Clopidogrel_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.103941
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0770857
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0619369
TMEM41B transmembrane protein 41B 0.0582365
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0573524
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0562712
BIRC6 baculoviral IAP repeat containing 6 0.0524319
TXNRD1 thioredoxin reductase 1 0.050605
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0473166
DST dystonin 0.0465465
ERRFI1 ERBB receptor feedback inhibitor 1 0.0463742
AREG amphiregulin 0.0455699
ANXA1 annexin A1 0.0396515
MED13L mediator complex subunit 13-like 0.0393335
XPO1 exportin 1 0.0383602
ZBTB20 zinc finger and BTB domain containing 20 0.037874
NEK7 NIMA-related kinase 7 0.0364251
PDE4D phosphodiesterase 4D, cAMP-specific 0.0362811
VMP1 vacuole membrane protein 1 0.0359877
USP34 ubiquitin specific peptidase 34 0.0357329
MMP12 matrix metallopeptidase 12 0.0350901
ANKRD12 ankyrin repeat domain 12 0.0350347
KDM3A lysine (K)-specific demethylase 3A 0.0348826
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.0345565
CXADR coxsackie virus and adenovirus receptor 0.0337911
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0331388
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0327004
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0317328
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0312262
JMJD1C jumonji domain containing 1C 0.0306731
TENM3 teneurin transmembrane protein 3 0.0295106
SPAG9 sperm associated antigen 9 0.0287775
ZNF292 zinc finger protein 292 0.0283726
YBX3 Y box binding protein 3 0.0278527
NAP1L1 nucleosome assembly protein 1-like 1 0.0275016
NIPBL Nipped-B homolog (Drosophila) 0.0270306
CARD16 caspase recruitment domain family, member 16 0.0270097
ECT2 epithelial cell transforming 2 0.0266894
BCAS3 breast carcinoma amplified sequence 3 0.0266661
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0262687
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0261838
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0261347
STARD4 StAR-related lipid transfer (START) domain containing 4 0.0260324
FXR1 fragile X mental retardation, autosomal homolog 1 0.0260015
LMO7 LIM domain 7 0.0259921
GARS1 glycyl-tRNA synthetase 1 0.0254943
RAD21 RAD21 homolog (S. pombe) 0.0254114
GJA1 gap junction protein, alpha 1, 43kDa 0.0254012
NCAPD2 non-SMC condensin I complex, subunit D2 0.025344
TNPO1 transportin 1 0.0251248
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0250481
EIF4A2 eukaryotic translation initiation factor 4A2 0.0250244
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0250074
EXOC6B exocyst complex component 6B 0.0249357
CELF2 CUGBP, Elav-like family member 2 0.0249155
PDGFC platelet derived growth factor C 0.0245513
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0244286
CCN2 cellular communication network factor 2 0.0243866
PCBP2 poly(rC) binding protein 2 0.0243504
CEP192 centrosomal protein 192kDa 0.0238204
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.023812
PRKCI protein kinase C, iota 0.0236704
KLHL24 kelch-like family member 24 0.0234413
PGK1 phosphoglycerate kinase 1 0.0232441
YBX1 Y box binding protein 1 0.023172
ATP11A ATPase, class VI, type 11A 0.0231123
OXR1 oxidation resistance 1 0.0230729
SMYD3 SET and MYND domain containing 3 0.0230363
FBXO11 F-box protein 11 0.022903
OGA O-GlcNAcase 0.0225927
SPATS2 spermatogenesis associated, serine-rich 2 0.022347
PUM2 pumilio RNA-binding family member 2 0.0222411
NCEH1 neutral cholesterol ester hydrolase 1 0.0220482
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0220427
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0216123
CSNK1A1 casein kinase 1, alpha 1 0.0215825
ERBIN erbb2 interacting protein 0.0215291
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0214985
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0213047
RIMKLB ribosomal modification protein rimK-like family member B 0.0213032
CHD1 chromodomain helicase DNA binding protein 1 0.0212821
USP9X ubiquitin specific peptidase 9, X-linked 0.0211474
KLF6 Kruppel-like factor 6 0.020637
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0206343
KIF5B kinesin family member 5B 0.0206201
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.0204631
MBNL1 muscleblind-like splicing regulator 1 0.0204265
ADAM17 ADAM metallopeptidase domain 17 0.0202271
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0201943
CLDN1 claudin 1 0.0201107
CKAP5 cytoskeleton associated protein 5 0.0200949
ZNF217 zinc finger protein 217 0.0200092
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 0.0200084
PCM1 pericentriolar material 1 0.0199288
MARCHF6 membrane associated ring-CH-type finger 6 0.019656
SQSTM1 sequestosome 1 0.0196205
