Clopidogrel_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.191029
VIM vimentin 0.159013
AKAP12 A kinase (PRKA) anchor protein 12 0.105092
RPS6 ribosomal protein S6 0.093314
RPLP1 ribosomal protein, large, P1 0.0922284
RPL35A ribosomal protein L35a 0.0829809
RPL23 ribosomal protein L23 0.0817535
EIF1 eukaryotic translation initiation factor 1 0.0806608
FAM13A family with sequence similarity 13, member A 0.0740575
RPL19 ribosomal protein L19 0.0691384
B2M beta-2-microglobulin 0.0688809
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0663528
PLAT plasminogen activator, tissue 0.0641352
RPS12 ribosomal protein S12 0.0637179
RPL31 ribosomal protein L31 0.0615485
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0613013
MEF2A myocyte enhancer factor 2A 0.0602523
RPS24 ribosomal protein S24 0.0571479
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0560676
RPS8 ribosomal protein S8 0.0538314
PTMA prothymosin, alpha 0.0534427
RPLP0 ribosomal protein, large, P0 0.0528243
FTL ferritin, light polypeptide 0.0507161
RPL37A ribosomal protein L37a 0.0498017
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0493535
DCAF7 DDB1 and CUL4 associated factor 7 0.0490397
PDE4D phosphodiesterase 4D, cAMP-specific 0.0484219
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0484116
RPS3 ribosomal protein S3 0.0464596
RACK1 receptor for activated C kinase 1 0.0458429
TPT1 tumor protein, translationally-controlled 1 0.0455257
BIRC6 baculoviral IAP repeat containing 6 0.0448147
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0447706
RPS19 ribosomal protein S19 0.0444422
PCDH9 protocadherin 9 0.0432956
MED13 mediator complex subunit 13 0.043223
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0423454
RPL34 ribosomal protein L34 0.042257
DST dystonin 0.0414542
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 0.0405907
SETD5 SET domain containing 5 0.0405753
DTNA dystrobrevin, alpha 0.0402652
RPL26 ribosomal protein L26 0.0399881
BPTF bromodomain PHD finger transcription factor 0.0390269
S100A6 S100 calcium binding protein A6 0.0380959
RPS11 ribosomal protein S11 0.0372448
RPL36 ribosomal protein L36 0.036685
RPL36A ribosomal protein L36a 0.0354956
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.035446
RPS5 ribosomal protein S5 0.0347329
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0347024
RPL37 ribosomal protein L37 0.0343788
RSF1 remodeling and spacing factor 1 0.0335989
P4HB prolyl 4-hydroxylase, beta polypeptide 0.033587
NF1 neurofibromin 1 0.0330204
GPBP1 GC-rich promoter binding protein 1 0.0325225
RPS27 ribosomal protein S27 0.0324025
RPL27 ribosomal protein L27 0.0318922
RPL32 ribosomal protein L32 0.0311733
FNDC3B fibronectin type III domain containing 3B 0.0310793
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) 0.0309694
WDR45B WD repeat domain 45B 0.0307208
NAMPT nicotinamide phosphoribosyltransferase 0.0301412
RPS17 ribosomal protein S17 0.0289842
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0289543
MACF1 microtubule-actin crosslinking factor 1 0.0286821
SEC31A SEC31 homolog A (S. cerevisiae) 0.0286617
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0286083
IFI16 interferon, gamma-inducible protein 16 0.0281805
RPL12 ribosomal protein L12 0.0281745
CALD1 caldesmon 1 0.0280868
SIK2 salt-inducible kinase 2 0.0279912
TPST1 tyrosylprotein sulfotransferase 1 0.027982
RNF145 ring finger protein 145 0.0277813
ASPH aspartate beta-hydroxylase 0.0277614
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0277574
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0276928
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0275992
PCBP3 poly(rC) binding protein 3 0.0274565
FAM162A family with sequence similarity 162, member A 0.0274472
ZBTB20 zinc finger and BTB domain containing 20 0.0271344
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0267751
LPP LIM domain containing preferred translocation partner in lipoma 0.0265128
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0264399
RPL11 ribosomal protein L11 0.0262407
SEC23A Sec23 homolog A (S. cerevisiae) 0.0259773
VMP1 vacuole membrane protein 1 0.0259413
SLC38A2 solute carrier family 38, member 2 0.0259069
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 0.0258974
RPL7A ribosomal protein L7a 0.0255128
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 0.0253975
CSDE1 cold shock domain containing E1, RNA-binding 0.025134
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0248712
SP100 SP100 nuclear antigen 0.0247998
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0246586
RBM39 RNA binding motif protein 39 0.024627
RPLP2 ribosomal protein, large, P2 0.0245159
PRRC2C proline-rich coiled-coil 2C 0.0244753
ANKIB1 ankyrin repeat and IBR domain containing 1 0.0243498
FUT11 fucosyltransferase 11 (alpha (1,3) fucosyltransferase) 0.0240632

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.205079
LPIN1 lipin 1 -0.0947372
