| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Clonidine (hydrochloride) perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Clonidine (hydrochloride)_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE10A | phosphodiesterase 10A | 0.183092 |
| DST | dystonin | 0.125827 |
| PM20D1 | peptidase M20 domain containing 1 | 0.12355 |
| GRAMD1B | GRAM domain containing 1B | 0.0868406 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0807768 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0804567 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0722397 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0719489 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.0703681 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0694265 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0693133 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0676457 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0663299 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0648817 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | 0.0625825 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.0593165 |
| PRELID2 | PRELI domain containing 2 | 0.0547484 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0530807 |
| FMNL2 | formin-like 2 | 0.0529695 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.046252 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0462513 |
| INTS6 | integrator complex subunit 6 | 0.044603 |
| RAD51B | RAD51 paralog B | 0.0438962 |
| HDAC4 | histone deacetylase 4 | 0.0426376 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0418255 |
| RPH3AL | rabphilin 3A-like (without C2 domains) | 0.0405749 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0402582 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0392654 |
| KYNU | kynureninase | 0.039246 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0363789 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0363021 |
| CTBP2 | C-terminal binding protein 2 | 0.03558 |
| CREB3L2 | cAMP responsive element binding protein 3-like 2 | 0.0352067 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0348113 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0344516 |
| COL5A2 | collagen, type V, alpha 2 | 0.034308 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0328634 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0326813 |
| MCL1 | myeloid cell leukemia 1 | 0.0317351 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0316531 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.0309899 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0307273 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0304203 |
| ITPK1 | inositol-tetrakisphosphate 1-kinase | 0.0303681 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0290474 |
| GPC6 | glypican 6 | 0.0287242 |
| LSAMP | limbic system-associated membrane protein | 0.0284778 |
| CDH13 | cadherin 13 | 0.0272493 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0270912 |
| MAFK | v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K | 0.0265482 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0258257 |
| FLNA | filamin A, alpha | 0.0252988 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0246085 |
| SMAD2 | SMAD family member 2 | 0.0246015 |
| PRKAR1A | protein kinase, cAMP-dependent, regulatory, type I, alpha | 0.0245728 |
| WWOX | WW domain containing oxidoreductase | 0.0245662 |
| TPM3 | tropomyosin 3 | 0.0241763 |
| VCL | vinculin | 0.0239469 |
| SFPQ | splicing factor proline/glutamine-rich | 0.0237904 |
| FLRT2 | fibronectin leucine rich transmembrane protein 2 | 0.0235544 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.023279 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0230571 |
| MAP7 | microtubule-associated protein 7 | 0.022124 |
| FBXL7 | F-box and leucine-rich repeat protein 7 | 0.0220309 |
| DNER | delta/notch-like EGF repeat containing | 0.021841 |
| RPL3 | ribosomal protein L3 | 0.0216156 |
| PLEC | plectin | 0.02144 |
| MSN | moesin | 0.0214033 |
| CADM2 | cell adhesion molecule 2 | 0.0213146 |
| ARHGEF7 | Rho guanine nucleotide exchange factor (GEF) 7 | 0.021217 |
| AEBP2 | AE binding protein 2 | 0.0211124 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0205927 |
| PDE7B | phosphodiesterase 7B | 0.0205245 |
| PYGL | phosphorylase, glycogen, liver | 0.0203567 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0203527 |
| XYLT1 | xylosyltransferase I | 0.0202473 |
| SQSTM1 | sequestosome 1 | 0.0198025 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0195588 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0195149 |
| PRKAA2 | protein kinase, AMP-activated, alpha 2 catalytic subunit | 0.0194961 |
| EPHA5 | EPH receptor A5 | 0.0194364 |
| BMP6 | bone morphogenetic protein 6 | 0.0192497 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0190228 |
| AUTS2 | autism susceptibility candidate 2 | 0.0189712 |
| GLCE | glucuronic acid epimerase | 0.0189145 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0188895 |
| AHNAK | AHNAK nucleoprotein | 0.0188435 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0186147 |
| BACE2 | beta-site APP-cleaving enzyme 2 | 0.0183329 |
| PPFIA4 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 | 0.0183054 |
| BDNF | brain-derived neurotrophic factor | 0.0182195 |
| SEPTIN9 | septin 9 | 0.0180218 |
| FUS | FUS RNA binding protein | 0.0178848 |
| CEP72 | centrosomal protein 72kDa | 0.0178477 |
| DENND1A | DENN/MADD domain containing 1A | 0.0178041 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.017739 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0177344 |
| NRXN3 | neurexin 3 | 0.0176416 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0174919 |