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0195479
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0194745
CDK17 cyclin-dependent kinase 17 0.0194728
TMEM123 transmembrane protein 123 0.0194436

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18992
HMGA2 high mobility group AT-hook 2 -0.0635678
TMSB10 thymosin beta 10 -0.0634333
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0623538
ACTG1 actin gamma 1 -0.0591548
PTMA prothymosin, alpha -0.0587434
FTL ferritin, light polypeptide -0.0517383
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0387407
RPL35A ribosomal protein L35a -0.0361045
RPS23 ribosomal protein S23 -0.0335307
RPS29 ribosomal protein S29 -0.0302976
EGR1 early growth response 1 -0.0293928
HMGA1 high mobility group AT-hook 1 -0.0274232
POTEF POTE ankyrin domain family, member F -0.026776
INTS6 integrator complex subunit 6 -0.0267493
ATP5F1B ATP synthase F1 subunit beta -0.0248583
TPT1 tumor protein, translationally-controlled 1 -0.0248046
RPS8 ribosomal protein S8 -0.0247798
RAB7A RAB7A, member RAS oncogene family -0.0224755
RPS13 ribosomal protein S13 -0.0222064
RPS10 ribosomal protein S10 -0.0218511
RPL37A ribosomal protein L37a -0.020252
TBCA tubulin folding cofactor A -0.0201808
RPL31 ribosomal protein L31 -0.0198548
HSPB1 heat shock 27kDa protein 1 -0.0198392
RPS15 ribosomal protein S15 -0.0197851
RPS6 ribosomal protein S6 -0.0192296
LRRC23 leucine rich repeat containing 23 -0.0188219
RPL9 ribosomal protein L9 -0.0180469
S100A10 S100 calcium binding protein A10 -0.0177766
RPS26 ribosomal protein S26 -0.0176901
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0176683
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0167356
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0165804
TPM4 tropomyosin 4 -0.0163388
TUBA1B tubulin, alpha 1b -0.0161323
VDAC1 voltage-dependent anion channel 1 -0.0159305
RPL38 ribosomal protein L38 -0.0156022
RPS14 ribosomal protein S14 -0.0154683
HLA-B major histocompatibility complex, class I, B -0.0150456
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0149783
PDIA3 protein disulfide isomerase family A, member 3 -0.0148529
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0146978
RPS11 ribosomal protein S11 -0.0145531
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0141987
LOC102724023 ES1 protein homolog, mitochondrial -0.0138442
CALR calreticulin -0.0134982
RPL34 ribosomal protein L34 -0.0133166
MSRB3 methionine sulfoxide reductase B3 -0.0129832
LDHB lactate dehydrogenase B -0.0128526
S100A11 S100 calcium binding protein A11 -0.0128417
CCND1 cyclin D1 -0.0125164
TUBB4B tubulin, beta 4B class IVb -0.012437
CUX1 cut-like homeobox 1 -0.0122604
PA2G4 proliferation-associated 2G4, 38kDa -0.0118984
RPLP2 ribosomal protein, large, P2 -0.011775
LRRTM4 leucine rich repeat transmembrane neuronal 4 -0.0117169
RPS27 ribosomal protein S27 -0.0115523
GCG glucagon -0.01151
RAN RAN, member RAS oncogene family -0.0114796
RPS25 ribosomal protein S25 -0.0114663
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0113331
TUBB tubulin, beta class I -0.0112017
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0109665
CFAP70 cilia and flagella associated protein 70 -0.0109221
NHSL1 NHS-like 1 -0.0108987
NAV3 neuron navigator 3 -0.0108557
HMGB1 high mobility group box 1 -0.0108278
HLA-A major histocompatibility complex, class I, A -0.0105824
PRH1 proline-rich protein HaeIII subfamily 1 -0.0105334
RPL11 ribosomal protein L11 -0.0103465
ATN1 atrophin 1 -0.0103365
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0102598
CNRIP1 cannabinoid receptor interacting protein 1 -0.0102081
FADS2 fatty acid desaturase 2 -0.010158
FASN fatty acid synthase -0.0100746
SRSF3 serine/arginine-rich splicing factor 3 -0.0100569
RPL28 ribosomal protein L28 -0.00987117
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.00982829
TUBA1C tubulin, alpha 1c -0.00972624
RPL8 ribosomal protein L8 -0.00972014
COMMD10 COMM domain containing 10 -0.00966516
PCDH9 protocadherin 9 -0.00962734
PKM pyruvate kinase, muscle -0.0096187
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -0.00957841
RPL15 ribosomal protein L15 -0.00951093
C1S complement component 1, s subcomponent -0.00942639
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.00934476
TM4SF1 transmembrane 4 L six family member 1 -0.00929375
HSPE1 heat shock 10kDa protein 1 -0.00922287
FTH1 ferritin, heavy polypeptide 1 -0.00911329
TRAF3 TNF receptor-associated factor 3 -0.0091052
MYH15 myosin, heavy chain 15 -0.00899373
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.00887798
AHRR aryl-hydrocarbon receptor repressor -0.00883171
PDCD5 programmed cell death 5 -0.00877997
S100A9 S100 calcium binding protein A9 -0.00876803
SHISA5 shisa family member 5 -0.0086929
RPL23 ribosomal protein L23 -0.00865851
ATP5MF ATP synthase membrane subunit f -0.00849266