Clopidogrel_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LMO7 LIM domain 7 0.155181
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.136304
AHNAK AHNAK nucleoprotein 0.123448
CD44 CD44 molecule (Indian blood group) 0.110901
PGK1 phosphoglycerate kinase 1 0.109851
TRIO trio Rho guanine nucleotide exchange factor 0.0970138
MYOF myoferlin 0.0845712
FOXO1 forkhead box O1 0.0837922
TMSB4X thymosin beta 4, X-linked 0.0782678
MTSS1 metastasis suppressor 1 0.0769204
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0744532
CUL4B cullin 4B 0.0734919
PDLIM5 PDZ and LIM domain 5 0.0727356
MYH9 myosin, heavy chain 9, non-muscle 0.0726876
LDHA lactate dehydrogenase A 0.0711241
H1-0 H1.0 linker histone 0.0658955
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0604266
RBM39 RNA binding motif protein 39 0.0603122
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.059933
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0587
FLNB filamin B, beta 0.0584661
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0517291
VCL vinculin 0.05119
ASPH aspartate beta-hydroxylase 0.0501389
TIMP3 TIMP metallopeptidase inhibitor 3 0.0500661
CANX calnexin 0.0494644
ANLN anillin, actin binding protein 0.0489525
EMP1 epithelial membrane protein 1 0.0488303
RAI14 retinoic acid induced 14 0.0485754
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0484603
EXT1 exostosin glycosyltransferase 1 0.048015
MACF1 microtubule-actin crosslinking factor 1 0.0478174
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0477669
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0475678
JMJD1C jumonji domain containing 1C 0.0467451
CTNND1 catenin (cadherin-associated protein), delta 1 0.0443315
NRIP1 nuclear receptor interacting protein 1 0.0437904
OSMR oncostatin M receptor 0.0437297
AOPEP aminopeptidase O (putative) 0.043559
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0431324
NCOA3 nuclear receptor coactivator 3 0.0420848
RASAL2 RAS protein activator like 2 0.0414968
AKAP13 A kinase (PRKA) anchor protein 13 0.0410017
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.040724
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0405467
APP amyloid beta (A4) precursor protein 0.0405106
SOD2 superoxide dismutase 2, mitochondrial 0.0403704
OGA O-GlcNAcase 0.0402787
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0398745
YBX3 Y box binding protein 3 0.0386029
RAB10 RAB10, member RAS oncogene family 0.0384533
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0383787
DIAPH1 diaphanous-related formin 1 0.0379707
SLC45A4 solute carrier family 45, member 4 0.037362
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0372017
UBC ubiquitin C 0.0369441
ITCH itchy E3 ubiquitin protein ligase 0.0369308
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0368375
HLA-E major histocompatibility complex, class I, E 0.0363366
COPA coatomer protein complex, subunit alpha 0.0363312
NEK7 NIMA-related kinase 7 0.0357848
SQLE squalene epoxidase 0.0355658
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0352867
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0350179
IQGAP1 IQ motif containing GTPase activating protein 1 0.0349594
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0349087
COPB1 coatomer protein complex, subunit beta 1 0.0345703
HDLBP high density lipoprotein binding protein 0.0344463
ANXA2 annexin A2 0.0342992
INTS6 integrator complex subunit 6 0.0340369
PICALM phosphatidylinositol binding clathrin assembly protein 0.0339424
MBNL1 muscleblind-like splicing regulator 1 0.0336074
TPT1 tumor protein, translationally-controlled 1 0.0335489
DUSP6 dual specificity phosphatase 6 0.0335172
PDE4D phosphodiesterase 4D, cAMP-specific 0.0334952
SMAD3 SMAD family member 3 0.0332195
STAU1 staufen double-stranded RNA binding protein 1 0.0330421
PSD3 pleckstrin and Sec7 domain containing 3 0.0327131
SERINC3 serine incorporator 3 0.0326195
NRG1 neuregulin 1 0.032588
SEPTIN9 septin 9 0.0323114
ENO1 enolase 1, (alpha) 0.0321812
ANKRD33B ankyrin repeat domain 33B 0.0321046
PTK2 protein tyrosine kinase 2 0.0320338
FNIP1 folliculin interacting protein 1 0.0319438
KTN1 kinectin 1 (kinesin receptor) 0.0318193
ITSN1 intersectin 1 (SH3 domain protein) 0.0316614
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0312475
NAMPT nicotinamide phosphoribosyltransferase 0.0312198
NDRG1 N-myc downstream regulated 1 0.0308362
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0307487
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 0.0306125
BMAL2 basic helix-loop-helix ARNT like 2 0.0305953
ANKRD10 ankyrin repeat domain 10 0.0305727
RAD21 RAD21 homolog (S. pombe) 0.0300821
BCAR3 breast cancer anti-estrogen resistance 3 0.0299248
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0297276
STK4 serine/threonine kinase 4 0.0290424
WASF2 WAS protein family, member 2 0.0288389
NAP1L1 nucleosome assembly protein 1-like 1 0.0287021

