Clopidogrel_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.245405
VIM vimentin 0.155152
TRIO trio Rho guanine nucleotide exchange factor 0.152716
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.137057
SOD2 superoxide dismutase 2, mitochondrial 0.112157
IGFBP3 insulin-like growth factor binding protein 3 0.0988689
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0969303
LOX lysyl oxidase 0.0901312
FBN1 fibrillin 1 0.0893432
AHNAK AHNAK nucleoprotein 0.0889848
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0880729
COL3A1 collagen, type III, alpha 1 0.0733391
LOXL2 lysyl oxidase-like 2 0.0692507
LDHA lactate dehydrogenase A 0.0691208
DST dystonin 0.0678815
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0673068
DLG1 discs, large homolog 1 (Drosophila) 0.0671232
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0658855
NAV1 neuron navigator 1 0.0649992
SLC39A11 solute carrier family 39, member 11 0.061174
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0602721
APP amyloid beta (A4) precursor protein 0.0576194
CANX calnexin 0.0549016
COL5A1 collagen, type V, alpha 1 0.054232
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0538797
FNDC3B fibronectin type III domain containing 3B 0.0538556
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0537801
IQGAP1 IQ motif containing GTPase activating protein 1 0.0506874
MAP1B microtubule-associated protein 1B 0.048642
ANXA2 annexin A2 0.0482048
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0467954
PODXL podocalyxin-like 0.0466948
CDH13 cadherin 13 0.0465632
TMSB4X thymosin beta 4, X-linked 0.0462725
UBC ubiquitin C 0.0460065
OGA O-GlcNAcase 0.0456371
THBS2 thrombospondin 2 0.0445041
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0427558
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0418494
NAV2 neuron navigator 2 0.0418377
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0409887
ZBTB20 zinc finger and BTB domain containing 20 0.0409568
PLAT plasminogen activator, tissue 0.0408971
CALR calreticulin 0.040603
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0403453
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0400906
TNIP1 TNFAIP3 interacting protein 1 0.039944
PGK1 phosphoglycerate kinase 1 0.0388216
CD44 CD44 molecule (Indian blood group) 0.0387768
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0387718
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0374978
TPM3 tropomyosin 3 0.0360515
B2M beta-2-microglobulin 0.0357094
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0356542
COL5A2 collagen, type V, alpha 2 0.0355048
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.035254
MAP4 microtubule-associated protein 4 0.0348706
MACF1 microtubule-actin crosslinking factor 1 0.0344461
FSTL1 follistatin-like 1 0.034359
AUTS2 autism susceptibility candidate 2 0.0343307
FLNB filamin B, beta 0.0340953
SEPTIN9 septin 9 0.0336639
HDAC9 histone deacetylase 9 0.0334834
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0332752
ATP13A3 ATPase type 13A3 0.0327943
TTC3 tetratricopeptide repeat domain 3 0.0327263
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0327051
PBX3 pre-B-cell leukemia homeobox 3 0.0323194
RUNX1 runt-related transcription factor 1 0.0316618
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0315083
MYOF myoferlin 0.0314871
SOX9 SRY (sex determining region Y)-box 9 0.0314347
GPC6 glypican 6 0.0312707
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.030963
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0306069
DHRSX dehydrogenase/reductase (SDR family) X-linked 0.0305335
COPA coatomer protein complex, subunit alpha 0.0304554
ZEB1 zinc finger E-box binding homeobox 1 0.0303557
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0301588
FNIP1 folliculin interacting protein 1 0.0299628
MB21D2 Mab-21 domain containing 2 0.0299195
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0297695
DENND5A DENN/MADD domain containing 5A 0.0292784
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0292437
PRELID2 PRELI domain containing 2 0.0287474
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0287258
SPAG9 sperm associated antigen 9 0.0284887
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0282375
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0281983
ANO6 anoctamin 6 0.027997
BIRC6 baculoviral IAP repeat containing 6 0.0278374
BACE2 beta-site APP-cleaving enzyme 2 0.0278361
FRMD4A FERM domain containing 4A 0.0276872
BHLHE40 basic helix-loop-helix family, member e40 0.0274391
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0274097
DPYSL2 dihydropyrimidinase-like 2 0.0270968
MSI2 musashi RNA-binding protein 2 0.0270651
