Clopidogrel_KATO III Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in KATO III cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FGFR2 fibroblast growth factor receptor 2 0.430522
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.139648
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.105456
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.104401
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0710573
S100A6 S100 calcium binding protein A6 0.0677965
B2M beta-2-microglobulin 0.0667262
GOLGA4 golgin A4 0.0575457
PGK1 phosphoglycerate kinase 1 0.05676
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0518656
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0503737
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0496231
NPSR1 neuropeptide S receptor 1 0.0485635
PDIA6 protein disulfide isomerase family A, member 6 0.0470112
EIF1 eukaryotic translation initiation factor 1 0.0431263
RPS6 ribosomal protein S6 0.0391001
AKAP9 A kinase (PRKA) anchor protein 9 0.0387171
PABPC1 poly(A) binding protein, cytoplasmic 1 0.038028
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0378349
TMC5 transmembrane channel-like 5 0.0373965
PTMA prothymosin, alpha 0.037318
DSCAM Down syndrome cell adhesion molecule 0.0361438
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0356462
KRT18 keratin 18, type I 0.0356422
PDIA3 protein disulfide isomerase family A, member 3 0.0355542
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0336572
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0333716
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0331211
FTH1 ferritin, heavy polypeptide 1 0.0318703
TES testin LIM domain protein 0.0318513
H1-0 H1.0 linker histone 0.0314848
CEMIP cell migration inducing protein, hyaluronan binding 0.0313372
TMEM123 transmembrane protein 123 0.0310264
HYOU1 hypoxia up-regulated 1 0.0310138
CD46 CD46 molecule, complement regulatory protein 0.0307823
EPCAM epithelial cell adhesion molecule 0.0306435
BIRC6 baculoviral IAP repeat containing 6 0.0304419
MBNL2 muscleblind-like splicing regulator 2 0.029812
ITGA6 integrin, alpha 6 0.0286796
ADAM9 ADAM metallopeptidase domain 9 0.0286665
TMF1 TATA element modulatory factor 1 0.0285526
CALR calreticulin 0.0282384
EIF4A2 eukaryotic translation initiation factor 4A2 0.0275524
WWC1 WW and C2 domain containing 1 0.0275299
TMSB4X thymosin beta 4, X-linked 0.0274712
MGAM2 maltase-glucoamylase 2 (putative) 0.0272147
DSPP dentin sialophosphoprotein 0.0267063
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0260724
AGR2 anterior gradient 2 0.0256273
RAD21 RAD21 homolog (S. pombe) 0.0254215
ZCCHC7 zinc finger, CCHC domain containing 7 0.0250689
MACF1 microtubule-actin crosslinking factor 1 0.0248342
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0246047
CLTC clathrin, heavy chain (Hc) 0.024215
UGCG UDP-glucose ceramide glucosyltransferase 0.0239991
WDR45B WD repeat domain 45B 0.0239651
ANLN anillin, actin binding protein 0.0238199
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.0237714
SSR1 signal sequence receptor, alpha 0.0234723
FNDC3B fibronectin type III domain containing 3B 0.0234621
SOS1 son of sevenless homolog 1 (Drosophila) 0.0230723
TTC3 tetratricopeptide repeat domain 3 0.0230633
HM13 histocompatibility (minor) 13 0.023029
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0228879
LIMA1 LIM domain and actin binding 1 0.0227925
ENO1 enolase 1, (alpha) 0.0227642
CTNND1 catenin (cadherin-associated protein), delta 1 0.0227132
KTN1 kinectin 1 (kinesin receptor) 0.0226986
CD164 CD164 molecule, sialomucin 0.022064
AVL9 AVL9 homolog (S. cerevisiase) 0.0219859
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0219519
ARCN1 archain 1 0.021813
UBE4A ubiquitination factor E4A 0.0216527
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0215875
C6ORF62 chromosome 6 open reading frame 62 0.0213917
ARHGAP32 Rho GTPase activating protein 32 0.0211409
TXNRD1 thioredoxin reductase 1 0.0210839
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0210629
MYOF myoferlin 0.020902
CANX calnexin 0.0208414
SET SET nuclear proto-oncogene 0.0208363
AOPEP aminopeptidase O (putative) 0.0205023
ZNF292 zinc finger protein 292 0.0204356
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0203939
SRRM2 serine/arginine repetitive matrix 2 0.020208
MED13 mediator complex subunit 13 0.019933
GARS1 glycyl-tRNA synthetase 1 0.0199196
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0198971
RAI1 retinoic acid induced 1 0.019776
TPM4 tropomyosin 4 0.0195529
RPS3 ribosomal protein S3 0.0193456
PRSS3 protease, serine, 3 0.0193052
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.019059
CDK6 cyclin-dependent kinase 6 0.0190077
RPS12 ribosomal protein S12 0.0188189
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0187124
BAIAP2L1 BAI1-associated protein 2-like 1 0.0186881
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0186877
S100A11 S100 calcium binding protein A11 0.0185231
C1GALT1 core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 0.0184503

decreased expression

