Clopidogrel_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.102837
SPAG9 sperm associated antigen 9 0.0871491
MT2A metallothionein 2A 0.0779339
NDRG1 N-myc downstream regulated 1 0.0759572
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0653613
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0593374
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0589701
B2M beta-2-microglobulin 0.0562195
GRB10 growth factor receptor-bound protein 10 0.0556274
CXCL8 chemokine (C-X-C motif) ligand 8 0.0509204
HELZ helicase with zinc finger 0.050056
BAIAP2L1 BAI1-associated protein 2-like 1 0.0494106
PDE10A phosphodiesterase 10A 0.0445983
SOD2 superoxide dismutase 2, mitochondrial 0.0431906
MARCHF6 membrane associated ring-CH-type finger 6 0.0414067
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0410696
GLS2 glutaminase 2 (liver, mitochondrial) 0.0388468
RPS3 ribosomal protein S3 0.0375977
GSK3B glycogen synthase kinase 3 beta 0.0367613
BHLHE40 basic helix-loop-helix family, member e40 0.0365443
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0362522
NUP58 nucleoporin 58 0.0359924
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0357803
RPS16 ribosomal protein S16 0.0349239
MED13 mediator complex subunit 13 0.0339519
USP3 ubiquitin specific peptidase 3 0.0334978
RPL23 ribosomal protein L23 0.0334127
ATP13A3 ATPase type 13A3 0.033259
KDM2A lysine (K)-specific demethylase 2A 0.0331938
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 0.0327915
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0327732
RYBP RING1 and YY1 binding protein 0.0326918
TRIO trio Rho guanine nucleotide exchange factor 0.0321307
AREG amphiregulin 0.0321287
SEC24A SEC24 family member A 0.0319088
ZMYM2 zinc finger, MYM-type 2 0.0315981
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0315902
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.031465
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0313169
LAMB3 laminin, beta 3 0.0311887
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0301503
PRRC2C proline-rich coiled-coil 2C 0.0300217
RSAD2 radical S-adenosyl methionine domain containing 2 0.0297005
NBEAL1 neurobeachin-like 1 0.0296226
RPL11 ribosomal protein L11 0.0293365
PCBP2 poly(rC) binding protein 2 0.0287231
FAM13A family with sequence similarity 13, member A 0.028702
TMEM165 transmembrane protein 165 0.0283741
COG5 component of oligomeric golgi complex 5 0.0282673
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0282139
ELL2 elongation factor, RNA polymerase II, 2 0.027991
PDPK1 3-phosphoinositide dependent protein kinase 1 0.0276618
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0276
NAP1L1 nucleosome assembly protein 1-like 1 0.0275382
WDR45B WD repeat domain 45B 0.0272282
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0268075
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0267923
PNISR PNN-interacting serine/arginine-rich protein 0.0266532
ZSWIM6 zinc finger, SWIM-type containing 6 0.0263861
VEZT vezatin, adherens junctions transmembrane protein 0.0262935
STAU1 staufen double-stranded RNA binding protein 1 0.0262789
ZFR zinc finger RNA binding protein 0.0262694
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0260719
ARRDC3 arrestin domain containing 3 0.0259595
PTPRM protein tyrosine phosphatase, receptor type, M 0.0258867
RPL12 ribosomal protein L12 0.0256054
PKN2 protein kinase N2 0.0255567
TAOK3 TAO kinase 3 0.0255319
CCNY cyclin Y 0.0253272
PGK1 phosphoglycerate kinase 1 0.0253205
SLC38A1 solute carrier family 38, member 1 0.0248924
NAMPT nicotinamide phosphoribosyltransferase 0.0247549
RPL37A ribosomal protein L37a 0.0246832
RPS20 ribosomal protein S20 0.0245154
SNX9 sorting nexin 9 0.0244821
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0244516
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0244333
HLA-A major histocompatibility complex, class I, A 0.0243585
KMT2E lysine (K)-specific methyltransferase 2E 0.0242633
CANX calnexin 0.0239801
RACK1 receptor for activated C kinase 1 0.0238802
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0237726
THOC2 THO complex 2 0.023705
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0236061
PTK2 protein tyrosine kinase 2 0.0234991
IFRD1 interferon-related developmental regulator 1 0.0233519
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0233429
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0229359
ZNF292 zinc finger protein 292 0.0228361
PTGES2 prostaglandin E synthase 2 0.022751
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0226572
MCTP1 multiple C2 domains, transmembrane 1 0.0223195
POTEF POTE ankyrin domain family, member F 0.0221306
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0219219
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0218954
SMAD3 SMAD family member 3 0.0217639
FMNL2 formin-like 2 0.0217073
COPA coatomer protein complex, subunit alpha 0.0216417
RUNX1 runt-related transcription factor 1 0.0214479
HLA-B major histocompatibility complex, class I, B 0.0207192

decreased expression

Symbol Name Standardized Value
S100A9 S100 calcium binding protein A9 -0.0933278
PDE4D phosphodiesterase 4D, cAMP-specific -0.0808926
SEC31A SEC31 homolog A (S. cerevisiae) -0.0763605
