Clonidine (hydrochloride)_SW480 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clonidine (hydrochloride) perturbation in SW480 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clonidine (hydrochloride)_SW480 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.096579
MYH9 myosin, heavy chain 9, non-muscle 0.0659473
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0634828
RPL23 ribosomal protein L23 0.0609791
TMSB10 thymosin beta 10 0.0560175
MT2A metallothionein 2A 0.0546562
RPS19 ribosomal protein S19 0.0539474
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0506982
PTMA prothymosin, alpha 0.0444328
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0425596
PLEC plectin 0.0401262
SFPQ splicing factor proline/glutamine-rich 0.03864
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0372368
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0366893
RPS3 ribosomal protein S3 0.0344806
RPS12 ribosomal protein S12 0.0341043
MSN moesin 0.0333797
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0330908
SET SET nuclear proto-oncogene 0.0330885
TOP2A topoisomerase (DNA) II alpha 170kDa 0.031826
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0307471
RPL37A ribosomal protein L37a 0.0305991
DSPP dentin sialophosphoprotein 0.0298795
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0297409
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0296218
SMC1A structural maintenance of chromosomes 1A 0.0284099
SON SON DNA binding protein 0.0283342
RPS2 ribosomal protein S2 0.0282363
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0276544
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0276492
SRSF5 serine/arginine-rich splicing factor 5 0.027519
RPS6 ribosomal protein S6 0.0262315
TPI1 triosephosphate isomerase 1 0.0256142
KRT18 keratin 18, type I 0.025613
ACTN1 actinin, alpha 1 0.0255477
ARGLU1 arginine and glutamate rich 1 0.0254385
RPL35A ribosomal protein L35a 0.0252395
TMF1 TATA element modulatory factor 1 0.0252229
CENPF centromere protein F, 350/400kDa 0.0250969
RPL3 ribosomal protein L3 0.0250272
RPL18 ribosomal protein L18 0.0248895
KTN1 kinectin 1 (kinesin receptor) 0.024809
BRD2 bromodomain containing 2 0.0247755
RPLP2 ribosomal protein, large, P2 0.0246997
FLNA filamin A, alpha 0.0244082
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor 0.0241011
RPS17 ribosomal protein S17 0.024003
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0233442
PCM1 pericentriolar material 1 0.0233035
YAP1 Yes-associated protein 1 0.0231688
PCLO piccolo presynaptic cytomatrix protein 0.0231572
SAMD4A sterile alpha motif domain containing 4A 0.0225001
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0223028
EIF5B eukaryotic translation initiation factor 5B 0.0222341
EIF1 eukaryotic translation initiation factor 1 0.0221999
PCBP2 poly(rC) binding protein 2 0.0221835
H1-4 H1.4 linker histone, cluster member 0.0221536
RPL36 ribosomal protein L36 0.0217801
PRRC2C proline-rich coiled-coil 2C 0.021546
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0215409
FTL ferritin, light polypeptide 0.0215292
BRD4 bromodomain containing 4 0.0214748
RPL12 ribosomal protein L12 0.0209709
CPNE1 copine I 0.0208287
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0206482
FNDC3B fibronectin type III domain containing 3B 0.0206341
PABPN1 poly(A) binding protein, nuclear 1 0.0204945
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0204079
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0202878
TXNIP thioredoxin interacting protein 0.020256
EIF5 eukaryotic translation initiation factor 5 0.0200769
SMAD3 SMAD family member 3 0.0196708
RPL26 ribosomal protein L26 0.0191758
RNF43 ring finger protein 43 0.0191001
SMC4 structural maintenance of chromosomes 4 0.0189636
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0188477
CLTC clathrin, heavy chain (Hc) 0.0188245
RPS21 ribosomal protein S21 0.0185144
VIM vimentin 0.0184898
RBP1 retinol binding protein 1, cellular 0.0183857
H1-2 H1.2 linker histone, cluster member 0.0183213
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.017935
DIAPH3 diaphanous-related formin 3 0.017601
RPS14 ribosomal protein S14 0.0175391
ENO1 enolase 1, (alpha) 0.0172744
CTBP2 C-terminal binding protein 2 0.0171692
WWC1 WW and C2 domain containing 1 0.0170452
PTMS parathymosin 0.0168484
HMGB2 high mobility group box 2 0.0167634
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.016744
ACTN4 actinin, alpha 4 0.0167035
DOCK5 dedicator of cytokinesis 5 0.0166379
SRRM2 serine/arginine repetitive matrix 2 0.0166326
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0166198
PFN1 profilin 1 0.0166137
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9) 0.0165449
NUMA1 nuclear mitotic apparatus protein 1 0.0164487
RPS27A ribosomal protein S27a 0.0164277
TPX2 TPX2, microtubule-associated 0.0164064
EEF1G eukaryotic translation elongation factor 1 gamma 0.0163984

decreased expression

Symbol Name Standardized Value
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.360403