| EXOC4 | exocyst complex component 4 | 0.0172343 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.231937 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.205516 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.160556 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.130462 |
| GDA | guanine deaminase | -0.127107 |
| VIM | vimentin | -0.100855 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.086026 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0841892 |
| RASSF8 | Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 | -0.0828444 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0818259 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.079604 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | -0.0736572 |
| EFNA5 | ephrin-A5 | -0.0644791 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.059562 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0582986 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0571596 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0556724 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0554118 |
| CD109 | CD109 molecule | -0.0533883 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.0506131 |
| MYOF | myoferlin | -0.0505465 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0492218 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0477258 |
| TXNRD1 | thioredoxin reductase 1 | -0.0463437 |
| RTN4 | reticulon 4 | -0.0463307 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0457116 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0449597 |
| PTMA | prothymosin, alpha | -0.0434593 |
| ZEB2 | zinc finger E-box binding homeobox 2 | -0.0431696 |
| OSMR | oncostatin M receptor | -0.042747 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0424038 |
| S100A6 | S100 calcium binding protein A6 | -0.0420024 |
| STC1 | stanniocalcin 1 | -0.0419431 |
| CANX | calnexin | -0.0414285 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0412819 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0403419 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0368051 |
| MFF | mitochondrial fission factor | -0.0361337 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0360096 |
| TMX4 | thioredoxin-related transmembrane protein 4 | -0.0355043 |
| FTL | ferritin, light polypeptide | -0.0353036 |
| BMERB1 | bMERB domain containing 1 | -0.0349607 |
| SPAG9 | sperm associated antigen 9 | -0.0340956 |
| HLA-B | major histocompatibility complex, class I, B | -0.0316846 |
| NRCAM | neuronal cell adhesion molecule | -0.030951 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0307801 |
| LAMB1 | laminin, beta 1 | -0.0297314 |
| HLA-A | major histocompatibility complex, class I, A | -0.0296721 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0296495 |
| PTGR1 | prostaglandin reductase 1 | -0.0294322 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0286366 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0285925 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0279922 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | -0.0275261 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0274089 |
| RPLP1 | ribosomal protein, large, P1 | -0.0273987 |
| EGR1 | early growth response 1 | -0.0271174 |
| GOLGA4 | golgin A4 | -0.0264382 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0262808 |
| NF1 | neurofibromin 1 | -0.0261736 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.026085 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0256986 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0254849 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0254841 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | -0.0253452 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0251758 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0251308 |
| TBXT | T-box transcription factor T | -0.024952 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0248995 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0248372 |
| NPAS2 | neuronal PAS domain protein 2 | -0.024679 |
| TPM4 | tropomyosin 4 | -0.0246696 |
| ATAD1 | ATPase family, AAA domain containing 1 | -0.0244916 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0244477 |
| UBC | ubiquitin C | -0.0243008 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0238016 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -0.0234422 |
| SCN3A | sodium channel, voltage gated, type III alpha subunit | -0.0230376 |
| NEK7 | NIMA-related kinase 7 | -0.0229174 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0228632 |
| RPS6 | ribosomal protein S6 | -0.0228579 |
| ANXA2 | annexin A2 | -0.0228193 |
| SLC16A6 | solute carrier family 16, member 6 | -0.0227966 |
| IL6 | interleukin 6 | -0.0227577 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0227421 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0226851 |
| IER3 | immediate early response 3 | -0.022676 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0225707 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0224488 |
| ESM1 | endothelial cell-specific molecule 1 | -0.0224001 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0223367 |
| PGK1 | phosphoglycerate kinase 1 | -0.0222063 |
| RPS24 | ribosomal protein S24 | -0.022191 |
| NDRG1 | N-myc downstream regulated 1 | -0.0221863 |
| ABLIM1 | actin binding LIM protein 1 | -0.0221838 |
| TMSB10 | thymosin beta 10 | -0.0221603 |
| LDHA | lactate dehydrogenase A | -0.0219255 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.0218577 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0215193 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0214862 |
