Clopidogrel_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TMSB4X thymosin beta 4, X-linked 0.128903
EIF4A2 eukaryotic translation initiation factor 4A2 0.104402
AHNAK AHNAK nucleoprotein 0.0861274
DSCAM Down syndrome cell adhesion molecule 0.0706534
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0694825
ADAM10 ADAM metallopeptidase domain 10 0.0658673
PGK1 phosphoglycerate kinase 1 0.0622888
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0563532
PRELID2 PRELI domain containing 2 0.0562089
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.056176
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0553263
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.0489783
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.048583
ENO1 enolase 1, (alpha) 0.047829
TPT1 tumor protein, translationally-controlled 1 0.0461535
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0458843
NAP1L1 nucleosome assembly protein 1-like 1 0.0451165
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0444882
CAMTA1 calmodulin binding transcription activator 1 0.041074
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0408742
CPED1 cadherin-like and PC-esterase domain containing 1 0.0393309
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0382955
SOX6 SRY (sex determining region Y)-box 6 0.0377247
USP34 ubiquitin specific peptidase 34 0.0362228
TTC3 tetratricopeptide repeat domain 3 0.0353642
FHIT fragile histidine triad 0.0352712
TTC28 tetratricopeptide repeat domain 28 0.0351453
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0351168
TRIO trio Rho guanine nucleotide exchange factor 0.0342614
SMYD3 SET and MYND domain containing 3 0.0341444
GNPDA1 glucosamine-6-phosphate deaminase 1 0.034039
DLG1 discs, large homolog 1 (Drosophila) 0.0338323
SBF2 SET binding factor 2 0.0334906
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0328152
LPP LIM domain containing preferred translocation partner in lipoma 0.0325
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0324512
TGFBR3 transforming growth factor, beta receptor III 0.0319234
UBC ubiquitin C 0.0317457
PTMA prothymosin, alpha 0.0317226
YEATS2 YEATS domain containing 2 0.031641
TBC1D22A TBC1 domain family, member 22A 0.0312446
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0311525
RBM25 RNA binding motif protein 25 0.0306528
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0305118
PICALM phosphatidylinositol binding clathrin assembly protein 0.0299098
ANKRD36 ankyrin repeat domain 36 0.0294045
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0292471
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0291014
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0289304
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0288331
TENT4A terminal nucleotidyltransferase 4A 0.0287822
BIRC6 baculoviral IAP repeat containing 6 0.0284938
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0281216
CANX calnexin 0.0279651
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0277503
LRPPRC leucine-rich pentatricopeptide repeat containing 0.027192
GSE1 Gse1 coiled-coil protein 0.0268592
CKAP5 cytoskeleton associated protein 5 0.0266687
NPAS2 neuronal PAS domain protein 2 0.0262148
APP amyloid beta (A4) precursor protein 0.0261837
MACF1 microtubule-actin crosslinking factor 1 0.0261266
WSB1 WD repeat and SOCS box containing 1 0.0259843
RPL11 ribosomal protein L11 0.02561
MYOF myoferlin 0.0253479
ARID4B AT rich interactive domain 4B (RBP1-like) 0.0250304
SFPQ splicing factor proline/glutamine-rich 0.0247483
MXI1 MAX interactor 1, dimerization protein 0.0246468
RPLP0 ribosomal protein, large, P0 0.0242349
LDHA lactate dehydrogenase A 0.0240696
FBLN2 fibulin 2 0.0239622
MBNL1 muscleblind-like splicing regulator 1 0.0239273
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0238268
NFIA nuclear factor I/A 0.0235552
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0234153
RBM39 RNA binding motif protein 39 0.0233881
HECTD1 HECT domain containing E3 ubiquitin protein ligase 1 0.0233805
AP3B1 adaptor-related protein complex 3, beta 1 subunit 0.0231764
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0229358
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 0.0228967
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0228407
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0227816
GPHN gephyrin 0.0226239
RPS18 ribosomal protein S18 0.0225603
MYO5A myosin VA (heavy chain 12, myoxin) 0.0222608
CD47 CD47 molecule 0.0222538
HSPA8 heat shock 70kDa protein 8 0.0220598
DIAPH3 diaphanous-related formin 3 0.0220255
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0220104
ECPAS Ecm29 proteasome adaptor and scaffold 0.0219956
PDE4B phosphodiesterase 4B, cAMP-specific 0.0219649
CSE1L CSE1 chromosome segregation 1-like (yeast) 0.0218076
ARHGEF10 Rho guanine nucleotide exchange factor (GEF) 10 0.0217182
ARHGAP32 Rho GTPase activating protein 32 0.0215269
RFC3 replication factor C (activator 1) 3, 38kDa 0.0214292
ATXN1 ataxin 1 0.0213933
ANKRD12 ankyrin repeat domain 12 0.0213687
CENPE centromere protein E, 312kDa 0.0212343
FNIP1 folliculin interacting protein 1 0.0210032
