Clonidine (hydrochloride)_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clonidine (hydrochloride)_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MT2A metallothionein 2A 0.0607503
MYH9 myosin, heavy chain 9, non-muscle 0.060309
NSUN6 NOP2/Sun domain family, member 6 0.0602608
CXCL8 chemokine (C-X-C motif) ligand 8 0.0564172
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0546039
AREG amphiregulin 0.0526051
LAMB3 laminin, beta 3 0.0498311
MCL1 myeloid cell leukemia 1 0.0488135
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0463989
TES testin LIM domain protein 0.045441
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0453395
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0425608
BLZF1 basic leucine zipper nuclear factor 1 0.042375
DSCAM Down syndrome cell adhesion molecule 0.0419761
TPT1 tumor protein, translationally-controlled 1 0.0410059
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0401314
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0397271
ENO1 enolase 1, (alpha) 0.0379341
INTS6 integrator complex subunit 6 0.0377991
RPS3 ribosomal protein S3 0.0377034
STC1 stanniocalcin 1 0.0364452
NABP1 nucleic acid binding protein 1 0.0356245
EIF1 eukaryotic translation initiation factor 1 0.0346165
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0337325
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0325869
HOMER1 homer scaffolding protein 1 0.0325743
TOP1 topoisomerase (DNA) I 0.0325244
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric 0.0310353
NAP1L1 nucleosome assembly protein 1-like 1 0.0304956
ELL2 elongation factor, RNA polymerase II, 2 0.0293976
SPAG9 sperm associated antigen 9 0.0293895
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.028978
LAMA4 laminin, alpha 4 0.0288933
PYGL phosphorylase, glycogen, liver 0.0288259
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0287497
SEC61G Sec61 gamma subunit 0.0284546
VCL vinculin 0.0276211
SRSF5 serine/arginine-rich splicing factor 5 0.0275798
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0275303
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0274596
AKAP12 A kinase (PRKA) anchor protein 12 0.0267935
LMO7 LIM domain 7 0.0267119
TPI1 triosephosphate isomerase 1 0.0259595
BZW1 basic leucine zipper and W2 domains 1 0.0256749
CEMIP cell migration inducing protein, hyaluronan binding 0.025337
HSPA8 heat shock 70kDa protein 8 0.0250309
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0250234
ZSWIM6 zinc finger, SWIM-type containing 6 0.0249486
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0244207
SLTM SAFB-like, transcription modulator 0.0230382
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0228706
SIK3 SIK family kinase 3 0.0228005
CSNK1A1 casein kinase 1, alpha 1 0.0225225
RPL37A ribosomal protein L37a 0.0219315
RPL23 ribosomal protein L23 0.0215614
LAMC2 laminin, gamma 2 0.0215214
EZR ezrin 0.0213341
KRT18 keratin 18, type I 0.0208532
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0206557
PLEC plectin 0.0206251
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0201774
EXT1 exostosin glycosyltransferase 1 0.0201645
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta 0.0198648
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0198083
RPS12 ribosomal protein S12 0.0197786
BMP6 bone morphogenetic protein 6 0.0192989
RPS8 ribosomal protein S8 0.0192337
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0191596
RPS2 ribosomal protein S2 0.0190948
GOLGB1 golgin B1 0.018893
ANKRD11 ankyrin repeat domain 11 0.0185654
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0184462
SRRM2 serine/arginine repetitive matrix 2 0.0177986
RPLP0 ribosomal protein, large, P0 0.0176949
SYAP1 synapse associated protein 1 0.0175321
SON SON DNA binding protein 0.0175202
MYL12B myosin, light chain 12B, regulatory 0.0174009
DSPP dentin sialophosphoprotein 0.0173293
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0169542
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0165145
BRD2 bromodomain containing 2 0.0162059
PRRC2C proline-rich coiled-coil 2C 0.0161207
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0159873
SFPQ splicing factor proline/glutamine-rich 0.015933
MORF4L2 mortality factor 4 like 2 0.0156359
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0156122
SLC38A2 solute carrier family 38, member 2 0.0156041
NTSR1 neurotensin receptor 1 (high affinity) 0.0155979
RPL35A ribosomal protein L35a 0.0155509
ATP5F1E ATP synthase F1 subunit epsilon 0.0155486
S100A10 S100 calcium binding protein A10 0.0154133
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0153366
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0152136
PABPC1 poly(A) binding protein, cytoplasmic 1 0.015094
MSN moesin 0.0150201
PTMA prothymosin, alpha 0.0149237
MAP7 microtubule-associated protein 7 0.0144568
GPATCH2L G patch domain containing 2-like 0.0143492
AMOTL2 angiomotin like 2 0.0142425
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0142192

decreased expression

Symbol Name Standardized Value
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.32466
EGFR epidermal growth factor receptor -0.296984
