| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Clonidine (hydrochloride) perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Clonidine (hydrochloride)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.198061 |
| PM20D1 | peptidase M20 domain containing 1 | 0.146005 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.112088 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0931022 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0930148 |
| ASPH | aspartate beta-hydroxylase | 0.0825659 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0752265 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.069064 |
| MCL1 | myeloid cell leukemia 1 | 0.0635812 |
| FAM107B | family with sequence similarity 107, member B | 0.0624736 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0593156 |
| CAVIN1 | caveolae associated protein 1 | 0.0562737 |
| ANGPTL4 | angiopoietin-like 4 | 0.0550248 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0548158 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0526227 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0519001 |
| RPS2 | ribosomal protein S2 | 0.0485317 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.048503 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0471072 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0455656 |
| WWOX | WW domain containing oxidoreductase | 0.0446771 |
| TPI1 | triosephosphate isomerase 1 | 0.040376 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.040139 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0400563 |
| TPM3 | tropomyosin 3 | 0.0379124 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0355654 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0349191 |
| RPL3 | ribosomal protein L3 | 0.0345093 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0344096 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0333236 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0331454 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0331299 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0329891 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0326194 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0325463 |
| BMP6 | bone morphogenetic protein 6 | 0.0325438 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0320165 |
| PLEC | plectin | 0.0299374 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0296864 |
| LAMC2 | laminin, gamma 2 | 0.029316 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0291734 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0285497 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0278876 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0276477 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0273375 |
| FLNA | filamin A, alpha | 0.0270822 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | 0.0268145 |
| BRD2 | bromodomain containing 2 | 0.0260095 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0255322 |
| AHNAK | AHNAK nucleoprotein | 0.0251105 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0248065 |
| RPL4 | ribosomal protein L4 | 0.024569 |
| RPS3 | ribosomal protein S3 | 0.0242486 |
| EGR1 | early growth response 1 | 0.0242069 |
| BLTP2 | bridge-like lipid transfer protein family member 2 | 0.0238438 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0232964 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0231418 |
| ACTG1 | actin gamma 1 | 0.0231301 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0229828 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0227587 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.022681 |
| COTL1 | coactosin-like F-actin binding protein 1 | 0.0224512 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0223551 |
| RRM2 | ribonucleotide reductase M2 | 0.0222749 |
| TPR | translocated promoter region, nuclear basket protein | 0.0222094 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0222032 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0220601 |
| MYL12B | myosin, light chain 12B, regulatory | 0.0217991 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0211973 |
| STK17A | serine/threonine kinase 17a | 0.0210389 |
| ACTN1 | actinin, alpha 1 | 0.0208006 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0207958 |
| GDI2 | GDP dissociation inhibitor 2 | 0.0207686 |
| RPL23 | ribosomal protein L23 | 0.020767 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0206033 |
| KYNU | kynureninase | 0.0202404 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0202303 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0201884 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0201486 |
| NUMA1 | nuclear mitotic apparatus protein 1 | 0.0201164 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0200466 |
| MSN | moesin | 0.0199786 |
| SON | SON DNA binding protein | 0.019885 |
| PTPRF | protein tyrosine phosphatase, receptor type, F | 0.0198365 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0195677 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0195585 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0194346 |
| SRSF5 | serine/arginine-rich splicing factor 5 | 0.0193375 |
| CFAP298 | cilia and flagella associated protein 298 | 0.0191535 |
| NABP1 | nucleic acid binding protein 1 | 0.0191195 |
| TASOR2 | transcription activation suppressor family member 2 | 0.0190755 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0190698 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0189515 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0187722 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0187495 |
