Clonidine (hydrochloride)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

110 genes differentially expressed following the Clonidine (hydrochloride)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EGFR epidermal growth factor receptor 0.179694
DOCK5 dedicator of cytokinesis 5 0.168045
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.143043
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.142994
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.140493
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.134758
ACTN4 actinin, alpha 4 0.134323
LAMA4 laminin, alpha 4 0.129273
MYH14 myosin, heavy chain 14, non-muscle 0.127372
THSD4 thrombospondin, type I, domain containing 4 0.117587
FMNL2 formin-like 2 0.113873
GRAMD1B GRAM domain containing 1B 0.11083
LAMC2 laminin, gamma 2 0.104167
FBXO11 F-box protein 11 0.103377
CNKSR3 CNKSR family member 3 0.0981001
LMO7 LIM domain 7 0.096947
MED13L mediator complex subunit 13-like 0.0958596
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.094797
MYOF myoferlin 0.0938481
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0867474
ZNF292 zinc finger protein 292 0.0865214
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.084474
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.083183
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0829926
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0801435
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0782158
SAMD4A sterile alpha motif domain containing 4A 0.0753963
UBAP1 ubiquitin associated protein 1 0.0720153
DST dystonin 0.0715455
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0669103
LSAMP limbic system-associated membrane protein 0.0655323
AHNAK AHNAK nucleoprotein 0.0644649
BAIAP2L1 BAI1-associated protein 2-like 1 0.0606508
MYO1E myosin IE 0.0599925
ELL2 elongation factor, RNA polymerase II, 2 0.053568
RPS6 ribosomal protein S6 0.0528049
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0517267
INHBA inhibin, beta A 0.0487327
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0478973
TPT1 tumor protein, translationally-controlled 1 0.0469972
LIMS1 LIM and senescent cell antigen-like domains 1 0.0452908
ERRFI1 ERBB receptor feedback inhibitor 1 0.0430271
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0402222
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0372185
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0366938
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0365861
MACF1 microtubule-actin crosslinking factor 1 0.0355378
MAML3 mastermind-like 3 (Drosophila) 0.034323
PSD3 pleckstrin and Sec7 domain containing 3 0.0322672
COL6A3 collagen, type VI, alpha 3 0.032211
TMSB10 thymosin beta 10 0.0309291
PARD3 par-3 family cell polarity regulator 0.0308889
GOLGA4 golgin A4 0.0293546
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0290059
RPL23 ribosomal protein L23 0.0189419
RPL11 ribosomal protein L11 0.0187136
PTPRM protein tyrosine phosphatase, receptor type, M 0.0175671
FNBP1L formin binding protein 1-like 0.017248
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0170483
NALF1 NALCN channel auxiliary factor 1 0.014757
MBNL2 muscleblind-like splicing regulator 2 0.0117802
VCL vinculin 0.0109061
RAD51B RAD51 paralog B 0.0026493

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.246623
FN1 fibronectin 1 -0.199239
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.16845
EXT1 exostosin glycosyltransferase 1 -0.144967
PDE10A phosphodiesterase 10A -0.141758
NDRG1 N-myc downstream regulated 1 -0.141556
HMGA2 high mobility group AT-hook 2 -0.139366
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.136394
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.115193
JMJD1C jumonji domain containing 1C -0.100571
GPC6 glypican 6 -0.0867161
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0865014
AKAP12 A kinase (PRKA) anchor protein 12 -0.0783394
ATXN1 ataxin 1 -0.0763947
PTK2 protein tyrosine kinase 2 -0.0742049
CXCL8 chemokine (C-X-C motif) ligand 8 -0.074128
SETD5 SET domain containing 5 -0.0715669
NKD1 naked cuticle homolog 1 (Drosophila) -0.069599
CDH13 cadherin 13 -0.0642147
TRIO trio Rho guanine nucleotide exchange factor -0.0623938
WSB1 WD repeat and SOCS box containing 1 -0.0615667
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0543878
CD44 CD44 molecule (Indian blood group) -0.0524083
ASPH aspartate beta-hydroxylase -0.0475662
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0449278
CADM2 cell adhesion molecule 2 -0.0427638
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.0424753
PTMA prothymosin, alpha -0.03811
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0359383
EFNA5 ephrin-A5 -0.0347782
KTN1 kinectin 1 (kinesin receptor) -0.0334858
SMYD3 SET and MYND domain containing 3 -0.0298847
RORA RAR-related orphan receptor A -0.0279754
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0252865
RNF145 ring finger protein 145 -0.0212009
FNDC3A fibronectin type III domain containing 3A -0.0155666
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0138844
FNDC3B fibronectin type III domain containing 3B -0.0135354
PRKCA protein kinase C, alpha -0.0113118
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.00637306
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.00596916
ZNF608 zinc finger protein 608 -0.00502384
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.00353579
EIF1 eukaryotic translation initiation factor 1 -0.00232253
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.00229269
PDE4D phosphodiesterase 4D, cAMP-specific -5.73638E-4
P4HB prolyl 4-hydroxylase, beta polypeptide -3.61322E-4