Clopidogrel_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0720605
DSCAM Down syndrome cell adhesion molecule 0.0684289
INTS6 integrator complex subunit 6 0.0566949
CPEB4 cytoplasmic polyadenylation element binding protein 4 0.044788
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0446147
NRIP1 nuclear receptor interacting protein 1 0.0442932
MAN1A1 mannosidase, alpha, class 1A, member 1 0.0402835
PTBP3 polypyrimidine tract binding protein 3 0.0402037
SMAD3 SMAD family member 3 0.0381362
TXNIP thioredoxin interacting protein 0.0370399
PHF3 PHD finger protein 3 0.034092
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0340446
EXT1 exostosin glycosyltransferase 1 0.0339928
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0337265
IFNGR1 interferon gamma receptor 1 0.0326828
N4BP2L2 NEDD4 binding protein 2-like 2 0.0290413
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0278869
SPRED1 sprouty-related, EVH1 domain containing 1 0.0257001
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0250153
PTEN phosphatase and tensin homolog 0.0229341
MON2 MON2 homolog (S. cerevisiae) 0.0224855
RNF43 ring finger protein 43 0.0224829
COG6 component of oligomeric golgi complex 6 0.022313
ANKRD17 ankyrin repeat domain 17 0.0223061
PRELID2 PRELI domain containing 2 0.0219645
AKAP9 A kinase (PRKA) anchor protein 9 0.0211033
WDR26 WD repeat domain 26 0.0210866
EFNB2 ephrin-B2 0.0206151
APLP2 amyloid beta (A4) precursor-like protein 2 0.0204925
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0203042
PLSCR2 phospholipid scramblase 2 0.0201817
PDZD8 PDZ domain containing 8 0.0197733
RASSF6 Ras association (RalGDS/AF-6) domain family member 6 0.0197677
CHD1 chromodomain helicase DNA binding protein 1 0.0195834
CUL3 cullin 3 0.019044
ZMYM2 zinc finger, MYM-type 2 0.0185082
FNIP1 folliculin interacting protein 1 0.0181694
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0177458
SOD2 superoxide dismutase 2, mitochondrial 0.0169925
COPA coatomer protein complex, subunit alpha 0.01693
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0164959
NCOA3 nuclear receptor coactivator 3 0.0158804
TC2N tandem C2 domains, nuclear 0.0156167
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0155499
RHOBTB3 Rho-related BTB domain containing 3 0.0155152
RFFL ring finger and FYVE-like domain containing E3 ubiquitin protein ligase 0.0154045
ADAM10 ADAM metallopeptidase domain 10 0.0153283
ASPH aspartate beta-hydroxylase 0.0152141
ZNF451 zinc finger protein 451 0.0147982
ARHGAP32 Rho GTPase activating protein 32 0.0147055
KYNU kynureninase 0.014529
SPRED2 sprouty-related, EVH1 domain containing 2 0.0143981
NCKAP5 NCK-associated protein 5 0.0143127
PGK1 phosphoglycerate kinase 1 0.0142937
MEIS2 Meis homeobox 2 0.0142737
TUT7 terminal uridylyl transferase 7 0.0140112
EREG epiregulin 0.013985
EPB41 erythrocyte membrane protein band 4.1 0.0139263
XDH xanthine dehydrogenase 0.0136418
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0135101
MTUS1 microtubule associated tumor suppressor 1 0.0134073
YAP1 Yes-associated protein 1 0.0130598
KDM6A lysine (K)-specific demethylase 6A 0.0130394
CALU calumenin 0.0130357
CTNND1 catenin (cadherin-associated protein), delta 1 0.0130104
NIBAN2 niban apoptosis regulator 2 0.0129929
STAG2 stromal antigen 2 0.0128944
YTHDC1 YTH domain containing 1 0.0128753
HS2ST1 heparan sulfate 2-O-sulfotransferase 1 0.0127966
GOLGA4 golgin A4 0.0127703
KLF5 Kruppel-like factor 5 (intestinal) 0.0127257
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0127082
CD46 CD46 molecule, complement regulatory protein 0.0126859
TM9SF3 transmembrane 9 superfamily member 3 0.0126682
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) 0.0124939
SUCO SUN domain containing ossification factor 0.0124936
TBPL1 TBP-like 1 0.0123372
RPRD2 regulation of nuclear pre-mRNA domain containing 2 0.0122323
SEC24D SEC24 family member D 0.0120961
FRK fyn-related Src family tyrosine kinase 0.0120442
USP12 ubiquitin specific peptidase 12 0.0120266
LIMA1 LIM domain and actin binding 1 0.0119901
TSC22D1 TSC22 domain family, member 1 0.0118503
CNOT2 CCR4-NOT transcription complex, subunit 2 0.0116283
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.011614
CEMIP2 cell migration inducing hyaluronidase 2 0.0116128
SCFD1 sec1 family domain containing 1 0.0115971
ITCH itchy E3 ubiquitin protein ligase 0.0115527
TMEM263 transmembrane protein 263 0.0115019
ZSWIM6 zinc finger, SWIM-type containing 6 0.0114946
SRRM2 serine/arginine repetitive matrix 2 0.0114434
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0114151
RB1CC1 RB1-inducible coiled-coil 1 0.0113506
TNRC6C trinucleotide repeat containing 6C 0.0113362
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0113192
DNMBP dynamin binding protein 0.0112153
PADI1 peptidyl arginine deiminase, type I 0.0112058
SLC30A7 solute carrier family 30 (zinc transporter), member 7 0.0110629
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0110379
ZFP36L1 ZFP36 ring finger protein-like 1 0.0109028

decreased expression

