Clopidogrel_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.29624
DST dystonin 0.182736
MT2A metallothionein 2A 0.114868
PSD3 pleckstrin and Sec7 domain containing 3 0.11313
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0897268
RAI1 retinoic acid induced 1 0.0887961
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0864178
CD44 CD44 molecule (Indian blood group) 0.0825756
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0777102
CAPRIN2 caprin family member 2 0.0740741
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0695978
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0686602
MACF1 microtubule-actin crosslinking factor 1 0.0671891
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0668436
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0533812
ARHGAP5 Rho GTPase activating protein 5 0.0529194
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0524434
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0514652
KTN1 kinectin 1 (kinesin receptor) 0.0512989
BCAR3 breast cancer anti-estrogen resistance 3 0.0511891
CENPF centromere protein F, 350/400kDa 0.0510543
TP63 tumor protein p63 0.0505933
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0494468
PRELID2 PRELI domain containing 2 0.0492393
ADAM10 ADAM metallopeptidase domain 10 0.0484975
PTMA prothymosin, alpha 0.0480923
ANGPTL4 angiopoietin-like 4 0.0478158
SLC38A2 solute carrier family 38, member 2 0.0473506
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0457483
GCNT2 glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) 0.0454683
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0453992
LDHA lactate dehydrogenase A 0.0438751
TSC22D1 TSC22 domain family, member 1 0.0434799
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0434452
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0434424
TMSB4X thymosin beta 4, X-linked 0.0430569
TRIP12 thyroid hormone receptor interactor 12 0.0428655
SOD2 superoxide dismutase 2, mitochondrial 0.0427746
FNIP1 folliculin interacting protein 1 0.0426781
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.042423
RAD51B RAD51 paralog B 0.0415537
PDE10A phosphodiesterase 10A 0.0412374
RAB27B RAB27B, member RAS oncogene family 0.0406844
PGK1 phosphoglycerate kinase 1 0.0392748
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0384661
ANKRD12 ankyrin repeat domain 12 0.0381761
RPS8 ribosomal protein S8 0.0375799
VCL vinculin 0.0371769
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.037125
ESYT2 extended synaptotagmin-like protein 2 0.037083
ERRFI1 ERBB receptor feedback inhibitor 1 0.0367823
RPS12 ribosomal protein S12 0.0366159
HDAC9 histone deacetylase 9 0.0361738
DOCK11 dedicator of cytokinesis 11 0.0355751
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0353922
LPP LIM domain containing preferred translocation partner in lipoma 0.035231
MT1E metallothionein 1E 0.0349171
SMYD3 SET and MYND domain containing 3 0.0346777
FMNL2 formin-like 2 0.0343433
DSCAM Down syndrome cell adhesion molecule 0.0333121
CSMD3 CUB and Sushi multiple domains 3 0.0330759
WWTR1 WW domain containing transcription regulator 1 0.0330717
RPS6 ribosomal protein S6 0.0330105
PTK2 protein tyrosine kinase 2 0.0329711
ADAM17 ADAM metallopeptidase domain 17 0.0327298
GPAT3 glycerol-3-phosphate acyltransferase 3 0.032522
SDK1 sidekick cell adhesion molecule 1 0.0318762
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0315533
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0314819
ENO1 enolase 1, (alpha) 0.0312698
SRSF11 serine/arginine-rich splicing factor 11 0.0310967
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0303471
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.030313
RPS18 ribosomal protein S18 0.0298709
MYH9 myosin, heavy chain 9, non-muscle 0.0297934
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0295457
WARS1 tryptophanyl-tRNA synthetase 1 0.0294971
EREG epiregulin 0.0292176
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0283071
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0282599
KMT2E lysine (K)-specific methyltransferase 2E 0.0279698
SLK STE20-like kinase 0.0278953
CSNK1A1 casein kinase 1, alpha 1 0.0273672
RPL26 ribosomal protein L26 0.0270573
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0268945
ZNF292 zinc finger protein 292 0.026789
AFF4 AF4/FMR2 family, member 4 0.0267455
LOXL2 lysyl oxidase-like 2 0.0266255
CDK19 cyclin-dependent kinase 19 0.0265255
IFI6 interferon, alpha-inducible protein 6 0.0264137
EXOC4 exocyst complex component 4 0.0261998
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0260827
RTTN rotatin 0.025992
ZFP36L1 ZFP36 ring finger protein-like 1 0.0256808
BABAM2 BRISC and BRCA1 A complex member 2 0.0256073
PIAS2 protein inhibitor of activated STAT, 2 0.0255582
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0254632
CMIP c-Maf inducing protein 0.0254193
SETD5 SET domain containing 5 0.0253205
RPS3 ribosomal protein S3 0.0250117

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.209879
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.141085