Symbol Name Standardized Value
EMP1 epithelial membrane protein 1 -0.0298442
TMSB10 thymosin beta 10 -0.0271264
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0192013
VCL vinculin -0.0187591
HLA-C major histocompatibility complex, class I, C -0.0185626
ACTN4 actinin, alpha 4 -0.0171975
FUS FUS RNA binding protein -0.0151596
TRPS1 trichorhinophalangeal syndrome I -0.0137901
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0136082
INTS6 integrator complex subunit 6 -0.013577
TPT1 tumor protein, translationally-controlled 1 -0.0128297
PCDH7 protocadherin 7 -0.0125152
EZR ezrin -0.0124338
PDLIM5 PDZ and LIM domain 5 -0.0119013
KRT86 keratin 86, type II -0.011843
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.011803
ACTG1 actin gamma 1 -0.0115555
CATSPERB catsper channel auxiliary subunit beta -0.011396
UBASH3B ubiquitin associated and SH3 domain containing B -0.0110586
ST14 suppression of tumorigenicity 14 (colon carcinoma) -0.0109047
EGR1 early growth response 1 -0.0103293
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.010112
KLF6 Kruppel-like factor 6 -0.010034
NR4A1 nuclear receptor subfamily 4, group A, member 1 -0.010013
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0099898
NCOA7 nuclear receptor coactivator 7 -0.00994878
XAF1 XIAP associated factor 1 -0.00966595
TLE4 transducin-like enhancer of split 4 -0.00944792
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 -0.00944459
NDRG1 N-myc downstream regulated 1 -0.00906476
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.00889546
WWOX WW domain containing oxidoreductase -0.00889293
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.00874501
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.00859172
PLSCR2 phospholipid scramblase 2 -0.00853799
POF1B premature ovarian failure, 1B -0.00847701
IL1RAP interleukin 1 receptor accessory protein -0.00847248
MX1 MX dynamin-like GTPase 1 -0.00845845
RPL38 ribosomal protein L38 -0.00811462
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.00806049
STK17A serine/threonine kinase 17a -0.00783437
MAML3 mastermind-like 3 (Drosophila) -0.00780578
RSAD2 radical S-adenosyl methionine domain containing 2 -0.00770182
COTL1 coactosin-like F-actin binding protein 1 -0.00758584
NABP1 nucleic acid binding protein 1 -0.00750613
FHL2 four and a half LIM domains 2 -0.0073891
VAV2 vav 2 guanine nucleotide exchange factor -0.00738335
MAGI3 membrane associated guanylate kinase, WW and PDZ domain containing 3 -0.00732991
SPTAN1 spectrin, alpha, non-erythrocytic 1 -0.007238
ABLIM2 actin binding LIM protein family, member 2 -0.00721416
FASN fatty acid synthase -0.00715197
HSPA8 heat shock 70kDa protein 8 -0.00711636
IGF1R insulin-like growth factor 1 receptor -0.00707665
NINL ninein-like -0.00692699
PIWIL4 piwi-like RNA-mediated gene silencing 4 -0.00687424
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.00683415
EFNB2 ephrin-B2 -0.00678321
TIAM2 T-cell lymphoma invasion and metastasis 2 -0.00677067
IFRD1 interferon-related developmental regulator 1 -0.00661748
ERRFI1 ERBB receptor feedback inhibitor 1 -0.00653028
CFAP161 cilia and flagella associated protein 161 -0.00650629
ATF7IP2 activating transcription factor 7 interacting protein 2 -0.00640596
RIGI RNA sensor RIG-I -0.00635022
LAMA5 laminin, alpha 5 -0.00626875
FLOT1 flotillin 1 -0.0062341
STAT2 signal transducer and activator of transcription 2, 113kDa -0.0061517
TNS4 tensin 4 -0.00613072
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit -0.0060797
TUBB4B tubulin, beta 4B class IVb -0.00602
FLNA filamin A, alpha -0.00599719
BTBD9 BTB (POZ) domain containing 9 -0.00597998
WDPCP WD repeat containing planar cell polarity effector -0.00592771
EPPK1 epiplakin 1 -0.00592464
RNF213 ring finger protein 213 -0.00583821
AMZ1 archaelysin family metallopeptidase 1 -0.00578654
TRIO trio Rho guanine nucleotide exchange factor -0.00578502
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.00578461
DOCK1 dedicator of cytokinesis 1 -0.00575096
LOC112694756 uncharaterized LOC112694756 -0.00573596
SKAP1 src kinase associated phosphoprotein 1 -0.0056992
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.00569753
RPS15 ribosomal protein S15 -0.00563268
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.00560376
AHNAK2 AHNAK nucleoprotein 2 -0.0055496
MX2 MX dynamin-like GTPase 2 -0.00553833
PBX3 pre-B-cell leukemia homeobox 3 -0.00551738
CMPK2 cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial -0.0054869
RPL28 ribosomal protein L28 -0.00543563
RPL27 ribosomal protein L27 -0.00542021
NCEH1 neutral cholesterol ester hydrolase 1 -0.00540853
AXIN2 axin 2 -0.00532467
TRA2B transformer 2 beta homolog (Drosophila) -0.00527882
SPIDR scaffolding protein involved in DNA repair -0.00520673
EXOSC3 exosome component 3 -0.00518259
MECOM MDS1 and EVI1 complex locus -0.00513218
NOP56 NOP56 ribonucleoprotein -0.00512052
LAMP1 lysosomal-associated membrane protein 1 -0.00509938
MUC17 mucin 17, cell surface associated -0.00509241
HSPB1 heat shock 27kDa protein 1 -0.00509193
STXBP5 syntaxin binding protein 5 (tomosyn) -0.00505904