Clonidine (hydrochloride)_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clonidine (hydrochloride)_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.154687
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.148193
LAMC2 laminin, gamma 2 0.108603
PLEC plectin 0.0952404
LAMB3 laminin, beta 3 0.0894812
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0879367
DSPP dentin sialophosphoprotein 0.0837761
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0658363
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.049255
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0474532
HSPA8 heat shock 70kDa protein 8 0.0463893
SAMD4A sterile alpha motif domain containing 4A 0.0462457
MSN moesin 0.042638
AHNAK AHNAK nucleoprotein 0.0406957
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0387274
HMGB2 high mobility group box 2 0.0370907
NAMPT nicotinamide phosphoribosyltransferase 0.0369065
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0358484
ELL2 elongation factor, RNA polymerase II, 2 0.0339723
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0339116
RPS2 ribosomal protein S2 0.0322231
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0322223
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0307446
MYO5B myosin VB 0.0306438
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0303563
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0299114
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0297571
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0296108
TACSTD2 tumor-associated calcium signal transducer 2 0.0294223
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0290734
SDC4 syndecan 4 0.0284
RPL3 ribosomal protein L3 0.0276407
SMAD3 SMAD family member 3 0.0272416
ASPH aspartate beta-hydroxylase 0.0269758
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0250098
DST dystonin 0.0247603
APLP2 amyloid beta (A4) precursor-like protein 2 0.0242344
FHIT fragile histidine triad 0.0241988
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0241499
AFDN afadin, adherens junction formation factor 0.0237101
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0237087
NAV2 neuron navigator 2 0.0235794
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0231276
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0228139
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0217074
TPM3 tropomyosin 3 0.0216851
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0215407
ERRFI1 ERBB receptor feedback inhibitor 1 0.0215347
APP amyloid beta (A4) precursor protein 0.0214473
TNIP1 TNFAIP3 interacting protein 1 0.0211996
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0211572
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0209137
KIAA1217 KIAA1217 0.0205857
FXR1 fragile X mental retardation, autosomal homolog 1 0.0204758
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0202131
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0200782
RAD21 RAD21 homolog (S. pombe) 0.0199753
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.0197248
INTS6 integrator complex subunit 6 0.0195162
BRD2 bromodomain containing 2 0.0189756
ALCAM activated leukocyte cell adhesion molecule 0.0189377
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0186113
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0184476
NAP1L1 nucleosome assembly protein 1-like 1 0.0183121
NFE2L1 nuclear factor, erythroid 2-like 1 0.0179012
ANO6 anoctamin 6 0.0174353
NABP1 nucleic acid binding protein 1 0.0169337
MAST4 microtubule associated serine/threonine kinase family member 4 0.0168599
NUMA1 nuclear mitotic apparatus protein 1 0.0168174
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0168016
HYOU1 hypoxia up-regulated 1 0.0167884
RPSA ribosomal protein SA 0.0166877
SFPQ splicing factor proline/glutamine-rich 0.0165444
EGFR epidermal growth factor receptor 0.0162058
ZBTB38 zinc finger and BTB domain containing 38 0.0161572
KTN1 kinectin 1 (kinesin receptor) 0.0160753
BIRC3 baculoviral IAP repeat containing 3 0.0160049
AHNAK2 AHNAK nucleoprotein 2 0.0159623
SGMS2 sphingomyelin synthase 2 0.0158897
PCM1 pericentriolar material 1 0.0158493
CD44 CD44 molecule (Indian blood group) 0.015672
EHBP1L1 EH domain binding protein 1-like 1 0.0155431
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0152719
CKAP5 cytoskeleton associated protein 5 0.0151433
DSCAM Down syndrome cell adhesion molecule 0.0150731
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0150166
STEAP4 STEAP family member 4 0.0150147
FLNA filamin A, alpha 0.0148189
SEPTIN9 septin 9 0.0148155
SLC38A2 solute carrier family 38, member 2 0.0147728
AHR aryl hydrocarbon receptor 0.014525
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.014483
CENPF centromere protein F, 350/400kDa 0.0144098
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0142992
CHD4 chromodomain helicase DNA binding protein 4 0.0142187
CXCL8 chemokine (C-X-C motif) ligand 8 0.0141904