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.062917
NKD1 naked cuticle homolog 1 (Drosophila) -0.0594278
THBS1 thrombospondin 1 -0.0565879
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0562163
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) -0.0551284
EXT1 exostosin glycosyltransferase 1 -0.0544028
TSHZ2 teashirt zinc finger homeobox 2 -0.0536012
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0517794
MAML2 mastermind-like 2 (Drosophila) -0.0515826
LRMDA leucine rich melanocyte differentiation associated -0.051452
SIK3 SIK family kinase 3 -0.0509369
CLIP1 CAP-GLY domain containing linker protein 1 -0.0496906
ZMYND8 zinc finger, MYND-type containing 8 -0.0495672
RAB10 RAB10, member RAS oncogene family -0.0457941
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.0454658
GOLGB1 golgin B1 -0.0452112
CADM2 cell adhesion molecule 2 -0.0446708
JMJD1C jumonji domain containing 1C -0.044327
KCNK1 potassium channel, two pore domain subfamily K, member 1 -0.042982
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0427415
RAI14 retinoic acid induced 14 -0.0406981
MAML3 mastermind-like 3 (Drosophila) -0.040487
HMGA2 high mobility group AT-hook 2 -0.0401616
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0398143
GRIK5 glutamate receptor, ionotropic, kainate 5 -0.0391967
ABHD17C abhydrolase domain containing 17C -0.0391864
ADNP activity-dependent neuroprotector homeobox -0.039151
EXOC4 exocyst complex component 4 -0.0386935
CDC27 cell division cycle 27 -0.0384012
EFNA5 ephrin-A5 -0.0382238
ZBTB20 zinc finger and BTB domain containing 20 -0.0377371
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0377186
FN1 fibronectin 1 -0.0375476
SNX14 sorting nexin 14 -0.0374568
FRMD5 FERM domain containing 5 -0.036169
ZEB1 zinc finger E-box binding homeobox 1 -0.0355744
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0354999
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.035148
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0349289
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0344986
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0339607
PDE4B phosphodiesterase 4B, cAMP-specific -0.0338593
KDM1A lysine (K)-specific demethylase 1A -0.0332523
SLC38A2 solute carrier family 38, member 2 -0.0332234
MAST4 microtubule associated serine/threonine kinase family member 4 -0.0331348
CEMIP cell migration inducing protein, hyaluronan binding -0.0330283
MAP3K20 mitogen-activated protein kinase kinase kinase 20 -0.0328817
LRP12 low density lipoprotein receptor-related protein 12 -0.0328711
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0322374
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0318112
FLNB filamin B, beta -0.0317697
UBE2E1 ubiquitin-conjugating enzyme E2E 1 -0.0314909
UGCG UDP-glucose ceramide glucosyltransferase -0.0313666
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0313347
PDIA3 protein disulfide isomerase family A, member 3 -0.03119
GRAMD2B GRAM domain containing 2B -0.0311621
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0308637
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0302928
TM4SF1 transmembrane 4 L six family member 1 -0.0302583
SLC12A6 solute carrier family 12 (potassium/chloride transporter), member 6 -0.0301791
TBL1X transducin (beta)-like 1X-linked -0.0299437
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) -0.0299284
PSD3 pleckstrin and Sec7 domain containing 3 -0.0298131
CSNK1G1 casein kinase 1, gamma 1 -0.0297747
NEK7 NIMA-related kinase 7 -0.0291893
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0290538
NPC1 Niemann-Pick disease, type C1 -0.0287664
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0287507
ADAM9 ADAM metallopeptidase domain 9 -0.0285063
CAMK2D calcium/calmodulin-dependent protein kinase II delta -0.0284064
PDLIM5 PDZ and LIM domain 5 -0.0283693
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0283171
EZR ezrin -0.0283068
DSCAM Down syndrome cell adhesion molecule -0.028283
KCNH8 potassium channel, voltage gated eag related subfamily H, member 8 -0.0280576
RBM47 RNA binding motif protein 47 -0.0276968
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0275686
SOS1 son of sevenless homolog 1 (Drosophila) -0.0275379
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0275222
BPTF bromodomain PHD finger transcription factor -0.0274697
THSD4 thrombospondin, type I, domain containing 4 -0.0271452
RPS14 ribosomal protein S14 -0.0269994
LOC112694756 uncharaterized LOC112694756 -0.0269913
AP1G1 adaptor-related protein complex 1, gamma 1 subunit -0.0267009
RIOK3 RIO kinase 3 -0.0264822
ITPRID2 ITPR interacting domain containing 2 -0.026277
MAPK6 mitogen-activated protein kinase 6 -0.0262007
DOCK4 dedicator of cytokinesis 4 -0.0260935
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -0.0260775
CCNI cyclin I -0.025644
ANKRD11 ankyrin repeat domain 11 -0.0256151
PICALM phosphatidylinositol binding clathrin assembly protein -0.0254572
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0253334
DIDO1 death inducer-obliterator 1 -0.0251417
RPS27A ribosomal protein S27a -0.0249584
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0247226
MBD5 methyl-CpG binding domain protein 5 -0.0245955