Clopidogrel_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS6 ribosomal protein S6 0.121734
LSAMP limbic system-associated membrane protein 0.1198
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.106892
CSNK1A1 casein kinase 1, alpha 1 0.105533
PSD3 pleckstrin and Sec7 domain containing 3 0.101889
PDE10A phosphodiesterase 10A 0.0951151
BIRC6 baculoviral IAP repeat containing 6 0.09336
ANKRD11 ankyrin repeat domain 11 0.092313
FAM13A family with sequence similarity 13, member A 0.0915153
PDE4D phosphodiesterase 4D, cAMP-specific 0.0876244
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.084508
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0813548
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0808545
JMJD1C jumonji domain containing 1C 0.0781758
FNDC3B fibronectin type III domain containing 3B 0.0762956
LAMA4 laminin, alpha 4 0.0733679
H3-3B H3.3 histone B 0.0710066
UBE2H ubiquitin-conjugating enzyme E2H 0.0704297
ZNF292 zinc finger protein 292 0.0688396
PRKCA protein kinase C, alpha 0.0679988
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0678642
ERRFI1 ERBB receptor feedback inhibitor 1 0.0661883
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0630376
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0629562
SEC24A SEC24 family member A 0.0611413
PIBF1 progesterone immunomodulatory binding factor 1 0.059859
DOCK5 dedicator of cytokinesis 5 0.0572016
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0542338
OGA O-GlcNAcase 0.053748
WAC WW domain containing adaptor with coiled-coil 0.0537344
PGK1 phosphoglycerate kinase 1 0.0535709
GNAS GNAS complex locus 0.0530994
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0519437
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0501557
CDK13 cyclin-dependent kinase 13 0.0488794
ZSWIM6 zinc finger, SWIM-type containing 6 0.0487603
RBM39 RNA binding motif protein 39 0.0481068
RPL37A ribosomal protein L37a 0.0466349
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0461649
FTH1 ferritin, heavy polypeptide 1 0.0455547
KMT2C lysine (K)-specific methyltransferase 2C 0.0449922
HELZ helicase with zinc finger 0.0448802
AFF4 AF4/FMR2 family, member 4 0.0444403
ERBIN erbb2 interacting protein 0.0439635
SETD5 SET domain containing 5 0.0439521
RBM25 RNA binding motif protein 25 0.0433116
AKAP9 A kinase (PRKA) anchor protein 9 0.043103
RAD51B RAD51 paralog B 0.0419303
VMP1 vacuole membrane protein 1 0.0383438
PICALM phosphatidylinositol binding clathrin assembly protein 0.0379699
RPL11 ribosomal protein L11 0.037731
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0369856
OSMR oncostatin M receptor 0.0367395
RACK1 receptor for activated C kinase 1 0.0358534
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0354692
GLIS3 GLIS family zinc finger 3 0.0354558
GIGYF2 GRB10 interacting GYF protein 2 0.0349807
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0349664
EIF1 eukaryotic translation initiation factor 1 0.0349452
SND1 staphylococcal nuclease and tudor domain containing 1 0.0346226
ATXN1 ataxin 1 0.0340255
RNF145 ring finger protein 145 0.0338753
EXT1 exostosin glycosyltransferase 1 0.0333434
SMYD3 SET and MYND domain containing 3 0.0319535
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0311794
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0308313
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0306899
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0305556
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0301236
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase 0.0299336
PCBP2 poly(rC) binding protein 2 0.029689
DSCAM Down syndrome cell adhesion molecule 0.0291992
CHRM3 cholinergic receptor, muscarinic 3 0.0272369
BBX bobby sox homolog (Drosophila) 0.0270021
GLG1 golgi glycoprotein 1 0.0268802
COG5 component of oligomeric golgi complex 5 0.0267993
KDM4C lysine (K)-specific demethylase 4C 0.026634
FNDC3A fibronectin type III domain containing 3A 0.0253841
PRRC2C proline-rich coiled-coil 2C 0.0253523
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0250977
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 0.0247485
PTK2 protein tyrosine kinase 2 0.0242548
MACF1 microtubule-actin crosslinking factor 1 0.0239162
USP3 ubiquitin specific peptidase 3 0.0236939
AHNAK AHNAK nucleoprotein 0.0236208
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0235293
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0232665
NAP1L1 nucleosome assembly protein 1-like 1 0.0232584
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0231739
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0231673
ACTG1 actin gamma 1 0.0226456
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 0.0223566
STC1 stanniocalcin 1 0.0218576
CARD16 caspase recruitment domain family, member 16 0.0216899
CALU calumenin 0.0216368
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0209689
ITCH itchy E3 ubiquitin protein ligase 0.0204028
ASPH aspartate beta-hydroxylase 0.0201285