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0208908
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0206064

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.140627
EGFR epidermal growth factor receptor -0.0583946
PKM pyruvate kinase, muscle -0.0469569
POTEF POTE ankyrin domain family, member F -0.0456258
EEF2 eukaryotic translation elongation factor 2 -0.0444199
RPL35A ribosomal protein L35a -0.0427819
DSTN destrin (actin depolymerizing factor) -0.0397208
ACTG1 actin gamma 1 -0.0333625
RPL9 ribosomal protein L9 -0.0314589
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0305219
ENO2 enolase 2 (gamma, neuronal) -0.0284788
CCNL1 cyclin L1 -0.0266688
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 -0.026537
BRD4 bromodomain containing 4 -0.0258978
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -0.0250058
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0244619
RPL34 ribosomal protein L34 -0.0236942
ATF4 activating transcription factor 4 -0.0231232
PDE4D phosphodiesterase 4D, cAMP-specific -0.0224962
NAA15 N(alpha)-acetyltransferase 15, NatA auxiliary subunit -0.0222901
NCEH1 neutral cholesterol ester hydrolase 1 -0.0222541
CCDC88A coiled-coil domain containing 88A -0.0209427
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0207128
EXOC6B exocyst complex component 6B -0.020605
AGO3 argonaute RISC catalytic component 3 -0.0206019
RPL10A ribosomal protein L10a -0.0200962
EEF1G eukaryotic translation elongation factor 1 gamma -0.0190054
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0189182
PDE7B phosphodiesterase 7B -0.018611
PLSCR1 phospholipid scramblase 1 -0.0185113
IARS1 isoleucyl-tRNA synthetase 1 -0.0184752
RPS15 ribosomal protein S15 -0.017907
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0176558
KIF2A kinesin heavy chain member 2A -0.0173273
PRDX2 peroxiredoxin 2 -0.0171615
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0168704
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0167067
BCAS3 breast carcinoma amplified sequence 3 -0.016561
LOC102724023 ES1 protein homolog, mitochondrial -0.0165589
TRRAP transformation/transcription domain-associated protein -0.0165565
PFN1 profilin 1 -0.0163371
IFITM3 interferon induced transmembrane protein 3 -0.0158858
NACA nascent polypeptide-associated complex alpha subunit -0.0157813
HSPB1 heat shock 27kDa protein 1 -0.0157807
RIGI RNA sensor RIG-I -0.015427
ADNP activity-dependent neuroprotector homeobox -0.0152603
S100A4 S100 calcium binding protein A4 -0.0152082
EMP3 epithelial membrane protein 3 -0.0151967
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0149444
NBEA neurobeachin -0.0148457
RHOA ras homolog family member A -0.0147591
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0147563
IFI6 interferon, alpha-inducible protein 6 -0.0147512
TUBB4B tubulin, beta 4B class IVb -0.0146989
SSBP2 single-stranded DNA binding protein 2 -0.0144955
CTIF CBP80/20-dependent translation initiation factor -0.0143644
NDRG1 N-myc downstream regulated 1 -0.014328
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0141475
BSG basigin (Ok blood group) -0.0140409
RPL28 ribosomal protein L28 -0.014015
PDS5B PDS5 cohesin associated factor B -0.0138575
PCBP2 poly(rC) binding protein 2 -0.0138145
TTC17 tetratricopeptide repeat domain 17 -0.0137367
STRN3 striatin, calmodulin binding protein 3 -0.0137091
DHX36 DEAH (Asp-Glu-Ala-His) box polypeptide 36 -0.0135373
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0134344
ETNK1 ethanolamine kinase 1 -0.0133465
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -0.0133459
KPNB1 karyopherin (importin) beta 1 -0.0133446
RPLP2 ribosomal protein, large, P2 -0.0132501
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 -0.0132407
WARS1 tryptophanyl-tRNA synthetase 1 -0.0131855
ARL4C ADP-ribosylation factor-like 4C -0.013104
LDHB lactate dehydrogenase B -0.013067
CNOT9 CCR4-NOT transcription complex subunit 9 -0.0129541
NOCT nocturnin -0.0128258
SLC38A2 solute carrier family 38, member 2 -0.0127582
DEK DEK proto-oncogene -0.0127127
CORIN corin, serine peptidase -0.0127097
SEC62 SEC62 homolog (S. cerevisiae) -0.0127011
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0126198
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0125899
CSF1 colony stimulating factor 1 (macrophage) -0.0124499
PARP9 poly (ADP-ribose) polymerase family, member 9 -0.0124482
RPS14 ribosomal protein S14 -0.0124107
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0123647
ATE1 arginyltransferase 1 -0.0123392
ZNF438 zinc finger protein 438 -0.0123156
UBE2K ubiquitin-conjugating enzyme E2K -0.0122963
SREK1 splicing regulatory glutamine/lysine-rich protein 1 -0.0122236
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0121474
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -0.0120709
RPS10 ribosomal protein S10 -0.0120504
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0120193
KIF5C kinesin family member 5C -0.0119554
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0119182
XPR1 xenotropic and polytropic retrovirus receptor 1 -0.0117835
RUFY2 RUN and FYVE domain containing 2 -0.0116449
RUSC2 RUN and SH3 domain containing 2 -0.0116297
UTRN utrophin -0.0116203