Clonidine (hydrochloride)_SHP-77 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in SHP-77 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clonidine (hydrochloride)_SHP-77 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE10A phosphodiesterase 10A 0.138048
SMOC1 SPARC related modular calcium binding 1 0.0581398
VGF VGF nerve growth factor inducible 0.0544907
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0399827
SNAP25 synaptosomal-associated protein, 25kDa 0.0394746
FAT1 FAT atypical cadherin 1 0.0363319
MYH9 myosin, heavy chain 9, non-muscle 0.0348111
FNDC3A fibronectin type III domain containing 3A 0.0297809
TENM1 teneurin transmembrane protein 1 0.021983
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0210686
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0194016
IRS2 insulin receptor substrate 2 0.0180524
RPH3AL rabphilin 3A-like (without C2 domains) 0.0179545
GRAMD4 GRAM domain containing 4 0.0173697
HDAC4 histone deacetylase 4 0.0167038
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0165684
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 0.016258
UBE2QL1 ubiquitin-conjugating enzyme E2Q family-like 1 0.0146819
TMEM255B transmembrane protein 255B 0.0144055
TRIO trio Rho guanine nucleotide exchange factor 0.0143398
KDM3A lysine (K)-specific demethylase 3A 0.0139615
DDX39B DEAD (Asp-Glu-Ala-Asp) box polypeptide 39B 0.013463
ACTN4 actinin, alpha 4 0.0134601
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0128273
SFPQ splicing factor proline/glutamine-rich 0.0126033
RUNX1 runt-related transcription factor 1 0.0125082
CKAP5 cytoskeleton associated protein 5 0.0124962
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0123919
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0117588
AHCTF1 AT hook containing transcription factor 1 0.0117372
EML6 echinoderm microtubule associated protein like 6 0.0117339
PDE4D phosphodiesterase 4D, cAMP-specific 0.0116368
ZMAT4 zinc finger, matrin-type 4 0.0116045
WDFY3 WD repeat and FYVE domain containing 3 0.0112563
PCSK1 proprotein convertase subtilisin/kexin type 1 0.0110928
SGMS2 sphingomyelin synthase 2 0.0109418
ARHGAP26 Rho GTPase activating protein 26 0.0108431
AOPEP aminopeptidase O (putative) 0.0108007
MEF2D myocyte enhancer factor 2D 0.0107396
PLEC plectin 0.01066
DIDO1 death inducer-obliterator 1 0.0106138
CDK5RAP2 CDK5 regulatory subunit associated protein 2 0.010609
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0105419
TBCD tubulin folding cofactor D 0.0104384
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0102184
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0101934
SIK2 salt-inducible kinase 2 0.0101741
BBS9 Bardet-Biedl syndrome 9 0.0101713
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.00981677
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.00976271
AFDN afadin, adherens junction formation factor 0.00947441
NUMA1 nuclear mitotic apparatus protein 1 0.00938019
SCLT1 sodium channel and clathrin linker 1 0.00936071
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 0.00934404
WDR25 WD repeat domain 25 0.00920879
ZNF292 zinc finger protein 292 0.00917224
CHST8 carbohydrate (N-acetylgalactosamine 4-0) sulfotransferase 8 0.00911818
PRRC2A proline-rich coiled-coil 2A 0.00908463
ZFC3H1 zinc finger, C3H1-type containing 0.00899624
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.00898587
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.00884576
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 0.0087577
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.00863671
CEMIP cell migration inducing protein, hyaluronan binding 0.00862659
MYH10 myosin, heavy chain 10, non-muscle 0.00861719
YY1AP1 YY1 associated protein 1 0.00855164
XPO1 exportin 1 0.00853221
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.00852787
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0085151
MACF1 microtubule-actin crosslinking factor 1 0.00845105
MAP7 microtubule-associated protein 7 0.00843999
INCENP inner centromere protein antigens 135/155kDa 0.00835918
SESTD1 SEC14 and spectrin domains 1 0.00835702
USP9X ubiquitin specific peptidase 9, X-linked 0.00831112
KDM5C lysine (K)-specific demethylase 5C 0.00826374
SART1 squamous cell carcinoma antigen recognized by T cells 0.00824763
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 0.00824722
MPP2 membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) 0.00823341
PPP2R1B protein phosphatase 2, regulatory subunit A, beta 0.00819882
POLE polymerase (DNA directed), epsilon, catalytic subunit 0.00818391
FIP1L1 factor interacting with PAPOLA and CPSF1 0.00815906
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.00815008
TXNIP thioredoxin interacting protein 0.00814134
TMEM14B transmembrane protein 14B 0.00812844
CDH12 cadherin 12, type 2 (N-cadherin 2) 0.00807677
ECT2 epithelial cell transforming 2 0.00807622
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.00807551
TPX2 TPX2, microtubule-associated 0.0079862
FTO fat mass and obesity associated 0.00797633
KIAA1328 KIAA1328 0.00793995
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 0.00791279
SH3PXD2A SH3 and PX domains 2A 0.00773399
BLTP1 bridge-like lipid transfer protein family member 1 0.00772536
U2AF2 U2 small nuclear RNA auxiliary factor 2 0.00761472
CNOT4 CCR4-NOT transcription complex, subunit 4 0.00760823
JADE1 jade family PHD finger 1 0.00757587
