Clopidogrel_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Clopidogrel perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Clopidogrel_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial 0.354764
NAMPT nicotinamide phosphoribosyltransferase 0.0932731
UGCG UDP-glucose ceramide glucosyltransferase 0.0666362
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0649542
OGA O-GlcNAcase 0.0618129
ELL2 elongation factor, RNA polymerase II, 2 0.0617949
PGK1 phosphoglycerate kinase 1 0.0573303
FNDC3B fibronectin type III domain containing 3B 0.0571583
MYH9 myosin, heavy chain 9, non-muscle 0.055224
TRIO trio Rho guanine nucleotide exchange factor 0.0479359
RB1CC1 RB1-inducible coiled-coil 1 0.0443836
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0441588
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0439204
ZNF292 zinc finger protein 292 0.0411463
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0392006
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0369678
ARRDC3 arrestin domain containing 3 0.0366109
SPAG9 sperm associated antigen 9 0.0356739
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0319614
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0317306
USP9X ubiquitin specific peptidase 9, X-linked 0.0299855
NAV2 neuron navigator 2 0.0294296
MYOF myoferlin 0.0290094
JMJD1C jumonji domain containing 1C 0.0287992
ANLN anillin, actin binding protein 0.0286631
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0284585
KLF6 Kruppel-like factor 6 0.0278813
SDC4 syndecan 4 0.0270182
UBA6 ubiquitin-like modifier activating enzyme 6 0.0258285
LDHA lactate dehydrogenase A 0.025216
FNIP1 folliculin interacting protein 1 0.0248893
ESYT2 extended synaptotagmin-like protein 2 0.0246486
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.024344
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0240149
CADM1 cell adhesion molecule 1 0.0236866
DSCAM Down syndrome cell adhesion molecule 0.0234556
TENT5A terminal nucleotidyltransferase 5A 0.0234228
MKI67 marker of proliferation Ki-67 0.0226438
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0223425
AFDN afadin, adherens junction formation factor 0.0219117
WTAP Wilms tumor 1 associated protein 0.0217456
RAI1 retinoic acid induced 1 0.0216526
CD164 CD164 molecule, sialomucin 0.0212565
RBM39 RNA binding motif protein 39 0.020953
KIF4A kinesin family member 4A 0.0208946
DIAPH3 diaphanous-related formin 3 0.0205905
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0205261
TNIP1 TNFAIP3 interacting protein 1 0.0202977
SBF2 SET binding factor 2 0.0201048
RPS18 ribosomal protein S18 0.0200909
CTNND1 catenin (cadherin-associated protein), delta 1 0.019613
ARFGEF3 ARFGEF family member 3 0.0195205
KDM3A lysine (K)-specific demethylase 3A 0.0194725
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0192362
MXI1 MAX interactor 1, dimerization protein 0.0191591
RAD21 RAD21 homolog (S. pombe) 0.019101
FLNB filamin B, beta 0.0189872
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 0.0189649
B2M beta-2-microglobulin 0.018938
UBC ubiquitin C 0.0188777
SMAD3 SMAD family member 3 0.0188616
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0185782
CENPF centromere protein F, 350/400kDa 0.0184358
BRWD3 bromodomain and WD repeat domain containing 3 0.0182137
UBE2B ubiquitin-conjugating enzyme E2B 0.0180847
AKAP9 A kinase (PRKA) anchor protein 9 0.0180352
CDK19 cyclin-dependent kinase 19 0.01785
TPX2 TPX2, microtubule-associated 0.0177444
PHIP pleckstrin homology domain interacting protein 0.0177438
GAS2L3 growth arrest-specific 2 like 3 0.0176995
ANXA2 annexin A2 0.0171761
PTBP3 polypyrimidine tract binding protein 3 0.0169299
WSB1 WD repeat and SOCS box containing 1 0.0163982
RTN4 reticulon 4 0.0162854
LCORL ligand dependent nuclear receptor corepressor-like 0.0162764
AFF4 AF4/FMR2 family, member 4 0.016055
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0158362
APP amyloid beta (A4) precursor protein 0.0158207
ZNF654 zinc finger protein 654 0.0156277
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 0.0156224
NT5C2 5'-nucleotidase, cytosolic II 0.0154634
KLF7 Kruppel-like factor 7 (ubiquitous) 0.015443
FOXO3 forkhead box O3 0.0153282
MICU1 mitochondrial calcium uptake 1 0.0152578
NKTR natural killer cell triggering receptor 0.0151183
YEATS2 YEATS domain containing 2 0.0146103
WDFY1 WD repeat and FYVE domain containing 1 0.0145917
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0145912
NPEPPS aminopeptidase puromycin sensitive 0.0145812
SERINC1 serine incorporator 1 0.0145424
NRIP1 nuclear receptor interacting protein 1 0.014435
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0144099
XPO1 exportin 1 0.014397
TMSB4X thymosin beta 4, X-linked 0.0143701
IGF2R insulin-like growth factor 2 receptor 0.0143135
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0143098
IL1RAP interleukin 1 receptor accessory protein 0.0142726
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0141956
