Clopidogrel_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NAMPT nicotinamide phosphoribosyltransferase 0.208097
SOD2 superoxide dismutase 2, mitochondrial 0.157724
SMAD3 SMAD family member 3 0.0775906
FNDC3B fibronectin type III domain containing 3B 0.071735
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0714473
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0692962
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0690704
RBM39 RNA binding motif protein 39 0.0650679
PRELID2 PRELI domain containing 2 0.0624222
DSCAM Down syndrome cell adhesion molecule 0.0610755
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0600906
USP34 ubiquitin specific peptidase 34 0.0585099
EFNA5 ephrin-A5 0.0565931
TRIO trio Rho guanine nucleotide exchange factor 0.0556494
NAV2 neuron navigator 2 0.0531369
KDM3A lysine (K)-specific demethylase 3A 0.0496775
OGA O-GlcNAcase 0.0492774
FBXL13 F-box and leucine-rich repeat protein 13 0.0491534
CTNND1 catenin (cadherin-associated protein), delta 1 0.0485712
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0483123
GOLGA4 golgin A4 0.044567
OS9 osteosarcoma amplified 9, endoplasmic reticulum lectin 0.0434711
FAM20C family with sequence similarity 20, member C 0.0430125
AKAP12 A kinase (PRKA) anchor protein 12 0.0423462
NCOA7 nuclear receptor coactivator 7 0.0420871
TAS2R14 taste receptor, type 2, member 14 0.0401675
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0385892
PDE4D phosphodiesterase 4D, cAMP-specific 0.0363889
RUNX1 runt-related transcription factor 1 0.0347317
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0337058
NPC1 Niemann-Pick disease, type C1 0.0333364
ELL2 elongation factor, RNA polymerase II, 2 0.0331535
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0329629
RB1CC1 RB1-inducible coiled-coil 1 0.0327691
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0325622
NBAS neuroblastoma amplified sequence 0.0325116
FAM13A family with sequence similarity 13, member A 0.0317837
KMT2C lysine (K)-specific methyltransferase 2C 0.0308053
AKAP9 A kinase (PRKA) anchor protein 9 0.0306955
SPAG9 sperm associated antigen 9 0.0306453
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0303211
CANX calnexin 0.0299913
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0298888
LRRC49 leucine rich repeat containing 49 0.0295624
DOCK5 dedicator of cytokinesis 5 0.0293394
APP amyloid beta (A4) precursor protein 0.0291269
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.028387
MYH9 myosin, heavy chain 9, non-muscle 0.028076
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0277328
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0272551
CALU calumenin 0.0271412
ZNF292 zinc finger protein 292 0.0265956
NGLY1 N-glycanase 1 0.0264668
KANSL1 KAT8 regulatory NSL complex subunit 1 0.0263641
BACE2 beta-site APP-cleaving enzyme 2 0.0260047
CNOT2 CCR4-NOT transcription complex, subunit 2 0.025548
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0252777
TPR translocated promoter region, nuclear basket protein 0.0251835
KDM2A lysine (K)-specific demethylase 2A 0.0248528
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0244757
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0244372
EIF3B eukaryotic translation initiation factor 3, subunit B 0.0242265
BIRC6 baculoviral IAP repeat containing 6 0.0241628
SBF2 SET binding factor 2 0.0240481
RAD51B RAD51 paralog B 0.0237762
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0236134
YME1L1 YME1-like 1 ATPase 0.0235832
SEC23A Sec23 homolog A (S. cerevisiae) 0.0234967
SKAP2 src kinase associated phosphoprotein 2 0.0234677
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0234498
YEATS2 YEATS domain containing 2 0.0232601
MAP2K1 mitogen-activated protein kinase kinase 1 0.0229742
CD44 CD44 molecule (Indian blood group) 0.0229724
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 0.0229202
ZFC3H1 zinc finger, C3H1-type containing 0.0228683
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.022566
MON2 MON2 homolog (S. cerevisiae) 0.0223485
SUN1 Sad1 and UNC84 domain containing 1 0.0222969
COG5 component of oligomeric golgi complex 5 0.0222105
BASP1 brain abundant, membrane attached signal protein 1 0.0218734
METTL15 methyltransferase like 15 0.0218031
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0216512
MARCHF6 membrane associated ring-CH-type finger 6 0.021574
UBE2O ubiquitin-conjugating enzyme E2O 0.0215393
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0215381
MIB1 mindbomb E3 ubiquitin protein ligase 1 0.0214347
EIF4A2 eukaryotic translation initiation factor 4A2 0.0213273
USP9X ubiquitin specific peptidase 9, X-linked 0.0212526
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0210935
SAMD4A sterile alpha motif domain containing 4A 0.0210659
TBC1D5 TBC1 domain family, member 5 0.0209995
RARB retinoic acid receptor, beta 0.020935
GPHN gephyrin 0.0208071
PTPRR protein tyrosine phosphatase, receptor type, R 0.0207767
HDLBP high density lipoprotein binding protein 0.020759
FAM107B family with sequence similarity 107, member B 0.020733
