Clopidogrel_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.212386
NPSR1 neuropeptide S receptor 1 0.114939
KRT18 keratin 18, type I 0.114173
TXNIP thioredoxin interacting protein 0.100456
PPARG peroxisome proliferator-activated receptor gamma 0.0933915
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0903638
ITGA6 integrin, alpha 6 0.087608
ANXA2 annexin A2 0.0820957
PGK1 phosphoglycerate kinase 1 0.0791579
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0772545
NDRG1 N-myc downstream regulated 1 0.0762967
GREB1L growth regulation by estrogen in breast cancer-like 0.0681757
MACF1 microtubule-actin crosslinking factor 1 0.0667187
PERP PERP, TP53 apoptosis effector 0.0667164
LDHA lactate dehydrogenase A 0.0659722
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0656781
ASPH aspartate beta-hydroxylase 0.0611727
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0611544
BAIAP2L1 BAI1-associated protein 2-like 1 0.0611496
DSPP dentin sialophosphoprotein 0.0610992
S100A6 S100 calcium binding protein A6 0.0610589
RPS6 ribosomal protein S6 0.0594734
FLNB filamin B, beta 0.0592876
ESYT2 extended synaptotagmin-like protein 2 0.0569679
CD46 CD46 molecule, complement regulatory protein 0.0568238
PRSS3 protease, serine, 3 0.0565494
TPM4 tropomyosin 4 0.0564511
ALCAM activated leukocyte cell adhesion molecule 0.0561431
EREG epiregulin 0.0556244
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0547801
FTH1 ferritin, heavy polypeptide 1 0.0528356
PTMA prothymosin, alpha 0.0515387
PTPRR protein tyrosine phosphatase, receptor type, R 0.0507093
CEMIP cell migration inducing protein, hyaluronan binding 0.0506096
ARHGAP32 Rho GTPase activating protein 32 0.0504775
EPCAM epithelial cell adhesion molecule 0.0502013
BIRC6 baculoviral IAP repeat containing 6 0.0498825
PSD3 pleckstrin and Sec7 domain containing 3 0.0498071
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0495127
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0490454
TMEM45B transmembrane protein 45B 0.0474641
KLF3 Kruppel-like factor 3 (basic) 0.0468728
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0465863
PATJ PATJ crumbs cell polarity complex component 0.0463629
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0455702
PTBP3 polypyrimidine tract binding protein 3 0.045542
NALF1 NALCN channel auxiliary factor 1 0.045343
H1-0 H1.0 linker histone 0.0450784
RNF217 ring finger protein 217 0.0444705
TPT1 tumor protein, translationally-controlled 1 0.0443807
RPLP0 ribosomal protein, large, P0 0.0440803
RPL35A ribosomal protein L35a 0.0436287
TNS4 tensin 4 0.043119
LGALS4 lectin, galactoside-binding, soluble, 4 0.0430898
CCNY cyclin Y 0.0424444
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 0.0423773
ABHD17C abhydrolase domain containing 17C 0.0422617
EZR ezrin 0.0420518
CD44 CD44 molecule (Indian blood group) 0.041988
CALB1 calbindin 1, 28kDa 0.0413549
AREG amphiregulin 0.0408615
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0404564
LMO7 LIM domain 7 0.0394961
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0391255
SH3D19 SH3 domain containing 19 0.0390637
KRT19 keratin 19, type I 0.0383484
MLEC malectin 0.0382152
LPP LIM domain containing preferred translocation partner in lipoma 0.0365115
PRELID2 PRELI domain containing 2 0.0364173
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0364124
MT2A metallothionein 2A 0.0363489
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.0362024
CD164 CD164 molecule, sialomucin 0.0359535
TJP2 tight junction protein 2 0.0356114
FERMT1 fermitin family member 1 0.0352799
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0351582
GCC2 GRIP and coiled-coil domain containing 2 0.0346924
TFF3 trefoil factor 3 (intestinal) 0.034386
ABHD2 abhydrolase domain containing 2 0.0340496
ANTXR2 anthrax toxin receptor 2 0.0337753
ATP8B1 ATPase, aminophospholipid transporter, class I, type 8B, member 1 0.0330617
UBA6 ubiquitin-like modifier activating enzyme 6 0.0325407
TMEM123 transmembrane protein 123 0.0322497
MAML3 mastermind-like 3 (Drosophila) 0.0313933
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.031372
KIF13A kinesin family member 13A 0.0309785
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0309113
IER3 immediate early response 3 0.0307334
MED13 mediator complex subunit 13 0.0306846
CAB39 calcium binding protein 39 0.0302944
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0300467
PARD3 par-3 family cell polarity regulator 0.0299821
AKAP13 A kinase (PRKA) anchor protein 13 0.0295393
TMSB4X thymosin beta 4, X-linked 0.0294569
ITPRID2 ITPR interacting domain containing 2 0.0294403
LIMA1 LIM domain and actin binding 1 0.0294245
CD2AP CD2-associated protein 0.0291888
MYOF myoferlin 0.0290929
FNBP1L formin binding protein 1-like 0.0289217
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0285532

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.218787
EEF2 eukaryotic translation elongation factor 2 -0.119133
RPS27A ribosomal protein S27a -0.0862394
PDIA4 protein disulfide isomerase family A, member 4 -0.0802205
UBC ubiquitin C -0.0758777