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0141748
ANXA5 annexin A5 0.0140288
USP9X ubiquitin specific peptidase 9, X-linked 0.0139016
RYBP RING1 and YY1 binding protein 0.0138919

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.230387
TMSB10 thymosin beta 10 -0.20735
FTL ferritin, light polypeptide -0.143352
PTMA prothymosin, alpha -0.135444
POTEF POTE ankyrin domain family, member F -0.119032
S100A6 S100 calcium binding protein A6 -0.107116
ACTG1 actin gamma 1 -0.0897091
IFI27 interferon, alpha-inducible protein 27 -0.0874567
KRT7 keratin 7, type II -0.0864697
RPL35A ribosomal protein L35a -0.0843022
LPP LIM domain containing preferred translocation partner in lipoma -0.077023
CCND1 cyclin D1 -0.071716
UBC ubiquitin C -0.0712982
ISG15 ISG15 ubiquitin-like modifier -0.0689676
RPS23 ribosomal protein S23 -0.0683617
RPLP1 ribosomal protein, large, P1 -0.065362
TPT1 tumor protein, translationally-controlled 1 -0.0645122
HLA-B major histocompatibility complex, class I, B -0.0645012
LIMCH1 LIM and calponin homology domains 1 -0.0641603
TPM4 tropomyosin 4 -0.0634184
CSTB cystatin B (stefin B) -0.0614033
NPEPPS aminopeptidase puromycin sensitive -0.0589015
IFI6 interferon, alpha-inducible protein 6 -0.0585968
TMEM165 transmembrane protein 165 -0.0581576
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0580629
RPS13 ribosomal protein S13 -0.0575479
LDHA lactate dehydrogenase A -0.0568555
HSPB1 heat shock 27kDa protein 1 -0.056774
FBXO32 F-box protein 32 -0.0567197
ITCH itchy E3 ubiquitin protein ligase -0.0552199
S100A10 S100 calcium binding protein A10 -0.0548511
GOLGA4 golgin A4 -0.0548218
RPS29 ribosomal protein S29 -0.0537835
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0534358
HMGA1 high mobility group AT-hook 1 -0.052931
IFITM1 interferon induced transmembrane protein 1 -0.0524384
HLA-A major histocompatibility complex, class I, A -0.0514946
IFITM3 interferon induced transmembrane protein 3 -0.0511237
F3 coagulation factor III (thromboplastin, tissue factor) -0.0510806
MDK midkine (neurite growth-promoting factor 2) -0.0494599
RPLP2 ribosomal protein, large, P2 -0.0489511
SOX4 SRY (sex determining region Y)-box 4 -0.0482251
ACBD3 acyl-CoA binding domain containing 3 -0.0474456
RPS24 ribosomal protein S24 -0.0473965
IGFBP3 insulin-like growth factor binding protein 3 -0.0470808
VIM vimentin -0.046826
RPL8 ribosomal protein L8 -0.0467099
LY6E lymphocyte antigen 6 complex, locus E -0.046571
GNAS GNAS complex locus -0.0462924
RPS6 ribosomal protein S6 -0.0446994
FTH1 ferritin, heavy polypeptide 1 -0.0441084
RAB1A RAB1A, member RAS oncogene family -0.0440548
RPL32 ribosomal protein L32 -0.0432697
H3-3B H3.3 histone B -0.0414534
TM4SF1 transmembrane 4 L six family member 1 -0.0412934
CTSD cathepsin D -0.0412803
RAB7A RAB7A, member RAS oncogene family -0.041268
RPL34 ribosomal protein L34 -0.0407487
UBE2H ubiquitin-conjugating enzyme E2H -0.0406251
RPS25 ribosomal protein S25 -0.0404471
WASF2 WAS protein family, member 2 -0.0398447
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0397603
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0393291
ENO2 enolase 2 (gamma, neuronal) -0.0390508
RPL15 ribosomal protein L15 -0.0386783
EPCAM epithelial cell adhesion molecule -0.0382437
SEC31A SEC31 homolog A (S. cerevisiae) -0.0382182
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0381514
KMT2C lysine (K)-specific methyltransferase 2C -0.0379437
RPS8 ribosomal protein S8 -0.0378194
RPL9 ribosomal protein L9 -0.037309
SLC38A1 solute carrier family 38, member 1 -0.0371854
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0370788
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0357458
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0350464
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0349223
MAP3K13 mitogen-activated protein kinase kinase kinase 13 -0.0343747
RPS21 ribosomal protein S21 -0.0342925
KDM5B lysine (K)-specific demethylase 5B -0.0342229
TMEM263 transmembrane protein 263 -0.0331936
RPS16 ribosomal protein S16 -0.0331581
RPL28 ribosomal protein L28 -0.0329416
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0327235
AKAP9 A kinase (PRKA) anchor protein 9 -0.0326134
GPBP1 GC-rich promoter binding protein 1 -0.0325497
RPL19 ribosomal protein L19 -0.0324191
NDRG1 N-myc downstream regulated 1 -0.0324091
KMT2E lysine (K)-specific methyltransferase 2E -0.0322491
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0322106
CD2AP CD2-associated protein -0.0320166
RPS19 ribosomal protein S19 -0.0317769
RPS14 ribosomal protein S14 -0.031557
RPL30 ribosomal protein L30 -0.031239
RPL31 ribosomal protein L31 -0.0311013
RPL37 ribosomal protein L37 -0.0309633
YY1 YY1 transcription factor -0.0308548
STRN3 striatin, calmodulin binding protein 3 -0.0308355
SEC24D SEC24 family member D -0.0302717
RHOA ras homolog family member A -0.0302326
RPL11 ribosomal protein L11 -0.0300286