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0141402
BIRC6 baculoviral IAP repeat containing 6 0.014124

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.10889
GLIS3 GLIS family zinc finger 3 -0.0980156
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0885333
HMGA2 high mobility group AT-hook 2 -0.0604875
CDH13 cadherin 13 -0.056524
FTH1 ferritin, heavy polypeptide 1 -0.0512687
TMSB10 thymosin beta 10 -0.0485894
COL6A3 collagen, type VI, alpha 3 -0.0429143
FTL ferritin, light polypeptide -0.0398316
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0395722
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0371656
FRMD4A FERM domain containing 4A -0.036619
IER3 immediate early response 3 -0.0355719
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0353843
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0352431
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0346297
VEGFA vascular endothelial growth factor A -0.0341018
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0329822
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0326575
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0324831
HLA-B major histocompatibility complex, class I, B -0.0323929
EGR1 early growth response 1 -0.0318901
RAI14 retinoic acid induced 14 -0.0315349
VCL vinculin -0.0315229
FN1 fibronectin 1 -0.0306667
EFNA5 ephrin-A5 -0.0279954
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0277371
TPM1 tropomyosin 1 (alpha) -0.0273699
SOX5 SRY (sex determining region Y)-box 5 -0.0272831
CTSD cathepsin D -0.026403
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) -0.0258424
DST dystonin -0.025652
CLMP CXADR-like membrane protein -0.025378
EGFR epidermal growth factor receptor -0.0249462
C3 complement component 3 -0.0249267
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0246579
ADAM12 ADAM metallopeptidase domain 12 -0.0244325
FRMPD4 FERM and PDZ domain containing 4 -0.0243167
AKAP12 A kinase (PRKA) anchor protein 12 -0.0239623
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0239422
HLA-A major histocompatibility complex, class I, A -0.0236152
CD44 CD44 molecule (Indian blood group) -0.0234484
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0233793
EEF2 eukaryotic translation elongation factor 2 -0.0232654
ASPH aspartate beta-hydroxylase -0.0231267
TGFBI transforming growth factor, beta-induced, 68kDa -0.0227407
SAMD3 sterile alpha motif domain containing 3 -0.0226621
HMGA1 high mobility group AT-hook 1 -0.0224609
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0222601
ACTG1 actin gamma 1 -0.0216143
TMEM132D transmembrane protein 132D -0.0214651
VIM vimentin -0.0214482
FBXL7 F-box and leucine-rich repeat protein 7 -0.0212992
NAV1 neuron navigator 1 -0.0212133
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0211345
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0211335
AFF3 AF4/FMR2 family, member 3 -0.0205404
SFRP1 secreted frizzled-related protein 1 -0.0194094
NABP1 nucleic acid binding protein 1 -0.0193737
RPS6 ribosomal protein S6 -0.0191983
CTSB cathepsin B -0.0185234
DIAPH2 diaphanous-related formin 2 -0.0184284
VCAN versican -0.0183841
COL5A1 collagen, type V, alpha 1 -0.0180906
ENO2 enolase 2 (gamma, neuronal) -0.0180594
RAD51B RAD51 paralog B -0.0179508
NRP1 neuropilin 1 -0.0177302
INTS6 integrator complex subunit 6 -0.0176953
BICC1 BicC family RNA binding protein 1 -0.0176497
MACF1 microtubule-actin crosslinking factor 1 -0.0175117
COL6A1 collagen, type VI, alpha 1 -0.0172078
WDR27 WD repeat domain 27 -0.0170783
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0170175
RNF213 ring finger protein 213 -0.0169743
ZMYND8 zinc finger, MYND-type containing 8 -0.0168486
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) -0.0164585
SLC38A1 solute carrier family 38, member 1 -0.0161535
PRKG1 protein kinase, cGMP-dependent, type I -0.0160525
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0158809
ADAMTS12 ADAM metallopeptidase with thrombospondin type 1 motif, 12 -0.0157693
TENM2 teneurin transmembrane protein 2 -0.0155819
BNC2 basonuclin 2 -0.0154692
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0153495
PTPRK protein tyrosine phosphatase, receptor type, K -0.0152285
NCKAP5 NCK-associated protein 5 -0.0150281
IARS1 isoleucyl-tRNA synthetase 1 -0.0149928
EPAS1 endothelial PAS domain protein 1 -0.0149097
PLIN2 perilipin 2 -0.014744
MAML2 mastermind-like 2 (Drosophila) -0.0146537
PKM pyruvate kinase, muscle -0.0145162
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A -0.0143237
ZBTB20 zinc finger and BTB domain containing 20 -0.0141741
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0141346
RPS10 ribosomal protein S10 -0.0139742
CNTN6 contactin 6 -0.0139417
PALLD palladin, cytoskeletal associated protein -0.0138504
KRT19 keratin 19, type I -0.0136883
DPYD dihydropyrimidine dehydrogenase -0.0136805
RPL37A ribosomal protein L37a -0.0136539
LOX lysyl oxidase -0.0136229