| PRSS23 | protease, serine, 23 | 0.0187242 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | 0.0185016 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0184441 |
| MT1X | metallothionein 1X | 0.0184207 |
| BDP1 | B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB | 0.0182603 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | -0.230287 |
| MT2A | metallothionein 2A | -0.220232 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.199843 |
| FTL | ferritin, light polypeptide | -0.129482 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.127304 |
| VIM | vimentin | -0.121323 |
| TMSB10 | thymosin beta 10 | -0.106956 |
| TXNRD1 | thioredoxin reductase 1 | -0.10582 |
| IGF2 | insulin-like growth factor 2 | -0.102812 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.102296 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0847419 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0569584 |
| RPLP1 | ribosomal protein, large, P1 | -0.0561265 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.051946 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0506696 |
| POTEF | POTE ankyrin domain family, member F | -0.0503008 |
| RPS29 | ribosomal protein S29 | -0.0467784 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0464503 |
| ERBIN | erbb2 interacting protein | -0.0462933 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0445823 |
| TPD52 | tumor protein D52 | -0.0438113 |
| RPS6 | ribosomal protein S6 | -0.0423566 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0414034 |
| CD99 | CD99 molecule | -0.0406527 |
| ATP5F1B | ATP synthase F1 subunit beta | -0.0406122 |
| RPL36 | ribosomal protein L36 | -0.0405864 |
| EGFR | epidermal growth factor receptor | -0.0400171 |
| PFN1 | profilin 1 | -0.0398174 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0396425 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0389786 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0376382 |
| IGFBP4 | insulin-like growth factor binding protein 4 | -0.0371896 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0364684 |
| RTN4 | reticulon 4 | -0.0360732 |
| RPL28 | ribosomal protein L28 | -0.0359657 |
| RPS19 | ribosomal protein S19 | -0.0359635 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0359181 |
| PARD3 | par-3 family cell polarity regulator | -0.0347881 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0346761 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0345567 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0341721 |
| RPS25 | ribosomal protein S25 | -0.0338993 |
| RPS27 | ribosomal protein S27 | -0.0338583 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0337371 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0333119 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0332092 |
| NRG1 | neuregulin 1 | -0.032827 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0327792 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0326583 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0324695 |
| FGB | fibrinogen beta chain | -0.0319709 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0314499 |
| SVIL | supervillin | -0.0310616 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0309809 |
| MAP1B | microtubule-associated protein 1B | -0.0309215 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0308016 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0306572 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0300055 |
| RPS16 | ribosomal protein S16 | -0.029904 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0298482 |
| RNF145 | ring finger protein 145 | -0.0298257 |
| RHOA | ras homolog family member A | -0.0294469 |
| TPM1 | tropomyosin 1 (alpha) | -0.0290476 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0288494 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0286592 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0280965 |
| PKM | pyruvate kinase, muscle | -0.0278343 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0278028 |
| RASAL2 | RAS protein activator like 2 | -0.0276358 |
| BICC1 | BicC family RNA binding protein 1 | -0.0276224 |
| MLLT10 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 | -0.0273684 |
| IL6 | interleukin 6 | -0.0273165 |
| RPS23 | ribosomal protein S23 | -0.0271788 |
| TPM4 | tropomyosin 4 | -0.0270869 |
| RPL19 | ribosomal protein L19 | -0.0267911 |
| WDR43 | WD repeat domain 43 | -0.0267644 |
| YY1 | YY1 transcription factor | -0.0264395 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0263647 |
| DENND4A | DENN/MADD domain containing 4A | -0.0263634 |
| ZNF292 | zinc finger protein 292 | -0.0262695 |
| HMGA1 | high mobility group AT-hook 1 | -0.0261544 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.0261189 |
| CA2 | carbonic anhydrase II | -0.026086 |
| ZNF609 | zinc finger protein 609 | -0.0260426 |
| MYADM | myeloid-associated differentiation marker | -0.025922 |
| CUX1 | cut-like homeobox 1 | -0.0255997 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0255161 |
| USP3 | ubiquitin specific peptidase 3 | -0.0255104 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0252806 |
| S100A10 | S100 calcium binding protein A10 | -0.0250448 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0250077 |
| NOP58 | NOP58 ribonucleoprotein | -0.0246141 |
| SBF2 | SET binding factor 2 | -0.024614 |
| PTK2 | protein tyrosine kinase 2 | -0.0245297 |
| AK1 | adenylate kinase 1 | -0.0243547 |
| PACS1 | phosphofurin acidic cluster sorting protein 1 | -0.0240933 |
| CYRIB | CYFIP related Rac1 interactor B | -0.0240215 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0239274 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0237953 |
| COG5 | component of oligomeric golgi complex 5 | -0.0237818 |