CALR calreticulin -0.0643194
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0616556
TMSB10 thymosin beta 10 -0.0586558
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.047001
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0436691
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0425539
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0421655
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0416536
PCBP2 poly(rC) binding protein 2 -0.0355441
KITLG KIT ligand -0.0350577
CEMIP2 cell migration inducing hyaluronidase 2 -0.0340215
NEBL nebulette -0.0334875
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0327855
RPL23 ribosomal protein L23 -0.0327402
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0319215
GOLGB1 golgin B1 -0.0315792
PDIA3 protein disulfide isomerase family A, member 3 -0.0309532
ZFAND3 zinc finger, AN1-type domain 3 -0.0308191
COG5 component of oligomeric golgi complex 5 -0.0306054
PDZD8 PDZ domain containing 8 -0.0299521
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.029671
ATF3 activating transcription factor 3 -0.0283892
ANKRD11 ankyrin repeat domain 11 -0.0278124
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0275233
MON2 MON2 homolog (S. cerevisiae) -0.027392
MBNL2 muscleblind-like splicing regulator 2 -0.0264279
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0263254
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0259505
WDR43 WD repeat domain 43 -0.0257964
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0257098
GOLGA4 golgin A4 -0.0253121
EWSR1 EWS RNA-binding protein 1 -0.0252934
GARS1 glycyl-tRNA synthetase 1 -0.0250832
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) -0.0243622
RRBP1 ribosome binding protein 1 -0.0240721
HYOU1 hypoxia up-regulated 1 -0.0239357
IARS1 isoleucyl-tRNA synthetase 1 -0.0238876
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0238414
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 -0.0238224
RPL3 ribosomal protein L3 -0.0234478
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0230929
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0229238
RPL5 ribosomal protein L5 -0.022785
ADGRV1 adhesion G protein-coupled receptor V1 -0.0220605
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0220438
ZFC3H1 zinc finger, C3H1-type containing -0.0220203
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0219709
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.021852
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0216215
FDXR ferredoxin reductase -0.0216175
PTPRG protein tyrosine phosphatase, receptor type, G -0.0215881
MCTP2 multiple C2 domains, transmembrane 2 -0.0215386
SARAF store-operated calcium entry-associated regulatory factor -0.0213107
KDM3A lysine (K)-specific demethylase 3A -0.0211279
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0206328
FNDC3A fibronectin type III domain containing 3A -0.0205933
PSAT1 phosphoserine aminotransferase 1 -0.0204928
SRP54 signal recognition particle 54kDa -0.0204908
HDLBP high density lipoprotein binding protein -0.0204871
ADARB1 adenosine deaminase, RNA-specific, B1 -0.0202519
BRD2 bromodomain containing 2 -0.0201483
HBP1 HMG-box transcription factor 1 -0.0201229
XPC xeroderma pigmentosum, complementation group C -0.0197091
TNRC18 trinucleotide repeat containing 18 -0.0196817
SFPQ splicing factor proline/glutamine-rich -0.0195996
RBM39 RNA binding motif protein 39 -0.0195718
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0194876
SEL1L sel-1 suppressor of lin-12-like (C. elegans) -0.0194661
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) -0.0194578
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0193706
CFAP73 cilia and flagella associated protein 73 -0.0190191
ISG15 ISG15 ubiquitin-like modifier -0.0188033
SENP5 SUMO1/sentrin specific peptidase 5 -0.0185821
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.018482
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0184752
KDM4B lysine (K)-specific demethylase 4B -0.0183681
TMCO3 transmembrane and coiled-coil domains 3 -0.018312
NPR2 natriuretic peptide receptor 2 -0.0182655
SUPT6H suppressor of Ty 6 homolog (S. cerevisiae) -0.0180538
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0180465
PDIA5 protein disulfide isomerase family A, member 5 -0.0180244
FOXN3 forkhead box N3 -0.0179839
JUN jun proto-oncogene -0.017869
TAF3 TAF3 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 140kDa -0.0178064
SLC10A7 solute carrier family 10, member 7 -0.0177748
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0177155
SAFB2 scaffold attachment factor B2 -0.0176225
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 -0.0176132
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0175341
TRAPPC9 trafficking protein particle complex 9 -0.0174828
CHRM3 cholinergic receptor, muscarinic 3 -0.0174201
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0173045
ATF6 activating transcription factor 6 -0.0172591
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0171917
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0170454