Clopidogrel_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.233491
FN1 fibronectin 1 0.21705
PDE4D phosphodiesterase 4D, cAMP-specific 0.140556
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.113954
SOD2 superoxide dismutase 2, mitochondrial 0.108409
EFNA5 ephrin-A5 0.105157
TM4SF1 transmembrane 4 L six family member 1 0.103738
PGK1 phosphoglycerate kinase 1 0.102781
NAMPT nicotinamide phosphoribosyltransferase 0.0870258
CANX calnexin 0.0825176
PSD3 pleckstrin and Sec7 domain containing 3 0.0804773
ASPH aspartate beta-hydroxylase 0.0800146
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0688819
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0686386
PCBP3 poly(rC) binding protein 3 0.0678591
MCL1 myeloid cell leukemia 1 0.0650381
BZW1 basic leucine zipper and W2 domains 1 0.0637589
DST dystonin 0.0605817
INHBA inhibin, beta A 0.0600309
CDH13 cadherin 13 0.0597668
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0575024
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0574916
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.056771
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0556563
TPT1 tumor protein, translationally-controlled 1 0.0531519
GDA guanine deaminase 0.0528089
STC1 stanniocalcin 1 0.0522924
FNDC3A fibronectin type III domain containing 3A 0.0521577
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0516316
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0514011
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0513502
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0507195
ELL2 elongation factor, RNA polymerase II, 2 0.0496824
LIMCH1 LIM and calponin homology domains 1 0.0496784
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.04961
ITPRID2 ITPR interacting domain containing 2 0.0483516
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0466899
PM20D1 peptidase M20 domain containing 1 0.0466153
TRIO trio Rho guanine nucleotide exchange factor 0.0459573
SAMD4A sterile alpha motif domain containing 4A 0.0437425
BASP1 brain abundant, membrane attached signal protein 1 0.0434
ERRFI1 ERBB receptor feedback inhibitor 1 0.0432559
OGA O-GlcNAcase 0.0429491
SPTBN1 spectrin, beta, non-erythrocytic 1 0.042286
FMNL2 formin-like 2 0.0411996
PDE10A phosphodiesterase 10A 0.0411705
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0403386
MYOF myoferlin 0.039624
DGKD diacylglycerol kinase, delta 130kDa 0.0394911
SH3KBP1 SH3-domain kinase binding protein 1 0.0391945
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0389502
AKAP13 A kinase (PRKA) anchor protein 13 0.0385203
NT5C2 5'-nucleotidase, cytosolic II 0.03811
ESYT2 extended synaptotagmin-like protein 2 0.0378265
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0377015
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0376989
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0375061
CXCL8 chemokine (C-X-C motif) ligand 8 0.0365591
PRELID2 PRELI domain containing 2 0.0364935
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0361051
AHNAK AHNAK nucleoprotein 0.0360546
FNDC3B fibronectin type III domain containing 3B 0.035728
TGFBR1 transforming growth factor, beta receptor 1 0.0356154
BIRC6 baculoviral IAP repeat containing 6 0.0354362
ADGRD1 adhesion G protein-coupled receptor D1 0.0351308
LDHA lactate dehydrogenase A 0.0347656
CTSL cathepsin L 0.0337125
UBC ubiquitin C 0.0334444
KDM3A lysine (K)-specific demethylase 3A 0.0328956
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0324798
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0322481
DNER delta/notch-like EGF repeat containing 0.0321525
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0321442
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0313615
DOCK5 dedicator of cytokinesis 5 0.0309458
RBM39 RNA binding motif protein 39 0.0309278
CD44 CD44 molecule (Indian blood group) 0.0308771
SLC38A2 solute carrier family 38, member 2 0.0308205
FNIP1 folliculin interacting protein 1 0.0299006
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0298076
BMERB1 bMERB domain containing 1 0.0297323
SOX4 SRY (sex determining region Y)-box 4 0.0296847
TMSB4X thymosin beta 4, X-linked 0.029664
PRRC2C proline-rich coiled-coil 2C 0.0293297
NAP1L1 nucleosome assembly protein 1-like 1 0.0292564
DOCK4 dedicator of cytokinesis 4 0.0291175
ZC3H11A zinc finger CCCH-type containing 11A 0.0290258
USP34 ubiquitin specific peptidase 34 0.0287718
TBXT T-box transcription factor T 0.0287357
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0285082
IQGAP1 IQ motif containing GTPase activating protein 1 0.0278768
MAML3 mastermind-like 3 (Drosophila) 0.0277524
CALU calumenin 0.0274444
SPAG9 sperm associated antigen 9 0.0273239
ENO1 enolase 1, (alpha) 0.0271852
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0270904
TFPI2 tissue factor pathway inhibitor 2 0.0268859
