RPL11 ribosomal protein L11 -0.0373712
LAMB3 laminin, beta 3 -0.0370807
RPL30 ribosomal protein L30 -0.0368007
C6ORF132 chromosome 6 open reading frame 132 -0.0362434
S100A6 S100 calcium binding protein A6 -0.0356065
RPL37 ribosomal protein L37 -0.0354879
KTN1 kinectin 1 (kinesin receptor) -0.033764
RPL18 ribosomal protein L18 -0.0324143
CAV2 caveolin 2 -0.0322742
S100A10 S100 calcium binding protein A10 -0.0320589
DSG2 desmoglein 2 -0.0319888
HMGA1 high mobility group AT-hook 1 -0.0318514
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0317702
LIMA1 LIM domain and actin binding 1 -0.0314704
FOSL1 FOS-like antigen 1 -0.0309417
EIF1 eukaryotic translation initiation factor 1 -0.030774
RPL19 ribosomal protein L19 -0.0304127
IFI27 interferon, alpha-inducible protein 27 -0.0301713
LAMA4 laminin, alpha 4 -0.0300118
RPS14 ribosomal protein S14 -0.0299874
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0294781
MUC13 mucin 13, cell surface associated -0.0293838
RPS27 ribosomal protein S27 -0.0292323
NACA nascent polypeptide-associated complex alpha subunit -0.0291351
TPI1 triosephosphate isomerase 1 -0.029015
IFI6 interferon, alpha-inducible protein 6 -0.0286476
RPS6KA5 ribosomal protein S6 kinase, 90kDa, polypeptide 5 -0.0277186
TPM4 tropomyosin 4 -0.0275224
RBM25 RNA binding motif protein 25 -0.0275203
TJP1 tight junction protein 1 -0.0275155
KRT19 keratin 19, type I -0.0274691
SLK STE20-like kinase -0.0273385
RPS25 ribosomal protein S25 -0.0267224
PFN1 profilin 1 -0.0266113
RPL35 ribosomal protein L35 -0.0265813
RAB7A RAB7A, member RAS oncogene family -0.0265599
PKM pyruvate kinase, muscle -0.0264975
RPS21 ribosomal protein S21 -0.0261707
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0261419
MCU mitochondrial calcium uniporter -0.0257775
RPS23 ribosomal protein S23 -0.0255893
KRT18 keratin 18, type I -0.0255237
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0251883
EGR1 early growth response 1 -0.0249129
SERBP1 SERPINE1 mRNA binding protein 1 -0.0248318
RPL32 ribosomal protein L32 -0.0247989
TMBIM6 transmembrane BAX inhibitor motif containing 6 -0.0247625
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0247221
GOLGA4 golgin A4 -0.0247066
RPL5 ribosomal protein L5 -0.024624