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0442349
TRIB2 tribbles pseudokinase 2 -0.0436727
TRIO trio Rho guanine nucleotide exchange factor -0.032258
NRG1 neuregulin 1 -0.0314887
MEIS2 Meis homeobox 2 -0.0311027
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0249455
FMN1 formin 1 -0.0245315
PDE8A phosphodiesterase 8A -0.0242338
IARS1 isoleucyl-tRNA synthetase 1 -0.024233
UNC5C unc-5 homolog C (C. elegans) -0.0242316
NALF1 NALCN channel auxiliary factor 1 -0.023738
HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 -0.0229604
RHEB Ras homolog enriched in brain -0.0218643
NCOR1 nuclear receptor corepressor 1 -0.0216141
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.0215423
EEF2 eukaryotic translation elongation factor 2 -0.0209343
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0205121
IGF2R insulin-like growth factor 2 receptor -0.0203104
MAPK10 mitogen-activated protein kinase 10 -0.0202127
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0196915
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0196392
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0191238
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0190649
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0180128
CANX calnexin -0.0177481
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 -0.0177251
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.017675
GOLGB1 golgin B1 -0.0174877
MATR3 matrin 3 -0.0174851
LARP4B La ribonucleoprotein domain family, member 4B -0.017449
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha -0.0172911
FOXK2 forkhead box K2 -0.0169523
ADGRL3 adhesion G protein-coupled receptor L3 -0.016771
EGFR epidermal growth factor receptor -0.0166514
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase -0.0165362
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0164688
KDM3B lysine (K)-specific demethylase 3B -0.0162339
GPHN gephyrin -0.0161128
DUSP10 dual specificity phosphatase 10 -0.0158512
CHD6 chromodomain helicase DNA binding protein 6 -0.0152379
PRKD1 protein kinase D1 -0.0151247
BCAS3 breast carcinoma amplified sequence 3 -0.0147848
ARL15 ADP-ribosylation factor-like 15 -0.014708
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0147055
ZFAND6 zinc finger, AN1-type domain 6 -0.014632
RBM26 RNA binding motif protein 26 -0.0145638
ARID3A AT rich interactive domain 3A (BRIGHT-like) -0.0145554
ILF3 interleukin enhancer binding factor 3, 90kDa -0.0145514
STX18 syntaxin 18 -0.0145281
USP36 ubiquitin specific peptidase 36 -0.0143112
ATXN10 ataxin 10 -0.0142991
COL1A1 collagen, type I, alpha 1 -0.0142609
EWSR1 EWS RNA-binding protein 1 -0.0142456
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0141765
MIDEAS mitotic deacetylase associated SANT domain protein -0.0140912
SRBD1 S1 RNA binding domain 1 -0.014017
SRSF1 serine/arginine-rich splicing factor 1 -0.0138077
UBAP2L ubiquitin associated protein 2-like -0.0137362
EVL Enah/Vasp-like -0.0137272
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa -0.013722
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited) -0.0137108
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -0.0135055
PCDH15 protocadherin-related 15 -0.0134111
TRIP12 thyroid hormone receptor interactor 12 -0.0133993
RNF213 ring finger protein 213 -0.0133694
KAT6A K(lysine) acetyltransferase 6A -0.0133458
NOTCH1 notch 1 -0.0132832
PPP4R3B protein phosphatase 4 regulatory subunit 3B -0.0132639
LMAN1 lectin, mannose-binding, 1 -0.0132535
AFF3 AF4/FMR2 family, member 3 -0.0132285
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 -0.0131947
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha -0.0131236
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0131182
MMP2 matrix metallopeptidase 2 -0.0131109
KCNT2 potassium channel, sodium activated subfamily T, member 2 -0.0130779
ZDHHC17 zinc finger, DHHC-type containing 17 -0.0130358
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 -0.0130264
PLCB4 phospholipase C, beta 4 -0.0130056
ABI2 abl-interactor 2 -0.0129465
TNRC6B trinucleotide repeat containing 6B -0.0129315
DICER1 dicer 1, ribonuclease type III -0.0129175
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -0.0129033
ATOSA atos homolog A -0.0129017
EPG5 ectopic P-granules autophagy protein 5 homolog (C. elegans) -0.0128214
HMGA2 high mobility group AT-hook 2 -0.0127577
EIF4B eukaryotic translation initiation factor 4B -0.012694
FRMD4A FERM domain containing 4A -0.0126857
TFRC transferrin receptor -0.0126813
NCOR2 nuclear receptor corepressor 2 -0.0126744
KIRREL1 kirre like nephrin family adhesion molecule 1 -0.0126483
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 -0.0126342
FOXO3 forkhead box O3 -0.0125085
USO1 USO1 vesicle transport factor -0.0124923
PUM2 pumilio RNA-binding family member 2 -0.0123786
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0123767
GOLGA4 golgin A4 -0.0123644
RYK receptor-like tyrosine kinase -0.0123384
SH3RF1 SH3 domain containing ring finger 1 -0.0121753