PRSS23 protease, serine, 23 0.026851
COPB1 coatomer protein complex, subunit beta 1 0.026491
MYH9 myosin, heavy chain 9, non-muscle 0.0262034

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.10447
TMSB10 thymosin beta 10 -0.102189
MT2A metallothionein 2A -0.0788569
POTEF POTE ankyrin domain family, member F -0.0377581
FTL ferritin, light polypeptide -0.0364533
RPL23 ribosomal protein L23 -0.0288773
RPS19 ribosomal protein S19 -0.0287574
IFITM3 interferon induced transmembrane protein 3 -0.0277814
RPL35A ribosomal protein L35a -0.0263152
RPLP2 ribosomal protein, large, P2 -0.0248965
RPL36 ribosomal protein L36 -0.0248142
RPLP1 ribosomal protein, large, P1 -0.024472
RPL32 ribosomal protein L32 -0.0231672
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0229233
ISG15 ISG15 ubiquitin-like modifier -0.0213392
PFN1 profilin 1 -0.0210395
RPS15 ribosomal protein S15 -0.0205305
RPS8 ribosomal protein S8 -0.0197221
RPS6 ribosomal protein S6 -0.019297
RPL34 ribosomal protein L34 -0.018969
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0188978
PTMA prothymosin, alpha -0.0186341
TPT1 tumor protein, translationally-controlled 1 -0.0183786
RPL35 ribosomal protein L35 -0.0176587
SEC61G Sec61 gamma subunit -0.0176162
ACTG1 actin gamma 1 -0.0173878
HSPB1 heat shock 27kDa protein 1 -0.0164915
FOSL1 FOS-like antigen 1 -0.0163406
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0158925
RPL12 ribosomal protein L12 -0.0155154
EGR1 early growth response 1 -0.0155066
RPL28 ribosomal protein L28 -0.0154077
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -0.0152989
RPL9 ribosomal protein L9 -0.0150148
RPS27A ribosomal protein S27a -0.0147015
CYB5R3 cytochrome b5 reductase 3 -0.0145459
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.014318
IFITM1 interferon induced transmembrane protein 1 -0.0142398
RPL11 ribosomal protein L11 -0.0140351
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0139817
RPL26 ribosomal protein L26 -0.0138886
RPL37A ribosomal protein L37a -0.013693
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0135522
DEPP1 DEPP autophagy regulator 1 -0.0134163
VEGFA vascular endothelial growth factor A -0.012975
NDRG1 N-myc downstream regulated 1 -0.0129741
GUK1 guanylate kinase 1 -0.0128624
RPS23 ribosomal protein S23 -0.0128431
RPS14 ribosomal protein S14 -0.0127322
RPL38 ribosomal protein L38 -0.0126456
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0123173
RPL31 ribosomal protein L31 -0.0122875
CD81 CD81 molecule -0.0122642
RPS12 ribosomal protein S12 -0.0122226
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0120607
CD99 CD99 molecule -0.0120272
RPS29 ribosomal protein S29 -0.0120148
RPS13 ribosomal protein S13 -0.011693
HMGB1 high mobility group box 1 -0.0114693
RPS3 ribosomal protein S3 -0.0114573
S100A9 S100 calcium binding protein A9 -0.0113922
TMEM259 transmembrane protein 259 -0.0113502
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 -0.0112932
MIDEAS mitotic deacetylase associated SANT domain protein -0.0112774
RPS5 ribosomal protein S5 -0.0112541
TXNIP thioredoxin interacting protein -0.0111037
RPS11 ribosomal protein S11 -0.0110985
RPS21 ribosomal protein S21 -0.0110714
ATP5F1E ATP synthase F1 subunit epsilon -0.0110246
RPL7A ribosomal protein L7a -0.0108414
TAGLN2 transgelin 2 -0.0108389
HLA-B major histocompatibility complex, class I, B -0.0108082
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0106787
RPS27 ribosomal protein S27 -0.0106183
IER3 immediate early response 3 -0.0106013
RPS16 ribosomal protein S16 -0.0104847
TIMP2 TIMP metallopeptidase inhibitor 2 -0.010396
IFI6 interferon, alpha-inducible protein 6 -0.010335
HLA-C major histocompatibility complex, class I, C -0.0101778
NDUFA4 NDUFA4, mitochondrial complex associated -0.010166
EEF2 eukaryotic translation elongation factor 2 -0.0101382
MKNK2 MAP kinase interacting serine/threonine kinase 2 -0.0100303
MEF2D myocyte enhancer factor 2D -0.00998489
MNT MAX network transcriptional repressor -0.00993622
RPL19 ribosomal protein L19 -0.0099011
CST3 cystatin C -0.00975072
RPL21 ribosomal protein L21 -0.00969237
RPL36A ribosomal protein L36a -0.00967755
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0096515
RPS4X ribosomal protein S4, X-linked -0.00958006
UBB ubiquitin B -0.00940091
ATF4 activating transcription factor 4 -0.00939922
UQCRB ubiquinol-cytochrome c reductase binding protein -0.00939247
RPS10 ribosomal protein S10 -0.00937926
RPS2 ribosomal protein S2 -0.00931956
AGRN agrin -0.00927079
RPL23A ribosomal protein L23a -0.00925574
RPS25 ribosomal protein S25 -0.0092395
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.00923198
TAPBP TAP binding protein (tapasin) -0.00916212