| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Clonidine (hydrochloride) perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Clonidine (hydrochloride)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SAMD4A | sterile alpha motif domain containing 4A | 0.157336 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.137574 |
| LAMB3 | laminin, beta 3 | 0.126614 |
| MYO1E | myosin IE | 0.104384 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0996698 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0904127 |
| KYNU | kynureninase | 0.0880159 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.079356 |
| MAST4 | microtubule associated serine/threonine kinase family member 4 | 0.0770642 |
| LAMC2 | laminin, gamma 2 | 0.0756975 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0718061 |
| TNFAIP8 | tumor necrosis factor, alpha-induced protein 8 | 0.0701919 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0697929 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0684611 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0656623 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0640841 |
| FN1 | fibronectin 1 | 0.0626188 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0613657 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.056844 |
| FMN1 | formin 1 | 0.0558352 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | 0.055627 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0538553 |
| PRELID2 | PRELI domain containing 2 | 0.0537754 |
| RIGI | RNA sensor RIG-I | 0.0534309 |
| MCL1 | myeloid cell leukemia 1 | 0.052815 |
| GRAMD1B | GRAM domain containing 1B | 0.0521031 |
| SMAD3 | SMAD family member 3 | 0.0518672 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.051757 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0516734 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0507287 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0498159 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0492143 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0491123 |
| LAMA4 | laminin, alpha 4 | 0.0489991 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.04843 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | 0.0479916 |
| SDC4 | syndecan 4 | 0.0478623 |
| MXD1 | MAX dimerization protein 1 | 0.0474022 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0470179 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0465631 |
| ASPH | aspartate beta-hydroxylase | 0.0439048 |
| ARHGAP5 | Rho GTPase activating protein 5 | 0.043857 |
| PPP2R2C | protein phosphatase 2, regulatory subunit B, gamma | 0.0425957 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0416876 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0413454 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0410547 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0409361 |
| HOOK2 | hook microtubule-tethering protein 2 | 0.0399483 |
| PAG1 | phosphoprotein membrane anchor with glycosphingolipid microdomains 1 | 0.0390938 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | 0.0390745 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0388901 |
| PFKP | phosphofructokinase, platelet | 0.0382817 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0382484 |
| KLC1 | kinesin light chain 1 | 0.0381751 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.0380596 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0380199 |
| ARB2A | ARB2 cotranscriptional regulator A | 0.0377556 |
| USP53 | ubiquitin specific peptidase 53 | 0.037496 |
| DTNA | dystrobrevin, alpha | 0.0374591 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0373496 |
| RBM47 | RNA binding motif protein 47 | 0.0372592 |
| RIMKLB | ribosomal modification protein rimK-like family member B | 0.037123 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0363767 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0361464 |
| OSMR | oncostatin M receptor | 0.036107 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.035248 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0350638 |
| RAD51B | RAD51 paralog B | 0.0348644 |
| MSN | moesin | 0.0343987 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0342065 |
| EGFR | epidermal growth factor receptor | 0.0341019 |
| KIAA1328 | KIAA1328 | 0.0331987 |
| GRAMD2B | GRAM domain containing 2B | 0.0330832 |
| CADM1 | cell adhesion molecule 1 | 0.0329941 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0329279 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.032733 |
| KRT17 | keratin 17, type I | 0.0325143 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0320909 |
| CHST15 | carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 | 0.0320797 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0317481 |
| APP | amyloid beta (A4) precursor protein | 0.0315905 |
| FLNB | filamin B, beta | 0.0314873 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0310833 |
| SEC24A | SEC24 family member A | 0.0310565 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0308834 |
| CALU | calumenin | 0.0308544 |
| METTL15 | methyltransferase like 15 | 0.0305803 |
| GPC6 | glypican 6 | 0.0305212 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0304177 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0301835 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0299232 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.029779 |
| RND3 | Rho family GTPase 3 | 0.0297342 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0295809 |
| AFF4 | AF4/FMR2 family, member 4 | 0.0292997 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0292985 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0288932 |
| TENM3 | teneurin transmembrane protein 3 | 0.0287979 |
