Clonidine (hydrochloride)_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clonidine (hydrochloride)_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EXT1 exostosin glycosyltransferase 1 0.102772
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0908044
ASPH aspartate beta-hydroxylase 0.0824888
TMSB10 thymosin beta 10 0.0761511
PTMA prothymosin, alpha 0.0683311
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0659294
VIM vimentin 0.060437
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0588869
B2M beta-2-microglobulin 0.0570166
SEPTIN9 septin 9 0.0554335
PRRC2C proline-rich coiled-coil 2C 0.0542035
HLA-B major histocompatibility complex, class I, B 0.0533883
MT2A metallothionein 2A 0.0532574
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0523705
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0500546
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.049259
FTL ferritin, light polypeptide 0.0476773
IFI27 interferon, alpha-inducible protein 27 0.0471484
VCL vinculin 0.0465263
FNDC3A fibronectin type III domain containing 3A 0.0463634
TOP1 topoisomerase (DNA) I 0.0438156
S100A6 S100 calcium binding protein A6 0.04262
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.042532
SFTPA2 surfactant protein A2 0.0403448
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0386592
TPT1 tumor protein, translationally-controlled 1 0.037819
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0376921
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0376489
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0362789
TPI1 triosephosphate isomerase 1 0.0336544
EIF4A1 eukaryotic translation initiation factor 4A1 0.0335486
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0332421
S100A10 S100 calcium binding protein A10 0.0322785
PLEC plectin 0.0316995
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.031344
MYOF myoferlin 0.0311661
LMNA lamin A/C 0.0311435
HILPDA hypoxia inducible lipid droplet-associated 0.030916
RPS12 ribosomal protein S12 0.0308039
INTS6 integrator complex subunit 6 0.0304056
AHNAK AHNAK nucleoprotein 0.0303899
RPL26 ribosomal protein L26 0.0300732
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A 0.0299467
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0297587
TMSB4X thymosin beta 4, X-linked 0.0295255
BPTF bromodomain PHD finger transcription factor 0.02896
FERMT2 fermitin family member 2 0.0286817
SPAG9 sperm associated antigen 9 0.0283998
NTN4 netrin 4 0.0283653
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0280241
NRIP1 nuclear receptor interacting protein 1 0.0277011
RPS6 ribosomal protein S6 0.027334
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0271497
MYH9 myosin, heavy chain 9, non-muscle 0.0269924
RPS3 ribosomal protein S3 0.0268224
ENO2 enolase 2 (gamma, neuronal) 0.0267904
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0265026
RPS19 ribosomal protein S19 0.0263779
RAB31 RAB31, member RAS oncogene family 0.0261284
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0259377
AFDN afadin, adherens junction formation factor 0.0251375
FAT1 FAT atypical cadherin 1 0.0251366
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0248632
IFI6 interferon, alpha-inducible protein 6 0.0247248
SMAD3 SMAD family member 3 0.0245021
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0243268
GOLGB1 golgin B1 0.0242674
RPS27A ribosomal protein S27a 0.0241057
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0240527
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0239646
RPS27 ribosomal protein S27 0.0237037
PDLIM5 PDZ and LIM domain 5 0.0235152
NIPBL Nipped-B homolog (Drosophila) 0.0234225
CLIP2 CAP-GLY domain containing linker protein 2 0.0232962
NPTN neuroplastin 0.0232488
CTNND1 catenin (cadherin-associated protein), delta 1 0.0229128
RPL23 ribosomal protein L23 0.0226561
ERRFI1 ERBB receptor feedback inhibitor 1 0.0222557
EIF1 eukaryotic translation initiation factor 1 0.0222261
TXNIP thioredoxin interacting protein 0.0221251
PGK1 phosphoglycerate kinase 1 0.022041
PLIN2 perilipin 2 0.0218793
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0214531
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0214192
CSNK1A1 casein kinase 1, alpha 1 0.0213875
DSCAM Down syndrome cell adhesion molecule 0.0213668
AGO2 argonaute RISC catalytic component 2 0.0211983
ACTN4 actinin, alpha 4 0.0209396
RPL37A ribosomal protein L37a 0.0208147
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0206606
KTN1 kinectin 1 (kinesin receptor) 0.0204566
SRRM2 serine/arginine repetitive matrix 2 0.0203446
KLF10 Kruppel-like factor 10 0.0201436
GPATCH2L G patch domain containing 2-like 0.0200728
SMYD3 SET and MYND domain containing 3 0.0200016
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0199912
WDR33 WD repeat domain 33 0.0198554
FLNA filamin A, alpha 0.019685
XPO1 exportin 1 0.0192095
RPL19 ribosomal protein L19 0.019089

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.268199