UNC80 unc-80 homolog (C. elegans) 0.00756489
ELAPOR2 endosome-lysosome associated apoptosis and autophagy regulator family member 2 0.00754786
MYRIP myosin VIIA and Rab interacting protein 0.0075424
CHERP calcium homeostasis endoplasmic reticulum protein 0.00749987

decreased expression

Symbol Name Standardized Value
NALF1 NALCN channel auxiliary factor 1 -0.200318
GPC6 glypican 6 -0.150758
NRG1 neuregulin 1 -0.125004
SNTG1 syntrophin, gamma 1 -0.0855967
MAP1B microtubule-associated protein 1B -0.084499
NDRG1 N-myc downstream regulated 1 -0.0815443
CALCA calcitonin-related polypeptide alpha -0.0775189
NKAIN2 Na+/K+ transporting ATPase interacting 2 -0.0763498
IGFBP5 insulin-like growth factor binding protein 5 -0.0651297
IGFBP2 insulin-like growth factor binding protein 2, 36kDa -0.0639915
RIMS2 regulating synaptic membrane exocytosis 2 -0.057329
RORA RAR-related orphan receptor A -0.0558609
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0551471
ACTG1 actin gamma 1 -0.0550864
ESRRG estrogen-related receptor gamma -0.0536658
GRIK1 glutamate receptor, ionotropic, kainate 1 -0.053493
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0532653
PTMA prothymosin, alpha -0.0525061
ENO1 enolase 1, (alpha) -0.0524504
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0515029
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.051456
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) -0.0496324
CACNA1D calcium channel, voltage-dependent, L type, alpha 1D subunit -0.0492454
CPE carboxypeptidase E -0.0489389
ZBTB20 zinc finger and BTB domain containing 20 -0.0485656
SMYD3 SET and MYND domain containing 3 -0.0478532
KCNB2 potassium channel, voltage gated Shab related subfamily B, member 2 -0.0471029
KCND2 potassium channel, voltage gated Shal related subfamily D, member 2 -0.0470051
ADGRL2 adhesion G protein-coupled receptor L2 -0.0455104
EGR1 early growth response 1 -0.0447971
STC1 stanniocalcin 1 -0.0434539
MCTP1 multiple C2 domains, transmembrane 1 -0.043313
WWOX WW domain containing oxidoreductase -0.0420797
GPC5 glypican 5 -0.0420049
DTNA dystrobrevin, alpha -0.0414023
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0412266
TSHZ2 teashirt zinc finger homeobox 2 -0.0411138
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0389623
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0385385
KTN1 kinectin 1 (kinesin receptor) -0.0354592
RPS6 ribosomal protein S6 -0.0349233
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0346002
SCG2 secretogranin II -0.0341603
LSAMP limbic system-associated membrane protein -0.0339135
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0338355
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.033397
RPS8 ribosomal protein S8 -0.0326266
SYT1 synaptotagmin I -0.0324526
CHGB chromogranin B -0.0322822
DGKB diacylglycerol kinase, beta 90kDa -0.0315981
PDIA3 protein disulfide isomerase family A, member 3 -0.030057
KLHL29 kelch-like family member 29 -0.0299028
TMSB4X thymosin beta 4, X-linked -0.0291121
RPS25 ribosomal protein S25 -0.0288342
DENND4A DENN/MADD domain containing 4A -0.0287171
CNTNAP2 contactin associated protein-like 2 -0.0286542
FAM13A family with sequence similarity 13, member A -0.0282821
DOCK5 dedicator of cytokinesis 5 -0.0282532
KCTD8 potassium channel tetramerization domain containing 8 -0.0282398
EPHA6 EPH receptor A6 -0.0281549
EYA2 EYA transcriptional coactivator and phosphatase 2 -0.027866
GMDS GDP-mannose 4,6-dehydratase -0.027786
IFI6 interferon, alpha-inducible protein 6 -0.0272511
DSTN destrin (actin depolymerizing factor) -0.0266853
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0264523
NELL1 NEL-like 1 (chicken) -0.0258782
HM13 histocompatibility (minor) 13 -0.0255816
PTCHD4 patched domain containing 4 -0.0252539
RPL37 ribosomal protein L37 -0.0250344
POTEF POTE ankyrin domain family, member F -0.0250287
KIF26B kinesin family member 26B -0.0250261
CCDC88A coiled-coil domain containing 88A -0.0250132
ARFGEF3 ARFGEF family member 3 -0.0249449
STAT1 signal transducer and activator of transcription 1, 91kDa -0.024933
PEG10 paternally expressed 10 -0.0241895
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0241534
GNL3L guanine nucleotide binding protein-like 3 (nucleolar)-like -0.0239226
RIT2 Ras-like without CAAX 2 -0.0239125
TPT1 tumor protein, translationally-controlled 1 -0.0238168
TPM4 tropomyosin 4 -0.0235655
RPS3 ribosomal protein S3 -0.0234567
RPL37A ribosomal protein L37a -0.0234165
GPHN gephyrin -0.023176
ZBTB7C zinc finger and BTB domain containing 7C -0.0230975
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0230652
KPNB1 karyopherin (importin) beta 1 -0.0229468
PCDH9 protocadherin 9 -0.0229396
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0225575
ERLEC1 endoplasmic reticulum lectin 1 -0.0224897
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0224405
FOXC1 forkhead box C1 -0.0223232
KCNMB3 potassium channel subfamily M regulatory beta subunit 3 -0.0222759
RPS21 ribosomal protein S21 -0.022097
RPL8 ribosomal protein L8 -0.0219908
S100A9 S100 calcium binding protein A9 -0.0219458
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0219325
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0219104
SIPA1L3 signal-induced proliferation-associated 1 like 3 -0.0217002
PDIA6 protein disulfide isomerase family A, member 6 -0.0216956
SCFD1 sec1 family domain containing 1 -0.021581