RAB10 RAB10, member RAS oncogene family 0.0195966
NAMPT nicotinamide phosphoribosyltransferase 0.0191134

decreased expression

Symbol Name Standardized Value
FN1 fibronectin 1 -0.177737
EGFR epidermal growth factor receptor -0.117588
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.116041
MYO6 myosin VI -0.0974885
YBX3 Y box binding protein 3 -0.0972769
PDIA3 protein disulfide isomerase family A, member 3 -0.0854593
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0833903
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -0.0813891
MYO1E myosin IE -0.0802443
KTN1 kinectin 1 (kinesin receptor) -0.0776507
LDHA lactate dehydrogenase A -0.0750719
MT2A metallothionein 2A -0.0725163
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0706039
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0665455
SLTM SAFB-like, transcription modulator -0.0655656
PDE8A phosphodiesterase 8A -0.0637562
RNF149 ring finger protein 149 -0.0637199
SAMD4A sterile alpha motif domain containing 4A -0.0634959
SYNGAP1 synaptic Ras GTPase activating protein 1 -0.0634398
RUNX1 runt-related transcription factor 1 -0.0626451
TPM4 tropomyosin 4 -0.060644
PIAS1 protein inhibitor of activated STAT, 1 -0.0604416
RPS13 ribosomal protein S13 -0.0602869
RPL4 ribosomal protein L4 -0.0596422
FMNL2 formin-like 2 -0.0596202
TSC22D2 TSC22 domain family, member 2 -0.0595281
ARRDC3 arrestin domain containing 3 -0.0581622
NRIP1 nuclear receptor interacting protein 1 -0.0572922
FOXO3 forkhead box O3 -0.0558542
TMSB10 thymosin beta 10 -0.0532613
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0530512
TNRC6B trinucleotide repeat containing 6B -0.0519732
RPL32 ribosomal protein L32 -0.0514723
ARHGAP29 Rho GTPase activating protein 29 -0.0493486
ELL2 elongation factor, RNA polymerase II, 2 -0.0483179
RPL12 ribosomal protein L12 -0.0480669
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0478688
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0459397
COL1A2 collagen, type I, alpha 2 -0.045825
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0455908
COL6A1 collagen, type VI, alpha 1 -0.0436852
ZBTB20 zinc finger and BTB domain containing 20 -0.0416134
HOOK3 hook microtubule-tethering protein 3 -0.0413544
MCL1 myeloid cell leukemia 1 -0.0405227
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 -0.0404655
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0397433
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0394506
PRKG1 protein kinase, cGMP-dependent, type I -0.0388187
USP34 ubiquitin specific peptidase 34 -0.0387695
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0378144
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0365492
TMEM165 transmembrane protein 165 -0.0362693
GPC6 glypican 6 -0.0358555
TRIO trio Rho guanine nucleotide exchange factor -0.0356514
MRPS6 mitochondrial ribosomal protein S6 -0.0352265
ACTN1 actinin, alpha 1 -0.0345925
EXOC4 exocyst complex component 4 -0.0344035
GOLGB1 golgin B1 -0.0343435
RPL35A ribosomal protein L35a -0.0339667
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0336989
CCNI cyclin I -0.0335272
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0333073
EMP1 epithelial membrane protein 1 -0.032881
INHBA inhibin, beta A -0.0318037
ANXA2 annexin A2 -0.0314957
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0313453
RORA RAR-related orphan receptor A -0.0310809
RPL7 ribosomal protein L7 -0.0307887
CD44 CD44 molecule (Indian blood group) -0.0304405
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0300814
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0296433
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0284538
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0281866
SPG11 spastic paraplegia 11 (autosomal recessive) -0.0280789
HMGA2 high mobility group AT-hook 2 -0.0276657
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0271554
SRRM2 serine/arginine repetitive matrix 2 -0.026032
ENO1 enolase 1, (alpha) -0.0252552
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0252536
GPHN gephyrin -0.0248459
RPL19 ribosomal protein L19 -0.0247365
RAB7A RAB7A, member RAS oncogene family -0.0242307
WDFY3 WD repeat and FYVE domain containing 3 -0.0242087
EIF4A2 eukaryotic translation initiation factor 4A2 -0.0241631
ZNF609 zinc finger protein 609 -0.0240286
FTL ferritin, light polypeptide -0.0238931
ARHGAP32 Rho GTPase activating protein 32 -0.0234382
CCNL1 cyclin L1 -0.0233178
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0231072
NIPBL Nipped-B homolog (Drosophila) -0.0209933
CADM2 cell adhesion molecule 2 -0.0208446
ANKRD17 ankyrin repeat domain 17 -0.0201538
MAP4 microtubule-associated protein 4 -0.0200324
TGFBI transforming growth factor, beta-induced, 68kDa -0.0199631
HDAC9 histone deacetylase 9 -0.0199232
MED13L mediator complex subunit 13-like -0.0199193
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase -0.0196042
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.01907
NF1 neurofibromin 1 -0.0188141
MLEC malectin -0.0187291