CDH13 cadherin 13 -0.127379
NKD1 naked cuticle homolog 1 (Drosophila) -0.111865
NAV2 neuron navigator 2 -0.10326
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.10054
VCL vinculin -0.0986925
MAML2 mastermind-like 2 (Drosophila) -0.0808292
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0735162
ANXA2 annexin A2 -0.0712243
PDE4D phosphodiesterase 4D, cAMP-specific -0.0685222
SKAP1 src kinase associated phosphoprotein 1 -0.0683396
CDK6 cyclin-dependent kinase 6 -0.0662904
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0646669
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0608507
ZBTB20 zinc finger and BTB domain containing 20 -0.0605037
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0594451
CCND1 cyclin D1 -0.0569129
ADGRL2 adhesion G protein-coupled receptor L2 -0.0547301
ANO1 anoctamin 1, calcium activated chloride channel -0.0542799
TMEM123 transmembrane protein 123 -0.0542563
TAS2R14 taste receptor, type 2, member 14 -0.0503059
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0493064
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0488409
SNTB1 syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) -0.048163
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0465887
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0436679
FRMD5 FERM domain containing 5 -0.0431681
LDHA lactate dehydrogenase A -0.042213
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0421671
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0397555
WWOX WW domain containing oxidoreductase -0.0380768
RAD51B RAD51 paralog B -0.0375887
NPAS2 neuronal PAS domain protein 2 -0.0372912
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0370729
USP34 ubiquitin specific peptidase 34 -0.0370061
ANKRD28 ankyrin repeat domain 28 -0.0369655
EGR1 early growth response 1 -0.0369222
DIAPH2 diaphanous-related formin 2 -0.0362206
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0356426
PIBF1 progesterone immunomodulatory binding factor 1 -0.0352014
PERP PERP, TP53 apoptosis effector -0.0351041
ANKRD10 ankyrin repeat domain 10 -0.035097
BACE2 beta-site APP-cleaving enzyme 2 -0.0349377
SLC38A1 solute carrier family 38, member 1 -0.034734
TPM4 tropomyosin 4 -0.0346374
OSBPL3 oxysterol binding protein-like 3 -0.0343514
ETNK1 ethanolamine kinase 1 -0.0343305
SDK1 sidekick cell adhesion molecule 1 -0.034308
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0338794
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0326155
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0325776
GMDS GDP-mannose 4,6-dehydratase -0.0317065
AHNAK AHNAK nucleoprotein -0.0312903
IGF1R insulin-like growth factor 1 receptor -0.0312222
WDFY2 WD repeat and FYVE domain containing 2 -0.0307895
EZR ezrin -0.030636
COBL cordon-bleu WH2 repeat protein -0.0305957
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0305952
ATXN1 ataxin 1 -0.0305059
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0304519
PATJ PATJ crumbs cell polarity complex component -0.0302081
MACC1 metastasis associated in colon cancer 1 -0.030198
RPS24 ribosomal protein S24 -0.0296098
LPP LIM domain containing preferred translocation partner in lipoma -0.0295866
MRPS6 mitochondrial ribosomal protein S6 -0.0292874
TCF12 transcription factor 12 -0.0292173
EMP1 epithelial membrane protein 1 -0.0290529
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.0288001
NF1 neurofibromin 1 -0.0287905
ITGB4 integrin, beta 4 -0.0285511
SPDYA speedy/RINGO cell cycle regulator family member A -0.0284597
HDAC8 histone deacetylase 8 -0.0281845
SBF2 SET binding factor 2 -0.0274895
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0270406
KDM4C lysine (K)-specific demethylase 4C -0.0268488
KIZ kizuna centrosomal protein -0.0261947
ARHGAP32 Rho GTPase activating protein 32 -0.0261762
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0260473
BIRC6 baculoviral IAP repeat containing 6 -0.0258571
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0254546
SPATA13 spermatogenesis associated 13 -0.025384
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0252744
JMJD1C jumonji domain containing 1C -0.0252599
PHF14 PHD finger protein 14 -0.0252493
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0252459
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0251732
LMCD1 LIM and cysteine-rich domains 1 -0.0250524
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0250082
EXOC4 exocyst complex component 4 -0.0245553
TBC1D5 TBC1 domain family, member 5 -0.0244573
FTH1 ferritin, heavy polypeptide 1 -0.0244226
SH3D19 SH3 domain containing 19 -0.0243442
AOPEP aminopeptidase O (putative) -0.024254
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) -0.0241382
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0240642
SERINC5 serine incorporator 5 -0.0240625
TNS3 tensin 3 -0.0238508
KDM3A lysine (K)-specific demethylase 3A -0.0237889
KLF5 Kruppel-like factor 5 (intestinal) -0.0237084
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0234006