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0265484
SMAD2 SMAD family member 2 0.0262744
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0262451

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.18586
FTL ferritin, light polypeptide -0.083531
FTH1 ferritin, heavy polypeptide 1 -0.0560134
RPLP1 ribosomal protein, large, P1 -0.0530866
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0514587
TMSB10 thymosin beta 10 -0.0503664
RPS6 ribosomal protein S6 -0.0417863
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0409619
RPL35A ribosomal protein L35a -0.0372841
RPS19 ribosomal protein S19 -0.0338036
HILPDA hypoxia inducible lipid droplet-associated -0.0322897
EEF2 eukaryotic translation elongation factor 2 -0.0305242
RPL23 ribosomal protein L23 -0.0298045
RPS2 ribosomal protein S2 -0.0288088
RPL36 ribosomal protein L36 -0.0276096
EGR1 early growth response 1 -0.026015
RPL28 ribosomal protein L28 -0.0256724
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0254513
RPS8 ribosomal protein S8 -0.0252377
POTEF POTE ankyrin domain family, member F -0.0245506
PKM pyruvate kinase, muscle -0.0225836
PFN1 profilin 1 -0.022517
RPL37A ribosomal protein L37a -0.0223097
RPS12 ribosomal protein S12 -0.0215048
YBX1 Y box binding protein 1 -0.0202624
RPS23 ribosomal protein S23 -0.0189715
RPS29 ribosomal protein S29 -0.0189286
ASTN2 astrotactin 2 -0.0183679
RPS27 ribosomal protein S27 -0.0182706
RPS20 ribosomal protein S20 -0.0181937
RPS17 ribosomal protein S17 -0.0180265
RPL39 ribosomal protein L39 -0.0168834
RPL31 ribosomal protein L31 -0.0168507
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0165971
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0164694
ATP5F1E ATP synthase F1 subunit epsilon -0.016422
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0161931
HMGA1 high mobility group AT-hook 1 -0.0158665
RPL27 ribosomal protein L27 -0.0157831
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0157303
RPL9 ribosomal protein L9 -0.0156767
ATP5F1B ATP synthase F1 subunit beta -0.0156257
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0155155
RPL35 ribosomal protein L35 -0.0153915
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.015191
HLA-A major histocompatibility complex, class I, A -0.0151641
RPL11 ribosomal protein L11 -0.0151235
ANTXR1 anthrax toxin receptor 1 -0.0151145
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0149063
RPS5 ribosomal protein S5 -0.0147811
RPLP2 ribosomal protein, large, P2 -0.0145429
RPL21 ribosomal protein L21 -0.0141134
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.0139424
RPS14 ribosomal protein S14 -0.0137429
RPL26 ribosomal protein L26 -0.0135936
RPL5 ribosomal protein L5 -0.0135811
FOSL1 FOS-like antigen 1 -0.0135223
ATF4 activating transcription factor 4 -0.0134753
PCBP2 poly(rC) binding protein 2 -0.0132365
ACTG1 actin gamma 1 -0.0131545
RPL34 ribosomal protein L34 -0.013097
TUBA1B tubulin, alpha 1b -0.0130347
RPS25 ribosomal protein S25 -0.0129717
LAMA5 laminin, alpha 5 -0.0129591
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0129085
LDHB lactate dehydrogenase B -0.0123075
RPS16 ribosomal protein S16 -0.0122706
RPS21 ribosomal protein S21 -0.0121468
GNAS GNAS complex locus -0.0119375
TSC22D2 TSC22 domain family, member 2 -0.0118225
GUK1 guanylate kinase 1 -0.011731
CADM2 cell adhesion molecule 2 -0.0114516
ZFP36 ZFP36 ring finger protein -0.0112412
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0110489
ISG15 ISG15 ubiquitin-like modifier -0.011016
COX7C cytochrome c oxidase subunit VIIc -0.010819
LOC112694756 uncharaterized LOC112694756 -0.0108022
LYPLAL1 lysophospholipase-like 1 -0.0107576
TOB1 transducer of ERBB2, 1 -0.0106649
PDIA3 protein disulfide isomerase family A, member 3 -0.0105276
RNF145 ring finger protein 145 -0.0105235
RPS10 ribosomal protein S10 -0.0104134
RPS4X ribosomal protein S4, X-linked -0.0102508
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0101981
RPS13 ribosomal protein S13 -0.0101227
S100A10 S100 calcium binding protein A10 -0.0101201
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0100993
RPL32 ribosomal protein L32 -0.0100365
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.00998105
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.00994918
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.00992033
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.00971833
DSTN destrin (actin depolymerizing factor) -0.00943643
MEF2D myocyte enhancer factor 2D -0.00933845
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0093224
RPL27A ribosomal protein L27a -0.00930704
AP1S3 adaptor-related protein complex 1, sigma 3 subunit -0.00930551
RPL37 ribosomal protein L37 -0.00906575
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.00906472
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.00885061