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.150883
TXNRD1 thioredoxin reductase 1 -0.14525
LRP1B low density lipoprotein receptor-related protein 1B -0.129466
FTH1 ferritin, heavy polypeptide 1 -0.101326
EFNA5 ephrin-A5 -0.0988656
PTPRM protein tyrosine phosphatase, receptor type, M -0.0868724
NDRG1 N-myc downstream regulated 1 -0.0856789
ZMYND8 zinc finger, MYND-type containing 8 -0.0764358
AKR1C1 aldo-keto reductase family 1, member C1 -0.0726507
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 -0.0641418
GCLC glutamate-cysteine ligase, catalytic subunit -0.0639436
FNDC3B fibronectin type III domain containing 3B -0.0629297
OSMR oncostatin M receptor -0.0590409
IGFBP3 insulin-like growth factor binding protein 3 -0.058152
NAMPT nicotinamide phosphoribosyltransferase -0.057416
TMEM165 transmembrane protein 165 -0.0536797
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0519252
FAM13A family with sequence similarity 13, member A -0.0501052
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0485301
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0477688
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.04723
BIRC3 baculoviral IAP repeat containing 3 -0.0470029
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.046838
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0441991
TNS3 tensin 3 -0.0441797
RNF213 ring finger protein 213 -0.0440933
PATJ PATJ crumbs cell polarity complex component -0.0438227
SMAD3 SMAD family member 3 -0.0432376
SOD2 superoxide dismutase 2, mitochondrial -0.0423664
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0421078
CES1 carboxylesterase 1 -0.041825
NRIP1 nuclear receptor interacting protein 1 -0.0417563
LIMCH1 LIM and calponin homology domains 1 -0.040496
NCOA3 nuclear receptor coactivator 3 -0.0386385
TPD52 tumor protein D52 -0.0381181
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0376677
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0373148
RIN2 Ras and Rab interactor 2 -0.0369831
KCMF1 potassium channel modulatory factor 1 -0.0362389
KDM2A lysine (K)-specific demethylase 2A -0.0362232
PDE4D phosphodiesterase 4D, cAMP-specific -0.0353926
ANXA2 annexin A2 -0.0348316
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0344861
PARD3 par-3 family cell polarity regulator -0.033737
SLMAP sarcolemma associated protein -0.0333391
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0329913
SLC38A1 solute carrier family 38, member 1 -0.0328077
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0317033
CST3 cystatin C -0.0316397
LPP LIM domain containing preferred translocation partner in lipoma -0.0312238
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 -0.0311056
ARHGAP32 Rho GTPase activating protein 32 -0.0310519
RAB27B RAB27B, member RAS oncogene family -0.0303688
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0299807
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0297011
RAB10 RAB10, member RAS oncogene family -0.029502
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0292162
USP34 ubiquitin specific peptidase 34 -0.0290495
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0290227
PTEN phosphatase and tensin homolog -0.0288182
PDE8A phosphodiesterase 8A -0.0285786
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0283411
AHNAK AHNAK nucleoprotein -0.0282571
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0278488
TRIM56 tripartite motif containing 56 -0.0276975
RNF145 ring finger protein 145 -0.027464
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0273797
CAV1 caveolin 1, caveolae protein, 22kDa -0.027345
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0271765
LGALS12 lectin, galactoside-binding, soluble, 12 -0.0264247
BIRC6 baculoviral IAP repeat containing 6 -0.0262967
MX1 MX dynamin-like GTPase 1 -0.0262949
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0260079
KRT7 keratin 7, type II -0.0259921
ADAM9 ADAM metallopeptidase domain 9 -0.0258983
ADGRF1 adhesion G protein-coupled receptor F1 -0.0257059
THSD4 thrombospondin, type I, domain containing 4 -0.0256218
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0254395
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0253157
CCSER1 coiled-coil serine-rich protein 1 -0.0249995
GPC6 glypican 6 -0.0245414
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0243883
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0243779
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0238329
DOCK5 dedicator of cytokinesis 5 -0.0238282
NT5C2 5'-nucleotidase, cytosolic II -0.0234495
APP amyloid beta (A4) precursor protein -0.0234288
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 -0.0233633
PKM pyruvate kinase, muscle -0.0233312
CUX1 cut-like homeobox 1 -0.0228366
CCND1 cyclin D1 -0.0227507
AFF1 AF4/FMR2 family, member 1 -0.0226733
BRWD1 bromodomain and WD repeat domain containing 1 -0.0226273
PACS1 phosphofurin acidic cluster sorting protein 1 -0.0226243
FRY furry homolog (Drosophila) -0.0224628
BRWD3 bromodomain and WD repeat domain containing 3 -0.0219446
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0217504
ZNF292 zinc finger protein 292 -0.0217401