decreased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F -0.0637715
HSPG2 heparan sulfate proteoglycan 2 -0.0543169
TMSB10 thymosin beta 10 -0.0510252
SLCO4A1 solute carrier organic anion transporter family, member 4A1 -0.0435197
LAMA5 laminin, alpha 5 -0.0379087
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0302034
IFITM3 interferon induced transmembrane protein 3 -0.0301157
S100A2 S100 calcium binding protein A2 -0.027341
TGM2 transglutaminase 2 -0.0266538
PFN1 profilin 1 -0.0266367
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0264314
HMGA1 high mobility group AT-hook 1 -0.0256664
GNAS GNAS complex locus -0.0255757
RPS19 ribosomal protein S19 -0.025339
CYB5R3 cytochrome b5 reductase 3 -0.0246151
RPLP1 ribosomal protein, large, P1 -0.0237948
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 -0.0233596
MEF2A myocyte enhancer factor 2A -0.0228792
MT2A metallothionein 2A -0.0220872
RPS27 ribosomal protein S27 -0.0215516
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0214764
PCDH1 protocadherin 1 -0.021457
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0212728
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.0202766
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.019546
RPS2 ribosomal protein S2 -0.019478
GUK1 guanylate kinase 1 -0.0193932
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0189993
PCBP2 poly(rC) binding protein 2 -0.0188043
RPL28 ribosomal protein L28 -0.0187488
SEC61G Sec61 gamma subunit -0.0186996
TINAGL1 tubulointerstitial nephritis antigen-like 1 -0.0185828
RPL37A ribosomal protein L37a -0.0185387
RPS12 ribosomal protein S12 -0.018151
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0180498
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0179407
RPL35 ribosomal protein L35 -0.0176694
S100A9 S100 calcium binding protein A9 -0.0174481
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0173294
LRRC8A leucine rich repeat containing 8 family, member A -0.0171178
ZMIZ2 zinc finger, MIZ-type containing 2 -0.016455
FOSL1 FOS-like antigen 1 -0.0160848
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.0160806
RPS21 ribosomal protein S21 -0.0160183
MIDEAS mitotic deacetylase associated SANT domain protein -0.0157
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0156397
TAGLN2 transgelin 2 -0.0154577
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 -0.0152773
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0151583
RPL36 ribosomal protein L36 -0.0149043
SERTAD2 SERTA domain containing 2 -0.0148274
ISG15 ISG15 ubiquitin-like modifier -0.0146379
DSTN destrin (actin depolymerizing factor) -0.0145113
FTL ferritin, light polypeptide -0.0143974
RPS17 ribosomal protein S17 -0.0143484
ZNF292 zinc finger protein 292 -0.0142925
FBXO42 F-box protein 42 -0.0142878
SPINK5 serine peptidase inhibitor, Kazal type 5 -0.0140998
RPL5 ribosomal protein L5 -0.0138533
IFI44L interferon-induced protein 44-like -0.0137731
HDGF hepatoma-derived growth factor -0.0136708
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -0.0136571
PTMA prothymosin, alpha -0.0134149
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -0.0133447
MIER1 mesoderm induction early response 1, transcriptional regulator -0.0133143
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0132831
RNF24 ring finger protein 24 -0.0132479
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0132203
TP73 tumor protein p73 -0.0131851
EIF5B eukaryotic translation initiation factor 5B -0.012994
GATA6 GATA binding protein 6 -0.0128885
RPLP2 ribosomal protein, large, P2 -0.0127962
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) -0.0127674
BSG basigin (Ok blood group) -0.0125597
ANKRD11 ankyrin repeat domain 11 -0.012504
TBC1D2 TBC1 domain family, member 2 -0.0124817
RPL18 ribosomal protein L18 -0.0123808
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0123164
RPS20 ribosomal protein S20 -0.0122373
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0121575
VPS72 vacuolar protein sorting 72 homolog (S. cerevisiae) -0.0121368
RPS6 ribosomal protein S6 -0.0120945
GARS1 glycyl-tRNA synthetase 1 -0.0120606
RPS14 ribosomal protein S14 -0.0120459
NECTIN1 nectin cell adhesion molecule 1 -0.0117791
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.0116789
CDCP1 CUB domain containing protein 1 -0.0116521
RNASEH2A ribonuclease H2, subunit A -0.0113651
RPL27 ribosomal protein L27 -0.0112431
CYBA cytochrome b-245, alpha polypeptide -0.0112265
EEF2 eukaryotic translation elongation factor 2 -0.011172
EHD4 EH-domain containing 4 -0.0110761
RPL35A ribosomal protein L35a -0.0110698
RPS29 ribosomal protein S29 -0.0110577
SAMHD1 SAM domain and HD domain 1 -0.0110447
SMC4 structural maintenance of chromosomes 4 -0.0110046
PKM pyruvate kinase, muscle -0.0109692
RPL9 ribosomal protein L9 -0.0109628
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0109545
MEF2D myocyte enhancer factor 2D -0.010948