NRG1 neuregulin 1 -0.240244
TMEM156 transmembrane protein 156 -0.121271
EFNA5 ephrin-A5 -0.114494
NAMPT nicotinamide phosphoribosyltransferase -0.104384
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0892804
ITGA1 integrin, alpha 1 -0.0860919
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0831017
GLIS3 GLIS family zinc finger 3 -0.0775104
FN1 fibronectin 1 -0.0774291
SYT1 synaptotagmin I -0.0726956
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0635188
PDE4D phosphodiesterase 4D, cAMP-specific -0.0573006
KLHL5 kelch-like family member 5 -0.0570604
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) -0.056756
FTH1 ferritin, heavy polypeptide 1 -0.0559255
FNDC3B fibronectin type III domain containing 3B -0.0552767
HMGA2 high mobility group AT-hook 2 -0.0534599
ETV6 ets variant 6 -0.0504189
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0469453
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0425236
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0405218
BAZ2B bromodomain adjacent to zinc finger domain, 2B -0.0386967
OSMR oncostatin M receptor -0.0386334
NRP1 neuropilin 1 -0.0381896
TAS2R14 taste receptor, type 2, member 14 -0.0362724
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0362355
RUNX2 runt-related transcription factor 2 -0.0358734
FOXP1 forkhead box P1 -0.0355836
DNAH5 dynein, axonemal, heavy chain 5 -0.0354526
TRIO trio Rho guanine nucleotide exchange factor -0.0346313
LRMDA leucine rich melanocyte differentiation associated -0.0344105
MAML2 mastermind-like 2 (Drosophila) -0.0338748
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0338174
AOPEP aminopeptidase O (putative) -0.0332493
MRPS6 mitochondrial ribosomal protein S6 -0.0328717
TNS3 tensin 3 -0.0315963
CXCL8 chemokine (C-X-C motif) ligand 8 -0.031585
TXNRD1 thioredoxin reductase 1 -0.0312269
MCTP2 multiple C2 domains, transmembrane 2 -0.0301983
HIPK2 homeodomain interacting protein kinase 2 -0.0301405
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.029034
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0289797
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0288838
MX1 MX dynamin-like GTPase 1 -0.0286999
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0279081
VMP1 vacuole membrane protein 1 -0.0274704
STC2 stanniocalcin 2 -0.0274691
TIPARP TCDD-inducible poly(ADP-ribose) polymerase -0.0274597
SOS1 son of sevenless homolog 1 (Drosophila) -0.0273035
CADM1 cell adhesion molecule 1 -0.027296
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0272046
TRPS1 trichorhinophalangeal syndrome I -0.0269852
AHI1 Abelson helper integration site 1 -0.0266153
SOX5 SRY (sex determining region Y)-box 5 -0.0264121
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0262684
RAI14 retinoic acid induced 14 -0.0260452
ARHGAP35 Rho GTPase activating protein 35 -0.0256441
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0254905
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0247165
TGFA transforming growth factor, alpha -0.024319
RANBP17 RAN binding protein 17 -0.0241892
UBXN4 UBX domain protein 4 -0.0239206
FBN1 fibrillin 1 -0.0235891
LIMCH1 LIM and calponin homology domains 1 -0.0232546
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0232461
AHRR aryl-hydrocarbon receptor repressor -0.0230621
DENND5B DENN/MADD domain containing 5B -0.0229909
ARF4 ADP-ribosylation factor 4 -0.022282
TSC22D1 TSC22 domain family, member 1 -0.0220026
CD109 CD109 molecule -0.0218922
HPCAL1 hippocalcin-like 1 -0.0215728
DHFR dihydrofolate reductase -0.0214453
MON2 MON2 homolog (S. cerevisiae) -0.0214167
ATP9A ATPase, class II, type 9A -0.0213228
LMCD1 LIM and cysteine-rich domains 1 -0.0210773
LRP5 low density lipoprotein receptor-related protein 5 -0.0209468
TSHZ2 teashirt zinc finger homeobox 2 -0.0199585
IRAK3 interleukin-1 receptor-associated kinase 3 -0.0198955
PTBP3 polypyrimidine tract binding protein 3 -0.0198819
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0198335
PDGFC platelet derived growth factor C -0.0197984
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0197975
FBXO32 F-box protein 32 -0.0196213
PUM2 pumilio RNA-binding family member 2 -0.0195482
BICC1 BicC family RNA binding protein 1 -0.0195132
COG5 component of oligomeric golgi complex 5 -0.0194923
PLSCR1 phospholipid scramblase 1 -0.0193952
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0193389
BRWD3 bromodomain and WD repeat domain containing 3 -0.0191623
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0190782
OSBPL3 oxysterol binding protein-like 3 -0.0189574
RIGI RNA sensor RIG-I -0.018862
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0187763
PCED1B PC-esterase domain containing 1B -0.0186937
FAM20C family with sequence similarity 20, member C -0.0185091
TMEM263 transmembrane protein 263 -0.0184673
WDR27 WD repeat domain 27 -0.0183415
PELO pelota homolog (Drosophila) -0.0180424
DOCK4 dedicator of cytokinesis 4 -0.0180097