TMSB10 thymosin beta 10 -0.058637
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0450001
LOC112694756 uncharaterized LOC112694756 -0.0380846
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0366021
ACTG1 actin gamma 1 -0.0308968
TFRC transferrin receptor -0.0305228
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0296249
FUS FUS RNA binding protein -0.0271057
FTL ferritin, light polypeptide -0.0260548
KDM3A lysine (K)-specific demethylase 3A -0.025624
NPR2 natriuretic peptide receptor 2 -0.0250754
FTH1 ferritin, heavy polypeptide 1 -0.0248141
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0240251
GARS1 glycyl-tRNA synthetase 1 -0.0219161
GNAS GNAS complex locus -0.0218953
EEF2 eukaryotic translation elongation factor 2 -0.0217492
TXNRD1 thioredoxin reductase 1 -0.0193633
IARS1 isoleucyl-tRNA synthetase 1 -0.0192875
RPL38 ribosomal protein L38 -0.0191431
RPL8 ribosomal protein L8 -0.0184572
LRRC23 leucine rich repeat containing 23 -0.0175209
EIF1 eukaryotic translation initiation factor 1 -0.0174261
TSC22D2 TSC22 domain family, member 2 -0.0170366
CAVIN1 caveolae associated protein 1 -0.0168135
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.016572
ASTN2 astrotactin 2 -0.0157263
RAB7A RAB7A, member RAS oncogene family -0.0153525
WDR45B WD repeat domain 45B -0.0152033
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0144307
KCMF1 potassium channel modulatory factor 1 -0.0135034
TNFRSF10D tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain -0.0134707
CKS2 CDC28 protein kinase regulatory subunit 2 -0.01324
PSMC6 proteasome (prosome, macropain) 26S subunit, ATPase, 6 -0.0132087
INTS6 integrator complex subunit 6 -0.0130929
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0130115
HMGA1 high mobility group AT-hook 1 -0.0129454
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0129106
RPS10 ribosomal protein S10 -0.0127953
JUN jun proto-oncogene -0.0127141
SRSF7 serine/arginine-rich splicing factor 7 -0.0121882
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0120646
ARF1 ADP-ribosylation factor 1 -0.0120601
RLF rearranged L-myc fusion -0.0119536
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0118783
SEPTIN7 septin 7 -0.0117687
IFRD1 interferon-related developmental regulator 1 -0.0115734
POTEF POTE ankyrin domain family, member F -0.0115611
FOXK2 forkhead box K2 -0.011469
POU2F1 POU class 2 homeobox 1 -0.0114594
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0112757
RPL6 ribosomal protein L6 -0.0109558
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0109047
HDLBP high density lipoprotein binding protein -0.0105238
MEMO1 mediator of cell motility 1 -0.0104473
TXNL1 thioredoxin-like 1 -0.010404
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) -0.0100313
KIF5B kinesin family member 5B -0.00990563
RPS20 ribosomal protein S20 -0.00977662
SGK1 serum/glucocorticoid regulated kinase 1 -0.00974254
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.00972202
RPS15 ribosomal protein S15 -0.00951635
PNRC1 proline-rich nuclear receptor coactivator 1 -0.00940449
FBXL2 F-box and leucine-rich repeat protein 2 -0.00935306
VDAC3 voltage-dependent anion channel 3 -0.00933581
LMAN1 lectin, mannose-binding, 1 -0.00926112
NEK10 NIMA-related kinase 10 -0.00925133
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.00901805
PPP6R2 protein phosphatase 6, regulatory subunit 2 -0.00887143
GTF2IRD1 GTF2I repeat domain containing 1 -0.00884902
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.00884696
UBE2I ubiquitin-conjugating enzyme E2I -0.0088442
PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 -0.00881777
GTF2B general transcription factor IIB -0.00862242
TMEM123 transmembrane protein 123 -0.00861965
VKORC1L1 vitamin K epoxide reductase complex, subunit 1-like 1 -0.00858002
SLC9A1 solute carrier family 9, subfamily A (NHE1, cation proton antiporter 1), member 1 -0.00853183
MYC v-myc avian myelocytomatosis viral oncogene homolog -0.00850349
EGR1 early growth response 1 -0.00835853
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.00828489
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.00826551
BZW2 basic leucine zipper and W2 domains 2 -0.00821804
HMGB1 high mobility group box 1 -0.00821033
NF1 neurofibromin 1 -0.00819618
GUK1 guanylate kinase 1 -0.00815506
ALKBH5 AlkB family member 5, RNA demethylase -0.00814269
RPL11 ribosomal protein L11 -0.00809288
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.00805625
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0080441
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae) -0.00803367
ACACA acetyl-CoA carboxylase alpha -0.00795546
RYBP RING1 and YY1 binding protein -0.00783433
RBM27 RNA binding motif protein 27 -0.00777917
FAM53C family with sequence similarity 53, member C -0.00773378
RSL1D1 ribosomal L1 domain containing 1 -0.00767551
HSPH1 heat shock 105kDa/110kDa protein 1 -0.00766673
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.00766115
USP3 ubiquitin specific peptidase 3 -0.00759825
INO80 INO80 complex subunit -0.00759002