Symbol Name Standardized Value
EPSTI1 epithelial stromal interaction 1 (breast) -0.173309
GMDS GDP-mannose 4,6-dehydratase -0.114109
LYZ lysozyme -0.113872
RNF213 ring finger protein 213 -0.106061
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0952546
ITGA6 integrin, alpha 6 -0.0851958
MX2 MX dynamin-like GTPase 2 -0.0839259
ARHGAP26 Rho GTPase activating protein 26 -0.0818783
RIGI RNA sensor RIG-I -0.0813288
EZR ezrin -0.0793425
GCLC glutamate-cysteine ligase, catalytic subunit -0.0773371
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid) -0.0756169
MX1 MX dynamin-like GTPase 1 -0.0743286
RABGAP1L RAB GTPase activating protein 1-like -0.0719
TSHZ2 teashirt zinc finger homeobox 2 -0.0702124
XAF1 XIAP associated factor 1 -0.0695396
PRKCA protein kinase C, alpha -0.0656718
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0654762
PTMA prothymosin, alpha -0.0649222
LOC102724023 ES1 protein homolog, mitochondrial -0.0641519
SPATA13 spermatogenesis associated 13 -0.0616298
NPSR1 neuropeptide S receptor 1 -0.0596778
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0594085
LCN2 lipocalin 2 -0.0583983
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0578425
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0576105
C6ORF132 chromosome 6 open reading frame 132 -0.0550101
EPHB2 EPH receptor B2 -0.0534337
TPT1 tumor protein, translationally-controlled 1 -0.0532489
MSI2 musashi RNA-binding protein 2 -0.0518463
JUN jun proto-oncogene -0.0514923
MAML2 mastermind-like 2 (Drosophila) -0.0508968
SP100 SP100 nuclear antigen -0.0504777
B2M beta-2-microglobulin -0.0498822
RRBP1 ribosome binding protein 1 -0.0493638
TRIO trio Rho guanine nucleotide exchange factor -0.0476459
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0469546
STS steroid sulfatase (microsomal), isozyme S -0.0463939
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0436671
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0434361
EGR1 early growth response 1 -0.0429505
SQSTM1 sequestosome 1 -0.0424117
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0421324
IFI6 interferon, alpha-inducible protein 6 -0.0418121
RSAD2 radical S-adenosyl methionine domain containing 2 -0.041487
PARP4 poly (ADP-ribose) polymerase family, member 4 -0.0410606
ATP11A ATPase, class VI, type 11A -0.0409536
PLSCR1 phospholipid scramblase 1 -0.0407506
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0406186
ANXA2 annexin A2 -0.0400237
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0395869
ABLIM1 actin binding LIM protein 1 -0.039525
ITPKC inositol-trisphosphate 3-kinase C -0.0391098
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0380261
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0377909
HLA-B major histocompatibility complex, class I, B -0.0368331
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0360994
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -0.0356053
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1 -0.0355109
MYO1E myosin IE -0.0350971
MACC1 metastasis associated in colon cancer 1 -0.0341852
RUNX1 runt-related transcription factor 1 -0.0338161
TMC5 transmembrane channel-like 5 -0.0336823
TRERF1 transcriptional regulating factor 1 -0.0334583
IGF1R insulin-like growth factor 1 receptor -0.0332631
APOL6 apolipoprotein L, 6 -0.0331054
PMP22 peripheral myelin protein 22 -0.0326532
ARHGEF38 Rho guanine nucleotide exchange factor (GEF) 38 -0.0326418
ACTG1 actin gamma 1 -0.0322998
IFI27 interferon, alpha-inducible protein 27 -0.0317351
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0316299
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0310175
IRF1 interferon regulatory factor 1 -0.0305361
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -0.0302961
SAMD9 sterile alpha motif domain containing 9 -0.0301028
TPM4 tropomyosin 4 -0.0297686
HLA-E major histocompatibility complex, class I, E -0.0286114
ATP10B ATPase, class V, type 10B -0.0281276
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0280761
KLF6 Kruppel-like factor 6 -0.0278023
MECOM MDS1 and EVI1 complex locus -0.027722
TMSB10 thymosin beta 10 -0.0275979
RPL19 ribosomal protein L19 -0.0275693
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0275344
ACTN4 actinin, alpha 4 -0.0274358
H1-0 H1.0 linker histone -0.0273363
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 -0.0271852
SAMD9L sterile alpha motif domain containing 9-like -0.0269832
WDR45B WD repeat domain 45B -0.0266411
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide -0.0266226
SPIDR scaffolding protein involved in DNA repair -0.0265837
XRN1 5'-3' exoribonuclease 1 -0.0263961
OASL 2'-5'-oligoadenylate synthetase-like -0.0262819
TFRC transferrin receptor -0.0261704
IGFBP3 insulin-like growth factor binding protein 3 -0.0261013
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0258329
IFIH1 interferon induced with helicase C domain 1 -0.0257228
MACF1 microtubule-actin crosslinking factor 1 -0.0256483
ETV6 ets variant 6 -0.0256148
APP amyloid beta (A4) precursor protein -0.0248999