NAP1L1 nucleosome assembly protein 1-like 1 0.0206955
BZW1 basic leucine zipper and W2 domains 1 0.0206459
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0205613
RPL4 ribosomal protein L4 0.0203942

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.188429
FN1 fibronectin 1 -0.170274
TMSB10 thymosin beta 10 -0.0877445
GLCCI1 glucocorticoid induced 1 -0.0809483
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0720708
FTL ferritin, light polypeptide -0.0692481
IGFBP3 insulin-like growth factor binding protein 3 -0.0689638
LOX lysyl oxidase -0.0646718
HMGA2 high mobility group AT-hook 2 -0.0643561
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0637775
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0601346
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0520291
FTH1 ferritin, heavy polypeptide 1 -0.0518028
NRG1 neuregulin 1 -0.0473001
DPYD dihydropyrimidine dehydrogenase -0.046302
NTN4 netrin 4 -0.0453264
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0407762
HMGA1 high mobility group AT-hook 1 -0.0385907
NDRG1 N-myc downstream regulated 1 -0.0383314
STC1 stanniocalcin 1 -0.0376237
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0375147
TFPI2 tissue factor pathway inhibitor 2 -0.0359031
MEF2A myocyte enhancer factor 2A -0.0350235
PSD3 pleckstrin and Sec7 domain containing 3 -0.0349378
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0345057
MTSS1 metastasis suppressor 1 -0.0342887
CDH13 cadherin 13 -0.0333822
EGR1 early growth response 1 -0.0331434
SYT1 synaptotagmin I -0.0323284
PRR16 proline rich 16 -0.0305331
NRP1 neuropilin 1 -0.0301647
LOC102724023 ES1 protein homolog, mitochondrial -0.0297303
PTMA prothymosin, alpha -0.0295208
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0294347
MAP1B microtubule-associated protein 1B -0.0293514
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0292985
ANTXR2 anthrax toxin receptor 2 -0.0290223
CLMP CXADR-like membrane protein -0.0288266
RAI14 retinoic acid induced 14 -0.0276257
POTEF POTE ankyrin domain family, member F -0.0269377
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0268743
ANKRD28 ankyrin repeat domain 28 -0.0266087
S100A6 S100 calcium binding protein A6 -0.0255404
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) -0.0252101
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0245553
PRRX1 paired related homeobox 1 -0.0245523
RASAL2 RAS protein activator like 2 -0.0232681
AADAC arylacetamide deacetylase -0.0231168
SNX9 sorting nexin 9 -0.0228106
WLS wntless Wnt ligand secretion mediator -0.0226159
PFN1 profilin 1 -0.022475
VRK2 vaccinia related kinase 2 -0.0223963
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.022178
TGFB1 transforming growth factor, beta 1 -0.022065
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0216327
PDIA3 protein disulfide isomerase family A, member 3 -0.0212621
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0209718
ENO2 enolase 2 (gamma, neuronal) -0.0207289
PKM pyruvate kinase, muscle -0.0207095
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0202506
CDK14 cyclin-dependent kinase 14 -0.0201283
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0199659
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0198118
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0197403
S100A10 S100 calcium binding protein A10 -0.0196462
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0196066
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.019534
OXSR1 oxidative stress responsive 1 -0.0193591
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0193015
TRPS1 trichorhinophalangeal syndrome I -0.0192374
PRSS23 protease, serine, 23 -0.0191637
CDK2AP2 cyclin-dependent kinase 2 associated protein 2 -0.0190126
RPL28 ribosomal protein L28 -0.0187347
RPS19 ribosomal protein S19 -0.0185512
NAV3 neuron navigator 3 -0.0184764
FBN1 fibrillin 1 -0.0184579
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0184041
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0180503
MECOM MDS1 and EVI1 complex locus -0.0179453
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0174852
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0174329
ARL4C ADP-ribosylation factor-like 4C -0.017151
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0170861
ATF7 activating transcription factor 7 -0.0169296
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0167976
RPL35A ribosomal protein L35a -0.016652
CP ceruloplasmin (ferroxidase) -0.0163327
PLIN2 perilipin 2 -0.0161511
FHL2 four and a half LIM domains 2 -0.0158202
ZNF804A zinc finger protein 804A -0.0157845
ABCA6 ATP-binding cassette, sub-family A (ABC1), member 6 -0.0157682
LTBP1 latent transforming growth factor beta binding protein 1 -0.0157486
CCDC88A coiled-coil domain containing 88A -0.0156868
IFI44L interferon-induced protein 44-like -0.0156532
BMERB1 bMERB domain containing 1 -0.0155634
RGS17 regulator of G-protein signaling 17 -0.0155085
SEPTIN9 septin 9 -0.0154386
HILPDA hypoxia inducible lipid droplet-associated -0.0154178
RND3 Rho family GTPase 3 -0.0153949
MSRB3 methionine sulfoxide reductase B3 -0.0153849