| NSD1 | nuclear receptor binding SET domain protein 1 | 0.0287047 |
| TXNIP | thioredoxin interacting protein | 0.0286792 |
| Symbol | Name | Standardized Value |
|---|---|---|
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.123883 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.110546 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.107702 |
| PTMA | prothymosin, alpha | -0.0988756 |
| RPS6 | ribosomal protein S6 | -0.0916052 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0883226 |
| LMO7 | LIM domain 7 | -0.0827456 |
| ATOSA | atos homolog A | -0.0815666 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0794375 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0776079 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0763267 |
| RPS25 | ribosomal protein S25 | -0.0737928 |
| MUC16 | mucin 16, cell surface associated | -0.071861 |
| VIM | vimentin | -0.0666496 |
| RPL37A | ribosomal protein L37a | -0.062981 |
| TMSB10 | thymosin beta 10 | -0.0600551 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0568874 |
| RIOK3 | RIO kinase 3 | -0.0568827 |
| RPL31 | ribosomal protein L31 | -0.0564169 |
| NDRG1 | N-myc downstream regulated 1 | -0.0546708 |
| FTL | ferritin, light polypeptide | -0.0503853 |
| POTEF | POTE ankyrin domain family, member F | -0.049365 |
| RPL35A | ribosomal protein L35a | -0.048736 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0459767 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0458176 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0454671 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0445795 |
| RPS19 | ribosomal protein S19 | -0.044349 |
| STAT6 | signal transducer and activator of transcription 6, interleukin-4 induced | -0.0431362 |
| LDHA | lactate dehydrogenase A | -0.0431248 |
| RPL19 | ribosomal protein L19 | -0.0424121 |
| KLF5 | Kruppel-like factor 5 (intestinal) | -0.0416635 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0414493 |
| THOC2 | THO complex 2 | -0.0405182 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0389528 |
| RPL15 | ribosomal protein L15 | -0.0385151 |
| RPLP0 | ribosomal protein, large, P0 | -0.0384814 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0384582 |
| RPLP1 | ribosomal protein, large, P1 | -0.0384326 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0384322 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0384285 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0383697 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0380911 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0377907 |
| S100A8 | S100 calcium binding protein A8 | -0.0377779 |
| RPL23 | ribosomal protein L23 | -0.0371249 |
| ANXA1 | annexin A1 | -0.0369605 |
| FDPS | farnesyl diphosphate synthase | -0.0368828 |
| RPL9 | ribosomal protein L9 | -0.0364806 |
| RPS13 | ribosomal protein S13 | -0.0364308 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0364131 |
| ATXN2 | ataxin 2 | -0.0362288 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0361891 |
| RALA | v-ral simian leukemia viral oncogene homolog A (ras related) | -0.0361879 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0358508 |
| CALR | calreticulin | -0.0356125 |
| RPS29 | ribosomal protein S29 | -0.0354849 |
| DENND1A | DENN/MADD domain containing 1A | -0.0352591 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | -0.0351669 |
| H3-3B | H3.3 histone B | -0.0350219 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0340984 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0340562 |
| JMJD1C | jumonji domain containing 1C | -0.0339071 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0337891 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0335807 |
| RPLP2 | ribosomal protein, large, P2 | -0.0334848 |
| TOP1 | topoisomerase (DNA) I | -0.0333444 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0333251 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0330492 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0329485 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0327752 |
| MYO6 | myosin VI | -0.0325718 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0325595 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.032174 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | -0.032123 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0318742 |
| EZR | ezrin | -0.0318449 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0317167 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.0316116 |
| FOXO3 | forkhead box O3 | -0.0308787 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0308269 |
| NACA | nascent polypeptide-associated complex alpha subunit | -0.0308135 |
| HLA-B | major histocompatibility complex, class I, B | -0.0307151 |
| MYOF | myoferlin | -0.030639 |
| MTUS1 | microtubule associated tumor suppressor 1 | -0.0305667 |
| RPS20 | ribosomal protein S20 | -0.0303103 |
| RPL11 | ribosomal protein L11 | -0.0301982 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0300902 |
| CLINT1 | clathrin interactor 1 | -0.029379 |
| RPL12 | ribosomal protein L12 | -0.0293209 |
| RPS12 | ribosomal protein S12 | -0.0289419 |
| FNBP1L | formin binding protein 1-like | -0.0289255 |
| RPL7 | ribosomal protein L7 | -0.0288329 |
| TMEM41B | transmembrane protein 41B | -0.0287651 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0285905 |
| ABHD17C | abhydrolase domain containing 17C | -0.0284617 |
| RPL36A | ribosomal protein L36a | -0.0283791 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0281524 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.0281122 |
| SMG7 | SMG7 nonsense mediated mRNA decay factor | -0.0280794 |
